Research output per year
Research output per year
Research output
Search results
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2018
Localization of microRNA-375 in perinatal rat pancreas
Nielsen, J. H., 2018, In: Non-Coding RNAs in Endocrinology. 3Research output: Contribution to journal › Journal article › Research › peer-review
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Trefoil factor 3 in perinatal pancreas is increased by gestational low protein diet and associated with accelerated beta-cell maturation
Winkel, L., Bagge, A., Larsen, L., Haase, T. N., Rasmussen, M., Lykke, J., Holmgaard, D. B., Thim, L., Nielsen, J. H. & Dalgaard, L. T., 4 May 2018, In: Islets. 10, 3, p. 124–135Research output: Contribution to journal › Journal article › Research › peer-review
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2017
Impact of maternal obesity and diabetes on fetal pancreatic development
Nielsen, J. H., Jaksch, C. A. M., Lessi, I. & Damasceno, D. C., 1 Jan 2017, Fetal and Early Postnatal Programming and its Influence on Adult Health. Boca Raton: CRC Press, p. 125-140 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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2016
Beta cell adaptation in pregnancy: a tribute to Claes Hellerström
Nielsen, J. H., 2 Apr 2016, In: Upsala Journal of Medical Sciences. 121, 2, p. 151-154 4 p.Research output: Contribution to journal › Review › peer-review
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Effect of Diabetes on Circulating Pancreatic Hormones in Pregnant Rats and Their Offspring
Iessi, I. L., Sinzato, Y. K., Gallego, F. Q., Nielsen, J. H. & Damasceno, D. C., 1 Sept 2016, In: Hormone and Metabolic Research. 48, 10, p. 682-686 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo
Horn, S., Kirkegaard, J. S., Hoelper, S., Seymour, P. A., Rescan, C., Nielsen, J. H., Madsen, O. D., Jensen, J. N., Kruger, M., Gronborg, M. & Ahnfelt-Rønne, J., Jan 2016, In: Molecular endocrinology (Baltimore, Md.). 30, 1, p. 133-143 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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β-Cell Adaptability during Pregnancy
Nielsen, J. H., Horn, S., Kirkegaard, J. S., Nalla, A. & Søstrup, B., 2016, Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes. Bentham Science Publishers, p. 123-168 45 p. (Current and Future Developments in Physiology, Vol. 1).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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2014
Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy
Søstrup, B., Gaarn, L. W., Nalla, A., Billestrup, N. & Nielsen, J. H., 1 Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1190-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients
Fløyel, T., Brorsson, C., Nielsen, L. B., Miani, M., Bang-Berthelsen, C. H., Friedrichsen, M., Overgaard, A. J., Berchtold, L. A., Wiberg, A., Poulsen, P., Hansen, L., Rosinger, S., Boehm, B. O., Ram, R., Nguyen, Q., Mehta, M., Morahan, G., Concannon, P., Bergholdt, R. & Nielsen, J. H. & 7 others, , 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. 10305-10310 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of fetal and neonatal environment on beta cell function and development of diabetes
Nielsen, J. H., Haase, T. N., Jaksch, C., Nalla, A., Søstrup, B., Nalla, A. A., Larsen, L., Rasmussen, M., Dalgaard, L. T., Gaarn, L. W., Thams, P., Kofod, H. & Billestrup, N., 1 Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1109-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy
Nalla, A., Ringholm, L., Søstrup, B., Højrup, P., Thim, L., Levery, S. B., Vakhrushev, S. Y., Billestrup, N., Mathiesen, E. R., Damm, P. & Nielsen, J. H., 1 Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1181-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Programming of glucose-insulin homoeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model
