Kristine Freude

2019

Cell type specific expression of toll-like receptors in human brains and implications in Alzheimer's disease

Frederiksen, H. R., Haukedal, H. & Freude, K., 2019, In: BioMed Research International. 2019, 18 p., 7420189.

Research output: Contribution to journal › Review › peer-review

14 Citations (Scopus)

15 Downloads (Pure)

Dementia, Brain Disorders and Molecular Mechanisms

Freude, K. & Krauss, S., 19 Apr 2019, In: Journal of Molecular Biology. 431, 9, p. 1709-1710

Research output: Contribution to journal › Editorial

1 Citation (Scopus)

Generation of two iPSC lines with either a heterozygous V717I or a heterozygous KM670/671NL mutation in the APP gene

Frederiksen, H. R., Holst, B., Ramakrishna, S., Muddashetty, R., Schmid, B. & Freude, K., 1 Jan 2019, In: Stem Cell Research. 34, 5 p., 101368.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

61 Downloads (Pure)

Generation of two isogenic iPSC lines with either a heterozygous or a homozygous E280A mutation in the PSEN1 gene.

Frederiksen, H. R. S., Holst, B., Mau-Holzmann, U. A., Freude, K. & Schmid, B., Mar 2019, In: Stem Cell Research. 35, 4 p., 101403.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

44 Downloads (Pure)

Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Haukedal, H. & Freude, K., 19 Apr 2019, In: Journal of Molecular Biology. 431, 9, p. 1818-1829

Research output: Contribution to journal › Review › peer-review

14 Citations (Scopus)

Induced pluripotent stem cells throughout the animal kingdom: Availability and applications

Pessôa, L. V. D. F., Bressan, F. F. & Freude, K. K., 2019, In: World Journal of Stem Cells. 11, 8, p. 491-505 15 p.

Research output: Contribution to journal › Review › peer-review

15 Citations (Scopus)

12 Downloads (Pure)

Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

Kobolák, J., Molnár, K., Varga, E., Bock, I., Jezsó, B., Téglási, A., Zhou, S., Lo Giudice, M., Hoogeveen-Westerveld, M., Pijnappel, WWM. P., Phanthong, P., Varga, N., Kitiyanant, N., Freude, K., Nakanishi, H., László, L., Hyttel, P. & Dinnyés, A., 2019, In: Experimental Cell Research. 380, 2, p. 216-233 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

42 Downloads (Pure)

Oocytes, embryos and pluripotent stem cells from a biomedical perspective

Hyttel, P., Pessôa, L. V. D. F., Secher, J. B. M., Dittlau, K. S., Freude, K., Hall, V. J., Fair, T., Assey, R. J., Laurincik, J., Callesen, H., Greve, T. & Stroebech, L. B., 2019, In: Animal Reproduction. 16, 3, p. 508-523 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

13 Downloads (Pure)

2018

Essential Roles of Lactate in Müller Cell Survival and Function

Vohra, R., Aldana Garcia, B. I., Skytt, D. M., Freude, K., Waagepetersen, H. S., Bergersen, L. H. & Kolko, M., 1 Dec 2018, In: Molecular Neurobiology. 55, 12, p. 9108-9121 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Generation of transgene-free porcine intermediate type induced pluripotent stem cells

Li, D., Secher, J., Hyttel, P., Ivask, M., Kolko, M., Hall, V. J. & Freude, K. K., 2018, In: Cell Cycle. 17, 23, p. 2547-2563 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Mammalian embryo comparison identifies novel pluripotency genes associated with the naive or primed state

Bernardo, A. S., Jouneau, A., Marks, H., Kensche, P., Kobolak, J., Freude, K., Hall, V., Feher, A., Polgar, Z., Sartori, C., Bock, I., Louet, C., Faial, T., Kerstens, H. H. D., Bouissou, C., Parsonage, G., Mashayekhi, K., Smith, J. C., Lazzari, G., Hyttel, P., & 4 othersStunnenberg, H. G., Huynen, M., Pedersen, R. A. & Dinnyes, A., 2018, In: Biology Open. 7, 8, 17 p., bio033282.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

72 Downloads (Pure)

Muller cell survival and function is maintained by the presence of lactate

Vohra, R., Skytt, D. M., Aldana, B. I., Freude, K., Waagepetersen, H., Bergersen, L. H. & Kolko, M., Jul 2018, p. 1480. 1 p.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

WebCircRNA: Classifying the Circular RNA Potential of Coding and Noncoding RNA.

