Christian Janfelt

2019

Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

Hendel, K. K., Bagger, C., Olesen, U. H., Janfelt, C., Hansen, S. H., Haedersdal, M. & Lerche, C. M., 1 Jan 2019, In: Drug Delivery. 26, 1, p. 244-251 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

41 Downloads (Pure)

Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery

Handler, A. M., Marxen, E., Jacobsen, J. & Janfelt, C., 15 Jan 2019, In: European Journal of Pharmaceutical Sciences. 127, p. 276-281 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2018

Buccal delivery of small molecules - Impact of levulinic acid, oleic acid, sodium dodecyl sulfate and hypotonicity on ex vivo permeability and spatial distribution in mucosa

Hansen, S. E., Marxen, E., Janfelt, C. & Jacobsen, J., Dec 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 250-257

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Delivery of amitriptyline by intravenous and intraperitoneal administration compared in the same animal by whole-body mass spectrometry imaging of a stable isotope labelled drug substance in mice

Morineau, L., Jacobsen, S. C., Kleberg, K., Hansen, H. S. & Janfelt, C., 2 Dec 2018, In: Expert Opinion on Drug Delivery. 15, 12, p. 1157-1163

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

Marxen, E., Jin, L., Jacobsen, J., Janfelt, C., Hyrup, B. & Nicolazzo, J. A., 1 Mar 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

MALDI imaging of enzymatic degradation of glycerides by lipase on textile surface

Hall-Andersen, J., Kaasgaard, S. G. & Janfelt, C., Mar 2018, In: Chemistry and Physics of Lipids. 211, p. 100-106

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging

Marxen, E., Jacobsen, J., Hyrup, B. & Janfelt, C., 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia

Gallage, N. J., Jørgensen, K., Janfelt, C., Nielsen, A. J. Z., Naake, T., Dunski, E., Dalsten, L., Grisoni, M. & Møller, B. L., 1 Feb 2018, In: Plant and Cell Physiology. 59, 2, p. 304-318 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

101 Downloads (Pure)

The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

Ozgür, B., Saaby, L., Eneberg, E., Langthaler, K., Jacobsen, A-M., Janfelt, C., Badolo, L., Montanari, D. & Brodin, B., 22 Jun 2018.

Research output: Contribution to conference › Poster › Research › peer-review

The Spatial Distribution of Alkaloids in Psychotria prunifolia (Kunth) Steyerm and Palicourea coriacea (Cham.) K. Schum Leaves Analysed by Desorption Electrospray Ionisation Mass Spectrometry Imaging

Kato, L., Moraes, A. P., de Oliveira, C. M. A., Vaz, B. G., de Almeida Gonçalves, L., E Silva, E. C. & Janfelt, C., 1 Jan 2018, In: Phytochemical Analysis. 29, p. 69-76

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

79 Downloads (Pure)

2017

Combination of MALDI-MSI and cassette dosing for evaluation of drug distribution in human skin explant

Sørensen, I. S., Janfelt, C., Nielsen, M. M. B., Mortensen, R. W., Knudsen, N. Ø., Eriksson, A. H., Pedersen, A. J. & Nielsen, K. T., 1 Aug 2017, In: Analytical and Bioanalytical Chemistry. 409, 21, p. 4993-5005 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

Fractional laser-assisted topical delivery leads to enhanced, accelerated and deeper cutaneous 5-fluorouracil uptake

Wenande, E., Olesen, U. H., Nielsen, M. M. B., Janfelt, C., Hansen, S. H., Anderson, R. & Haedersdal, M., 4 Mar 2017, In: Expert Opinion on Drug Delivery. 14, 3, p. 307-317 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

2016

Aspects of Quantitation in Mass Spectrometry Imaging Investigated on Cryo-Sections of Spiked Tissue Homogenates