Kongsted, A. H., Tygesen, M. P., Husted, S. V., Oliver, M. H., Tolver, A., Christensen, V. G., Nielsen, J. H. & Nielsen, M. O., Jan 2014, In: Acta Physiologica (Print). 210, 1, p. 84-98 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl
Haase, T. N., Gustafsson, A., Nalla, A., Ringholm, L., Damm, P., Mathiesen, E. R., Dahlback, B., Billestrup, N. & Nielsen, J. H., Sept 2014, In: Diabetologia. 57, 1 Suppl, p. S173-S174 408.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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2013
Beta Cell Workshop 2013 Kyoto
Heller, R. S., Madsen, O. D. & Nielsen, J. H., May 2013, In: Islets. 5, 3, p. 107-110 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional characteristics of neonatal rat β cells with distinct markers
Martens, G. A., Motté, E., Kramer, G., Stangé, G., Gaarn, L. W., Hellemans, K., Nielsen, J. H., Aerts, J. M., Ling, Z. & Pipeleers, D., 18 Sept 2013, In: Journal of Molecular Endocrinology. 52, 1, p. 11-28 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell
Haase, T. N., Rasmussen, M., Jaksch, C. A. M., Gaarn, L. W., Petersen, C. K., Billestrup, N. & Nielsen, J. H., Apr 2013, In: Diabetologia. 56, 4, p. 763-773 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2012
MicroRNA-29a is up-regulated in beta-cells by glucose and decreases glucose-stimulated insulin secretion
Bagge, A., Clausen, T. R., Larsen, S., Ladefoged, M., Rosenstierne, M. W., Larsen, L., Vang, O., Nielsen, J. H. & Dalgaard, L. T., 21 Sept 2012, In: Biochemical and Biophysical Research Communications. 426, 2, p. 266-72 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Workshop on programming beta cell development, impairment and regeneration
Heller, S. & Nielsen, J. H., Mar 2012, In: Islets. 4, 2, p. 119-22 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2011
Expression and Localization of microRNAs in Perinatal Rat Pancreas: Role of miR-21 in Regulation of Cholesterol Metabolism
Larsen, L., Rosenstierne, M. W., Gaarn, L. W., Bagge, A., Pedersen, L., Dahmcke, C. M., Nielsen, J. H. & Dalgaard, L. T., 11 Oct 2011, In: PLOS ONE. 6, 10, p. e25997 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Suppression of FAT/CD36 mRNA by human growth hormone in pancreatic ß-cells
Dalgaard, L. T., Thams, P. G., Gaarn, L. W., Jensen, J., Lee, Y. C. & Nielsen, J. H., 1 Jul 2011, In: Biochemical and Biophysical Research Communications. 410, 2, p. 345-350 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
10 Citations (Scopus) -
2010
AKAP 18 a and g have opposing effects on insulin release in INS 1E cells
Nielsen, J. H., Lee, Y. C. & Thams, P. G., 2010, In: FEBS Letter. 584, p. 81-85Research output: Contribution to journal › Journal article › Research › peer-review
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2009
CXCL12/SDF-1 over-expression in human insulinomas and its biological relevance
Ilhan, A., Nabokikh, A., Maj, M., Vidakovic, M., Nielsen, J. H., Prikoszovich, T., Niederle, B., Base, W., Luger, A. & Wagner, L., 2009, In: Molecular and Cellular Endocrinology. 298, 1-2, p. 1-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Expression profiling of human genetic and protein interaction networks in type 1 diabetes
Bergholdt, R., Brorsson, C., Lage, K., Nielsen, J. H., Brunak, S. & Pociot, F., 2009, In: PLoS ONE. 4, 7, p. e6250Research output: Contribution to journal › Journal article › Research › peer-review
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2008
Regulation of beta cell replication.
Lee, Y. C. & Nielsen, J. H., 2008, In: Molecular and Cellular Endocrinology.Research output: Contribution to journal › Journal article › Research › peer-review
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STAT5 activity in pancreatic beta cells.
