N-acylation of phosphatidylethanolamine and its biological functions in mammals

Niels Wellner; Thi Ai Diep; Christian Janfelt; Harald Severin Hansen

doi:10.1016/j.bbalip.2012.08.019

N-acylation of phosphatidylethanolamine and its biological functions in mammals

Niels Wellner, Thi Ai Diep, Christian Janfelt, Harald Severin Hansen

62 Citations (Scopus)

Abstract

N-acylphosphatidylethanolamine (NAPE) and N-acylplasmenylethanolamine (pNAPE) are widely found phospholipids, and they are precursors for N-acylethanolamines, a group of compounds that has a variety of biological effects and encompasses the endocannabinoid anandamide. NAPE and pNAPE are synthesized by the transfer of an acyl chain from a donor phospholipid, to the amine in phosphatidylethanolamine or plasmenylethanolamine. NAPE has been reported to stabilize model membranes during brain ischemia, and to modulate food intake in rodents, thus having bioactive effects besides its precursor role. This paper reviews the metabolism, occurrence and assay of NAPE and pNAPE, and discusses the putative biological functions in mammals of these phospholipids. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.

Original language	English
Journal	BBA General Subjects
Volume	1831
Issue number	3
Pages (from-to)	652-62
Number of pages	11
ISSN	0304-4165
DOIs	https://doi.org/10.1016/j.bbalip.2012.08.019
Publication status	Published - Mar 2013

Keywords

Acylation
Animals
Appetite Regulation
Arachidonic Acids
Brain
Endocannabinoids
Ethanolamines
Humans
Lysosomes
Phosphatidylethanolamines
Phospholipase D
Polyunsaturated Alkamides
Rodentia
Signal Transduction
Type C Phospholipases

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10.1016/j.bbalip.2012.08.019

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title = "N-acylation of phosphatidylethanolamine and its biological functions in mammals",

abstract = "N-acylphosphatidylethanolamine (NAPE) and N-acylplasmenylethanolamine (pNAPE) are widely found phospholipids, and they are precursors for N-acylethanolamines, a group of compounds that has a variety of biological effects and encompasses the endocannabinoid anandamide. NAPE and pNAPE are synthesized by the transfer of an acyl chain from a donor phospholipid, to the amine in phosphatidylethanolamine or plasmenylethanolamine. NAPE has been reported to stabilize model membranes during brain ischemia, and to modulate food intake in rodents, thus having bioactive effects besides its precursor role. This paper reviews the metabolism, occurrence and assay of NAPE and pNAPE, and discusses the putative biological functions in mammals of these phospholipids. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.",

keywords = "Acylation, Animals, Appetite Regulation, Arachidonic Acids, Brain, Endocannabinoids, Ethanolamines, Humans, Lysosomes, Phosphatidylethanolamines, Phospholipase D, Polyunsaturated Alkamides, Rodentia, Signal Transduction, Type C Phospholipases",

author = "Niels Wellner and Diep, {Thi Ai} and Christian Janfelt and Hansen, {Harald Severin}",

year = "2013",

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doi = "10.1016/j.bbalip.2012.08.019",

language = "English",

volume = "1831",

pages = "652--62",

journal = "B B A - General Subjects",

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TY - JOUR

T1 - N-acylation of phosphatidylethanolamine and its biological functions in mammals

AU - Wellner, Niels

AU - Diep, Thi Ai

AU - Janfelt, Christian

AU - Hansen, Harald Severin

PY - 2013/3

Y1 - 2013/3

N2 - N-acylphosphatidylethanolamine (NAPE) and N-acylplasmenylethanolamine (pNAPE) are widely found phospholipids, and they are precursors for N-acylethanolamines, a group of compounds that has a variety of biological effects and encompasses the endocannabinoid anandamide. NAPE and pNAPE are synthesized by the transfer of an acyl chain from a donor phospholipid, to the amine in phosphatidylethanolamine or plasmenylethanolamine. NAPE has been reported to stabilize model membranes during brain ischemia, and to modulate food intake in rodents, thus having bioactive effects besides its precursor role. This paper reviews the metabolism, occurrence and assay of NAPE and pNAPE, and discusses the putative biological functions in mammals of these phospholipids. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.

AB - N-acylphosphatidylethanolamine (NAPE) and N-acylplasmenylethanolamine (pNAPE) are widely found phospholipids, and they are precursors for N-acylethanolamines, a group of compounds that has a variety of biological effects and encompasses the endocannabinoid anandamide. NAPE and pNAPE are synthesized by the transfer of an acyl chain from a donor phospholipid, to the amine in phosphatidylethanolamine or plasmenylethanolamine. NAPE has been reported to stabilize model membranes during brain ischemia, and to modulate food intake in rodents, thus having bioactive effects besides its precursor role. This paper reviews the metabolism, occurrence and assay of NAPE and pNAPE, and discusses the putative biological functions in mammals of these phospholipids. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.

KW - Acylation

KW - Animals

KW - Appetite Regulation

KW - Arachidonic Acids

KW - Brain

KW - Endocannabinoids

KW - Ethanolamines

KW - Humans

KW - Lysosomes

KW - Phosphatidylethanolamines

KW - Phospholipase D

KW - Polyunsaturated Alkamides

KW - Rodentia

KW - Signal Transduction

KW - Type C Phospholipases

U2 - 10.1016/j.bbalip.2012.08.019

DO - 10.1016/j.bbalip.2012.08.019

M3 - Journal article

C2 - 23000428

SN - 0304-4165

VL - 1831

SP - 652

EP - 662

JO - B B A - General Subjects

JF - B B A - General Subjects

IS - 3

ER -

N-acylation of phosphatidylethanolamine and its biological functions in mammals

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Keywords

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