Mette Rosenkilde

Research output

Research output per year 1997 2004 2006 2011 2012 2014 2015 2016 2017 2018 2019 2020

• 154 Journal article
• 5 Review
• 4 Book chapter
• 3 Conference article
• 6 More
  • 2 Conference abstract in journal
  • 1 Report chapter
  • 1 Conference abstract for conference
  • 1 Letter
  • 1 Patent

Research output per year

Research output per year

Search results

• 2011

  EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors

  Nørregaard, K., Benned-Jensen, T. & Rosenkilde, M. M., 2011, In: Current Topics in Medicinal Chemistry. 11, 6, p. 618-28 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Drug Target 100%
  • Complement 3d Receptors 67%
  • Drug Industry 50%
  • Human Genome 45%
  • Pharmaceutical Industry 45%
  9 Citations (Scopus)

• Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

  Torekov, S. S., Ma, L., Grarup, N., Hartmann, B., Hainerová, I. A., Kielgast, U., Kissow, H., Rosenkilde, M., Lebl, J., Witte, D. R., Jørgensen, T., Sandbaek, A., Lauritzen, T., Madsen, O. D., Wang, J., Linneberg, A., Madsbad, S., Holst, J. J., Hansen, T., Pedersen, O., & 1 othersGIANT Consortium, Nov 2011, In: Diabetologia. 54, 11, p. 2820-31 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Glucagon 88%
  • Fasting 68%
  • Alleles 62%
  • Insulin 58%
  13 Citations (Scopus)

• Ligand Modulation of the Epstein-Barr Virus-induced Seven-transmembrane Receptor EBI2: IDENTIFICATION OF A POTENT AND EFFICACIOUS INVERSE AGONIST

  Benned-Jensen, T., Smethurst, C., Holst, P. J., Page, K. R., Sauls, H., Sivertsen, B. B., Schwartz, T. W., Blanchard, A., Jepras, R. & Rosenkilde, M. M., 19 Aug 2011, In: Journal of Biological Chemistry. 286, p. 29292-29302 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Complement 3d Receptors 100%
  • Inverse Agonist 91%
  • Virus Receptors 87%
  • Human Herpesvirus 4 64%
  • 8-(3-(4-chlorophenyl)prop-2-enoyl)-3-((3,4-dichlorophenyl)methyl)-1-oxa-3,8-diazaspiro(4.5)decan-2-one 49%
  25 Citations (Scopus)

• Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues

  Farrell, H. E., Abraham, A. M., Cardin, R. D., Sparre-Ulrich, A. H., Rosenkilde, M. M., Spiess, K., Jensen, T. H., Kledal, T. N. & Davis-Poynter, N., Jun 2011, In: Journal of Virology. 85, 12, p. 6091-5 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • cytomegalovirus receptor 100%
  • Murid betaherpesvirus 1 99%
  • chemokine receptors 81%
  • Human betaherpesvirus 5 77%
  • Muromegalovirus 73%
  26 Citations (Scopus)

• Reversed binding of a small molecule ligand in homologous chemokine receptors – differential role of extracellular loop 2.

  Rummel, P. C., Thiele, S., Steen, A. M. F., Elder, A., Kolbech, R., Ghosh, S., Frimurer, T. M. & Rosenkilde, M. M., 2011, In: British Journal of Pharmacology. 166

  Research output: Contribution to journal › Journal article › Research › peer-review

• The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling

  Benned-Jensen, T., Mokrosinski, J. & Rosenkilde, M. M., 13 Sept 2011, In: P L o S One. 6, 9, p. e24644

  Research output: Contribution to journal › Journal article › Research › peer-review

  • arrestins 100%
  • Receptor, Melanocortin, Type 1 99%
  • Arrestin 92%
  • alpha-melanocyte-stimulating hormone 83%
  • Receptor 81%
  24 Citations (Scopus)

• Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain

  Ugleholdt, R., Pedersen, J., Bassi, M. R., Füchtbauer, E-M., Jørgensen, S. M., Kissow, H., Nytofte, N., Poulsen, S. S., Rosenkilde, M. M., Seino, Y., Thams, P., Holst, P. J. & Holst, J. J., 30 Dec 2011, In: The Journal of Biological Chemistry. 286, 52, p. 44632-44645 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • gastric inhibitory polypeptide receptor 100%
  • Insulinotropic 99%
  • Weight Gain 75%
  • High Fat Diet 59%
  • Fat 58%
  30 Citations (Scopus)
• 2010

  Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

  Benned-Jensen, T. & Rosenkilde, M. M., Mar 2010, In: British Journal of Pharmacology. 159, 5, p. 1092-105 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Protein Isoforms 100%
  • Ligands 87%
  • cysteinyl-leukotriene 35%
  • Uracil Nucleotides 19%
  • Uridine Diphosphate Galactose 19%
  49 Citations (Scopus)

• The minor binding pocket: a major player in 7TM receptor activation

  Rosenkilde, M. M., Benned-Jensen, T., Frimurer, T. M. & Schwartz, T. W., Dec 2010, In: Trends in Pharmacological Sciences. 31, 12, p. 567-574 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proline Residue 100%
  • Angiotensin 96%
  • Proline 80%
  • Arrestin 54%
  • Hydrogen Bond 45%
  94 Citations (Scopus)

• Treatment of insulin resistance and obesity by stimulating GLP-1 release

  Hansen, H. S., Diep, T. A., Holst, J. J., Rosenkilde, M. M. & Andersen, N. W., 29 Dec 2010, IPC No. A61K 31/23, Patent No. PCT/DK2010/050161, 24 Jun 2010

  Research output: Patent
• 2009

  Chapter 8. Activation mechanisms of chemokine receptors

  Jensen, P. C. & Rosenkilde, M. M., 2009, In: Methods in Enzymology. 461, p. 171-90 19 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chemokine Receptors 100%
  • Chemokines 69%
  • Ligands 62%
  • Ligand 27%
  • Allosteric Site 21%
  13 Citations (Scopus)

• Ligand binding and micro-switches in 7TM receptor structures

  Nygaard, R., Frimurer, T. M., Holst, B., Rosenkilde, M. M. & Schwartz, T. W., 2009, In: TIPS - Trends in Pharmacological Sciences. 30, 5, p. 249-59 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • GTP-Binding Proteins 100%
  • Antagonist 92%
  • Inverse Agonist 70%
  • Ligands 70%
  • Peptide Fragments 66%
  255 Citations (Scopus)

• Targeting CXCR4 in HIV Cell-Entry Inhibition

  Steen, A., Schwartz, T. W. & Rosenkilde, M. M., Dec 2009, In: Mini reviews in medicinal chemistry. 9, 14, p. 1605-21 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptoids 100%
  • Chemokine Receptor CXCR4 Antagonist 98%
  • HIV-1 97%
  • Chemokines 79%
  • Antagonist 78%
  24 Citations (Scopus)

• The role of transmembrane segment II in 7TM receptor activation

  Benned-Jensen, T. & Rosenkilde, M. M., Jun 2009, In: Current Molecular Pharmacology. 2, 2, p. 140-8 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ghrelin 100%
  • Melanocortin 92%
  • Retinal 68%
  • Melanocortin Receptors 45%
  • Ghrelin Receptor 42%
  10 Citations (Scopus)
• 2008

  Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

  Jensen, P. C., Thiele, S., Ulven, T., Schwartz, T. W. & Rosenkilde, M. M., 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-8 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CCR1 Receptors 100%
  • Agonist 55%
  • Chemokines 54%
  • Ligands 40%
  • Enhancer 34%
  42 Citations (Scopus)

• Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

  Jensen, P. C., Thiele, S., Ulven, T., Schwartz, T. W. & Rosenkilde, M. M., 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CCR1 Receptors 100%
  • Agonist 55%
  • Chemokines 54%
  • Ligands 40%
  • Enhancer 34%

• Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist

  Benned-Jensen, T. & Rosenkilde, M. M., 2008, In: Molecular Pharmacology. 74, 4, p. 1008-21 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Guanosine 5'-O-(3-Thiotriphosphate) 100%
  • Activation Analysis 99%
  • Cyclic AMP Response Element-Binding Protein 88%
  • Static Electricity 82%
  • Drug Development 66%
  24 Citations (Scopus)

• Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors

  Rosenkilde, M. M., Smit, M. J. & Waldhoer, M., 2008, In: British Journal of Pharmacology. 153 Suppl 1, p. S154-66

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chemokine Receptors 100%
  • Chemokines 83%
  • Virus Receptors 80%
  • seven-transmembrane G-protein-coupled receptor 46%
  • Immune Evasion 37%
  39 Citations (Scopus)
• 2007

  Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.

