Research output per year
Research output per year
Personal profile
Short presentation
I study the interplay between the process by which viruses enter their host cells to begin replication and the mechanisms by which the adaptive immune response attempts to curb this; such as the induction of potentially neutralizing antibodies. Understanding these interactions fully has great importance for vaccine development.
My research currently focuses on hepatitis C virus, which is a pervasive cause of end-stage liver disease. The acute infection is often asymptomatic and treatment is very expensive, leading to a high number of terminally ill patients. Vaccine development has proven very difficult.
Short presentation
Jeg studerer sammenhængen mellem virus entry og de mekanismer hvorved det adaptive immunrespons forsøget at forhindre dette; såsom induktionen af potentielt neutraliserende antistoffer. Forståelsen af disse interaktioner er af stor betydning for vaccineudvikling.
Min forskning er fokuseret på hepatitis C virus, som er en vigtig årsag til leversygdom, kræft i særdeleshed. Den akutte infektion er ofte asymptomatisk og behandlingen dyr, hvilket fører til en høj mortalitet. Vaccineudvikling har vist sig at være meget vanskelig.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design
Keck, Z. Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentoe, J., Velázquez-Moctezuma, R., Walker, M. R., Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, J., Lloyd, A. R. & Foung, S. K. H., 2019, In: P L o S Pathogens. 15, 5, 28 p., e1007772.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies
Tzarum, N., Giang, E., Kong, L., He, L., Prentoe, J., Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, J., Zhu, J., Wilson, I. A. & Law, M., 2019, In: Science Advances. 5, 1, 12 p., eaav1882.Research output: Contribution to journal › Journal article › Research › peer-review
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Hepatitis C Virus–Escape Studies for Human Monoclonal Antibody AR4A Reveal Isolate-Specific Resistance and a High Barrier to Resistance
Velázquez-moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J., 1 Jan 2019, In: The Journal of Infectious Diseases. 219, 1, p. 68-79Research output: Contribution to journal › Journal article › Research › peer-review
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Hepatitis C virus escape studies of human antibody AR3a reveal a high barrier to resistance and novel insights on viral antibody evasion mechanisms
Velázquez-Moctezuma, R., Galli, A., Law, M., Bukh, J. & Prentoe, J., 2019, In: Journal of Virology. 93, 4, e0190918.Research output: Contribution to journal › Journal article › Research › peer-review
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Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations
Prentoe, J., Velázquez-Moctezuma, R., Augestad, E. H., Galli, A., Wang, R., Law, M., Alter, H. & Bukh, J., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10039-10047 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro neutralization assay using cultured hepatitis C virus
Prentoe, J. & Bukh, J., 2019, Hepatitis C Virus Protocols. Humana Press, p. 433-439 7 p. (Methods in Molecular Biology, Vol. 1911).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals
Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentoe, J., Fahnøe, U., Krarup, H., Bukh, J. & Gottwein, J. M., 2018, In: Scientific Reports. 8, 1, 13 p., 17505.Research output: Contribution to journal › Journal article › Research › peer-review
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Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
Prentoe, J. & Bukh, J., 27 Sept 2018, In: Frontiers in Immunology. 9, 11 p., 2146.Research output: Contribution to journal › Review › peer-review