Gertrud Malene Hjortø

Research output

Research output per year 2004 2005 2007 2011 2013 2015 2016 2018 2019 2019

• 23 Journal article
• 1 Book chapter
• 1 Conference article

Research output per year

Research output per year

Search results

• 2019

  Arrestin-independent constitutive endocytosis of GPR125/ADGRA3

  Spiess, K., Bagger, S. O., Torz, L. J., Jensen, K. H. R., Walser, A. L., Kvam, J. M., Mogelmose, A-S. K., Daugvilaite, V., Junnila, R. K., Hjorto, G. M. & Rosenkilde, M. M., 2019, In: Annals of the New York Academy of Sciences.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Arrestin 100%
  • Internalization 77%
  • Endocytosis 69%
  • Cell Marker 56%
  • Adhesion 53%
  6 Citations (Scopus)

  15 Downloads (Pure)

• Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

  Jorgensen, A. S., Larsen, O., Uetz-von Allmen, E., Lückmann, M., Legler, D. F., Frimurer, T. M., Veldkamp, C. T., Hjortø, G. M. & Rosenkilde, M. M., 13 Sept 2019, In: Frontiers in Immunology. 10, 14 p., 2156.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chemokines 100%
  • Ligands 75%
  • Chemokine Receptors 71%
  • beta-Arrestin 1 69%
  • Mutagenesis 62%
  5 Citations (Scopus)

  15 Downloads (Pure)
• 2018

  Biased signaling of G protein-coupled receptors: rom a chemokine receptor CCR7 perspective

  Jørgensen, A. S., Rosenkilde, M. M. & Hjortø, G. M., 1 Mar 2018, In: General and Comparative Endocrinology. 258, SI, p. 4-14

  Research output: Contribution to journal › Conference article › Research › peer-review

  • cytokine receptors 100%
  • chemokines 84%
  • G-protein coupled receptors 78%
  • Cytokine Receptors 76%
  • G-Protein-Coupled Receptors 63%
  14 Citations (Scopus)

• CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells

  Jorgensen, A. S., Adogamhe, P. E., Laufer, J. M., Legler, D. F., Veldkamp, C. T., Rosenkilde, M. M. & Hjorto, G. M., Aug 2018, In: Journal of Leukocyte Biology. 104, 2, p. 401-411

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chemotaxis 100%
  • Glycosaminoglycans 99%
  • Dendritic Cells 83%
  • Chemokine CCL21 38%
  • Calcium 31%
  6 Citations (Scopus)

• Ligand-selective small molecule modulators of the constitutively active vGPCR US28

  Amarandi, R-M., Luckmann, M., Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, K., Hjorto, G. M., Pui, A., Frimurer, T. M. & Rosenkilde, M. M., 15 Jul 2018, In: European Journal of Medicinal Chemistry. 155, p. 244-254

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Endocytosis 100%
  • Cytomegalovirus 98%
  • Anti HCMV 86%
  • CX3C Chemokine Receptor 1 82%
  • Arrestin 71%
  3 Citations (Scopus)

• Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

  Miles, T. F., Spiess, K., Jude, K. M., Tsutsumi, N., Burg, J. S., Ingram, J. R., Waghray, D., Hjorto, G. M., Larsen, O., Ploegh, H. L., Rosenkilde, M. M. & Garcia, K. C., 8 Jun 2018, In: eLife. 7, 23 p., e35850 .

  Research output: Contribution to journal › Journal article › Research › peer-review

  13 Citations (Scopus)

  55 Downloads (Pure)
• 2017

  Signaling via G proteins mediates tumorigenic effects of GPR87

  Arfelt, K. N., Fares, S., Sparre-Ulrich, A. H., Hjorto, G. M., Gasbjerg, L. S., Molleskov-Jensen, A-S., Benned-Jensen, T. & Rosenkilde, M. M., 1 Jan 2017, In: Cellular Signalling. 30, p. 9-18

  Research output: Contribution to journal › Journal article › Research › peer-review

  • GTP-Binding Proteins 100%
  • Cluster Analysis 44%
  • G-Protein-Coupled Receptors 33%
  • Ligands 23%
  • HEK293 Cells 18%
  13 Citations (Scopus)
• 2016

  Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21

  Hansen, M., Met, Ö., Larsen, N. B., Rosenkilde, M. M., Andersen, M. H., Svane, I. M. & Hjorto, G. M., 1 Sept 2016, In: Cytotherapy. 18, 9, p. 1187-1196

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dendritic Cells 100%
  • Cell Movement 91%
  • Dinoprostone 22%
  • Chemotaxis 18%
  • In Vitro Techniques 10%
  9 Citations (Scopus)

• Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

  Hjorto, G. M., Larsen, O., Steen, A., Daugvilaite, V., Berg, C., Fares, S., Hansen, M., Ali, S. & Rosenkilde, M. M., 9 Dec 2016, In: Frontiers in Immunology. 7, 568.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CC Chemokines 100%
  • Chemotaxis 84%
  • Dendritic Cells 70%
  • Chemokine Receptors 58%
  • polysialic acid 41%
  28 Citations (Scopus)

  414 Downloads (Pure)

• Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3

  Milanos, L., Brox, R., Frank, T., Poklukar, G., Palmisano, R., Waibel, R., Einsiedel, J., Dürr, M., Ivanović-Burmazović, I., Larsen, O., Hjortø, G. M., Rosenkilde, M. M. & Tschammer, N., 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2222-2243 22 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • beta-Arrestin 1 100%
  • Chemokine Receptors 69%
  • GTP-Binding Proteins 61%
  • Agonist 58%
  • Structure-Activity Relationship 48%
  14 Citations (Scopus)

• Probing Biased Signaling in Chemokine Receptors

  Amarandi, R. M., Hjortø, G. M., Rosenkilde, M. M. & Karlshøj, S., 2016, Methods in Enzymology. Academic Press, Vol. 570. p. 155-186 32 p. (Methods in Enzymology, Vol. 570).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  • Chemokine Receptors 100%
  • Chemokines 83%
  • Ligands 41%
  • GTP-Binding Proteins 29%
  • Arrestin 21%
  13 Citations (Scopus)
• 2015

  Confinement dependent chemotaxis in two-photon polymerized linear migration constructs with highly definable concentration gradients

  Hjorto, G. M., Olsen, M. H., Svane, I. M. & Larsen, N. B., Apr 2015, In: Biomedical Microdevices. 17, 2, p. 1-10 10 p., 30.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Photons 100%
  • Chemotaxis 91%
  • Pore size 65%
  • Polymerization 63%
  • Tissue 48%
  3 Citations (Scopus)

• Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

  Spiess, K., Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjorto, G. M., Larsen, O., Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N. & Rosenkilde, M. M., 7 Jul 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8427-8432 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cytomegalovirus Infections 100%
  • Viral Proteins 96%
  • G-Protein-Coupled Receptors 90%
  • Chemokines 85%
  • Cytomegalovirus 60%
  25 Citations (Scopus)
• 2013

  Comparison of clinical grade type 1 polarized and standard matured dendritic cells for cancer immunotherapy

  Hansen, M., Hjortø, G. M., Donia, M., Met, O., Larsen, N. B., Andersen, M. H., Thor Straten, P. & Svane, I. M., 11 Jan 2013, In: Vaccine. 31, 4, p. 639-46 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • immunotherapy 100%
  • dendritic cells 99%
  • cancer 68%
  • Dendritic Cells 67%
  • Immunotherapy 66%
  23 Citations (Scopus)

• Human cytomegalovirus chemokine receptor US28 induces migration of cells on a CX3CL1-presenting surface

  Hjortø, G. M., Kiilerich-Pedersen, K., Selmeczi, D., Kledal, T. N. & Larsen, N. B., May 2013, In: The Journal of general virology. 94, Pt 5, p. 1111-20 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • cytomegalovirus receptor 100%
  • Chemokine Receptors 58%
  • Cell Movement 42%
  • Cytomegalovirus 12%
  • CX3C Chemokines 11%
  12 Citations (Scopus)

• In-chip fabrication of free-form 3D constructs for directed cell migration analysis

  Olsen, M. H., Hjortø, G. M., Hansen, M., Met, Ö., Svane, I. M. & Larsen, N. B., 21 Dec 2013, In: Lab On a Chip. 13, 24, p. 4800-4809 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pore size 100%
  • Chemotactic Factors 97%
  • Dendritic Cells 96%
  • Chemoattractant 84%
  • Polymers 77%
  41 Citations (Scopus)
• 2012

