Publikationer pr. år
Publikationer pr. år
Personlig profil
Primære forskningsområder
Population PKPD modelling
Aktuel forskning
Pharmacometrics
We optimise pharmacotherapy and clinical trial designs by characterising pharmacokinetic-pharmacodynamic relationships using mathematical models that identify sources of variability in drug response.
Examples of projects in our group:
•Fixed dose combinations in drug development - Design of Trials for Identifying Optimal Combination Ratios using Advanced Computer Modelling Tools
•Model-based dose finding in clinical drug development
•The development of fixed-dose combinations (FDCs) through improved methodology – regulatory perspective
•Linking rescue medication with pain intensity using PKPD modelling in clinical pain trials
•PK meta-model on morphine and active metabolite based on 22 clinical studies
•PKPD modelling on synergistic effects of gabapentin and morphine
•Modelling on effect of high-dose target-controlled naloxone infusion on pain and hyperalgesia in patients following groin-hernia-repair
•Differences in metabolic activity of CYP enzymes in obese and lean children
Undervisnings- og vejledningsområder
Pharmacokinetics and Pharmacodynamics on the following courses:
Basic pharmacology, Principles of Pharmacology, Organ-related pharmacology
Elective course in Pharmacokinetics and -dynamics and post graduate MIND courses and PhD course
Fingeraftryk
Dyk ned i forskningsemnerne, hvor Trine Meldgaard Lund er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.
- 11 Lignende profiler
Samarbejde og topforskningsområder i de sidste fem år
Seneste eksterne samarbejde på lande-/områdeniveau. Dyk ned i detaljerne ved at klikke på prikkerne eller
Publikation
-
Midazolam Pharmacokinetics in Obese and Non-obese Children and Adolescents
Gade, C., Sverrisdóttir, E., Dalhoff, K., Sonne, J., Johansen, M. Ø., Christensen, H. R., Burhenne, J., Mikus, G., Holm, J. C., Lund, T. M. & Holst, H., 1 maj 2020, I: Clinical Pharmacokinetics.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Body of evidence and approaches applied in the clinical development programme of fixed-dose combinations in the European Union from 2010 to 2016
Nøhr-Nielsen, A., De Bruin, M. L., Thomsen, M., Pipper, C. B., Lange, T., Bjerrum, O. J. & Lund, T. M., aug. 2019, I: British Journal of Clinical Pharmacology. 85, 8, s. 1829-1840 12 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Dose Finding in the Clinical Development of 60 US Food and Drug Administration-Approved Drugs Compared With Learning vs. Confirming Recommendations
Lyauk, Y. K., Jonker, D. M. & Lund, T. M., 1 sep. 2019, I: Clinical and Translational Science.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.
Papathanasiou, T., Springborg, A., Kongstad, K. T., Stærk, D., Møller, K., Taylor, B. K., Lund, T. M. & Werner, M. U., aug. 2019, I: British Journal of Anaesthesia. 123, s. e204-e214Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Optimizing Dose-Finding Studies for Drug Combinations Based on Exposure-Response Models
Papathanasiou, T., Strathe, A., Overgaard, R. V., Lund, T. M. & Hooker, A. C., 1 sep. 2019, I: The AAPS Journal. 21, 5, s. 95Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Simultaneous quantification of high-dose naloxone and naloxone-3-β-D-glucuronide in human plasma by UHPLC-MS/MS
Kongstad, K. T., Papathanasiou, T., Springborg, A., Lund, T. M., Werner, M. U. & Stærk, D., feb. 2019, I: Bioanalysis. 11, s. 165-173Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Feasibility of Exposure-Response Analyses for Clinical Dose-Ranging Studies of Drug Combinations
Papathanasiou, T., Strathe, A., Hooker, A. C., Lund, T. M. & Overgaard, R. V., 1 maj 2018, I: The AAPS Journal. 20, 13 s., 64.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches
Juul, R. V., Nyberg, J., Kreilgaard, M., Christrup, L. L., Simonsson, U. S. H. & Lund, T. M., 1 aug. 2017, I: Journal of Pharmacokinetics and Pharmacodynamics. 44, 4, s. 325-333 8 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
-
Organizer and chairman for Symposium: The role of genotypes in precision medicine
Trine Meldgaard Lund (Deltager)
20 nov. 2018Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Organisation af og deltagelse i konference
-
Organizer of Symposium for Danish Pharmaceutical Society: Optimal Design and Analysis of Clinical Trials
Trine Meldgaard Lund (Deltager)
9 nov. 2017Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Organisation af og deltagelse i konference
-
Co-organizer of symposium for Danish Society of Clinical Chemical Pharmacology: Therapeutic Drug Monitoring in the Future
Trine Meldgaard Lund (Deltager)
8 nov. 2017Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Organisation af og deltagelse i konference
-
Co-organizer of Workshop at Annual Meeting for Danish Society for Pharmacology: Drug toxicity and overdose (Vitamin D)
Trine Meldgaard Lund (Deltager)
18 jan. 2017Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Organisation af og deltagelse i konference
-
Co-organizer of symposium for Danish Clinical Chemical Society: Clinical study design and statistical considerations
Trine Meldgaard Lund (Deltager)
28 nov. 2016Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Organisation af og deltagelse i konference
-
Co-organizer of Workshop at Annual Meeting for Danish Society for Pharmacology: Therapeutic Drug Management in psychiatric patients
Trine Meldgaard Lund (Deltager)
20 jan. 2016Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Organisation af og deltagelse i konference
-
Foredragsholder: Population PKPD modelling in children
Trine Meldgaard Lund (Foredragsholder)
28 nov. 2015Aktivitet: Tale eller præsentation - typer › Foredrag og mundtlige bidrag
-
Co-organizer of symposium for Danish Society for Clinical Chemical Pharmacology: Development of biologics - Pharmaceutical, clinical and analytical challenges
Trine Meldgaard Lund (Deltager)
29 okt. 2015Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Organisation af og deltagelse i konference