Dalgaard, L. T., Billestrup, N. & Nielsen, J. H., 2008, In: Expert Review of Endocrinology & Metabolism. 3, 4, p. 423-439 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
5 Citations (Scopus) -
2007
Reduced TGF-beta1 expression and its target genes in human insulinomas
Nabokikh, A., Ilhan, A., Bilban, M., Gartner, W., Vila, G., Niederle, B., Nielsen, J. H., Wagner, O., Base, W., Luger, A. & Wagner, L., 2007, In: Experimental and Clinical Endocrinology and Diabetes. 115, 10, p. 674-682 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
22 Citations (Scopus) -
Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell-mediated liver regeneration.
Jelnes, P., Santoni-Rugiu, E., Rasmussen, M., Friis, S. L., Nielsen, J. H., Tygstrup, N. & Bisgaard, H. C., 2007, In: Hepatology. 45, 6, p. 1462-70 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets
Bergholdt, R., Karlsen, A. E., Hagedorn, P. H., Aalund, M., Nielsen, J. H., Kruhoffer, M., Orntoft, T., Wang, H., Wollheim, C. B., Nerup, J. & Pociot, F. M., 2007, In: Genes and Immunity. 8, 3, p. 232-238 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
7 Citations (Scopus) -
2006
Cytokine signalling in embryonic stem cells.
Kristensen, D. M., Kalisz, M. & Nielsen, J. H., 2006, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 113, 11-12, p. 756-72 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.
Jackerott, M., Møldrup, A., Thams, P., Galsgaard, E. D., Knudsen, J., Lee, Y. C. & Nielsen, J. H., 2006, In: Diabetes. 55, 10, p. 2705-12 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.
Friedrichsen, B. N., Neubauer, N., Lee, Y. C., Gram, V. K., Blume, N., Petersen, J. S., Nielsen, J. H. & Møldrup, A., 2006, In: Journal of Endocrinology. 188, 3, p. 481-92 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone.
Jackerott, M., Lee, Y. C., Møllgård, K., Kofod, H., Jensen, J., Rohleder, S., Neubauer, N., Gaarn, L. W., Lykke, J., Dodge, R., Dalgaard, L. T., Søstrup, B., Jensen, D. B., Thim, L., Nexø, E., Thams, P., Bisgaard, H. C. & Nielsen, J. H., 2006, In: Endocrinology. 147, 12, p. 5752-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2005
STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production.
Jensen, J., Galsgaard, E. D., Karlsen, A. E., Lee, Y. C. & Nielsen, J. H., 2005, In: Journal of Endocrinology. 187, 1, p. 25-36 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2004
Development and Life Cycle of a β-Cell
Serup, P. & Nielsen, J. H., 2004, International Textbook of Diabetes Mellitus, Third Edition. Chichester: IEEE Computer Society Press, p. 59-78Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
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2003
Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications
Friedrichsen, B. N., Carlsson, C., Møldrup, A., Michelsen, B., Jensen, C. H., Teisner, B. & Nielsen, J. H., Feb 2003, In: Journal of Endocrinology. 176, 2, p. 257-66 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
37 Citations (Scopus) -
Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells
Friedrichsen, B. N., Richter, H. E., Hansen, J. A., Rhodes, C. J., Nielsen, J. H., Billestrup, N. & Møldrup, A., May 2003, In: Molecular endocrinology (Baltimore, Md.). 17, 5, p. 945-58 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2001
Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells
Galsgaard, E. D., Friedrichsen, B. N., Møldrup, A. & Nielsen, J. H., 2001, In: Diabetes. 50 Suppl 1, Vol.50, Suppl.1, p. 40-41Research output: Contribution to journal › Journal article › Research › peer-review
15 Citations (Scopus) -
Expression of SMAD signal transduction molecules in the pancreas
Brorson, M., Hougaard, D., Nielsen, J. H., Tornehave, D. & Larsson, L.-I., 2001, In: Histochemistry and Cell Biology. 116, 3, p. 263-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Growth hormone - and prolactin- induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5)
