Research output per year
Research output per year
Personal profile
Primary fields of research
My current research focus is in the area of molecular and cellular tumor immunology, particularly the development of gene-engineered T cells, tailored to treat cancer:
(1) engineering of T cells with tumor-specific synthetic TCRs or chimeric antigen receptors (CARs) for adoptive immunotherapy (ACT)
(2) manipulate co-stimulatory pathways to improve expansion of tumor-resident tumor-infiltrating lymphocytes (TILs) enriched for tumor specificity
(3) genome editing using CRISPR/Cas9 to target cell-intrinsic pathways that restrict T-cell effector functions and their anti-tumor potential
(4) Development of isolation and expansion methods for TIL therapy and to produce large-scale GMP-grade TIL products for ACT clinical trials of melanoma and other solid tumors
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Copenhagen University Hospital, Herlev
1 Sept 2006 → …
Keywords
- Faculty of Health and Medical Sciences
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Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome
Hu, T., Buus, T. B., Krejsgaard, T., Nansen, A., Lundholt, B. K., Spee, P., Fredholm, S., Petersen, D. L., Blümel, E., Gluud, M., Monteiro, M. N., Willerslev-Olsen, A., Andersen, M. H., Straten, P. T., Met, Ö., Stolearenco, V., Fogh, H., Gniadecki, R., Nastasi, C. & Litman, T. & 3 others, , 1 Aug 2019, In: OncoTarget. 10, 47, p. 4894-4906 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MERTK Acts as a costimulatory receptor on human cd8 t cells
Peeters, M. J. W., Dulkeviciute, D., Draghi, A., Ritter, C., Rahbech, A., Skadborg, S. K., Seremet, T., Simoes, A. M. C., Martinenaite, E., Halldorsdottir, H. R., Andersen, M. H., Olofsson, G. H., Svane, I. M., Rasmussen, L. J., Met, O., Becker, J. C., Donia, M., Desler, C. & Straten, P. T., 2019, In: Cancer Immunology Research. 7, 9, p. 1472-1484 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Principles of adoptive T cell therapy in cancer
Met, Ö., Jensen, K. M., Chamberlain, C. A., Donia, M. & Svane, I. M., 11 Jan 2019, In: Seminars in Immunopathology. 41, 1, p. 49–58Research output: Contribution to journal › Journal article › Research › peer-review
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T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients
Viborg, N., Ramskov, S., Andersen, R. S., Sturm, T., Fugmann, T., Bentzen, A. K., Rafa, V. M., Straten, P. T., Svane, I. M., Met, Ö. & Hadrup, S. R., 2 Dec 2019, In: OncoImmunology. 8, 12, 11 p., 1663107.Research output: Contribution to journal › Journal article › Research › peer-review
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Tumor necrosis factor induces rapid down-regulation of TXNIP in human T cells
Levring, T. B., Kongsbak-Wismann, M., Rode, A. K. O., Al-Jaberi, F. A. H., Lopez, D. V., Met, Ö., Woetmann, A., Bonefeld, C. M., Ødum, N. & Geisler, C., 2019, In: Scientific Reports. 9, 13 p., 16725.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model
Idorn, M., Skadborg, S. K., Kellermann, L., Halldórsdóttir, H. R., Holmen Olofsson, G., Met, Ö. & thor Straten, P., 2018, In: OncoImmunology. 7, 8, 10 p., e1450715.Research output: Contribution to journal › Journal article › Research › peer-review
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Frequent adaptive immune responses against arginase-1
Martinenaite, E., Mortensen, R. E. J., Hansen, M., Orebo Holmström, M., Munir Ahmad, S., Grønne Dahlager Jørgensen, N., Met, Ö., Donia, M., Svane, I. M. & Andersen, M. H., 4 Mar 2018, In: OncoImmunology. 7, 3, 9 p., e1404215.Research output: Contribution to journal › Journal article › Research › peer-review
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Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction
Idorn, M., Olsen, M., Halldórsdóttir, H. R., Skadborg, S. K., Pedersen, M., Høgdall, C., Høgdall, E., Met, Ö. & thor Straten, P., 3 Apr 2018, In: OncoImmunology. 7, 4, 12 p., e1412029.Research output: Contribution to journal › Journal article › Research › peer-review