Tomas Laursen

Research output

Research output per year 2009 2013 2016 2018 2020

• 16 Journal article
• 2 Poster
• 2 Conference abstract in journal
• 2 Review
• 2 More
  • 1 Book chapter
  • 1 Letter

Research output per year

Research output per year

Search results

• 2020

  Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent

  Knudsen, C., Bavishi, K., Viborg, K. M., Drew, D. P., Simonsen, H. T., Motawia, M. S., Møller, B. L. & Laursen, T., Feb 2020, In: Phytochemistry. 170

  Research output: Contribution to journal › Journal article › Research › peer-review

  6 Citations (Scopus)
• 2019

  Declining incidence of dementia: a national registry-based cohort study over twenty years

  Taudorf, L., Nørgaard, A., Islamoska, S., Jørgensen, K., Laursen, T. M. & Waldemar, G., Nov 2019, In: European Journal of Neurology. 26, Supplement 1, p. 85-86 2 p., O3114.

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  • Dementia 100%
  • Registries 94%
  • Cohort Studies 81%
  • Incidence 58%
  • Health Planning 30%
  9 Citations (Scopus)

• Molecular snapshots of dynamic membrane-bound metabolons

  Bassard, J. E. & Laursen, T., 1 Jan 2019, Methods in Enzymology. Academic Press, Vol. 617. p. 1-27 27 p. (Methods in Enzymology, Vol. 617).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  • dhurrin 100%
  • Molecular Dynamics Simulation 95%
  • Detergents 90%
  • Sorghum 71%
  • maleic acid 61%
• 2018

  Bifunctional glycosyltransferases catalyze both extension and termination of pectic galactan oligosaccharides

  Laursen, T., Stonebloom, S. H., Pidatala, V. R., Birdseye, D. S., Clausen, M. H., Mortimer, J. C. & Scheller, H. V., Apr 2018, In: Plant Journal. 94, 2, p. 340-351 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Galactans 100%
  • galactans 76%
  • Glycosyltransferases 76%
  • glycosyltransferases 68%
  • Oligosaccharides 63%
  9 Citations (Scopus)

• Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strength

  Bavishi, K., Li, D., Eiersholt, S., Hooley, E. N., Petersen, T. C., Møller, B. L., Hatzakis, N. & Laursen, T., 1 Dec 2018, In: Scientific Reports. 8, 9 p., 6817.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Osmolar Concentration 100%
  • Cytochrome P-450 Enzyme System 93%
  • Oxidoreductases 88%
  • Observation 68%
  • Membranes 57%
  19 Citations (Scopus)

  91 Downloads (Pure)

• Dynamic metabolic solutions to the sessile life style of plants

  Baden, C. K., Gallage, N. J., Hansen, C. I. C., Møller, B. L. & Laursen, T., 2018, In: Natural Product Reports. 35, 11, p. 1140-1155 16 p.

  Research output: Contribution to journal › Review › peer-review

  • Phytochemicals 100%
  • Biosynthesis 90%
  • Life Style 87%
  • Metabolic 87%
  • Plastic Property 83%
  20 Citations (Scopus)

  116 Downloads (Pure)

• Natural Deep Eutectic Solvents for functionalization and storage of natural products and enzymes

  Baden, C. K., Montini, L., Bassard, J-É. A., Viborg, K. M., Jørgensen, K., Bjarnholt, N., Møller, B. L. & Laursen, T., 15 Jul 2018.

  Research output: Contribution to conference › Poster › Research

  8 Downloads (Pure)

• The Three Members of the Arabidopsis Glycosyltransferase Family 92 are Functional β-1,4-Galactan Synthases

  Ebert, B., Birdseye, D., Liwanag, A. J. M., Laursen, T., Rennie, E. A., Guo, X., Catena, M., Rautengarten, C., Stonebloom, S. H., Gluza, P., Pidatala, V., Andersen, M. C. F., Cheetamun, R., Mortimer, J. C., Heazlewood, J. L., Bacic, A., Clausen, M. H., Willats, W. G. T. & Scheller, H. V., 2018, In: Plant and Cell Physiology. 59, 12, p. 2624-2636 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Galactans 100%
  • rhamnogalacturonan I 83%
  • galactans 76%
  • Glycosyltransferases 76%
  • Arabidopsis 74%
  12 Citations (Scopus)
• 2017

  Assembly of dynamic P450-mediated metabolons - order versus chaos

  Bassard, J-É. A., Møller, B. L. & Laursen, T., 2017, In: Current Biology. 3, 1, p. 37-51 15 p.