Pan, X., Xiong, K., Anthon, C., Hyttel, P., Freude, K., Jensen, L. J. & Gorodkin, J., 6 Nov 2018, In: Genes. 9, 11, 11 p., 536.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

43 Downloads (Pure)

2017

Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons

Aldana, B. I., Zhang, Y., Lihme, M. F., Bak, L. K., Nielsen, J. E., Holst, B., Hyttel, P., Freude, K. K. & Waagepetersen, H. S., Jun 2017, In: Neurochemistry International. 106, p. 48-61

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

45 Downloads (Pure)

Evaluation of porcine stem cell competence for somatic cell nuclear transfer and production of cloned animals

Secher, J. O. B., Liu, Y., Petkov, S. G., Li, D., Hall, V. J., Schmidt, M., Callesen, H., Freude, K. & Hyttel, P., 1 Mar 2017, In: Animal Reproduction Science. 178, p. 40-49

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Identification of potential biomarkers in donor cows for in vitro embryo production by granulosa cell transcriptomics

Mazzoni, G., Salleh, S. M., Freude, K., Pedersen, H. S., Stroebech, L., Callesen, H., Hyttel, P. & Kadarmideen, H. N., 2017, In: PLOS ONE. 12, 4, 27 p., e0175464.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

76 Downloads (Pure)

Identification of SSEA-1 expressing enhanced reprogramming (SEER) cells in porcine embryonic fibroblasts

Li, D., Secher, J. O. B., Juhl, M., Mashayekhi-Nezamabadi, K., Nielsen, T. T., Holst, B., Hyttel, P., Freude, K. & Hall, V. J., 3 Jun 2017, In: Cell Cycle. 16, 11, p. 1070-1084

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

In vitro production of bovine embryos: Cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competence

Mazzoni, G., Razza, E., Pedersen, H. S., Secher, J., Kadarmideen, H. N., Callesen, H., Stroebech, L., Freude, K. & Hyttel, P., 2017, In: Animal Reproduction. 14, 3, p. 482-489 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency

Yan, Z., Al-Saaidi, R. A., Fernandez Guerra, P., Freude, K., Olsen, R. K. J., Jensen, U. B., Gregersen, N., Hyttel, P., Bolund, L., Aagaard, L., Bross, P. & Luo, Y., 1 Feb 2017, In: Stem Cells and Development. 26, 3, p. 166-176

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges

Poon, A., Zhang, Y., Chandrasekaran, A., Phanthong, P., Schmid, B., Nielsen, T. T. & Freude, K. K., 25 Oct 2017, In: New Biotechnology. 39, Part B, p. 190-198

Research output: Contribution to journal › Review › peer-review

27 Citations (Scopus)

Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Ochalek, A., Mihalik, B., Avci, H. X., Chandrasekaran, A., Téglási, A., Bock, I., Giudice, M. L., Táncos, Z., Molnár, K., László, L., Nielsen, J. E., Holst, B., Freude, K., Hyttel, P., Kobolák, J. & Dinnyés, A., Dec 2017, In: Alzheimer's Research and Therapy. 9, 1, 19 p., 90.

Research output: Contribution to journal › Journal article › Research › peer-review

75 Citations (Scopus)

115 Downloads (Pure)

Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B

Zhang, Y., Schmid, B., Nikolaisen, N. K., Rasmussen, M. A., Garcia, B. I. A., Agger, M., Callø, K., Stummann, T. C., Larsen, H. M., Nielsen, T. T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E., Consortium, T. FRA., & 4 othersHolst, B., Clausen, C., Hyttel, P. & Freude, K., 14 Mar 2017, In: Stem Cell Reports. 8, 3, p. 648-658

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

471 Downloads (Pure)

RNA-Guided Activation of Pluripotency Genes in Human Fibroblasts

Xiong, K., Zhou, Y., Blichfeld, K. A., Hyttel, P., Bolund, L., Freude, K. K. & Luo, Y., Jun 2017, In: Cellular Reprogramming. 19, 3, p. 189-198 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Systematic in vitro and in vivo characterization of Leukemia-inhibiting factor- and Fibroblast growth factor-derived porcine induced pluripotent stem cells

