Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

Nicolai J Wewer Albrechtsen; Philipp E Geyer; Sophia Doll; Peter V Treit; Kirstine N Bojsen-Møller; Christoffer Martinussen; Nils B Jørgensen; Signe S Torekov; Florian Meier; Lili Niu; Alberto Santos; Eva C Keilhauer; Jens J Holst; Sten Madsbad; Matthias Mann

doi:10.1016/j.cels.2018.10.012

Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

Nicolai J Wewer Albrechtsen, Philipp E Geyer, Sophia Doll, Peter V Treit, Kirstine N Bojsen-Møller, Christoffer Martinussen, Nils B Jørgensen, Signe S Torekov, Florian Meier, Lili Niu, Alberto Santos, Eva C Keilhauer, Jens J Holst, Sten Madsbad, Matthias Mann

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Abstract

Bariatric surgery is the most effective intervention in morbidly obese individuals. It is followed by extensive weight loss and improved metabolic health status. We applied plasma proteome profiling, a recently developed mass spectrometric strategy, to quantify the levels of more than 500 circulating proteins in a longitudinal cohort of 47 individuals (total of 1,700 plasma proteins). The resulting global correlation map of the plasma proteome contained about 200,000 relationships and revealed functionally connected protein modules. This determined markers of inflammation, insulin sensitivity, and lipid metabolism.

Original language	English
Journal	Cell Systems
Volume	7
Issue number	6
Pages (from-to)	601-612
ISSN	2405-4712
DOIs	https://doi.org/10.1016/j.cels.2018.10.012
Publication status	Published - 26 Dec 2018

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Wewer Albrechtsen, N. J., Geyer, P. E., Doll, S., Treit, P. V., Bojsen-Møller, K. N., Martinussen, C., Jørgensen, N. B., Torekov, S. S., Meier, F., Niu, L., Santos, A., Keilhauer, E. C., Holst, J. J., Madsbad, S., & Mann, M. (2018). Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. Cell Systems, 7(6), 601-612. https://doi.org/10.1016/j.cels.2018.10.012

Wewer Albrechtsen, NJ, Geyer, PE, Doll, S, Treit, PV, Bojsen-Møller, KN, Martinussen, C, Jørgensen, NB, Torekov, SS, Meier, F, Niu, L , Santos, A, Keilhauer, EC, Holst, JJ , Madsbad, S & Mann, M 2018, 'Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery', Cell Systems, vol. 7, no. 6, pp. 601-612. https://doi.org/10.1016/j.cels.2018.10.012

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abstract = "Bariatric surgery is the most effective intervention in morbidly obese individuals. It is followed by extensive weight loss and improved metabolic health status. We applied plasma proteome profiling, a recently developed mass spectrometric strategy, to quantify the levels of more than 500 circulating proteins in a longitudinal cohort of 47 individuals (total of 1,700 plasma proteins). The resulting global correlation map of the plasma proteome contained about 200,000 relationships and revealed functionally connected protein modules. This determined markers of inflammation, insulin sensitivity, and lipid metabolism.",

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AU - Doll, Sophia

AU - Treit, Peter V

AU - Bojsen-Møller, Kirstine N

AU - Martinussen, Christoffer

AU - Jørgensen, Nils B

AU - Torekov, Signe S

AU - Meier, Florian

AU - Niu, Lili

AU - Santos, Alberto

AU - Keilhauer, Eva C

AU - Holst, Jens J

AU - Madsbad, Sten

AU - Mann, Matthias

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AB - Bariatric surgery is the most effective intervention in morbidly obese individuals. It is followed by extensive weight loss and improved metabolic health status. We applied plasma proteome profiling, a recently developed mass spectrometric strategy, to quantify the levels of more than 500 circulating proteins in a longitudinal cohort of 47 individuals (total of 1,700 plasma proteins). The resulting global correlation map of the plasma proteome contained about 200,000 relationships and revealed functionally connected protein modules. This determined markers of inflammation, insulin sensitivity, and lipid metabolism.

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DO - 10.1016/j.cels.2018.10.012

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ER -

Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

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