Dereck Edward Winston Chatterton

CV

Academic Degrees:

2002: Degree of Ph.D. Dept. of Molecular Biology, Protein Chemistry Laboratory, University of Aarhus, Denmark & jointly at Dept. of Nutrition, UC Davis California

1990: Degree of Master of Science (Biostructural Chemistry). University of Aarhus, Denmark.

1985: Degree of Batchelor of Science, University of Dundee, Scotland, Biochemistry

1982: Fellowship of the Institute of Medical Laboratory Sciences, 1982 Bristol Polytechnic, UK

1979: Higher National Diploma in Medical Laboratory Sciences, 1979. Bristol Polytechnic, UK

Academic Employment:

2016: Associate Professor, Bioactivity of Milk Proteins and Peptides (Tenure), ongoing

2015: Associate Professor of Dairy Biochemistry and Technology, FOOD and also Section of Comparative Paediatrics and Nutrition, Faculty of Health and Medical Sciences, University of Copenhagen

2014: Associate Professor of Dairy Biochemistry and Technology, FOOD, Faculty of Science andalso Department of Human Nutrition, Exercise and Sports, section of Clinical and Experimental Nutrition, University of Copenhagen

2009: Associate Professor of Dairy Biochemistry and Technology, FOOD, Faculty of Science, University of Copenhagen

2007: Senior Postdoctoral Research Fellow, Dublin Oxford Glycobiology Lab, UC Dublin

2006: Biochemist, Oligosaccharide Research Lab, Moorepark Food Research Centre, Ireland

2002-2006: Visiting researcher, (Post.doc), Dept. of Molecular Biology, Protein Chemistry Laboratory, University of Aarhus, Denmark

1995-2006: Biochemist, Arla Foods Innovation, Denmark

2000: Staff Research Associate, Dept. of Nutrition, University of California Davis

1998: Visiting Researcher, Dept. of Nutrition, University of California Davis

1995: Biochemist, R&D Laboratory MD Foods Ingredients, Denmark

1991: Biochemist, R&D Laboratory Danmark Protein, Denmark

1991: Clinical Research Assistant, Institute of Experimental Clinical Research, University of Aarhus 

Research Leadership:

• 15 years experience at Arla Foods Ingredients. Head, R&D Laboratory, several technical staff.
• Formal leadership training courses, Arla Foods.
• Project leader, Bioactive Milk Components; Alpha-lactalbumin, GMP, Osteopontin preclinical documentation.
• Co-investigator, since starting at University of Copenhagen in 2009, on several projects including DSF-FØSU grants.
• Extensive collaboration among local, national and international partners.
• International experience from 4 research stays abroad at University of California at Davis, Moorepark Food research Centre and University College, Dublin.
• Deputy research group leader of in Dairy Technology Section at FOOD.
• Main supervisor and co-supervisor of several students and PhD students.
• EU Project Coordination: Representative for Arla Foods within the Framework European Programme, MADGELAS, with partners from European universities, institutes and industries.
• Member of Cost Action “Infogest” Food Digestion Network, 200 participants, 60 institutions in 27 countries
• Dairy Internship Committee Member, University of Copenhagen
• Dairy Industry Coordination Group
• Chairman Innovation Committee June 2009-December 2009
• Research and Innovation Committee, (Responsible for Innovation) Department of Food Science, University of Copenhagen,
• Participation in Management Group, Department of Food Science, University of Copenhagen; Member, Industrigruppe for sikring af mejeriingeniøruddannelsens fremtid, FOOD Strategy Committee (from February 2013) Department of Food Science, University of Copenhagen.
• Member of the NEOCOL Innovation Fund Denmark project steering group
• Representative for the occupational health and safety committee (2018 ongoing)

Selected Publications:

~30 publications in international journals, including 3 US patents, 3 book chapters

Sun, J., Pan, X., Christiansen, L.I., Yuan, X.L., Skovgaard, K., Chatterton, D.E.W., Kaalund, S.S., Gao, F., Sangild, P.T., Pankratova, S.: (2018) Necrotizing enterocolitis is associated with acute brain responses in preterm pigs. J. Neuroinflammation 15(1): 180-

Li, Y., Nguyen, D.N., Obelitz-Ryom, K., Andersen, A.D., Thymann, T., Chatterton, D.E.W., Purup, S., Heckmann, A.B., Bering, S.B. & Sangild, P.T.: (2018) Bioactive whey protein concentrate and lactose stimulate gut function in formula-fed preterm pigs. J Pediatr Gastroenterol Nutr 66(1):128-134

NGUYEN, D.N., JIANG, P., STENSBALLE, A., BENDIXEN, E., SANGILD, P.T. & CHATTERTON, D.E.: (2016) Bovine lactoferrin regulates cell survival, apoptosis and inflammation in intestinal epithelial cells and preterm pig intestine. J Proteomics 139:95-102

