Uffe Kristiansen

Research output

Research output per year 1991 2002 2007 2011 2013 2014 2016 2019

• 39 Journal article
• 6 Book chapter
• 2 Conference abstract in journal
• 1 Poster
• 2 More
  • 1 Letter
  • 1 Review

Research output per year

Research output per year

Search results

• 2019

  Increasing cellular lifespan with a flow system in organotypic culture of the Laterodorsal Tegmentum (LDT)

  Leguizamon, C. R. R., Elnagar, M., Kristiansen, U. & Kohlmeier, K. A., 1 Dec 2019, In: Scientific Reports. p. 1 - 11 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Longevity 100%
  • Perfusion 84%
  • Tissue Survival 71%
  • Electrophysiology 62%
  • Neurosciences 59%
  4 Citations (Scopus)

  17 Downloads (Pure)
• 2018

  The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6^+/- mice

  von Schoubye, N. L., Frederiksen, K., Kristiansen, U., Petersen, A. V., Dalby, N. O., Grunnet, M., Jensen, H. S., Jespersen, T., Sohal, V. S. & Perrier, J-F., 1 Jan 2018, In: Neuroscience Letters. 662, p. 29-35 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sodium Channel Agonists 100%
  • Interneurons 57%
  • Schizophrenia 26%
  • NAV1.1 Voltage-Gated Sodium Channel 20%
  • Action Potentials 19%
  3 Citations (Scopus)
• 2017

  Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ-subunit-containing GABAA receptors in dentate gyrus granule cells

  Simonsen, C., Boddum, K., von Schoubye, N. L., Kloppenburg, A., Sønderskov, K., Hansen, S. L. & Kristiansen, U., Aug 2017, In: Pharmacology Research & Perspectives. 5, 4, 15 p., e00322.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • gaboxadol 100%
  • Pentylenetetrazole 78%
  • Dentate Gyrus 67%
  • GABA-A Receptors 66%
  • Animal Models 11%
  56 Downloads (Pure)
• 2016

  Astrocytic GABA transporter activity modulates excitatory neurotransmission

  Boddum, K., Jensen, T. P., Magloire, V., Kristiansen, U., Rusakov, D. A., Pavlov, I. & Walker, M. C., 25 Nov 2016, In: Nature Communications. 7, 10 p., 13572.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • GABA Plasma Membrane Transport Proteins 100%
  • GAT 99%
  • transporter 92%
  • adenosines 65%
  • Adenosine 62%
  66 Citations (Scopus)

  61 Downloads (Pure)

• Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 Receptors

  Gasiorek, A., Trattnig, S. M., Ahring, P. K., Kristiansen, U., Frølund, B., Frederiksen, K. & Jensen, A. A., 15 Jun 2016, In: Biochemical Pharmacology. 110-111, p. 92-108 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Receptors, Serotonin, 5-HT3 100%
  • Agonist 72%
  • Serotonin 64%
  • Partial Agonist 48%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 42%
  5 Citations (Scopus)

• Uterine contraction induced by Ghanaian plants used to induce abortion

  Larsen, B. HV., Soelberg, J., Kristiansen, U. & Jäger, A. K., 1 Sept 2016, In: South African Journal of Botany. 106, p. 137-39 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • uterine contraction 100%
  • abortion (plants) 86%
  • Musanga cecropioides 80%
  • Ghana 32%
  • acetylcholine 28%
  1 Citation (Scopus)
• 2015

  GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology

  Krall, J., Balle, T., Krogsgaard-Larsen, N., Sørensen, T. E., Krogsgaard-Larsen, P., Kristiansen, U. & Frølund, B., 2015, Diversity and functions of GABA receptors: A tribute to Hanns Möhler, Part A. Vol. 72. p. 201-27 27 p. (Advances in Pharmacology).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  • GABA-A Receptor Agonists 100%
  • GABA-A Receptor Antagonists 96%
  • GABA-A Receptors 76%
  • Pharmacology 47%
  • Binding Sites 18%
  24 Citations (Scopus)
• 2014

  Hippocampal P3-Like Auditory Event-Related Potentials are Disrupted in a Rat Model of Cholinergic Degeneration in Alzheimer's Disease: Reversal by Donepezil Treatment: Reversal by Donepezil Treatment

  Laursen, B., Mørk, A., Kristiansen, U. & Bastlund, J. F., 2 Jul 2014, In: Journal of Alzheimer's Disease. 42, 4, p. 1179–1189 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • P300 Event-Related Potentials 100%
  • Donepezil 97%
  • dementia 72%
  • Evoked Potentials 70%
  • Cholinergic Agents 67%
  9 Citations (Scopus)

