Troels Kasper Høyer Scheel

2019

Functional Interplay between RNA Viruses and Non-Coding RNA in Mammals

Damas, N. D., Fossat, N. & Scheel, T. K. H., 14 Jan 2019, In: Non-coding RNA. 5, 1, 7.

Research output: Contribution to journal › Review › peer-review

18 Citations (Scopus)

67 Downloads (Pure)

Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells

Wolfisberg, R., Holmbeck, K., Nielsen, L., Kapoor, A., Rice, C. M., Bukh, J. & Scheel, T. K. H., 1 Oct 2019, In: Journal of Virology.

Research output: Contribution to journal › Journal article › Research › peer-review

Replicons of a Rodent Hepatitis C Model Virus Permit Selection of Highly Permissive Cells

Wolfisberg, R., Holmbeck, K., Nielsen, L., Kapoor, A., Rice, C. M., Bukh, J. & Scheel, T. K. H., 1 Oct 2019, In: Journal of Virology. 93, 19

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

2018

Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1–7 and Escape Variants

Gottwein, J. M., Pham, L. V., Mikkelsen, L. S., Ghanem, L., Ramirez, S., Scheel, T. K. H., Carlsen, T. H. R. & Bukh, J., Apr 2018, In: Gastroenterology. 154, 5, p. 1435-1448 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

55 Citations (Scopus)

New Parvovirus Associated with Serum Hepatitis in Horses after Inoculation of Common Biological Product

Divers, T. J., Tennant, B. C., Kumar, A., McDonough, S., Cullen, J., Bhuva, N., Jain, K., Chauhan, L. S., Scheel, T. K. H., Lipkin, W. I., Laverack, M., Trivedi, S., Srinivasa, S., Beard, L., Rice, C. M., Burbelo, P. D., Renshaw, R. W., Dubovi, E. & Kapoor, A., Feb 2018, In: Emerging Infectious Diseases . 24, 2, p. 303-310 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

Viral persistence, liver disease, and host response in a hepatitis C–like virus rat model

Trivedi, S., Murthy, S., Sharma, H., Hartlage, A. S., Kumar, A., Gadi, S. V., Simmonds, P., Chauhan, L. V., Scheel, T. K. H., Billerbeck, E., Burbelo, P. D., Rice, C. M., Lipkin, W. I., Vandegrift, K., Cullen, J. M. & Kapoor, A., 1 Aug 2018, In: Hepatology. 68, 2, p. 435-448 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

2017

Global mapping of miRNA-target interactions in cattle (Bos taurus)

Scheel, T. K. H., Moore, M. J., Luna, J. M., Nishiuchi, E., Fak, J., Darnell, R. B. & Rice, C. M., 1 Dec 2017, In: Scientific Reports. 7, 1, 13 p., 8190.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

127 Downloads (Pure)

miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence

Yu, Y., Scheel, T. K. H., Luna, J. M., Chung, H., Nishiuchi, E., Scull, M. A., Echeverría, N., Ricardo-Lax, I., Kapoor, A., Lipkin, I. W., Divers, T. J., Antczak, D. F., Tennant, B. C. & Rice, C. M., 2017, In: PLOS Pathogens. 13, 10, 21 p., e1006694.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

88 Downloads (Pure)

Mouse models of acute and chronic hepacivirus infection

Billerbeck, E., Wolfisberg, R., Fahnøe, U., Xiao, J. W., Quirk, C., Luna, J. M., Cullen, J. M., Hartlage, A. S., Chiriboga, L., Ghoshal, K., Lipkin, W. I., Bukh, J., Scheel, T. K. H., Kapoor, A. & Rice, C. M., 2017, In: Science. 357, 6347, p. 204-208 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

2016

A Broad RNA Virus Survey Reveals Both miRNA Dependence and Functional Sequestration

Scheel, T. K. H., Luna, J. M., Liniger, M., Nishiuchi, E., Rozen-Gagnon, K., Shlomai, A., Auray, G., Gerber, M., Fak, J., Keller, I., Bruggmann, R., Darnell, R. B., Ruggli, N. & Rice, C. M., 9 Mar 2016, In: Cell Host & Microbe. 19, 3, p. 409-23 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

2015

Characterization of nonprimate hepacivirus and construction of a functional molecular clone

Scheel, T. K. H., Kapoor, A., Nishiuchi, E., Brock, K. V., Yu, Y., Andrus, L., Gu, M., Renshaw, R. W., Dubovi, E. J., McDonough, S. P., Van de Walle, G. R., Lipkin, W. I., Divers, T. J., Tennant, B. C. & Rice, C. M., 17 Feb 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. 2192-7 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