Støy, A.C., Sangild, P.T., Skovgaard, K., Thymann, T., Bjerre, M., Chatterton, D.E., Purup, S., Boye, M., Heegaard, P.M.: (2016) Spray-dried, pasteurised bovine colostrum protects against gut dysfunction and inflammation in preterm pigs. J. Pediatr Gastroenterol Nutr 63(2):280-287 

NGUYEN, D.N., SANGILD, P.T., Li, Y., BERING, S.B. & CHATTERTON, D.E. (2016) Processing of whey modulates proliferative and immune functions in intestinal epithelial cells. J Dairy Sci 99(2):959-969 

NGUYEN, D.N., JIANG, P., JACOBSEN, S., SANGILD, P.T., BENDIXEN, E., & CHATTERTON, D.E.: (2015)

Protective effects of transforming growth factor β2 in intestinal cells by regulation of proteins associated with stress and endotoxin responses. PloS One 10(2):e0117608

JENSEN, H.B., PEDERSEN, K.S., JOHANSEN, L.B., POULSEN, N.A., BAKMAN, M, CHATTERTON, D.E. & LARSEN, L.B.: (2015) Genetic variation and posttranslational modification of bovine κ-casein: effects on caseino-macropeptide release during renneting J Dairy Sci 98(2): 747-758

NGUYEN, D.N., SANGILD, P.T., OSTERGAARD, M.V., BERING, S.B. & CHATTERTON, D.E.: (2014) Tranforming growth factor-β2 and endotoxin interact to regulate homeostasis via interleukin-8 levels in the immature intestine. Am J Physiol Gastrointest Liver Physiol 307(7):G689-99

LI, Y., JENSEN, M.L., CHATTERTON, D.E.W., JENSEN, B.B., THYMANN, T., KVISTGAARD, A.S. & SANGILD, P.T.: (2014) Raw bovine milk improves gut responses to feeding relative infant formula in preterm piglets. Am J Physiol Gastrointest Liver Physiol 306(1):G81-G90

NGUYEN, D.N., Li, Y., SANGILD, P.T., BERING, S.B. & CHATTERTON, D.E.W.: (2014) Effects of bovine lactoferrin on the immature porcine intestine Br. J. Nutr 111(2): 321-331

LI, Y., OSTERGAARD, M.V., JIANG, P., CHATTERTON, D.E., THYMANN, T., KVISTGAARD, A.S. & SANGILD, P.T.: (2013) Whey protein processing influences formula-induced gut maturation in preterm pigs. J. Nutr 143(12):1934-1942

CHATTERTON, D.E.W., NGUYEN, D.N., BERING, S.B., SANGILD, P.T.: (2013) Anti-inflammatory mechanisms of bioactive milk proteins in the newborn intestine. Int J Biochem Cell Biol 45(8):1730-1747

STØY, A.C., SANGILD, P., SKOVGAARD, K., THYMANN, T., BJERRE, M., CHATTERTON, D., PURUP, S., BOYE, M., SCHMIDT, M., HEEGAARD, P.: (2013) Mild heat treatment does not reduce the colitis-protective effects of bovine colostrum in preterm pigs. J Pediatr Gastroenterol Nutr 56, Supplement 2, 401

LI, Y., THOMAS, T., KVISTGAARD, A.S., CHATTERTON, D:E:W., & SANGILD, P:T.: (2013) Heat treatment of milk reduces intestinal function and resistance to necrotizing enterocolitis in preterm pigs J Pediatr Gastroenterol Nutr 56, Supplement 2, 440

NGUYEN, D.N., LI, Y., SANGILD, P.T., BERING, S.B. & CHATTERTON, D.E.W.: (2013) Lactoferrin-enriched formula modulates necrotizing enterocolitis and intestinal inflammation in preterm pigs J Pediatr Gastroenterol Nutr 56, Supplement 2, 161

NGUYEN, D.N., OSTERGAARD, M.V., SANGILD, P.T., BERING, S.B. & CHATTERTON, D.: (2012) Transforming growth factor beta 2 (TGF-beta 2) effects on lipopolysaccharide (LPS)-induced cytokine secretion in developing intestinal epithelial cells PsIc1. Regulatory Peptides 177(1):S29-S29

(2010) PERSSON, B.A., LUND, M., FORSMAN, J., CHATTERTON, D.E.W., & ÅKESSON, T.:

Molecular evidence of stereo-specific lactoferrin dimers in solution. Biophys Chem 151(3): 187-189

(2010) Ercan, A.,  CUI, J. CHATTERTON, D.E.W., DEANE, K.D., HAZEN, M.M., BRINTNELL, W., O´DONNELL, C.I., DERBER, L.A., WEINBLATT, M.E., SHADICK, N.A., BELL, D.A., CAIRNS, E., SOLOMON, D.H., HOLERS, V.M., RUDD, P.M., & LEE, D,M.: IgG galactosylation aberrancy precedes disease onset, correlates with disease activity and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis & Rheum, 62 (8), 2239-2248

(2006) CHATTERTON, D.E.W., SMITHERS, G., ROUPAS, P. & BRODKORB, A.: Bioactivity of β-Lactoglobulin and α-Lactalbumin – Technological Implications for Processing. International Dairy Journal, 16 (11) 1229-1240.