Hansen, H. T. & Janfelt, C., 6 Dec 2016, In: Analytical Chemistry. 88, 23, p. 11513−11520 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Characterization of midazolam metabolism in locusts: The role of CYP3A4-like enzyme in the formation of 1'-OH and 4-OH midazolam

Olsen, L. R., Gabel-Jensen, C., Wubshet, S. G., Kongstad, K. T., Janfelt, C., Badolo, L. & Hansen, S. H., 1 Feb 2016, In: Xenobiotica. 46, 2, p. 99–107 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Cryo-sectioning of mice for whole-body imaging of drugs and metabolites with desorption electrospray ionization mass spectrometry imaging - a simplified approach

Okutan, S., Hansen, H. S. & Janfelt, C., 1 Jun 2016, In: Proteomics. 16, 11-12, p. 1633-41 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Fractional laser-assisted drug delivery: Laser channel depth influences biodistribution and skin deposition of methotrexate

Taudorf, E. H., Lerche, C. M., Erlendsson, A. M., Philipsen, P. A., Hansen, S. H., Janfelt, C., Paasch, U., Anderson, R. R. & Haedersdal, M., 1 Jul 2016, In: Lasers in Surgery and Medicine. 48, 5, p. 519-529 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging

Kucharíková, A., Kimáková, K., Janfelt, C. & Cellárová, E., 1 May 2016, In: Physiologia Plantarum. 157, 1, p. 2-12 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia

Nielsen, M. M. B., Lambertsen, K. L., Clausen, B. H., Meyer, M., Bhandari, D. R., Larsen, S. T., Poulsen, S. S., Spengler, B., Janfelt, C. & Hansen, H. S., 22 Dec 2016, In: Scientific Reports. 6, p. 1-14 14 p., 39571.

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

2015

DESI-MS imaging of metabolites in various plant materials – a matter of sample preparation

Kato, L., Rook, F., Møller, B. L., Hansen, S. H. & Janfelt, C., 2015.

Research output: Contribution to conference › Poster › Research

Distribution of terfenadine and its metabolites in locusts studied by desorption electrospray ionization mass spectrometry imaging

Olsen, L. R., Hansen, S. H. & Janfelt, C., 1 Mar 2015, In: Analytical and Bioanalytical Chemistry. 407, 8, p. 2149–2158 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Topically applied methotrexate is rapidly delivered into skin by fractional laser ablation

Taudorf, E. H., Lerche, C., Vissing, A-C., Philipsen, P. A., Hannibal, J., D'Alvise, U. J. C., Hansen, S. H., Janfelt, C., Paasch, U., Anderson, R. R. & Hædersdal, M., 1 Jul 2015, In: Expert Opinion on Drug Delivery. 12, 7, p. 1059-1069 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

2014

Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect

Meng-Lund, E., Jacobsen, J., Jin, L., Janfelt, C., Holm, R., Müllertz, A. & Nicolazzo, J. A., Apr 2014, In: Journal of Pharmaceutical Sciences. 103, 4, p. 1133-1141 103.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Detection of follicular transport of lidocaine and metabolism in adipose tissue in pig ear skin by DESI mass spectrometry imaging

D'Alvise, J., Mortensen, R., Hansen, S. H. & Janfelt, C., Jun 2014, In: Analytical and Bioanalytical Chemistry. 406, 15, p. 3735-42 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Imaging of plant materials using indirect desorption electrospray ionization mass spectrometry

Janfelt, C., 31 Oct 2014, Mass Spectrometry Imaging of Small Molecules. He, L. (ed.). Humana Press, Vol. 1203. p. 91-7 7 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

2 Citations (Scopus)

Mass spectrometry imaging of plant metabolites – principles and possibilities

Bjarnholt, N., Li, B., D'Alvise, J. & Janfelt, C., Jun 2014, In: Natural Product Reports. 31, 6, p. 818-837 20 p.

