Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform

Tobias Melton Axelsen; Charlotte Amalie Emdal Navntoft; Søren Hofman Christiansen; Jakob Kisbye Dreyer; Jakob Balslev Sørensen; Ulrik Gether; David Paul Drucker Woldbye

Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform

Translated title of the contribution: Optogenetics brings hidden neural mechanisms into the light and could become a future therapy

Tobias Melton Axelsen, Charlotte Amalie Emdal Navntoft, Søren Hofman Christiansen, Jakob Kisbye Dreyer, Jakob Balslev Sørensen, Ulrik Gether, David Paul Drucker Woldbye

Abstract

Optogenetics is an emergent technology that combines light-sensitive proteins derived from algae, so-called opsins, with genetics. Viral vectors encoding opsins are injected into selective brain regions whereby specific cell populations can be controlled with high precision light pulses delivered via implanted optical fibres. This review focuses on explaining basic principles of optogenetics and describes important insights into neuropsychiatric mechanisms provided by the technology.

Translated title of the contribution	Optogenetics brings hidden neural mechanisms into the light and could become a future therapy
Original language	Danish
Article number	V06150501
Journal	Ugeskrift for Laeger
Volume	177
Issue number	34
Pages (from-to)	2-5
Number of pages	4
ISSN	0041-5782
Publication status	Published - 17 Aug 2015

Cite this

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abstract = "Optogenetics is an emergent technology that combines light-sensitive proteins derived from algae, so-called opsins, with genetics. Viral vectors encoding opsins are injected into selective brain regions whereby specific cell populations can be controlled with high precision light pulses delivered via implanted optical fibres. This review focuses on explaining basic principles of optogenetics and describes important insights into neuropsychiatric mechanisms provided by the technology.",

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AU - Axelsen, Tobias Melton

AU - Navntoft, Charlotte Amalie Emdal

AU - Christiansen, Søren Hofman

AU - Dreyer, Jakob Kisbye

AU - Sørensen, Jakob Balslev

AU - Gether, Ulrik

AU - Woldbye, David Paul Drucker

PY - 2015/8/17

Y1 - 2015/8/17

N2 - Optogenetics is an emergent technology that combines light-sensitive proteins derived from algae, so-called opsins, with genetics. Viral vectors encoding opsins are injected into selective brain regions whereby specific cell populations can be controlled with high precision light pulses delivered via implanted optical fibres. This review focuses on explaining basic principles of optogenetics and describes important insights into neuropsychiatric mechanisms provided by the technology.

AB - Optogenetics is an emergent technology that combines light-sensitive proteins derived from algae, so-called opsins, with genetics. Viral vectors encoding opsins are injected into selective brain regions whereby specific cell populations can be controlled with high precision light pulses delivered via implanted optical fibres. This review focuses on explaining basic principles of optogenetics and describes important insights into neuropsychiatric mechanisms provided by the technology.

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SN - 0041-5782

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IS - 34

M1 - V06150501

ER -

Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform

Abstract

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