  Increased adsorption of histidine-tagged proteins onto tissue culture polystyrene

  Holmberg, M., Hansen, T. S., Lind, J. U. & Hjortø, G. M., 1 Apr 2012, In: Colloids and Surfaces B: Biointerfaces. 92, p. 286-292 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tissue culture 100%
  • histidine 84%
  • Polystyrenes 74%
  • Histidine 66%
  • Adsorption 65%
  5 Citations (Scopus)
• 2011

  Cell culture plastics with immobilized interleukin-4 for monocyte differentiation

  Hansen, M., Hjortø, G. M., Met, Ö., Jakobsen, M. H., Svane, I. M. & Larsen, N., Feb 2011, In: Journal of Biomedical Materials Research. Part A. 96, 2, p. 372-83 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell culture 100%
  • Dendritic Cells 86%
  • Amines 61%
  • Plastics 56%
  • Adsorption 50%

• Cell culture plastics with immobilized interleukin-4 for monocyte differentiation

  Hansen, M., Hjortø, G. M., Met, O., Jakobsen, M. H., Svane, I. M. & Larsen, N. B., Feb 2011, In: Journal of Biomedical Materials Research. Part A. 96, 2, p. 372-83 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell culture 100%
  • Dendritic Cells 86%
  • Amines 61%
  • Plastics 56%
  • Adsorption 50%
• 2009

  Generating substrate bound functional chemokine gradients in vitro

  Hjortø, G. M., Hansen, M., Larsen, N. B. & Kledal, T. N., Oct 2009, In: Biomaterials. 30, 29, p. 5305-11 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Chemokine CX3CL1 100%
  • Molecules 65%
  • Chemokines 63%
  • Proteins 61%
  • Denaturation 53%
  13 Citations (Scopus)
• 2007

  Factor VIIa/tissue factor-dependent gene regulation and pro-coagulant activity: effect of factor VIIa concentration

  Petersen, L. C., Albrektsen, T., Hjortø, G. M., Kjalke, M., Bjørn, S. E. & Sørensen, B. L., Oct 2007, In: Thrombosis and Haemostasis. 98, 4, p. 909-11 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  15 Citations (Scopus)

• Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells

  Albrektsen, T., Sørensen, B. B., Hjortø, G. M., Fleckner, J., Rao, L. V. M. & Petersen, L. C., Aug 2007, In: Journal of Thrombosis and Haemostasis. 5, 8, p. 1588-97 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • PAR-2 Receptor 100%
  • PAR-1 Receptor 99%
  • Factor VIIa 94%
  • Thromboplastin 77%
  • Genes 15%
  87 Citations (Scopus)
• 2005

  Elk3 from hamster--a ternary complex factor with strong transcriptional repressor activity

  Hjortoe, G. M., Weilguny, D. & Willumsen, B. M., Jan 2005, In: D N A and Cell Biology. 24, 1, p. 35-42 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ternary Complex Factors 100%
  • Cricetulus 63%
  • Cricetinae 60%
  • Ovary 34%
  • Proto-Oncogene Proteins c-ets 30%
  3 Citations (Scopus)

• Factor VIIa binding and internalization in hepatocytes

  Hjortoe, G., Sorensen, B. B., Petersen, L. C. & Rao, L. V. M., Oct 2005, In: Journal of Thrombosis and Haemostasis. 3, 10, p. 2264-73 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Factor VIIa 100%
  • Hepatocytes 61%
  • Liver 8%
  • Phosphatidylserines 4%
  • Annexin A5 4%
  16 Citations (Scopus)
• 2004

  Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration

  Hjortoe, G. M., Petersen, L. C., Albrektsen, T., Sorensen, B. B., Norby, P. L., Mandal, S. K., Pendurthi, U. R. & Rao, L. V. M., 15 Apr 2004, In: Blood. 103, 8, p. 3029-37 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Factor VIIa 100%
  • Plasma Concentration 85%
  • Thromboplastin 82%
  • Thrombin 79%
  • Coagulation 75%
  215 Citations (Scopus)