Research output per year
Research output per year
Personal profile
Primary fields of research
Professor in Clinical cancer immune therapy and director of the translational research centre, Center for Cancer Immune Therapy (CCIT). CCIT is working translational and has a broad experience in preclinical as well as clinical research within cancer immunology and immunotherapy. Since 2005 CCIT has conducted numerous clinical trials including more than 200 cancer patients. It is an aim for CCIT to develop immunotherapeutic strategies for a broad spectrum of cancer diseases. Therefore, clinical trials have been carried out in diseases such as myeloma, melanoma, lung, -kidney, breast- and prostate cancer.
Current research
CCIT research includes e.g. more basic investigations on how the immune system reacts against cancer and which defect are involved in the sub-optimal function of the immune system leading to lack of cancer cell recognition and elimination.
Also, the research comprises clinical projects reaching from development and testing of peptide vaccines, dendritic cell based vaccines to T-cell therapy. The experimental treatments are frequently tested in combination with standard therapy such as chemotherapy with the intension of added efficacy.
Website: http://www.herlevhospital.dk/ccit-denmark/menu/
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
- Immune therapy
- Melanoma
- T-cell therapy
- Cancer vaccines
- Dendritic cells
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- 12 Similar Profiles
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Arginase-1-based vaccination against the tumor microenvironment: the identification of an optimal T-cell epitope
Martinenaite, E., Ahmad, S. M., Bendtsen, S. K., Jørgensen, M. A., Weis-Banke, S. E., Svane, I. M. & Andersen, M. H., 2019, In: Cancer Immunology, Immunotherapy. 68, 11, p. 1901-1907 7 p.Research output: Contribution to journal › Review › peer-review
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B-cell frequencies and immunoregulatory phenotypes in myeloproliferative neoplasms: Influence of ruxolitinib, interferon-α2, or combination treatment
Sørensen, A. L., Bjørn, M. E., Riley, C. H., Holmstrøm, M., Andersen, M. H., Svane, I. M., Mikkelsen, S. U., Skov, V., Kjaer, L., Hasselbalch, H. C. & Nielsen, C. H., 1 Oct 2019, In: European Journal of Haematology. p. 351-361 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma
Ascierto, P. A., Ferrucci, P. F., Fisher, R., Del Vecchio, M., Atkinson, V., Schmidt, H., Schachter, J., Queirolo, P., Long, G. V., Di Giacomo, A. M., Svane, I. M., Lotem, M., Bar-Sela, G., Couture, F., Mookerjee, B., Ghori, R., Ibrahim, N., Moreno, B. H. & Ribas, A., 1 Jun 2019, In: Nature Medicine. 25, 6, p. 941-946 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential effects of corticosteroids and anti-TNF on tumor-specific immune responses: implications for the management of irAEs
Draghi, A., Borch, T. H., Radic, H. D., Chamberlain, C. A., Gokuldass, A., Svane, I. M. & Donia, M., 1 Sept 2019, In: International Journal of Cancer.Research output: Contribution to journal › Journal article › Research › peer-review
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HER2 CAR-T cells eradicate uveal melanoma and T-cell therapy–resistant human melanoma in IL2 transgenic NOD/SCID IL2 receptor knockout mice
Forsberg, E. M. V., Lindberg, M. F., Jespersen, H., Alsen, S., Bagge, R. O., Donia, M., Svane, I. M., Nilsson, O., Ny, L., Nilsson, L. M. & Nilsson, J. A., 2019, In: Cancer Research. 79, 5, p. 899-904 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High frequencies of circulating memory T cells specific for calreticulin exon 9 mutations in healthy individuals
Holmström, M. O., Ahmad, S. M., Klausen, U., Bendtsen, S. K., Martinenaite, E., Riley, C. H., Svane, I. M., Kjær, L., Skov, V., Ellervik, C., Pallisgaard, N., Hasselbalch, H. C. & Andersen, M. H., 2019, In: Blood Cancer Journal. 9, 2, 8.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunoprofiles of colorectal cancer from Lynch syndrome
Walkowska, J., Kallemose, T., Jönsson, G., Jönsson, M., Andersen, O., Andersen, M. H., Svane, I. M., Langkilde, A., Nilbert, M. & Therkildsen, C., 2 Jan 2019, In: OncoImmunology. 8, 1, 9 p., e1515612.Research output: Contribution to journal › Journal article › Research › peer-review
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MERTK Acts as a costimulatory receptor on human cd8 t cells
Peeters, M. J. W., Dulkeviciute, D., Draghi, A., Ritter, C., Rahbech, A., Skadborg, S. K., Seremet, T., Simoes, A. M. C., Martinenaite, E., Halldorsdottir, H. R., Andersen, M. H., Olofsson, G. H., Svane, I. M., Rasmussen, L. J., Met, O., Becker, J. C., Donia, M., Desler, C. & Straten, P. T., 2019, In: Cancer Immunology Research. 7, 9, p. 1472-1484 13 p.Research output: Contribution to journal › Journal article › Research › peer-review