• Impaired GABAergic Inhibition in the Prefrontal Cortex of Early Postnatal Phencyclidine (PCP)-Treated Rats

  Kjaerby, C., Broberg, B. V., Kristiansen, U. & Dalby, N. O., Sept 2014, In: Cerebral Cortex. 24, 9, p. 2522-32 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Phencyclidine 100%
  • Pyramidal Cells 78%
  • Prefrontal Cortex 67%
  • Psychological Inhibition 60%
  • Interneurons 52%
  17 Citations (Scopus)

• Impaired hippocampal acetylcholine release parallels spatial memory deficits in Tg2576 mice subjected to basal forebrain cholinergic degeneration

  Laursen, B., Mørk, A., Plath, N., Kristiansen, U. & Bastlund, J. F., 16 Jan 2014, In: Brain Research. 1543, p. 253-262

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Basal Forebrain 100%
  • Spatial Memory 87%
  • Memory Disorders 84%
  • Cholinergic Agents 74%
  • Acetylcholine 73%
  23 Citations (Scopus)

• The GABAA Antagonist DPP-4-PIOL Selectively Antagonises Tonic over Phasic GABAergic Currents in Dentate Gyrus Granule Cells

  Boddum, K., Frølund, B. & Kristiansen, U., 4 Oct 2014, In: Neurochemical Research. 39, 11, p. 2078–2084 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 4 Aminobutyric Acid A Receptor Blocking Agent 100%
  • GABA-A Receptor Antagonists 73%
  • Hydrobromide 72%
  • Dentate Gyrus 59%
  • GABA-A Receptors 58%
  7 Citations (Scopus)
• 2013

  Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice

  Laursen, B., Mørk, A., Plath, N., Kristiansen, U. & Bastlund, J. F., 1 Mar 2013, In: Behavioural Brain Research. 240, 1, p. 146-52 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Saporins 100%
  • Cholinergic Agents 81%
  • Cognitive Dysfunction 71%
  • Basal Forebrain 16%
  • Choline O-Acetyltransferase 16%
  42 Citations (Scopus)

• Leukocyte infiltration in experimental stroke

  Grønberg, N. V., Johansen, F. F., Kristiansen, U. & Hasseldam, H., 18 Sept 2013, In: Journal of Neuroinflammation. 10, 9 p., 115.

  Research output: Contribution to journal › Review › peer-review

  • Leukocytes 100%
  • Stroke 86%
  • Granulocytes 41%
  • Neutrophils 32%
  • Macrophages 29%
  84 Citations (Scopus)

• Pharmacological evidence of functional inhibitory metabotrophic glutamate receptors on mouse arousal-related cholinergic laterodorsal tegmental neurons

  Kohlmeier, K. A., Christensen, M. H., Kristensen, M. P. & Kristiansen, U., Mar 2013, In: Neuropharmacology. 66, p. 99-113

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Glutamate Receptors 100%
  • LY 379268 95%
  • Arousal 90%
  • Cholinergic Agents 84%
  • Glutamic Acid 79%
  14 Citations (Scopus)

• Repeated potentiation of the metabotropic glutamate receptor 5 and the alpha 7 nicotinic acetylcholine receptor modulates behavioural and GABAergic deficits induced by early postnatal phencyclidine (PCP) treatment

  Kjaerby, C., Bundgaard, C., Fejgin, K., Kristiansen, U. & Dalby, N. O., Sept 2013, In: Neuropharmacology. 72, p. 157-68 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • S-(4-fluorophenyl)-(3-(3-(4-fluorophenyl)-(1,2,4)-oxadiazol-5-yl)piperidin-1-yl)methanone 100%
  • SSR180711 76%
  • Metabotropic Glutamate 5 Receptor 69%
  • Phencyclidine 61%
  • Nicotinic Receptors 50%
  15 Citations (Scopus)

• Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acid_A receptor agonists

  Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, C. G., Nielsen, B., Kehler, J., Frydenvang, K., Kristensen, J., Balle, T., Jensen, A. A., Kristiansen, U. & Frølund, B., 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Muscimol 100%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 75%
  • GABA-A Receptors 72%
  • GABAA Receptor Agonist 61%
  • Rmax 56%
  17 Citations (Scopus)

