Ulrik Gether

2020

G protein-coupled receptor pharmacology-The next generation

Bräuner-Osborne, H., Rosenkilde, M. M., Gether, U. & Gloriam, D. E., 1 Jun 2020, In: Basic & Clinical Pharmacology & Toxicology.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

2019

Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors

DiCarlo, G. E., Aguilar, J. I., Matthies, H. J. G., Harrison, F. E., Bundschuh, K. E., West, A., Hashemi, P., Herborg, F., Rickhag, M., Chen, H., Gether, U., Wallace, M. T. & Galli, A., 1 Aug 2019, In: Journal of Clinical Investigation. 129, 8, p. 3407-3419 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Chemogenetic Targeting of Dorsomedial Direct-pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice

Kønig, A. B., Ciriachi, C., Gether, U. & Rickhag, M., 1 Mar 2019, In: Neuroscience. 401, p. 106-116

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Conformational dynamics of the human serotonin transporter during substrate and drug binding

Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, S. G. F., Gether, U., Loland, C. J. & Rand, K. D., 1 Dec 2019, In: Nature Communications. 10, 1, 1687.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

24 Downloads (Pure)

Differential effects of chemogenetic inhibition on dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task

Fitzpatrick, C. M., Runegaard, A. H., Christiansen, S. H., Hansen, N. W., Jørgensen, S. H., McGirr, J. C., de Diego Ajenjo, A., Sørensen, A. T., Perrier, J-F., Petersen, A., Gether, U., Woldbye, D. P. D. & Andreasen, J. T., 2 Mar 2019, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 90, 2, p. 264-276 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

Giguère, N., Delignat-Lavaud, B., Herborg, F., Voisin, A., Li, Y., Jacquemet, V., Anand-Srivastava, M., Gether, U., Giros, B. & Trudeau, L-E., 2019, In: PLOS Genetics. 15, 8, 26 p., e1008352.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

12 Downloads (Pure)

Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol

Runegaard, A. H., Jensen, K. L., Wörtwein, G. & Gether, U., 1 Aug 2019, In: European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

Erlendsson, S., Thorsen, T. S., Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, K. L., Teilum, K., Gether, U. & Madsen, K. L., 2019, In: eLife. 8, p. 1-27 e39180.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

31 Downloads (Pure)

Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges

Runegaard, A. H., Fitzpatrick, C. M., Woldbye, D. P. D., Andreasen, J. T., Sørensen, A. T. & Gether, U., 1 Apr 2019, In: Pharmacological Reviews. 71, 2, p. 123-156 34 p.

Research output: Contribution to journal › Review › peer-review

18 Citations (Scopus)

2018

An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1

Herlo, R., Lund, V. K., Lycas, M. D., Jansen, A. M., Khelashvili, G., Andersen, R. C., Bhatia, V., Pedersen, T. S., Albornoz, P. B. C., Johner, N., Ammendrup-Johnsen, I., Christensen, N. R., Erlendsson, S., Stoklund, M., Larsen, J. B., Weinstein, H., Kjærulff, O., Stamou, D., Gether, U. & Madsen, K. L., 15 May 2018, In: Cell Reports. 23, 7, p. 2056-2069 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

104 Downloads (Pure)

An unsuspected role for organic cation transporter 3 in the actions of amphetamine

Mayer, F. P., Schmid, D., Owens, W. A., Gould, G. G., Apuschkin, M., Kudlacek, O., Salzer, I., Boehm, S., Chiba, P., Williams, P. H., Wu, H-H., Gether, U., Koek, W., Daws, L. C. & Sitte, H. H., 1 Nov 2018, In: Neuropsychopharmacology. 43, p. 2408-2417 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

39 Downloads (Pure)

Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

Runegaard, A. H., Sørensen, A. T., Fitzpatrick, C. M., Jørgensen, S. H., Petersen, A. V., Hansen, N. W., Weikop, P., Andreasen, J. T., Mikkelsen, J. D., Perrier, J-F., Woldbye, D., Rickhag, M., Wortwein, G. & Gether, U., 1 May 2018, In: eNeuro. 5, 3, 26 p., e0345.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

90 Downloads (Pure)

Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

Herborg, F., Andreassen, T. F., Berlin, F., Loland, C. J. & Gether, U., 11 May 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Obituary

Brøsen, K., Simonsen, U. & Gether, U., 2018, In: Basic & clinical pharmacology & toxicology. 123, 5, p. 521-522 2 p.

