Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

Katja Spiess; Mads G. Jeppesen; Mikkel Malmgaard-Clausen; Karen Krzywkowski; Kalpana Dulal; Tong Cheng; Gertrud M. Hjorto; Olav Larsen; John S. Burg; Michael A. Jarvis; K. Christopher Garcia; Hua Zhu; Thomas N. Kledal; Mette M. Rosenkilde

doi:10.1073/pnas.1509392112

Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

Katja Spiess, Mads G. Jeppesen, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Kalpana Dulal, Tong Cheng, Gertrud M. Hjorto, Olav Larsen, John S. Burg, Michael A. Jarvis, K. Christopher Garcia, Hua Zhu, Thomas N. Kledal, Mette M. Rosenkilde

Department of Neuroscience

25 Citations (Scopus)

Original language	English
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	112
Issue number	27
Pages (from-to)	8427-8432
Number of pages	6
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.1509392112
Publication status	Published - 7 Jul 2015

Keywords

HCMV
7TM GPCR
protein engineering
antiviral drug
chemokine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1073/pnas.1509392112

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Spiess, K., Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjorto, G. M., Larsen, O., Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N., & Rosenkilde, M. M. (2015). Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo. Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8427-8432. https://doi.org/10.1073/pnas.1509392112

Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo. / Spiess, Katja; Jeppesen, Mads G.; Malmgaard-Clausen, Mikkel et al.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 27, 07.07.2015, p. 8427-8432.

Research output: Contribution to journal › Journal article › Research › peer-review

Spiess, K, Jeppesen, MG, Malmgaard-Clausen, M, Krzywkowski, K, Dulal, K, Cheng, T, Hjorto, GM , Larsen, O, Burg, JS, Jarvis, MA, Garcia, KC, Zhu, H, Kledal, TN & Rosenkilde, MM 2015, 'Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 27, pp. 8427-8432. https://doi.org/10.1073/pnas.1509392112

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title = "Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo",

keywords = "HCMV, 7TM GPCR, protein engineering, antiviral drug, chemokine",

author = "Katja Spiess and Jeppesen, {Mads G.} and Mikkel Malmgaard-Clausen and Karen Krzywkowski and Kalpana Dulal and Tong Cheng and Hjorto, {Gertrud M.} and Olav Larsen and Burg, {John S.} and Jarvis, {Michael A.} and Garcia, {K. Christopher} and Hua Zhu and Kledal, {Thomas N.} and Rosenkilde, {Mette M.}",

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AU - Spiess, Katja

AU - Jeppesen, Mads G.

AU - Malmgaard-Clausen, Mikkel

AU - Krzywkowski, Karen

AU - Dulal, Kalpana

AU - Cheng, Tong

AU - Hjorto, Gertrud M.

AU - Larsen, Olav

AU - Burg, John S.

AU - Jarvis, Michael A.

AU - Garcia, K. Christopher

AU - Zhu, Hua

AU - Kledal, Thomas N.

AU - Rosenkilde, Mette M.

PY - 2015/7/7

Y1 - 2015/7/7

KW - HCMV

KW - 7TM GPCR

KW - protein engineering

KW - antiviral drug

KW - chemokine

U2 - 10.1073/pnas.1509392112

DO - 10.1073/pnas.1509392112

M3 - Journal article

C2 - 26080445

SN - 0027-8424

VL - 112

SP - 8427

EP - 8432

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 27

ER -

Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

Keywords

UN SDGs

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