• The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors

  Hoestgaard-Jensen, K., O'Connor, R. M., Dalby, N. O., Simonsen, C., Finger, B. C., Golubeva, A., Hammer, H., Bergmann, M. L., Kristiansen, U., Krogsgaard-Larsen, P., Bräuner-Osborne, H., Ebert, B., Frølund, B., Cryan, J. F. & Jensen, A. A., Oct 2013, In: British Journal of Pharmacology. 170, 4, p. 919-32 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 5-(4-piperidyl)-3-isothiazolol 100%
  • Neurotransmitter Receptor 50%
  • GABA-A Receptors 44%
  • Ligands 29%
  • gamma-Aminobutyric Acid 9%
  13 Citations (Scopus)
• 2012

  Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan

  Jeppesen, A. S., Kristiansen, U., Soelberg, J. & Jäger, A. K., 14 Jun 2012, In: Journal of Ethnopharmacology. 141, 3, p. 1077-1079 3 p.

  Research output: Contribution to journal › Letter › peer-review

  • Rubia 100%
  • Histamine Agents 84%
  • Histamine Antagonist 79%
  • Tick Bites 78%
  • Afghanistan 73%
  2 Citations (Scopus)

• Does brain slices from pentylenetetrazole-kindled mice provide a more predictive screening model for antiepileptic drugs?

  Hansen, S. L., Sterjev, Z., Werngreen, M., Simonsen, B. J., Knudsen, K. E., Nielsen, A. H., Pedersen, M. E., Badolo, L., Kristiansen, U. & Vestergaard, H. T., 5 May 2012, In: European Journal of Pharmacology. 682, 1-3, p. 43-9 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pentylenetetrazole 100%
  • Anticonvulsants 74%
  • Brain 38%
  • Seizures 30%
  • Carbamazepine 22%
  4 Citations (Scopus)
• 2011

  Acute but not delayed amphetamine treatment improves behavioral outcome in a rat embolic stroke model

  Rasmussen, R. S., Overgaard, K., Kristiansen, U. & Johansen, F. F., Sept 2011, In: Neurological Research. 33, 7, p. 774-782 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Time-to-Treatment 100%
  • Amphetamine 98%
  • Stroke 61%
  • Dextroamphetamine 6%
  • Middle Cerebral Artery 5%
  2 Citations (Scopus)

• Medicinalplanter og abort: ny viden kan hjælpe afrikanske kvinder

  Jäger, A., Kristiansen, U. & Rasch, V., Dec 2011, In: Lægemiddelforskning. 2011, p. 23-25

  Research output: Contribution to journal › Journal article › Communication

  1740 Downloads (Pure)

• Uterine contraction induced by Tanzanian plants used to induce abortion

  Nikolajsen, T., Nielsen, F., Rasch, V., Sørensen, P. H., Ismail, F., Kristiansen, U. & Jäger, A. K., 1 Sept 2011, In: Journal of Ethnopharmacology. 137, 1, p. 921-925

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Uterine Contraction 100%
  • Acetylcholine 54%
  • Force 51%
  • Plant Extracts 30%
  • Bidens pilosa plant extract 26%
  21 Citations (Scopus)
• 2010

  Effect of Rhoicissus digitata extracts on acetylcholine-mediated contraction in rat uterus

  Schou, J., Kristiansen, U., Stafford, G. I., van Heerden, F. & Jäger, A., Aug 2010, In: Planta Medica. 76, 12, p. 1217

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• GABAergic actions on cholinergic laterodorsal tegmental neurons: implications for control of behavioral state

  Kohlmeier, K. A. & Kristiansen, U., 15 Dec 2010, In: Neuroscience. 171, 3, p. 812-29 18 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • GABA-A Receptors 100%
  • Cholinergic Neurons 91%
  • gamma-Aminobutyric Acid 89%
  • Cholinergic Agents 87%
  • GABA-C receptor 62%
  15 Citations (Scopus)
• 2009

  GABAergic actions on cholinergic laterodorsal tegmental neurons: Implications for control of behavioral state

  Kohlmeier, K. A. & Kristiansen, U., 2009, In: Journal of Neuroscience.

  Research output: Contribution to journal › Conference abstract in journal › Research

• Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus

  Hansen, S. L., Nielsen, A. H., Knudsen, K. E., Artmann, A., Kristiansen, U., Hansen, S. H., Hansen, H. S. & Petersen, G., 2009, In: Neurochemistry International. 54, 3-4, p. 199-204

  Research output: Contribution to journal › Journal article › Research › peer-review

  • N-acylethanolamines 100%
  • Ketogenic Diet 81%
  • Pentylenetetrazole 73%
  • Endocannabinoids 47%
  • Hippocampus 46%
  31 Citations (Scopus)
• 2008

  Effect of acute injections of the ketone bodies in PTZ kindled mice

  Hansen, S. L., Riisberg, M., Nouri-Nejad, A., Skonberg, C., Kristiansen, U. & Hansen, H. S., 2008.

