Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

Nicolai J Wewer Albrechtsen; Philipp E Geyer; Sophia Doll; Peter V Treit; Kirstine N Bojsen-Møller; Christoffer Martinussen; Nils B Jørgensen; Signe S Torekov; Florian Meier; Lili Niu; Alberto Santos; Eva C Keilhauer; Jens J Holst; Sten Madsbad; Matthias Mann

doi:10.1016/j.cels.2018.10.012

Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

Nicolai J Wewer Albrechtsen, Philipp E Geyer, Sophia Doll, Peter V Treit, Kirstine N Bojsen-Møller, Christoffer Martinussen, Nils B Jørgensen, Signe S Torekov, Florian Meier, Lili Niu, Alberto Santos, Eva C Keilhauer, Jens J Holst, Sten Madsbad, Matthias Mann

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Abstract

Bariatric surgery is the most effective intervention in morbidly obese individuals. It is followed by extensive weight loss and improved metabolic health status. We applied plasma proteome profiling, a recently developed mass spectrometric strategy, to quantify the levels of more than 500 circulating proteins in a longitudinal cohort of 47 individuals (total of 1,700 plasma proteins). The resulting global correlation map of the plasma proteome contained about 200,000 relationships and revealed functionally connected protein modules. This determined markers of inflammation, insulin sensitivity, and lipid metabolism.

Originalsprog	Engelsk
Tidsskrift	Cell Systems
Vol/bind	7
Udgave nummer	6
Sider (fra-til)	601-612
ISSN	2405-4712
DOI	https://doi.org/10.1016/j.cels.2018.10.012
Status	Udgivet - 26 dec. 2018

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10.1016/j.cels.2018.10.012

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Wewer Albrechtsen, N. J., Geyer, P. E., Doll, S., Treit, P. V., Bojsen-Møller, K. N., Martinussen, C., Jørgensen, N. B., Torekov, S. S., Meier, F., Niu, L., Santos, A., Keilhauer, E. C., Holst, J. J., Madsbad, S., & Mann, M. (2018). Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. Cell Systems, 7(6), 601-612. https://doi.org/10.1016/j.cels.2018.10.012

Wewer Albrechtsen, NJ, Geyer, PE, Doll, S, Treit, PV, Bojsen-Møller, KN, Martinussen, C, Jørgensen, NB, Torekov, SS, Meier, F, Niu, L , Santos, A, Keilhauer, EC, Holst, JJ , Madsbad, S & Mann, M 2018, 'Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery', Cell Systems, bind 7, nr. 6, s. 601-612. https://doi.org/10.1016/j.cels.2018.10.012

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title = "Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery",

abstract = "Bariatric surgery is the most effective intervention in morbidly obese individuals. It is followed by extensive weight loss and improved metabolic health status. We applied plasma proteome profiling, a recently developed mass spectrometric strategy, to quantify the levels of more than 500 circulating proteins in a longitudinal cohort of 47 individuals (total of 1,700 plasma proteins). The resulting global correlation map of the plasma proteome contained about 200,000 relationships and revealed functionally connected protein modules. This determined markers of inflammation, insulin sensitivity, and lipid metabolism.",

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year = "2018",

month = dec,

day = "26",

doi = "10.1016/j.cels.2018.10.012",

language = "English",

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AU - Wewer Albrechtsen, Nicolai J

AU - Geyer, Philipp E

AU - Doll, Sophia

AU - Treit, Peter V

AU - Bojsen-Møller, Kirstine N

AU - Martinussen, Christoffer

AU - Jørgensen, Nils B

AU - Torekov, Signe S

AU - Meier, Florian

AU - Niu, Lili

AU - Santos, Alberto

AU - Keilhauer, Eva C

AU - Holst, Jens J

AU - Madsbad, Sten

AU - Mann, Matthias

PY - 2018/12/26

Y1 - 2018/12/26

N2 - Bariatric surgery is the most effective intervention in morbidly obese individuals. It is followed by extensive weight loss and improved metabolic health status. We applied plasma proteome profiling, a recently developed mass spectrometric strategy, to quantify the levels of more than 500 circulating proteins in a longitudinal cohort of 47 individuals (total of 1,700 plasma proteins). The resulting global correlation map of the plasma proteome contained about 200,000 relationships and revealed functionally connected protein modules. This determined markers of inflammation, insulin sensitivity, and lipid metabolism.

AB - Bariatric surgery is the most effective intervention in morbidly obese individuals. It is followed by extensive weight loss and improved metabolic health status. We applied plasma proteome profiling, a recently developed mass spectrometric strategy, to quantify the levels of more than 500 circulating proteins in a longitudinal cohort of 47 individuals (total of 1,700 plasma proteins). The resulting global correlation map of the plasma proteome contained about 200,000 relationships and revealed functionally connected protein modules. This determined markers of inflammation, insulin sensitivity, and lipid metabolism.

U2 - 10.1016/j.cels.2018.10.012

DO - 10.1016/j.cels.2018.10.012

M3 - Journal article

C2 - 30528273

SN - 2405-4712

VL - 7

SP - 601

EP - 612

JO - Cell Systems

JF - Cell Systems

IS - 6

ER -

Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

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