Secher, J. O. B., Ceylan, A., Mazzoni, G., Mashayekhi-Nezamabadi, K., Li, T., Muenthaisong, S., Nielsen, T., Li, D., Li, S., Petkov, S. G., Cirera Salicio, S., Luo, Y., Thombs, L., Kadarmideen, H., Dinnyés, A., Bolund, L., Roelen, B. A., Schmidt, M., Callesen, H., Hyttel, P., & 1 othersFreude, K., 1 Mar 2017, In: Molecular Reproduction and Development. 84, 3, p. 229-245

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development

Petkov, S., Freude, K., Mashayekhi-Nezamabadi, K., Hyttel, P. & Hall, V., 20 Mar 2017, Animal Models and Human Reproduction: Cell and Molecular Approaches with Reference to Human Reproduction. Schatten, H. & Constantinescu, G. M. (eds.). Wiley-Blackwell, p. 485-508 24 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

2016

Derivation of induced pluripotent stem cells from a familial Alzheimer's disease patient carrying the L282F mutation in presenilin 1

Poon, A. F-Y., Li, T., Pires, C., Nielsen, T. T., Nielsen, J. E., Holst, B., Dinnyes, A., Hyttel, P. & Freude, K., Nov 2016, In: Stem Cell Research. 17, 3, p. 470-473 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

72 Downloads (Pure)

Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1

Pires, C., Schmid, B., Petræus, C., Poon, A. F-Y., Nimsanor, N., Nielsen, T. T., Waldemar, G., Hjermind, L. E., Nielsen, J. E., Hyttel, P. & Freude, K., Sept 2016, In: Stem Cell Research. 17, 2, p. 285-288 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

100 Downloads (Pure)

Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1

Poon, A. F-Y., Schmid, B., Pires, C., Nielsen, T. T., Hjermind, L. E., Nielsen, J. E., Holst, B., Hyttel, P. & Freude, K., Nov 2016, In: Stem Cell Research. 17, 3, p. 466-469 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

115 Downloads (Pure)

Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B

Zhang, Y., Schmid, B., Nielsen, T. T., Nielsen, J. E., Clausen, C., Hyttel, P., Holst, B. & Freude, K., Jul 2016, In: Stem Cell Research. 17, 1, p. 148-150 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

142 Downloads (Pure)

Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B

Zhang, Y., Schmid, B., Nielsen, T. T., Nielsen, J. E., Clausen, C., Hyttel, P., Holst, B. & Freude, K. K., 2016, In: Stem Cell Research. 17, 1, p. 151-153 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

60 Downloads (Pure)

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1

Tubsuwan, A., Pires, C., Rasmussen, M. A., Schmid, B., Nielsen, J. E., Hjermind, L. E., Hall, V. J., Nielsen, T. T., Waldemar, G., Hyttel, P., Clausen, C., Kitiyanant, N., Freude, K. & Holst, B., 1 Jan 2016, In: Stem Cell Research. 16, 1, p. 110-112 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

68 Downloads (Pure)

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1

Li, T., Pires, C., Nielsen, T. T., Waldemar, G., Hjermind, L. E., Nielsen, J. E., Dinnyes, A., Holst, B., Hyttel, P. & Freude, K., 1 Mar 2016, In: Stem Cell Research. 16, 2, p. 334-337 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

89 Downloads (Pure)

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1

Li, T., Pires, C., Nielsen, T. T., Waldemar, G., Hjermind, L. E., Nielsen, J. E., Dinnyes, A., Hyttel, P. & Freude, K. K., 1 Mar 2016, In: Stem Cell Research. 16, 2, p. 229-332 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Generation of induced pluripotent stem cells (iPSCs) stably expressing CRISPR-based synergistic activation mediator (SAM)

Xiong, K., Zhou, Y., Hyttel, P., Bolund, L., Freude, K. & Luo, Y., Nov 2016, In: Stem Cell Research. 17, 3, p. 665-669 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

98 Downloads (Pure)

Human Induced Pluripotent stem cells and their derivatives for disease modeling and therapeutic applications in Alzheimer's disease

