Dereck Edward Winston Chatterton

CV

Academic Degrees:

2002: Degree of Ph.D. Dept. of Molecular Biology, Protein Chemistry Laboratory, University of Aarhus, Denmark & jointly at Dept. of Nutrition, UC Davis California

1990: Degree of Master of Science (Biostructural Chemistry). University of Aarhus, Denmark.

1985: Degree of Batchelor of Science, University of Dundee, Scotland, Biochemistry

1982: Fellowship of the Institute of Medical Laboratory Sciences, 1982 Bristol Polytechnic, UK

1979: Higher National Diploma in Medical Laboratory Sciences, 1979. Bristol Polytechnic, UK

Academic Employment:

2016: Associate Professor, Bioactivity of Milk Proteins and Peptides (Tenure), ongoing

2015: Associate Professor of Dairy Biochemistry and Technology, FOOD and also Section of Comparative Paediatrics and Nutrition, Faculty of Health and Medical Sciences, University of Copenhagen

2014: Associate Professor of Dairy Biochemistry and Technology, FOOD, Faculty of Science and also Department of Human Nutrition, Exercise and Sports, section of Clinical and Experimental Nutrition, University of Copenhagen

2009: Associate Professor of Dairy Biochemistry and Technology, FOOD, Faculty of Science, University of Copenhagen

2007: Senior Postdoctoral Research Fellow, Dublin Oxford Glycobiology Lab, UC Dublin

2006: Biochemist, Oligosaccharide Research Lab, Moorepark Food Research Centre, Ireland

2002-2006: Visiting researcher, (Post.doc), Dept. of Molecular Biology, Protein Chemistry Laboratory, University of Aarhus, Denmark

1995-2006: Biochemist, Arla Foods Innovation, Denmark

2000: Staff Research Associate, Dept. of Nutrition, University of California Davis

1998: Visiting Researcher, Dept. of Nutrition, University of California Davis

1995: Biochemist, R&D Laboratory MD Foods Ingredients, Denmark

1991: Biochemist, R&D Laboratory Danmark Protein, Denmark

1991: Clinical Research Assistant, Institute of Experimental Clinical Research, University of Aarhus 

Research Leadership:

• 15 years experience at Arla Foods Ingredients. Head, R&D Laboratory, several technical staff.
• Formal leadership training courses, Arla Foods.
• Project leader, Bioactive Milk Components; Alpha-lactalbumin, GMP, Osteopontin preclinical documentation.
• Co-investigator, since starting at University of Copenhagen in 2009, on several projects including DSF-FØSU grants.
• Extensive collaboration among local, national and international partners.
• International experience from 4 research stays abroad at University of California at Davis, Moorepark Food research Centre and University College, Dublin.
• Deputy research group leader of in Dairy Technology Section at FOOD.
• Main supervisor and co-supervisor of several students and PhD students.
• EU Project Coordination: Representative for Arla Foods within the Framework European Programme, MADGELAS, with partners from European universities, institutes and industries.
• Member of Cost Action “Infogest” Food Digestion Network, 200 participants, 60 institutions in 27 countries
• Dairy Internship Committee Member, University of Copenhagen
• Dairy Industry Coordination Group
• Chairman Innovation Committee June 2009-December 2009
• Research and Innovation Committee, (Responsible for Innovation) Department of Food Science, University of Copenhagen,
• Participation in Management Group, Department of Food Science, University of Copenhagen; Member, Industrigruppe for sikring af mejeriingeniøruddannelsens fremtid, FOOD Strategy Committee (from February 2013) Department of Food Science, University of Copenhagen.

Selected Publications:

~30 publications in international journals, including 3 US patents, 3 book chapters

NGUYEN, D.N., JIANG, P., STENSBALLE, A., BENDIXEN, E., SANGILD, P.T. & CHATTERTON, D.E.: (2015) Bovine lactoferrin regulates cell survival, apoptosis and iron-dependent pathways in intestinal epithelial cells and preterm pig intestine. Submitted.

