Maria Hauge Pedersen

Research output

Research output per year 2012 2013 2015 2016 2017 2017

• 11 Journal article

Research output per year

Research output per year

Search results

• 2017

  Gq and Gs signaling acting in synergy to control GLP-1 secretion

  Pedersen, M. H., Ekberg, J. H., Engelstoft, M. S., Timshel, P., Madsen, A. N. & Schwartz, T. W., 5 Jul 2017, In: Molecular and Cellular Endocrinology. 449, p. 64-73

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glucagon-Like Peptide 1 100%
  • Agonist 81%
  • Artificial Cells 39%
  • Glycerol 29%
  • Bile Acids and Salts 29%
  24 Citations (Scopus)

• Single-molecule analysis of ligand efficacy in β₂AR-G-protein activation

  Gregorio, G. G., Masureel, M., Hilger, D., Terry, D. S., Juette, M., Zhao, H., Zhou, Z., Perez-Aguilar, J. M., Hauge, M., Mathiasen, S., Javitch, J. A., Weinstein, H., Kobilka, B. K. & Blanchard, S. C., 6 Jul 2017, In: Nature. 547, 7661, p. 68–73

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Single Molecule Imaging 100%
  • GTP-Binding Proteins 72%
  • Adrenergic Receptors 69%
  • Nucleotides 58%
  • Ligands 51%
  129 Citations (Scopus)
• 2016

  Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119

  Hassing, H. A., Fares, S., Larsen, O., Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, T. W., Hansen, H. S. & Rosenkilde, M. M., 1 Nov 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • oleoylethanolamide 100%
  • AR 231453 85%
  • Agonist 56%
  • N-Acylethanolamine 50%
  • Emax 46%
  27 Citations (Scopus)

  170 Downloads (Pure)

• Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population

  Vestmar, M. A., Galijatovic, E. A. A., Christensen, C. R., Pedersen, M. H., Glümer, C., Linneberg, A., Witte, D. R., Jørgensen, M. E., Christensen, C., Brandslund, I., Lauritzen, T., Pedersen, O., Holst, B., Grarup, N., Schwartz, T. W. & Hansen, T., 1 Sept 2016, In: Journal of Medical Genetics. 53, 9, p. 616-23 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Arrestin 100%
  • Obesity 72%
  • Population 54%
  • Ligands 48%
  • In Vitro Techniques 45%
  10 Citations (Scopus)

• GPR119 - a major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Co-acting in Synergy with FFA1 (GPR40)

  Ekberg, J. H., Pedersen, M. H., Kristensen, L. V., Madsen, A. N., Engelstoft, M. S., Husted, A-S., Sichlau, R., Egerod, K. L., Timshel, P., Kowalski, T. J., Gribble, F. M., Reiman, F., Hansen, H. S., Howard, A. D., Holst, B. & Schwartz, T. W., Dec 2016, In: Endocrinology. 157, 12, p. 4561-4569 9 p., en20161334.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Triglyceride 100%
  • Agonist 90%
  • Triglycerides 76%
  • Metabolite 66%
  • Glucagon-Like Peptide 1 63%
  47 Citations (Scopus)
• 2015

  GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

  Pedersen, M. H., Bentsen, M. A., Husted, A. S., Ekberg, J. P., Wright, M. J., Di Salvo, J., Weinglass, A. B., Engelstoft, M. S., Madsen, A. N., Lückmann, M., Miller, M. W., Trujillo, M. E., Frimurer, T. M., Holst, B., Howard, A. D. & Schwartz, T. W., 1 Jan 2015, In: Molecular Metabolism. 4, 1, p. 3-14 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • TAK-875 100%
  • Incretins 89%
  • Secretagogues 84%
  • 3-cyclopropyl-3-(3-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-(1,1'-biphenyl)-4-yl)methoxy)phenyl)propanoic acid 79%
  • Glucagon-Like Peptide 1 60%
  124 Citations (Scopus)

• Mutation-Guided Unbiased Modeling of the Fat Sensor GPR119 for High-Yield Agonist Screening.

  Norn, C., Pedersen, M. H., Engelstoft, M. S., Kim, S. H., Lehmann, J., Jones, R. M., Schwartz, T. W. & Frimurer, T. M., 1 Dec 2015, In: Structure. 23, 12, p. 2377-2386 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • AR 231453 100%
  • Fat 90%
  • Agonist 87%
  • Fats 68%
  • Ligands 64%
  5 Citations (Scopus)
• 2014

  Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119

  Engelstoft, M. S., Norn, C., Pedersen, M. H., Holliday, N. D., Elster, L., Lehmann, J., Jones, R. M., Frimurer, T. M. & Schwartz, T. W., Dec 2014, In: British Journal of Pharmacology. 171, 24, p. 5774-89 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • AR 231453 100%
  • oleoylethanolamide 77%
  • Fats 34%
  • Ligands 32%
  • Drug Discovery 31%
  18 Citations (Scopus)
• 2013

  GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes

  Nøhr, M. K., Pedersen, M. H., Gille, A., Egerod, K. L., Engelstoft, M. S., Husted, A. S., Sichlau, R. M., Grunddal, K. V., Seier Poulsen, S., Han, S., Jones, R. M., Offermanns, S. & Schwartz, T. W., 1 Oct 2013, In: Endocrinology.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Enteroendocrine Cells 100%
  • Short-Chain Fatty Acid 97%
  • Enteric Coating 95%
  • Volatile Fatty Acids 88%
  • Nonesterified Fatty Acids 73%
  272 Citations (Scopus)

• Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

  Engelstoft, M. S., Park, W-M., Sakata, I., Kristensen, L. V., Husted, A. S., Osborne-Lawrence, S., Piper, P. K., Walker, A. K., Pedersen, M. H., Nøhr, M. K., Pan, J., Sinz, C. J., Carrington, P. E., Akiyama, T. E., Jones, R. M., Tang, C., Ahmed, K., Offermanns, S., Egerod, K. L., Zigman, J. M., & 1 othersSchwartz, T. W., Nov 2013, In: Molecular Metabolism. 2, 4, p. 376-92 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • seven-transmembrane G-protein-coupled receptor 100%
  • Ghrelin 75%
  • Stomach 45%
  • Pertussis Toxin 16%
  • secretin receptor 11%
  192 Citations (Scopus)
• 2012

  Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36

  Pedersen, S. L., Bhatia, V. K., Jurt, S., Paulsson, J. F., Pedersen, M. H., Jørgensen, R., Holst, B., Stamou, D., Vrang, N., Zerbe, O. & Jensen, K. J., Sept 2012, In: Journal of Peptide Science. 18, 9, p. 579-587 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Peptide Hormone 100%
  • Peptide Hormones 91%
  • Spin Label 45%
  • Membranes 45%
  • Peptide 44%
  7 Citations (Scopus)