Pires, C., Hall, V. & Freude, K. K., 20 May 2016, Alzheimer's disease. SMGroup, p. 1-25 25 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Initial embryology and pluripotent stem cells in the pig: the quest for establishing the pig as a model for cell therapy

Secher, J. O. B., Callesen, H., Freude, K. & Hyttel, P., 1 Jan 2016, In: Theriogenology. 85, 1, p. 162-171 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Neurosphere based differentiation of human iPSC improves astrocyte differentiation

Zhou, S., Szczesna, K., Ochalek, A., Kobolák, J., Varga, E., Nemes, C., Chandrasekaran, A., Rasmussen, M., Cirera Salicio, S., Hyttel, P., Dinnyés, A., Freude, K. & Avci, H. X., 2016, In: Stem Cells International. 2016, 15 p., 4937689.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

101 Downloads (Pure)

Systems Biology and Stem Cell Pluripotency: Revisiting the Discovery of Induced Pluripotent Stem Cell

Mashayekhi, K., Hall, V. J., Freude, K., Høffding, M. K., Labusca, L. & Hyttel, P., 1 Jan 2016, Systems Biology in Animal Production and Health. Kadarmideen, H. N. (ed.). 1 ed. Springer, Vol. 2. p. 127-154 28 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

2 Citations (Scopus)

The positional identity of iPSC-derived neural progenitor cells along the anterior-posterior axis is controlled in a dosage-dependent manner by bFGF and EGF

Zhou, S., Ochalek, A., Szczesna, K., Avci, H. X., Kobolak, J., Varga, E., Rasmussen, M., Holst, B., Cirera Salicio, S., Hyttel, P., Freude, K. K. & Dinnyes, A., 1 Oct 2016, In: Differentiation. 92, 4, p. 183-194 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

2015

Co-expression network analysis to identify pluripotency biomarkers in bovine and porcine embryos

Mazzoni, G., Freude, K. K., Hall, V. J., Mashayekhi-Nezamabadi, K., Hyttel, P., Dinnyés, A. & Kadarmideen, H., 2015. 1 p.

Research output: Contribution to conference › Poster › Research › peer-review

In vitro production of bovine embryos: revisiting oocyte development and application of systems biology

Stroebech, L., Mazzoni, G., Pedersen, H. S., Freude, K., Kadarmideen, H., Callesen, H. & Hyttel, P., 1 Aug 2015, In: Animal Reproduction. 12, 3, p. 465-472 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Optimization of three-dimensional imaging on in vitro produced porcine blastocysts and chimeras for stem cell testing: a technology report.

Secher, J. O. B., Freude, K., Li, R. & Callesen, H., 1 May 2015, In: Stem Cells and Development. 24, 9, p. 1141-1145 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2014

620 Downloads (Pure)

2012

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

Seymour, P. A., Shih, H. P., Patel, N. A., Freude, K. K., Xie, R., Lim, C. J. & Sander, M., 15 Sept 2012, In: Development. 139, 18, p. 3363-72 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

61 Citations (Scopus)

Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid

Walls, K. C., Coskun, P., Gallegos-Perez, J. L., Zadourian, N., Freude, K. K., Rasool, S., Blurton-Jones, M., Green, K. N. & LaFerla, F. M., 31 Aug 2012, In: Journal of Biological Chemistry. 287, 36, p. 30317-30327 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

2011

Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells

Freude, K. K., Penjwini, M., Davis, J. L., LaFerla, F. M. & Blurton-Jones, M., 8 Jul 2011, In: The Journal of Biological Chemistry. 286, 27, p. 24264-24274 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

2010

Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors

Schaffer, A. E., Freude, K. K., Nelson, S. B. & Sander, M., 16 Mar 2010, In: Developmental Cell. 18, 6, p. 1022-1029 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

170 Citations (Scopus)

2009

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

Prakash, N., Puelles, E., Freude, K. K., Trümbach, D., Omodei, D., Di Salvio, M., Sussel, L., Ericson, J., Sander, M., Simeone, A. & Wurst, W., 2009, In: Development (Cambridge, England). 136, 15, p. 2545-2555 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

48 Citations (Scopus)

Kristine Freude

Research output

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