Friedrichsen, B. N., Galsgaard, E. D., Nielsen, J. H. & Møldrup, A., 2001, In: Molecular Endocrinology. 15, p. 136-148Research output: Contribution to journal › Journal article › Research › peer-review
62 Citations (Scopus) -
Regulation of ß-cell mass by hormones and growth factors
Nielsen, J. H., Galsgaard, E. D., Møldrup, A., Friedrichsen, B. N., Billestrup, N., Hansen, J. A., Lee, Y. C. & Carlson, C., 2001, In: Diabetes. Vol.50. Suppl.1, p. 25-29Research output: Contribution to journal › Journal article › Research › peer-review
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Suppressor of cytokine signaling 3 (SOCS-3) protects ß-cells against interleukin-1ß- and interferon-¿- mediated toxicity
Karlsen, A. E., Rønn, S. G., Lindberg, K., Jonannesen, J., Galsgaard, E. D., Pociot, F., Nielsen, J. H., Mandrup-Poulsen, T. R., Nerup, J. & Billestrup, N., 2001, In: Proceedings of the National Academy of Science of the United States of America. Vol.98, p. 12191-12196Research output: Contribution to journal › Journal article › Research › peer-review
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1999
Beta cell proliferation and growth factors
Nielsen, J. H., Svensson, C., Møldrup, A., Galsgaard, E. D. & Billestrup, N., Jan 1999, In: Journal of Molecular Medicine. 77, 1, p. 62-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
109 Citations (Scopus) -
Developmental expression of proprotein convertase 1/3 in the rat
Lee, Y. C., Damholt, A. B., Billestrup, N., Kisbye, T., Galante, P., Michelsen, B., Kofod, H. & Nielsen, J. H., 10 Sept 1999, In: Molecular and Cellular Endocrinology. 155, 1-2, p. 27-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
22 Citations (Scopus) -
Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
Hansen, J. A., Lindberg, K., Hilton, D. J., Nielsen, J. H. & Billestrup, N., Nov 1999, In: Molecular endocrinology (Baltimore, Md.). 13, 11, p. 1832-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
169 Citations (Scopus) -
Regulation of prolactin receptor (PRLR) gene expression in insulin-producing cells. Prolactin and growth hormone activate one of the rat prlr gene promoters via STAT5a and STAT5b
Galsgaard, E. D., Møldrup, A. & Nielsen, J. H., 25 Jun 1999, In: The Journal of Biological Chemistry. 274, 26, p. 18686-92 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
59 Citations (Scopus) -
1998
Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation
Hansen, L. H., Madsen, B., Teisner, B., Nielsen, J. H. & Billestrup, N., Aug 1998, In: Molecular endocrinology (Baltimore, Md.). 12, 8, p. 1140-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
99 Citations (Scopus) -
Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling
Gromada, J., Bokvist, K., Ding, W. G., Holst, J. J., Nielsen, J. H. & Rorsman, P., 1998, In: Diabetes. 47, 1, p. 57-65 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
154 Citations (Scopus) -
Molecular mechanism of growth hormone signalling
Billestrup, N., Hansen, J. A., Hansen, L. H., Møldrup, A., Galsgaard, E. D. & Nielsen, J. H., Apr 1998, In: Endocrine Journal. 45 Suppl, p. S41-5Research output: Contribution to journal › Journal article › Research › peer-review
13 Citations (Scopus) -
1997
Beta-cell ontogeny: growth and death
Corbett, J., Serup, P., Bonner-Weir, S. & Nielsen, J. H., Oct 1997, In: Diabetologia. 40 Suppl 3, p. B27-32Research output: Contribution to journal › Journal article › Research › peer-review
27 Citations (Scopus) -
Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas
Carlsson, C., Tornehave, D., Lindberg, K., Galante, P., Billestrup, N., Michelsen, B., Larsson, L. I. & Nielsen, J. H., Sept 1997, In: Endocrinology. 138, 9, p. 3940-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
89 Citations (Scopus)