Research output: Contribution to journal › Comment/debate › Communication

PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

Jensen, K. L., Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, P., Wörtwein, G., Fink-Jensen, A., Madsen, K. L., Daws, L., Gether, U. & Rickhag, M., 1 May 2018, In: eNeuro. 5, 3

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

63 Downloads (Pure)

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg

Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, U., Løland, C. J. & Rand, K. D., 2018, In: Science Advances. 4, 5, 12 p., eaar6179.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

55 Downloads (Pure)

2017

Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake

Jensen, K. L., Runegaard, A. H., Weikop, P., Gether, U. & Rickhag, M., 21 Sept 2017, In: Journal of Visualized Experiments. 127, 10 p., e56093.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research

Jørgensen, S. H., Fitzpatrick, C. M., Gether, U., Woldbye, D. P. D. & Sørensen, A. T., Nov 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 5, p. 373-381 9 p.

Research output: Contribution to journal › Review › peer-review

3 Citations (Scopus)

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

Erlendsson, S., Gotfryd, K., Larsen, F. H., Mortensen, J. S., Geiger, M-A., van Rossum, B-J., Oschkinat, H., Gether, U., Teilum, K. & Løland, C. J., 24 Jan 2017, In: eLife. 6, 9 p., e19314.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

99 Downloads (Pure)

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer

Jacobsen, S. E., Gether, U. & Bräuner-Osborne, H., 18 Apr 2017, In: Scientific Reports. 7, 14 p., 46355.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

79 Downloads (Pure)

Neurotransmitter Transporters: Structure, Function, and Drug Binding

Løland, C. J. & Gether, U., 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice

Thomsen, A. H. R., Jensen, K. L., Fitzpatrick, C. M., Dencker, D., Weikop, P., Gether, U. & Rickhag, K. M., 1 Jan 2017, In: European Journal of Neuroscience. 45, 1, p. 121-128

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

Runegaard, A. H., Jensen, K. L., Dencker, D., Wörtwein, G. & Gether, U., 2017, In: Journal of Neuroscience Methods. 289, p. 85-92 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

Rahbek-Clemmensen, T., Lycas, M. D., Erlendsson, S., Eriksen, J., Apuschkin, M., Vilhardt, F., Jorgensen, T. N., Hansen, F. H. & Gether, U., 1 Dec 2017, In: Nature Communications. 8, 14 p., 740.

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

382 Downloads (Pure)

The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway

Jacobsen, S. E., Ammendrup-Johnsen, I., Jansen, A. M., Gether, U., Madsen, K. L. & Bräuner-Osborne, H., 28 Apr 2017, In: The Journal of Biological Chemistry. 292, 17, p. 6910-6926

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task

Fitzpatrick, C. M., Caballero-Puntiverio, M., Gether, U., Habekost, T., Bundesen, C., Vangkilde, S., Woldbye, D. P. D., Andreasen, J. T. & Petersen, A., 1 Mar 2017, In: Psychopharmacology. 234, 5, p. 845-855

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

2016

A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function

Vuorenpää, A. E., Ammendrup-Johnsen, I., Jorgensen, T. N. & Gether, U., 1 Sept 2016, In: Neurochemistry International. 98, p. 103-114

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu(290)

Khelashvili, G., Schmidt, S. G., Shi, L., Javitch, J. A., Gether, U., Loland, C. J. & Weinstein, H., 16 Sept 2016, In: Journal of Biological Chemistry. 291, 38, p. 19786-19799