  Research output: Contribution to conference › Poster › Research

• Ligands for the GABA recognition site at the GABAA receptor: Structure-activity studies

  Frølund, B. F., Kristiansen, U., Krogsgaard-Larsen, P. & Liljefors, T., 2008, Chemistry and molecular aspects of drug design and action. Rekka, E. A. & Kourounakis, P. N. (eds.). Boca Raton, Fl: CRC Press, p. 139-147

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
• 2007

  5-substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel ¿-aminobutyric acid_C receptor agonists

  Madsen, C., Jensen, A. A., Liljefors, T., Kristiansen, U., Nielsen, B., Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, P. & Frølund, B. F., 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4147-4161

  Research output: Contribution to journal › Journal article › Research › peer-review

  42 Citations (Scopus)

• 5-Substituted imidazole-4-acetic acid analogues: Synthesis, modeling, and pharmacological characterization of a series of novel γ-aminobutyric acidC receptor agonists

  Madsen, C., Jensen, A. A., Liljefors, T., Kristiansen, U., Nielsen, B., Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, P. & Frølund, B., 2007, In: Journal of Medicinal Chemistry. 50, p. 4147-4161

  Research output: Contribution to journal › Journal article › Research › peer-review

  42 Citations (Scopus)

• Differences in kinetics of structurally related competitive GABA_A receptor antagonists

  Vestergaard, H. T., Cannillo, C., Frølund, B. F. & Kristiansen, U., 2007, In: Neuropharmacology. 52, 3, p. 873-882

  Research output: Contribution to journal › Journal article › Research › peer-review

  5 Citations (Scopus)

• Probing the pharmacophore of ginkgolides as glycine receptor antagonists

  Jensen, A. A., Begum, N., Vogensen, S. B., Knapp, K. M., Gundertofte, K., Dzyuba, S. V., Ishii, H., Nakanishi, K., Kristiansen, U. & Strømgaard, K., 2007, In: Journal of Medicinal Chemistry. 50, 7, p. 1610-1617

  Research output: Contribution to journal › Journal article › Research › peer-review

  16 Citations (Scopus)
• 2006

  Effekt og bivirkninger: GABA fra A til C.

  Frølund, B., Madsen, C., Jensen, A. A., Kristiansen, U. & Liljefors, T., 2006, In: Lægemiddelforskning. p. 32-33

  Research output: Contribution to journal › Journal article › Communication

• Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

  Lolli, M. L., Hansen, S. L., Rolando, B., Nielsen, B., Wellendorph, P., Madsen, K., Larsen, O. M., Kristiansen, U., Fruttero, R., Gasco, A. & Johansen, T. N., 2006, In: J. Med. Chem.. 49, p. 4442-4446 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  27 Citations (Scopus)
• 2005

  Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA_A antagonists: Synthesis, pharmacology, and molecular modeling

  Frølund, B., Jensen, L. S., Guandalini, L., Canillo, C., Vestergaard, H. T., Kristiansen, U., Nielsen, B., Stensbøl, T. B., Madsen, C., Krogsgaard-Larsen, P. & Liljefors, T., 27 Jan 2005, In: Journal of Medicinal Chemistry. 48, 2, p. 427-439 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 4-PIOL 100%
  • 4 Aminobutyric Acid A Receptor Blocking Agent 88%
  • 5-(4-piperidyl)isoxazol-3-ol 71%
  • GABA-A Receptor Antagonists 64%
  • GABA-A Receptors 51%
  37 Citations (Scopus)
• 2004

  Activation on single heteromeric GABA_A receptor Ion channels by full and partial agonists

  Mortensen, M., Kristiansen, U., Ebert, B., Frølund, B., Krogsgaard-Larsen, P. & Smart, T., 2004, In: Journal of Physiology. p. 393–417

  Research output: Contribution to journal › Journal article › Research › peer-review

• Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay

  Jensen, A. A. & Kristiansen, U., 2004, In: Biochemical Pharmacology. 67, 9, p. 1789-99 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • glycine receptor alpha1 100%
  • Membrane Potential 46%
  • Membrane Potentials 42%
  • Glycine Receptors 39%
  • Fluorescence 35%
  37 Citations (Scopus)
• 2003

  Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA_A antagonists

  Frølund, B., Tagmose, L., Jørgensen, A. T., Kristiansen, U., Stensbøl, T. B., Liljefors, T. & Krogsgaard-Larsen, P., 2003, In: European Journal of Medicinal Chemistry. 38, p. 447–449