Research output: Contribution to journal › Review › peer-review

122 Citations (Scopus)

Natural products in Glycyrrhiza glabra (licorice) rhizome imaged at the cellular level by atmospheric pressure matrix-assisted laser desorption/ionization tandem mass spectrometry imaging

Li, B., Bhandari, D. R., Janfelt, C., Römpp, A. & Spengler, B., 1 Oct 2014, In: Plant Journal. 80, 1, p. 161-71 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

50 Citations (Scopus)

Studies of an insect model for drug metabolism by Desorption Electrospray Ionization Mass Spectrometry Imaging

Olsen, L. R., Hansen, S. H. & Janfelt, C., Aug 2014.

Research output: Contribution to conference › Poster › Research

2013

Direct imaging of plant metabolites in leaves and petals by Desorption Electrospray Ionization mass spectrometry

Li, B., Hansen, S. H. & Janfelt, C., 15 Aug 2013, In: International Journal of Mass Spectrometry. 348, p. 15-22

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

Displaced dual-mode imaging with desorption electrospray ionization for simultaneous mass spectrometry imaging in both polarities and with several scan modes

Janfelt, C., Wellner, N., Hansen, H. S. & Hansen, S. H., Mar 2013, In: Journal of Mass Spectrometry. 48, 3, p. 361-6 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

High-throughput analysis of drugs in biological fluids by desorption electrospray ionization mass spectrometry coupled with thin liquid membrane extraction

Rosting, C., Pedersen-Bjergaard, S., Hansen, S. H. & Janfelt, C., 21 Oct 2013, In: Analyst. 138, 20, p. 5965-72 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

N-acylation of phosphatidylethanolamine and its biological functions in mammals

Wellner, N., Diep, T. A., Janfelt, C. & Hansen, H. S., Mar 2013, In: BBA General Subjects. 1831, 3, p. 652-62 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

Visualizing metabolite distribution and enzymatic conversion in plant tissues by desorption electrospray ionization mass spectrometry imaging

Li, B., Baden, C. K., Hansen, N. K. K., Jørgensen, K., Kannangara, R. M., Bak, S., Takos, A. M., Rook, F., Hansen, S. H., Møller, B. L., Janfelt, C. & Bjarnholt, N., Jun 2013, In: Plant Journal. 74, 6, p. 1059-1071 74.

Research output: Contribution to journal › Journal article › Research › peer-review

53 Citations (Scopus)

2012

Ambient mass spectrometry imaging: a comparison of desorption ionization by sonic spray and electrospray

Janfelt, C. & Nørgaard, A. W., Oct 2012, In: Journal of The American Society for Mass Spectrometry. 23, 10, p. 1670-8 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Billeddannende massespektrometri

Janfelt, C., D'Alvise, J., Li, B. & Hansen, S. H., 2012, In: Dansk Kemi. 93, 6/7, p. 12-14 3 p.

Research output: Contribution to journal › Journal article › Communication

Billeddannende massespektrometri til analyse af vævsprøver

Janfelt, C., Wellner, N., D'Alvise, J. & Hansen, S. H., 2012, In: Dansk Kemi. 93, 8, p. 20-23

Research output: Contribution to journal › Journal article › Research

Direct and indirect imaging of secondary metabolites and enzymatic reactions in plant material by Desorption Electrospray Ionization

Li, B., Bjarnholt, N., Knudsen, C., D'Alvise, J., Hansen, S. H. & Janfelt, C., 2012.

Research output: Contribution to conference › Poster › Research › peer-review

Ischemia in neonatal rat brains analyzed by Desorption Electrospray Ionization Imaging mass spectrometry

Janfelt, C., Wellner, N., Leger, P-L., Kokesch-Himmelreich, J., Hansen, S. H., Charriaut-Marlangue, C. & Hansen, H. S., 2012.