(2004) CHATTERTON, D.E.W., RASMUSSEN, J.T., HEEGAARD, C.W., SØRENSEN, E.S. & PETERSEN, T.E.: In vitro digestion of novel milk protein ingredients for use in infant formulas: Identification of new biological functions. Trends in Food Science & Technology, 15 (7-8): 373-383.

(2003): BRÜCK, W.M., KELLEHER, S.L, GIBSON, G.R., NIELSEN, K.E., CHATTERTON, D.E.W. & LŌNNERDAL, B.: rRNA probes used to quantify the effects of glycomacropeptide and α-lactalbumin supplementation on the predominant groups of intestinal bacteria of infant rhesus monkeys challenged with enteropathogenic Escherichia coli.  J Pediatr Gastroenterol Nutr, 37 (3): 273-280.

(2003): KELLEHER, S.L., CHATTERTON, D., NIELSEN, K. & LŌNNERDAL, B.: Glycomacropeptide and α-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. Am J Clin Nutr, 77:1261-1268.

Short presentation

Responsible for graduate and post-graduate teaching of students in wide topics related to the effects of Milk Processing, such as pasteurization and thermal processes, such as spray-drying on milk proteins and peptides and their functions with a focus on bioactive ingredients. Research focus on the effects of digestion of processed milk protein and peptide ingredients, including minor bioactive factors for infant nutrition and has used models to study this (Rhesus monkey, cell culture and more recently piglet studies). Also the interaction and modulatory effects of milk proteins with each other is a research topic, such as in aggregation reactions and the effects of heat-treatments on the bioactivity of milk proteins. Extensive utilization of purification and protein chemistry techniques, including mass spectrometry, proteomics and glycobiology.

Primary fields of research

• Bioactivity of milk proteins and peptides especially related to infant nutrition.

Present projects include:

• Infant-I: Tailored processing of bioactive ingredients for high-end infant formula (The Danish Environmental Protection Agency (GUDP)) 
• UHT treatment and storage effects on the biological quality of liquid infant formulas (Danish Dairy Research Foundation) 
• NEOCOL: Colostrum for newborn infants (Innovation Fund Denmark)
• HAPFAM: Healthy and affordable protein rich foods for African markets (The Danish Agency for Science, Technology and Innovation)
• STRUCSAT: How food structure affects satiety (The Danish Agency for Science, Technology and Innovation)
• Mild heat treated bovine whey protein concentrate as a supplement for infant formula and donor human milk (Danish Dairy Research Foundation)
• NEOMUNE: Early milk and microbiota to improbve later immunity (The Danish Council for Strategic Research)
• Bioactive milk proteins against gastrointestinal inflammation - characterization of effects in the intestine (Danish Dairy Research Foundation).
• New Generation of Milk Protein Products to Protect Human Intestinal Cells - Use of Proteomics for Studying the Effects of a New Generation of Milk Protein Products on Human Intestinal Cell Transcription (Chinese Industrial Ph.D., Arla Foods Global Ingredients).

Current research

• Anvendelse af bioaktive mælkeproteiner mod tarminflammation - karakterisering af effekter i tarmen.
• Ny generation af mælkeprotein produkter til beskyttelse af menneskers tarmceller - Anvendelse af Proteomics for at undersøge effekten af en ny generation af mælkeprotein produkter på menneskelige tarmcelle transkription.

Teaching

• Diverse teaching at Arla Foods Ingredients, internally and abroad over 15 years. Course responsible and teacher; Analytical Techniques in Glycobiology. Applications to Biopharmaceutical Production, March 2008
• Launch of GlycoScience Ireland, Trinity College, Dublin, April 2008

Teaching:

• Responsible & teacher, Dairy Internship, BSc Food Science, University of Copenhagen,
• Teacher on the BSc course 'Quality of Raw Food Materials' (7.5 ECTS)
• Teacher on the MSc course 'Introduction to Dairy Technology' (7.5 ECTS)
• Teacher on the MSc E-learning course 'Introduction to Dairy Technology' (7.5 ECTS)
• Responsible & teacher on the MSc course 'Milk Processing' (7.5 ECTS)
• Censor on the MSc course 'Dairy Product Technology' (7.5 ECTS)
• Teacher on Ph.D. course in Food Proteins and Enzymes
• Teacher on Ph.D. course in Food Chemistry (Production of Food Proteins)