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2002

  GABA_A receptor ligands and their therapeutic potentials

  Frølund, B., Ebert, B., Kristiansen, U., Liljefors, T. & Krogsgaard-Larsen, P., 2002, In: Current Topics in Medicinal Chemistry. 2

  Research output: Contribution to journal › Journal article › Research › peer-review

• Ligands for the GABA_A receptor complex

  Krogsgaard-Larsen, P., Frølund, B., Kristiansen, U. & Ebert, B., 2002, Glutamate and GABA receptors of AMPA/kainate receptors and transporters. Taylor & Francis, p. 236–274

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

• Novel Class of Potent 4-Arylalkyl Substituted 3-Isoxazolol GABA_A Antagonists:Synthesis, Pharmacology, and Molecular Modeling

  Frølund, B., Jørgensen, A. T., Tagmose, L., Stensbøl, T. B., Vestergaard, H. T., Engblom, C., Kristiansen, U., Sanchez, C., Krogsgaard-Larsen, P. & Liljefors, T., 2002, In: Journal of Medicinal Chemistry. 45, p. 2454–2468

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2001

  Molecular determinants of desensitization and assembly of the chimeric GABA(A) receptor subunits (alpha1/gamma2) and (gamma2/alpha1) in combinations with beta2 and gamma2

  Elster, L., Kristiansen, U., Pickering, D. S., Olsen, R. W. & Schousboe, A., 2001, In: Neurochemistry International. 38, 7, p. 581-92 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • GABA Receptors 100%
  • Pentobarbital 45%
  • gamma-Aminobutyric Acid 39%
  • Flunitrazepam 28%
  • Sf9 Cells 28%
  1 Citation (Scopus)
• 2000

  A Novel Class of Potent 3-Isoxazolol GABA_A Antagonists: Design, Synthesis, and Pharmacology

  Frølund, B., Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, U. & Krogsgaard-Larsen, P., 2000, In: Journal of Medicinal Chemistry. 43, p. 4930–4933

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1997

  GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects

  Frølund, B., Krogsgaard-Larsen, P., Kristiansen, U., Frydenvang, K. A. & Ebert, B., 1997, In: European Journal of Pharmaceutical Sciences. 4, p. 355–384

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1996

  Stereospecific GABA-B receptor antagonism

  Frydenvang, K. A., Frølund, B., Kristiansen, U. & Krogsgaard-Larsen, P., 1996, GABA, receptors, transporters and metabolism. Tanaka, C. & Bowery, N. G. (eds.). Basel: Birkhäuser Verlag

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
• 1995

  GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer

  Frydenvang, K. A., Kristiansen, U., Frølund, B., Herdeis, C. & Krogsgaard-Larsen, P., 1995, In: Chirality. 7, p. 526–533

  Research output: Contribution to journal › Journal article › Research › peer-review

  3 Citations (Scopus)

• Partial GABA_A Receptor agonists. Synthesis and in vitro Pharmacology

  Frølund, B., Kristiansen, U., Brehm, L., Hansen, A. B., Krogsgaard-Larsen, P. & Falch, E., 1995, In: Journal of Medicinal Chemistry. 38, p. 3287–3296

  Research output: Contribution to journal › Journal article › Research › peer-review
• 1992

  Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships

  Kristiansen, U., Hedegaard, A., Herdeis, C., Lund, T. M., Nielsen, B., Hansen, J. J., Falch, E., Hjeds, H. & Krogsgaard-Larsen, P., Mar 1992, In: Journal of Neurochemistry. 58, 3, p. 1150-9 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 4,5-diaminopentanoic acid 100%
  • 5-aminovaleric acid 93%
  • hydroxide ion 56%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 55%
  • Antagonist 34%
  17 Citations (Scopus)
• 1991

  4-PIOL, a low-efficacy partial GABA-A agonist

  Frølund, B., Kristiansen, U., Nathan, T., Falch, E., Lambert, J. D. C. & Krogsgaard-Larsen, P., 1991, Drug Research related to Neuroactive Amino Acids. Munksgaard

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Novel (Gamma-Aminobutyric Acid)_A Agonists and Partial Agonists

  Krogsgaard-Larsen, P., Frølund, B., Kristiansen, U., Lambert, J. D. C., Falch, E. & Curtis, D. R., 1991, Transmitter Amino Acid Receptors. Barnard, E. A. & Costa, E. (eds.). Raven Press, p. 237–249

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review