Research output: Contribution to conference › Poster › Research › peer-review

Liquid-phase microextraction and desorption electrospray ionization mass spectrometry for identification and quantification of basic drugs in human urine

Thunig, J., Flø, L., Pedersen-Bjergaard, S., Hansen, S. H. & Janfelt, C., 30 Jan 2012, In: Rapid Communications in Massspectrometry. 26, 2, p. 133-140

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

Portable electrospray ionization mass spectrometry (ESI-MS) for analysis of contaminants in the field

Janfelt, C., Græsbøll, R. & Lauritsen, F. R., Apr 2012, In: International Journal of Environmental Analytical Chemistry. 92, 4, p. 397–404 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Visualization by mass spectrometry of 2-dimensional changes in rat brain lipids, including N-acylphosphatidylethanolamines, during neonatal brain ischemia

Janfelt, C., Wellner, N., Leger, P-L., Kokesch-Himmelreich, J., Hansen, S. H., Charriaut-Marlangue, C. & Hansen, H. S., Jun 2012, In: F A S E B Journal. 26, 6, p. 2667-2673

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

2011

Analysis of secondary plant metabolites by indirect desorption electrospray ionization imaging mas spectrometry

Thunig, U. J. C., Hansen, S. H. & Janfelt, C., 1 May 2011, In: Analytical Chemistry. 83, p. 3256-3259

Research output: Contribution to journal › Letter › peer-review

105 Citations (Scopus)

Characterization of a capillary spray cell for easy analysis of extracts of biological samples

Janfelt, C. & Lauritsen, F. R., 15 Jan 2011, In: International Journal of Mass Spectrometry. 299, p. 178-183

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Characterization of barley leaf tissue using direct and indirect desorption electrospray ionization imaging mass spectrometry

Li, B., Bjarnholt, N., Hansen, S. H. & Janfelt, C., Dec 2011, In: Journal of Mass Spectrometry. 46, 12, p. 1241-1246

Research output: Contribution to journal › Journal article › Research › peer-review

57 Citations (Scopus)

Indirect DESI imaging of secondary metabolites in plant material

Janfelt, C., Thunig, U. J. C., Li, B. & Hansen, S. H., 2011. 1 p.

Research output: Contribution to conference › Poster › Research

Massespektrometri viser fordelingen af lægemiddelstoffer i planter og væv

Janfelt, C., Thunig, J., Li, B., Andersen, N. W., Hansen, H. S. & Hansen, S. H., Dec 2011, In: Lægemiddelforskning. 2011, p. 10-12

Research output: Contribution to journal › Journal article › Communication

1775 Downloads (Pure)

Nebulization ionization and desorption ionization analysis of reactive organofunctionalized silanes in nanofilm products

Nørgaard, A. W., Janfelt, C., Benassi, M., Wolkoff, P. & Lauritsen, F. R., Apr 2011, In: Journal of Mass Spectrometry. 46, 4, p. 402-410

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2010

Direkte analyse med DESI-MS

Thunig, J., Lauritsen, F. R., Hansen, S. H., Janfelt, C. & Christophersen, C., 2010, In: Dansk Kemi. 91, 3, p. 21-23 3 p.

Research output: Contribution to journal › Journal article › Research

2009

Liquid-Phase MicroExtraction coupled to Desorption Electrospray Ionization Mass Spectrometry in pharmaceutical analysis

Janfelt, C., Thunig, U. J. C., Pedersen-Bjergaard, S. & Hansen, S. H., 2009.

Research output: Contribution to conference › Poster › Research

Release of VOCs and particles during use of nanofilm spray products

Nørgaard, A. W., Jensen, K. A., Janfelt, C., Lauritsen, F. R., Clausen, P. A. & Wolkoff, P., 2009, In: Environmental Science and Technology. 43, 20, p. 7824-7830 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

57 Citations (Scopus)

2008

Characterization and optimization of membrane inlets for a miniature ion trap mass spectrometer operating at a high background pressure of humid air

Janfelt, C., Graesboll, R. & Lauritsen, F. R., 2008, In: International Journal of Mass Spectrometry. 276, p. 17-23 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Christian Janfelt

Research output

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