  Simonsen, L., Pilgaard, S., Orskov, C., Rosenkilde, M. M., Hartmann, B., Holst, J. J. & Deacon, C. F., 2007, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G288-95

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Exenatide 100%
  • Dipeptidyl Peptidase 4 98%
  • Dipeptidyl-Peptidase IV Inhibitors 96%
  • Glucagon-Like Peptide 2 46%
  • NN 7201 37%
  31 Citations (Scopus)

• Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo

  Case, R., Sharp, E., Benned-Jensen, T., Rosenkilde, M. M., Davis-Poynter, N. & Farrell, H. E., 2007, In: Journal of Virology. 82, 4, p. 1884-98 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mouse cytomegalovirus 1 MCK-2 protein 100%
  • cytomegalovirus receptor 82%
  • chemokine receptors 67%
  • Muromegalovirus 60%
  • Cytomegalovirus 60%
  36 Citations (Scopus)

• Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3

  Lüttichau, H. R., Johnsen, A. H., Jurlander, J., Rosenkilde, M. M. & Schwartz, T. W., 2007, In: Journal of Biological Chemistry. 282, 24, p. 17794-805 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • lymphotactin 100%
  • Satellite Viruses 80%
  • Kaposi's Sarcoma 69%
  • Agonist 56%
  • Chemokines 55%
  33 Citations (Scopus)

• Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor

  Hatse, S., Huskens, D., Princen, K., Vermeire, K., Bridger, G. J., De Clercq, E., Rosenkilde, M. M., Schwartz, T. W. & Schols, D., 2007, In: Journal of Virology. 81, 7, p. 3632-9 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CXCR3 receptor 100%
  • CXCR3 Receptors 76%
  • Human immunodeficiency virus 67%
  • ligands 43%
  • Ligands 33%
  9 Citations (Scopus)

• Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8

  Jensen, P. C., Nygaard, R., Thiele, S., Elder, A., Zhu, G., Kolbeck, R., Ghosh, S., Schwartz, T. W. & Rosenkilde, M. M., 2007, In: Molecular Pharmacology. 72, 2, p. 327-40 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CCR Receptors 100%
  • Chemokine Receptors 73%
  • Amines 68%
  • Glutamic Acid 57%
  • Benzoic Acid 46%
  42 Citations (Scopus)

• Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor

  Rosenkilde, M. M., Gerlach, L-O., Hatse, S., Skerlj, R. T., Schols, D., Bridger, G. J. & Schwartz, T. W., 2007, In: Journal of Biological Chemistry. 282, 37, p. 27354-65 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • N-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylenebis(methylene))-2-(aminomethyl)- pyridine 100%
  • Chemokine Receptor CXCR4 Antagonist 84%
  • cyclam 77%
  • plerixafor octahydrochloride 70%
  • CXCR4 Receptors 66%
  96 Citations (Scopus)

• Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects

  Pedersen, N. B., Hjøllund, K. R., Johnsen, A. H., Ørskov, C., Rosenkilde, M. M., Hartmann, B. & Holst, J. J., 2007, In: Regulatory Peptides. 146, 1-3, p. 310-320 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 2 100%
  • Swine 39%
  • Pharmacological Metabolism 38%
  • Metabolic Clearance Rate 12%
  • valine-pyrrolidide 12%
  25 Citations (Scopus)
• 2006

  Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI

  Rosenkilde, M. M., Andersen, M. B., Nygaard, R., Frimurer, T. M. & Schwartz, T. W., 2006, In: Molecular Pharmacology. 71, 3, p. 930-41 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CXCR3 Receptors 100%
  • Chemokine Receptors 69%
  • Chelating Agents 69%
  • Metals 53%
  • Ions 51%
  40 Citations (Scopus)

• Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V

  Rosenkilde, M. M., David, R., Oerlecke, I., Benned-Jensen, T., Geumann, U., Beck-Sickinger, A. G. & Schwartz, T. W., 2006, In: Molecular Pharmacology. 70, 6, p. 1892-901 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Metals 100%
  • CXCR Receptors 97%
  • Ions 95%
  • Chemokines 54%
  • Human Herpesvirus 8 37%
  12 Citations (Scopus)

• GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.