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini

Vuorenpää, A. E., Jørgensen, T. N., Newman, A. H., Madsen, K. L., Scheinin, M. & Gether, U., 11 Mar 2016, In: Journal of Biological Chemistry. 291, 11, p. 5634-5651 18 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial

Knorr, U., Koefoed, P., Gluud, C., Wetterslev, J., Winkel, P., Gether, U., Vinberg, M. & Kessing, L. V., 18 May 2016, In: Nordic Journal of Psychiatry. 70, 4, p. 297-302 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial

Knorr, U., Koefoed, P., Soendergaard, M. H. G., Vinberg, M., Gether, U., Gluud, C., Wetterslev, J., Winkel, P. & Kessing, L. V., 1 Apr 2016, In: Acta Neuropsychiatrica. 28, 2, p. 101-109 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Structural biology: Antidepressants at work

Caron, M. G. & Gether, U., 21 Apr 2016, In: Nature. 532, p. 320-321 2 p.

Research output: Contribution to journal › Comment/debate › Research › peer-review

3 Citations (Scopus)

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter

Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, A. S., Bøgesø, K. P., Gether, U., Strømgaard, K., Bang-Andersen, B. & Loland, C. J., 1 Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

The Environment Shapes the Inner Vestibule of LeuT

Sohail, A., Jayaraman, K., Venkatesan, S., Gotfryd, K., Daerr, M., Gether, U., Loland, C. J., Wanner, K. T., Freissmuth, M., Sitte, H. H., Sandtner, W. & Stockner, T., Nov 2016, In: PLoS Computational Biology. 12, 11, 24 p., e1005197.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

306 Downloads (Pure)

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter

Billesbølle, C. B., Mortensen, J. S., Sohail, A., Schmidt, S. G., Shi, L., Sitte, H. H., Gether, U. & Loland, C. J., 28 Sept 2016, In: Nature Communications. 7, 12 p., 12755.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

100 Downloads (Pure)

2015

Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation

Rajamanickam, J., Annamalai, B., Rahbek-Clemmensen, T., Sundaramurthy, S., Gether, U., Jayanthi, L. D. & Ramamoorthy, S., 15 May 2015, In: Biochemical Journal. 468, 1, p. 177-190 14 p., BJ20140826.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

Amphetamine Action at the Cocaine- and Antidepressant-Sensitive Serotonin Transporter Is Modulated by αCaMKII

Steinkellner, T., Montgomery, T. R., Hofmaier, T., Kudlacek, O., Yang, J-W., Rickhag, K. M., Jung, G., Lubec, G., Gether, U., Freissmuth, M. & Sitte, H. H., 27 May 2015, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 21, p. 8258-8271 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity

Christiansen, M. A., Stilling, S., Rahbek-Clemmensen, T., Sørensen, G., Fortin, G., Herborg Hansen, F., Eriksen, J., Trudeau, L-E., Egerod, K., Gether, U. & Rickhag, K. M., 1 Oct 2015, In: European Journal of Neuroscience. 42, 7, p. 2438-2454 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Functional regulation of amphetamine-induced efflux by CaMKII

Sitte, H. H., Steinkellner, T., Montgomery, T. R., Hofmaier, T., Kudlacek, O., Yang, J-W., Jung, G., Lubec, G., Gether, U., Freissmuth, M. & Pollak, D. D., Aug 2015, In: Amino Acids. 47, 8, p. 1659-1659 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Mechanism of the Association between Na⁺ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

Stolzenberg, S., Quick, M., Zhao, C., Gotfryd, K., Khelashvili, G., Gether, U., Loland, C. J., Javitch, J. A., Noskov, S., Weinstein, H. & Shi, L., 29 May 2015, In: The Journal of Biological Chemistry. 290, 22, p. 13992-4003 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform

Translated title of the contribution: Optogenetics brings hidden neural mechanisms into the light and could become a future therapyAxelsen, T. M., Navntoft, C. A. E., Christiansen, S. H., Dreyer, J. K., Sørensen, J. B., Gether, U. & Woldbye, D. P. D., 17 Aug 2015, In: Ugeskrift for Laeger. 177, 34, p. 2-5 4 p., V06150501.

