Identification of a pegivirus (GB virus-like virus) that infects horses

Amit Kapoor; Peter Simmonds; John M Cullen; Troels K H Scheel; Jan L Medina; Federico Giannitti; Eiko Nishiuchi; Kenny V Brock; Peter D Burbelo; Charles M Rice; W Ian Lipkin

doi:10.1128/JVI.00324-13

Identification of a pegivirus (GB virus-like virus) that infects horses

Amit Kapoor, Peter Simmonds, John M Cullen, Troels K H Scheel, Jan L Medina, Federico Giannitti, Eiko Nishiuchi, Kenny V Brock, Peter D Burbelo, Charles M Rice, W Ian Lipkin

62 Citations (Scopus)

Abstract

The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.

Original language	English
Journal	Journal of Virology
Volume	87
Issue number	12
Pages (from-to)	7185-90
Number of pages	6
ISSN	0022-538X
DOIs	https://doi.org/10.1128/JVI.00324-13
Publication status	Published - Jun 2013

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title = "Identification of a pegivirus (GB virus-like virus) that infects horses",

abstract = "The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.",

keywords = "Amino Acid Sequence, Animals, Base Sequence, Flaviviridae, Flaviviridae Infections, Horse Diseases, Horses, Molecular Sequence Data, Phylogeny, Prevalence, Sequence Analysis, DNA, Species Specificity, United States, Viremia",

author = "Amit Kapoor and Peter Simmonds and Cullen, {John M} and Scheel, {Troels K H} and Medina, {Jan L} and Federico Giannitti and Eiko Nishiuchi and Brock, {Kenny V} and Burbelo, {Peter D} and Rice, {Charles M} and Lipkin, {W Ian}",

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doi = "10.1128/JVI.00324-13",

language = "English",

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T1 - Identification of a pegivirus (GB virus-like virus) that infects horses

AU - Kapoor, Amit

AU - Simmonds, Peter

AU - Cullen, John M

AU - Scheel, Troels K H

AU - Medina, Jan L

AU - Giannitti, Federico

AU - Nishiuchi, Eiko

AU - Brock, Kenny V

AU - Burbelo, Peter D

AU - Rice, Charles M

AU - Lipkin, W Ian

PY - 2013/6

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N2 - The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.

AB - The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - Flaviviridae

KW - Flaviviridae Infections

KW - Horse Diseases

KW - Horses

KW - Molecular Sequence Data

KW - Phylogeny

KW - Prevalence

KW - Sequence Analysis, DNA

KW - Species Specificity

KW - United States

KW - Viremia

U2 - 10.1128/JVI.00324-13

DO - 10.1128/JVI.00324-13

M3 - Journal article

C2 - 23596285

SN - 0022-538X

VL - 87

SP - 7185

EP - 7190

JO - Journal of Virology

JF - Journal of Virology

IS - 12

ER -

Identification of a pegivirus (GB virus-like virus) that infects horses

Abstract

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