  Deacon, C. F., Plamboeck, A., Rosenkilde, M. M., de Heer, J. & Holst, J. J., 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 3, p. E468-75

  Research output: Contribution to journal › Journal article › Research › peer-review

  • gastric inhibitory polypeptide (3-42) 100%
  • gastric inhibitory polypeptide (1-42) 70%
  • gastric inhibitory polypeptide receptor 16%
  • Dipeptidyl Peptidase 4 12%
  • Insulin 9%
  48 Citations (Scopus)

• GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors

  Rosenkilde, M. M. & Schwartz, T. W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-33 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chemokine Receptors 100%
  • Ligands 62%
  • Ligand 38%
  • Glutamic Acid Residue 20%
  • CCR1 Receptors 19%
  51 Citations (Scopus)

• GluVII : 06 - a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors

  Rosenkilde, M. M. & Schwartz, T. W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-1333 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Molecular mechanism of 7TM receptor activation--a global toggle switch model

  Schwartz, T. W., Frimurer, T. M., Holst, B., Rosenkilde, M. M. & Elling, C. E., 2006, In: Annual Review of Pharmacology and Toxicology. 46, p. 481-519 38 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Agonist 100%
  • Ligands 73%
  • Proline 55%
  • Adhesives 49%
  • Catalytic Domain 47%
  327 Citations (Scopus)

• Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity

  Rosenkilde, M. M., Benned-Jensen, T., Holst, P. J., Kledal, T. N., Lüttichau, H. R., Larsen, J. K., Christensen, J. P., Schwartz, T. W. & Andersen, H., 2006, In: Journal of Biological Chemistry. 281, 19, p. 13199-208 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Human Herpesvirus 4 100%
  • Pharmacology 67%
  • Inositol Phosphate 46%
  • Confocal Microscopy 38%
  • Green 23%
  79 Citations (Scopus)

• Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor

  Ugleholdt, R., Poulsen, M-L. H., Holst, P. J., Irminger, J-C., Orskov, C., Pedersen, J., Rosenkilde, M. M., Zhu, X., Steiner, D. F. & Holst, J. J., 2006, In: Journal of Biological Chemistry. 281, 16, p. 11050-7 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Insulinotropic 100%
  • Proprotein Convertase 1 99%
  • Prohormone 92%
  • Polypeptide 49%
  • Peptides 38%
  71 Citations (Scopus)

• Targeting herpesvirus reliance of the chemokine system

  Rosenkilde, M. M. & Kledal, T. N., 2006, In: Current Drug Targets. 7, 1, p. 103-18 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Herpesviridae 100%
  • Chemokines 81%
  • Chemokine Receptors 72%
  • Viruses 43%
  • Drug Target 39%
  18 Citations (Scopus)
• 2005

  AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

  Hatse, S., Princen, K., De Clercq, E., Rosenkilde, M. M., Schwartz, T. W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • N-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylenebis(methylene))-2-(aminomethyl)- pyridine 100%
  • Chemokine Receptor CXCR4 Antagonist 84%
  • plerixafor octahydrochloride 61%
  • Virus Internalization 59%
  • HIV 33%
  108 Citations (Scopus)

• Epstein Barr Virus encoded BILF1 is a constitutively active G-protein coupled receptor

  Paulsen, S., Rosenkilde, M. M., Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. Vol. 79, no. 1, p. 536-46

  Research output: Contribution to journal › Journal article › Research › peer-review

  97 Citations (Scopus)

• Epstein-Barr virus-kodet BILF1 er en konstitutivt aktiv G-protein-koblede receptor

  Paulsen, S. J., Rosenkilde, M. M., Eugen-Olsen, J. & Kledal, T. N., 2005, In: Journal of Virology. 79, 1, p. 536-46 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Human gammaherpesvirus 4 100%
  • Herpesviridae 89%
  • G-proteins 79%
  • GTP-Binding Proteins 74%
  • Human Herpesvirus 4 74%
  97 Citations (Scopus)

• High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3

  Rosenkilde, M. M., Kledal, T. N. & Schwartz, T. W., 2005, In: Molecular Pharmacology. 68, 1, p. 11-9 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Rhadinovirus 100%
  • GTP-Binding Proteins 60%
  • Open Reading Frames 58%
  • Inositol Phosphates 51%
  • Cyclic AMP Response Element-Binding Protein 51%
  51 Citations (Scopus)

• High content screening for G protein-coupled receptors using cell-based protein translocation assays