Research output: Contribution to journal › Journal article › Research › peer-review

Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors

Cartier, E., Hamilton, P. J., Belovich, A. N., Shekar, A., Campbell, N. G., Saunders, C., Andreassen, T. F., Gether, U., Veenstra-Vanderweele, J., Sutcliffe, J. S., Ulery-Reynolds, P. G., Erreger, K., Matthies, H. J. G. & Galli, A., Feb 2015, In: EBioMedicine. 2, 2, p. 135-146 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

Structure of dimeric and tetrameric complexes of the BAR domain protein PICK1 determined by small-angle X-Ray scattering

Karlsen, M. L., Thorsen, T. S., Johner, N., Ammendrup-Johnsen, I., Erlendsson, S., Tian, X., Simonsen, J. B., Hoiberg-Nielsen, R., Christensen, N. M., Khelashvili, G., Streicher, W., Teilum, K., Vestergaard, B., Weinstein, H., Gether, U., Arleth, L. & Madsen, K. L., 9 Jul 2015, In: Structure. 23, 7, p. 1258-1270 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter

Billesbolle, C. B., Kruger, M. B., Shi, L., Quick, M., Li, Z., Stolzenberg, S., Kniazeff, J., Gotfryd, K., Mortensen, J. S., Javitch, J. A., Weinstein, H., Loland, C. J. & Gether, U., 30 Oct 2015, In: Journal of Biological Chemistry. 290, 44, p. 26725-26738 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

25 Citations (Scopus)

2014

In vivo amphetamine action is contingent on αCaMKII

Steinkellner, T., Mus, L., Eisenrauch, B., Constantinescu, A., Leo, D., Konrad, L., Rickhag, K. M., Sørensen, G., Efimova, E. V., Kong, E., Willeit, M., Sotnikova, T. D., Kudlacek, O., Gether, U., Freissmuth, M., Pollak, D. D., Gainetdinov, R. R. & Sitte, H. H., 1 Oct 2014, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 39, 11, p. 2681-93 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD

Hansen, F. H., Skjørringe, T., Yasmeen, S., Arends, N. V., Sahai, M. A., Erreger, K., Andreassen, T. F., Holy, M., Hamilton, P. J., Neergheen, V., Karlsborg, M., Newman, A. H., Pope, S., Heales, S. J. R., Friberg, L., Law, I., Pinborg, L. H., Sitte, H. H., Loland, C., Shi, L., & 5 othersWeinstein, H., Galli, A., Hjermind, L. E., Møller, L. B. & Gether, U., 1 Jul 2014, In: The Journal of Clinical Investigation. 124, 7, p. 3107-20 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

73 Citations (Scopus)

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram

Kumar, V., Rahbek-Clemmensen, T., Billesbølle, C. B., Jorgensen, T. N., Gether, U. & Newman, A. H., 12 Jun 2014, In: A C S Medicinal Chemistry Letters. 5, 6, p. 696-9 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/Discs-Large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands

Erlendsson, S., Rathje, M., Heiðarsson, P. O., Poulsen, F. M., Madsen, K. L., Teilum, K. & Gether, U., 2014, In: Journal of Biological Chemistry. 289, 36, p. 25327-25340 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Reply to Wilkinson et al. Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling

Rathje, M., Fang, H., Bachman, J. L., Gether, U., Huganir, R. L. & Madsen, K. L., 21 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. E305 1 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Serotonin-induced down-regulation of cell surface serotonin transporter

Jørgensen, T. N., Christensen, P. M. & Gether, U., Jul 2014, In: Neurochemistry International. 73, p. 107-12 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Ulrik Gether

Research output

Search results