63 Citations (Scopus)

Hepatitis C virus RNA functionally sequesters miR-122

Luna, J. M., Scheel, T. K. H., Danino, T., Shaw, K. S., Mele, A., Fak, J. J., Nishiuchi, E., Takacs, C. N., Catanese, M. T., de Jong, Y. P., Jacobson, I. M., Rice, C. M. & Darnell, R. B., 15 Mar 2015, In: Cell. 160, 6, p. 1099-110 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

210 Citations (Scopus)

miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity

Moore, M. J., Scheel, T. K. H., Luna, J. M., Park, C. Y., Fak, J. J., Nishiuchi, E., Rice, C. M. & Darnell, R. B., 25 Nov 2015, In: Nature Communications. 6, 17 p., 8864.

Research output: Contribution to journal › Journal article › Research › peer-review

134 Citations (Scopus)

Surveying the global virome: identification and characterization of HCV-related animal hepaciviruses

Scheel, T. K. H., Simmonds, P. & Kapoor, A., Mar 2015, In: Antiviral Research. 115, p. 83-93 11 p.

Research output: Contribution to journal › Review › peer-review

56 Citations (Scopus)

2013

Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor

Gottwein, J. M., Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, T. K. H., Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, J., Dec 2013, In: Antimicrobial Agents and Chemotherapy. 57, 12, p. 6034-49 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7

Galli, A., Scheel, T. K. H., Prentoe, J. C., Mikkelsen, L. S., Gottwein, J. M. & Bukh, J., Oct 2013, In: The Journal of general virology. 94, Pt 10, p. 2221-35 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry

Carlsen, T. H. R., Scheel, T. K. H., Ramirez, S., Foung, S. K. H. & Bukh, J., Feb 2013, In: Journal of Virology. 87, 3, p. 1385-99 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses

Gottwein, J. M., Jensen, S. B., Li, Y-P., Ghanem, L., Scheel, T. K. H., Serre, S. B. N., Mikkelsen, L. & Bukh, J., Mar 2013, In: Antimicrobial Agents and Chemotherapy. 57, 3, p. 1291-303 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

Identification of a pegivirus (GB virus-like virus) that infects horses

Kapoor, A., Simmonds, P., Cullen, J. M., Scheel, T. K. H., Medina, J. L., Giannitti, F., Nishiuchi, E., Brock, K. V., Burbelo, P. D., Rice, C. M. & Lipkin, W. I., Jun 2013, In: Journal of Virology. 87, 12, p. 7185-90 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

62 Citations (Scopus)

Identification of rodent homologs of hepatitis C virus and pegiviruses

Kapoor, A., Simmonds, P., Scheel, T. K. H., Hjelle, B., Cullen, J. M., Burbelo, P. D., Chauhan, L. V., Duraisamy, R., Sanchez Leon, M., Jain, K., Vandegrift, K. J., Calisher, C. H., Rice, C. M. & Lipkin, W. I., 2013, In: mBio. 4, 2, p. e00216-13

Research output: Contribution to journal › Journal article › Research › peer-review

132 Citations (Scopus)

Productive homologous and non-homologous recombination of hepatitis C virus in cell culture

Scheel, T. K. H., Galli, A., Li, Y-P., Mikkelsen, L. S., Gottwein, J. M. & Bukh, J., Mar 2013, In: P L o S Pathogens. 9, 3, p. 1-12 13 p., e1003228.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

Scheel, T. K. H. & Rice, C. M., Jul 2013, In: Nature Medicine. 19, 7, p. 837-49 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

385 Citations (Scopus)

2012

Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems

Scheel, T. K. H., Prentoe, J., Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, J. M. & Bukh, J., May 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells

Saeed, M., Scheel, T. K. H., Gottwein, J. M., Marukian, S., Dustin, L. B., Bukh, J. & Rice, C. M., Oct 2012, In: Antimicrobial Agents and Chemotherapy. 56, 10, p. 5365-73 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

99 Citations (Scopus)

Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

Li, Y-P., Ramirez, S., Gottwein, J. M., Scheel, T. K. H., Mikkelsen, L., Purcell, R. H. & Bukh, J., 1 May 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 18, p. E1101-E1110 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

69 Citations (Scopus)

2011

Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A

Gottwein, J. M., Jensen, T. B., Mathiesen, C. K., Meuleman, P., Serre, S. B. N., Lademann, J. B., Ghanem, L., Scheel, T. K. H., Leroux-Roels, G. & Bukh, J., Sept 2011, In: Journal of Virology. 85, 17, p. 8913-28 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