  Grånäs, C., Lundholt, B. K., Heydorn, A., Linde, V., Pedersen, H-C., Krog-Jensen, C., Rosenkilde, M. M. & Pagliaro, L., 2005, In: Combinatorial Chemistry & High Throughput Screening. 8, 4, p. 301-9 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Assays 100%
  • Drug Target 98%
  • Protein Transport 95%
  • G-Protein-Coupled Receptors 86%
  • Screening 79%
  29 Citations (Scopus)

• Virus-encoded chemokine receptors--putative novel antiviral drug targets

  Rosenkilde, M. M., 2005, In: Neuropharmacology. 48, 1, p. 1-13 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chemokine Receptors 100%
  • Chemokines 83%
  • Antiviral Agents 76%
  • Viruses 59%
  • Carrier Proteins 25%
  30 Citations (Scopus)

• Virus-encoded chemokine receptors - putative novel innovative drug targets

  Rosenkilde, M. M., 2005, In: Neuropharmacology. Vol. 48, no. 1, p. 1-13

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2004

  A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity

  Kostenis, E., Martini, L., Ellis, J., Waldhoer, M., Heydorn, A., Rosenkilde, M. M., Norregaard, P. K., Jorgensen, R., Whistler, J. L. & Milligan, G., 2004, In: Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 78-87 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • GTP-Binding Protein alpha Subunits 100%
  • Glycine 70%
  • G-Protein-Coupled Receptors 69%
  • Proteins 25%
  • Guanine Nucleotides 12%
  46 Citations (Scopus)

• Constitutive and regulated activities of virus-encoded 7TM receptors

  Rosenkilde, M. M. & Schwartz, T. W., 2004, Handbook of Cellular Signalling. Chapter 29 ed. p. 173-76

  Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research

• Det chemokine system - en vigtig regulator af angiogenese i sundhed og sygdom

  Rosenkilde, M. M. & Schwartz, T. W., 2004, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 112, 7-8, p. 481-95 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chemokines 100%
  • Herpesviridae 27%
  • Interleukin-8 22%
  • Mite Infestations 19%
  • Interleukin-8B Receptors 18%
  197 Citations (Scopus)

• Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction

  Heydorn, A., Ward, R. J., Jorgensen, R., Rosenkilde, M. M., Frimurer, T. M., Milligan, G. & Kostenis, E., 2004, In: Molecular Pharmacology. Vol. 66, no. 2, p. 250-9

  Research output: Contribution to journal › Journal article › Research › peer-review

• Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist

  Princen, K., Hatse, S., Vermeire, K., Aquaro, S., De Clercq, E., Gerlach, L-O., Rosenkilde, M., Schwartz, T. W., Skerlj, R., Bridger, G. & Schols, D., 2004, In: Journal of Virology. 78, 23, p. 12996-3006 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 1-((2,6-dichloropyridin-4-yl)methyl)-1,4,8,11-tetrazacyclotetradecane 100%
  • Human immunodeficiency virus 54%
  • virus replication 43%
  • Virus Replication 39%
  • antagonists 33%
  74 Citations (Scopus)

• Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

  Rosenkilde, M. M., Gerlach, L-O., Jakobsen, J. S., Skerlj, R. T., Bridger, G. J. & Schwartz, T. W., 2004, In: Journal of Biological Chemistry. 279, 4, p. 3033-41 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CXCR3 Receptors 100%
  • plerixafor octahydrochloride 90%
  • CXCR4 Receptors 85%
  • Antagonist 57%
  • Viperidae 52%
  194 Citations (Scopus)

• Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

  Rosenkilde, M. M., Gerlach, L-O., Jakobsen, J. S., Skerlj, R. T., Bridger, G. & Schwartz, T. W., 2004, In: Journal of Biological Chemistry. VOl. 279, no. 4, p. 3033-41

  Research output: Contribution to journal › Journal article › Research › peer-review

  194 Citations (Scopus)

• Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74

  McLean, K. A., Holst, P. J., Martini, L., Schwartz, T. W. & Rosenkilde, M. M., 2004, In: Virology. 325, 2, p. 241-51 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • NFATC Transcription Factors 100%
  • Cyclic AMP Response Element-Binding Protein 94%
  • Herpesviridae 86%
  • Chemokine Receptors 83%
  • Cytomegalovirus 74%
  64 Citations (Scopus)

• The chemokine system - a major regulator of angiogenesis in health and disease

  Rosenkilde, M. M. & Schwartz, T. W., 2004, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. Vol. 112, 7-8, p. 481-95

  Research output: Contribution to journal › Journal article › Research › peer-review

  197 Citations (Scopus)