Research output per year
Research output per year
Personal profile
Short presentation
My current research interest is focused on establishing in vitro neuronal and glial cell models of neurodegenerative disorders from patient-specific induced pluripotent stem cells (iPS Cells), including generation of isogenic controls using CRISPR-Cas9 genome editing system to correct the inherited mutation, furthermore, identifying novel disease mechanisms as well as pharmaceutical targets through integrative high-throughput omics profiling and microscopic imaging.
Education/Academic qualification
Generation and characterization of porcine induced pluripotent stem cells reprogrammed from adipose-derived stem cells, Anhui Agricultural University
Sept 2010 → Jun 2013
Award Date: 1 Jul 2008
Modeling and study of frontotemporal dementia using genetically engineered human iPS cells, University of Copenhagen
Jan 2014 → …
External positions
Department of Drug Design and Pharmacology, KU
Jan 2017 → …
Keywords
- Faculty of Health and Medical Sciences
- Stem Cells
- Neuroscience
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Identification of the Gene Expression Rules That Define the Subtypes in Glioma
Cai, Y.-D., Zhang, S., Zhang, Y.-H., Pan, X., Feng, K., Chen, L., Huang, T. & Kong, X., Oct 2018, In: Journal of Clinical Medicine. 7, 10, 15 p., 350.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons
Aldana, B. I., Zhang, Y., Lihme, M. F., Bak, L. K., Nielsen, J. E., Holst, B., Hyttel, P., Freude, K. K. & Waagepetersen, H. S., Jun 2017, In: Neurochemistry International. 106, p. 48-61Research output: Contribution to journal › Journal article › Research › peer-review
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DOT1L inhibitor improves early development of porcine somatic cell nuclear transfer embryos
Tao, J., Zhang, Y., Zuo, X., Hong, R., Li, H., Liu, X., Huang, W., Cao, Z. & Zhang, Y., Jun 2017, In: PloS one. 12, 6, 12 p., e0179436.Research output: Contribution to journal › Journal article › Research › peer-review
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Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges
Poon, A., Zhang, Y., Chandrasekaran, A., Phanthong, P., Schmid, B., Nielsen, T. T. & Freude, K. K., 25 Oct 2017, In: New Biotechnology. 39, Part B, p. 190-198Research output: Contribution to journal › Review › peer-review
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Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B
Zhang, Y., Schmid, B., Nikolaisen, N. K., Rasmussen, M. A., Garcia, B. I. A., Agger, M., Callø, K., Stummann, T. C., Larsen, H. M., Nielsen, T. T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E. & Consortium, T. F. & 4 others, , 14 Mar 2017, In: Stem Cell Reports. 8, 3, p. 648-658Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B
Zhang, Y., Schmid, B., Nielsen, T. T., Nielsen, J. E., Clausen, C., Hyttel, P., Holst, B. & Freude, K., Jul 2016, In: Stem Cell Research. 17, 1, p. 148-150 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B
Zhang, Y., Schmid, B., Nielsen, T. T., Nielsen, J. E., Clausen, C., Hyttel, P., Holst, B. & Freude, K. K., 2016, In: Stem Cell Research. 17, 1, p. 151-153 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of porcine partially reprogrammed iPSCs from adipose-derived stem cells
Wei, C., Li, X., Zhang, P., Zhang, Y., Liu, T., Jiang, S., Han, F. & Zhang, Y., 1 May 2015, In: Reproduction. 149, 5, p. 485-496 12 p.Research output: Contribution to journal › Journal article › Research › peer-review