NGUYEN, D.N., SANGILD, P.T., Li, Y., BERING, S.B. & CHATTERTON, D.E. (2015) Processing of whey modulates proliferative and immune functions in intestinal epithelial cells. Submitted.

NGUYEN, D.N., JIANG, P., JACOBSEN, S., SANGILD, P.T., BENDIXEN, E., & CHATTERTON, D.E.: (2015)

Protective effects of transforming growth factor β2 in intestinal cells by regulation of proteins associated with stress and endotoxin responses. PloS One 10(2):e0117608

JENSEN, H.B., PEDERSEN, K.S., JOHANSEN, L.B., POULSEN, N.A., BAKMAN, M, CHATTERTON, D.E. & LARSEN, L.B.: (2015) Genetic variation and posttranslational modification of bovine κ-casein: effects on caseino-macropeptide release during renneting J Dairy Sci 98(2): 747-758

NGUYEN, D.N., SANGILD, P.T., OSTERGAARD, M.V., BERING, S.B. & CHATTERTON, D.E.: (2014) Tranforming growth factor-β2 and endotoxin interact to regulate homeostasis via interleukin-8 levels in the immature intestine. Am J Physiol Gastrointest Liver Physiol 307(7):G689-99

LI, Y., JENSEN, M.L., CHATTERTON, D.E.W., JENSEN, B.B., THYMANN, T., KVISTGAARD, A.S. & SANGILD, P.T.: (2014) Raw bovine milk improves gut responses to feeding relative infant formula in preterm piglets. Am J Physiol Gastrointest Liver Physiol 306(1):G81-G90

NGUYEN, D.N., Li, Y., SANGILD, P.T., BERING, S.B. & CHATTERTON, D.E.W.: (2014) Effects of bovine lactoferrin on the immature porcine intestine Br. J. Nutr 111(2): 321-331

LI, Y., OSTERGAARD, M.V., JIANG, P., CHATTERTON, D.E., THYMANN, T., KVISTGAARD, A.S. & SANGILD, P.T.: (2013) Whey protein processing influences formula-induced gut maturation in preterm pigs. J. Nutr 143(12):1934-1942

CHATTERTON, D.E.W., NGUYEN, D.N., BERING, S.B., SANGILD, P.T.: (2013) Anti-inflammatory mechanisms of bioactive milk proteins in the newborn intestine. Int J Biochem Cell Biol 45(8):1730-1747

STØY, A.C., SANGILD, P., SKOVGAARD, K., THYMANN, T., BJERRE, M., CHATTERTON, D., PURUP, S., BOYE, M., SCHMIDT, M., HEEGAARD, P.: (2013) Mild heat treatment does not reduce the colitis-protective effects of bovine colostrum in preterm pigs. J Pediatr Gastroenterol Nutr 56, Supplement 2, 401

LI, Y., THOMAS, T., KVISTGAARD, A.S., CHATTERTON, D:E:W., & SANGILD, P:T.: (2013) Heat treatment of milk reduces intestinal function and resistance to necrotizing enterocolitis in preterm pigs J Pediatr Gastroenterol Nutr 56, Supplement 2, 440

NGUYEN, D.N., LI, Y., SANGILD, P.T., BERING, S.B. & CHATTERTON, D.E.W.: (2013) Lactoferrin-enriched formula modulates necrotizing enterocolitis and intestinal inflammation in preterm pigs J Pediatr Gastroenterol Nutr 56, Supplement 2, 161

NGUYEN, D.N., OSTERGAARD, M.V., SANGILD, P.T., BERING, S.B. & CHATTERTON, D.: (2012) Transforming growth factor beta 2 (TGF-beta 2) effects on lipopolysaccharide (LPS)-induced cytokine secretion in developing intestinal epithelial cells PsIc1. Regulatory Peptides 177(1):S29-S29

(2010) PERSSON, B.A., LUND, M., FORSMAN, J., CHATTERTON, D.E.W., & ÅKESSON, T.:

Molecular evidence of stereo-specific lactoferrin dimers in solution. Biophys Chem 151(3): 187-189

(2010) Ercan, A.,  CUI, J. CHATTERTON, D.E.W., DEANE, K.D., HAZEN, M.M., BRINTNELL, W., O´DONNELL, C.I., DERBER, L.A., WEINBLATT, M.E., SHADICK, N.A., BELL, D.A., CAIRNS, E., SOLOMON, D.H., HOLERS, V.M., RUDD, P.M., & LEE, D,M.: IgG galactosylation aberrancy precedes disease onset, correlates with disease activity and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis & Rheum, 62 (8), 2239-2248

(2006) CHATTERTON, D.E.W., SMITHERS, G., ROUPAS, P. & BRODKORB, A.: Bioactivity of β-Lactoglobulin and α-Lactalbumin – Technological Implications for Processing. International Dairy Journal, 16 (11) 1229-1240.

(2004) CHATTERTON, D.E.W., RASMUSSEN, J.T., HEEGAARD, C.W., SØRENSEN, E.S. & PETERSEN, T.E.: In vitro digestion of novel milk protein ingredients for use in infant formulas: Identification of new biological functions. Trends in Food Science & Technology, 15 (7-8): 373-383.

(2003): BRÜCK, W.M., KELLEHER, S.L, GIBSON, G.R., NIELSEN, K.E., CHATTERTON, D.E.W. & LŌNNERDAL, B.: rRNA probes used to quantify the effects of glycomacropeptide and α-lactalbumin supplementation on the predominant groups of intestinal bacteria of infant rhesus monkeys challenged with enteropathogenic Escherichia coli.  J Pediatr Gastroenterol Nutr, 37 (3): 273-280.

(2003): KELLEHER, S.L., CHATTERTON, D., NIELSEN, K. & LŌNNERDAL, B.: Glycomacropeptide and α-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. Am J Clin Nutr, 77:1261-1268.

Kort præsentation

Responsible for graduate and post-graduate teaching of students in wide topics related to the effects of Milk Processing, such as pasteurization and thermal processes, such as spray-drying on milk proteins and peptides and their functions with a focus on bioactive ingredients. Research focus on the effects of digestion of processed milk protein and peptide ingredients, including minor bioactive factors for infant nutrition and has used models to study this (Rhesus monkey, cell culture and more recently piglet studies). Also the interaction and modulatory effects of milk proteins with each other is a research topic, such as in aggregation reactions and the effects of heat-treatments on the bioactivity of milk proteins. Extensive utilization of purification and protein chemistry techniques, including mass spectrometry, proteomics and glycobiology.

Primære forskningsområder

•  Bioaktivitet af mælkeproteiner og peptider især i forbindelse med spædbarnsernæring.

Aktuel forskning

• Anvendelse af bioaktive mælkeproteiner mod tarminflammation - karakterisering af effekter i tarmen.
• Ny generation af mælkeprotein produkter til beskyttelse af menneskers tarmceller - Anvendelse af Proteomics for at undersøge effekten af en ny generation af mælkeprotein produkter på menneskelige tarmcelle transkription.

Undervisnings- og vejledningsområder

• Kursusansvarlig og underviser for Mejeripraktik, BSc Fødevarer, kvalitet og teknologi, Københavns Universitet. 
• Underviser på bachelor kurset 'Quality of Raw Food Materials' (7.5 ECTS)
• Underviser på kandidat kurset 'Introduction to Dairy Technology' (7.5 ECTS)
• Underviser på kandidat e-lærings kurset 'Introduction to Dairy Technology' (7.5 ECTS)
• Kursusansvarlig og underviser på kandidat kurset 'Milk Processing' (7.5 ECTS)
• Censor på kandidat kurset 'Dairy Product Technology' (7.5 ECTS)
• Underviser på Ph.D. kurset 'Food Proteins and Enzymes'
• Underviser på PhD kurset 'Food Chemistry (Production of Food Proteins)'