69 Citations (Scopus)

Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses

Gottwein, J. M., Scheel, T. K. H., Jensen, T. B., Ghanem, L. & Bukh, J., Sept 2011, In: Gastroenterology Today. 141, 3, p. 1067-1079 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

115 Citations (Scopus)

Efficient Culture Adaptation of Hepatitis C Virus Recombinants with Genotype-Specific Core-NS2 by Using Previously Identified Mutations

Scheel, T. K. H., Gottwein, J. M., Carlsen, T. H. R., Li, Y., Jensen, T. B., Spengler, U., Weis, N. & Bukh, J., Mar 2011, In: Journal of Virology. 85, 6, p. 2891-2906 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

61 Citations (Scopus)

Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

Prentø, J. C., Jensen, T. B., Meuleman, P., Serre, S., Scheel, T. K. H., Leroux-Roels, G., Gottwein, J. & Bukh, J., Mar 2011, In: Journal of Virology. 85, 5, p. 2224-34 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

112 Citations (Scopus)

MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR

Li, Y., Gottwein, J., Scheel, T. K. H., Jensen, T. B. & Bukh, J., 22 Mar 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 12, p. 4991-4996

Research output: Contribution to journal › Journal article › Research › peer-review

151 Citations (Scopus)

Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-a

Scheel, T. K. H., Gottwein, J. M., Mikkelsen, L. S., Jensen, T. B. & Bukh, J., Mar 2011, In: Gastroenterology Today. 140, 3, p. 1032-42 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

119 Citations (Scopus)

2010

Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

Gottwein, J., Scheel, T., Callendret, B., Li, Y., Eccleston, H. B., Engle, R. E., Govindarajan, S., Satterfield, W., Purcell, R. H., Walker, C. M. & Bukh, J., May 2010, In: Journal of Virology. 84, 10, p. 5277-93 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

100 Citations (Scopus)

2009

DELETION OF HYPERVARIABLE REGION 1 (HVR1) OF E2 FROM HCV GENOTYPES 1-6 HAS DIFFERENTIAL EFFECT ON INFECTIVITY IN VITRO AND CAUSES INCREASED SUSCEPTIBILITY TO NEUTRALIZATION

Prentoe, J., Gottwein, J. M., Scheel, T. K. H., Jensen, T. B., Serre, S. & Bukh, J., 2009, In: Journal of Hepatology. 50, p. S34-S34

Research output: Contribution to journal › Journal article › Research › peer-review

Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

Gottwein, J. M., Scheel, T. K. H., Jensen, T. B., Lademann, J. B., Prentoe, J. C., Knudsen, M. L., Hoegh, A. M. & Bukh, J., 2009, In: Hepatology. 49, 2, p. 364-77 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

281 Citations (Scopus)

MONOCISTRONIC HEPATITIS C REPORTER VIRUS RECOMBINANTS OF ALL MAJOR GENOTYPES EXPRESSING ENHANCED GREEN FLUORESCENT PROTEIN TAGGED NS5A PROTEIN

Gottwein, J. M., Lademann, J. B., Scheel, T. K. H., Jensen, T. B., Prentoe, J. C. & Bukh, J., 2009, In: Journal of Hepatology. 50, p. S33-S33

Research output: Contribution to journal › Journal article › Research › peer-review

2008

Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

Scheel, T. K. H., Gottwein, J. M., Jensen, T. B., Prentø, J. C., Høegh, A. M., Alter, H. J., Eugen-Olsen, J. & Bukh, J., 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 3, p. 997-1002 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

149 Citations (Scopus)

Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection

Jensen, T. B., Gottwein, J. M., Scheel, T. K. H., Høgh, A. M., Eugen-Olsen, J. & Bukh, J., 2008, In: Journal of Infectious Diseases. 198, 12, p. 1756-1765 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

87 Citations (Scopus)

2007

Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses

Gottwein, J. M., Scheel, T. K. H., Hoegh, A. M., Lademann, J. B., Eugen-Olsen, J., Lisby, G. & Bukh, J., 2007, In: Gastroenterology. 133, 5, p. 1614-26 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

154 Citations (Scopus)

2006

Development and validation of a multiplex add-on assay for sepsis biomarkers using xMAP technology

Kofoed, K., Schneider, U. V., Scheel, T., Andersen, O. & Eugen-Olsen, J., Jul 2006, In: Clinical Chemistry. 52, 7, p. 1284-93 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

103 Citations (Scopus)

Troels Kasper Høyer Scheel

Research output

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