  Research output: Contribution to journal › Review › peer-review

  • Chaos (Dynamical) 100%
  • dhurrin 78%
  • Sorghum 56%
  • Metabolic 54%
  • Pharmacological Metabolism 51%
  41 Downloads (Pure)

• Controlling styrene maleic acid lipid particles through RAFT

  Smith, A. A. A., Autzen, H. E., Laursen, T., Wu, V., Yen, M., Hall, A., Hansen, S. D., Cheng, Y. & Xu, T., 13 Nov 2017, In: Biomacromolecules. 18, 11, p. 3706-3713 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lipids 100%
  • Maleic Acid 88%
  • Styrene 84%
  • Acids 67%
  • Polymers 54%
  22 Citations (Scopus)
• 2016

  Application of nanodisc technology for direct electrochemical investigation of plant cytochrome P450s and their NADPH P450 oxidoreductase

  Bavishi, K., Laursen, T., Martinez, K. L., Møller, B. L. & Della Pia, E. A., 8 Jul 2016, In: Scientific Reports. 6, 10 p., 29459.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • cytochrome P-450 CYP71E1 (sorghum) 100%
  • Cytochromes 93%
  • NADP 88%
  • Oxidoreductases 74%
  • Electrochemistry 67%
  7 Citations (Scopus)

  107 Downloads (Pure)

• Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum

  Laursen, T., Borch-Jensen, J., Baden, C. K., Bavishi, K., Torta, F., Martens, H. J., Silvestro, D., Hatzakis, N., Wenk, M. R., Dafforn, T. R., Olsen, C. E., Motawie, M. S., Hamberger, B. R., Møller, B. L. & Bassard, J-É. A., 18 Nov 2016, In: Science (New York, N.Y.). 354, 6314, p. 890-893 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • dhurrin 100%
  • Sorghum 71%
  • Glucosyltransferases 64%
  • Synthetic Biology 59%
  • Glucosides 57%
  122 Citations (Scopus)

• Evolution of NADPH-cytochrome P450 oxidoreductases (POR) in Apiales - POR 1 is missing

  Andersen, T. B., Hansen, N. B., Laursen, T., Weitzel, C. & Simonsen, H. T., 1 May 2016, In: Molecular Phylogenetics and Evolution. 98, p. 21-28 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Apiales 100%
  • NADPH-Ferrihemoprotein Reductase 77%
  • cytochrome 62%
  • oxidoreductases 61%
  • NADP (coenzyme) 54%
  5 Citations (Scopus)

• Links of conformational sampling to functional plasticity and clinical phenotypes by single molecule studies

  Moses, M. E., Thodberg, S., Bavishi, K., Eiersholt, S., Li, D., Stamou, D., Møller, B. L., Laursen, T. & Hatzakis, N., 2016, In: Biophysical Society. Annual Meeting. Abstracts. 110, 3, p. 397A 1 p.

  Research output: Contribution to journal › Conference abstract in journal › Research

  107 Downloads (Pure)
• 2015

  Nanodisc films for membrane protein studies by neutron reflection: effect of the protein scaffold choice

  Bertram, N., Laursen, T., Barker, R., Bavishi, K., Møller, B. L. & Cardenas Gomez, M., 4 Aug 2015, In: Langmuir. 31, 30, p. 8386-8391 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Neutron reflection 100%
  • Nanodisc 62%
  • Oxidoreductases 56%
  • Scaffolds 55%
  • Neutron 47%
  13 Citations (Scopus)

• Plasticity of specialized metabolism as mediated by dynamic metabolons

  Laursen, T., Møller, B. L. & Bassard, J-É. A., 1 Jan 2015, In: Trends in Plant Science. 20, 1, p. 20-32 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • plasticity 100%
  • metabolism 65%
  • Apodidae 50%
  • bioengineering 49%
  • metabolites 49%
  59 Citations (Scopus)
• 2014

  Single molecule activity measurements of cytochrome P450 oxidoreductase reveal the existence of two discrete functional states

  Laursen, T., Singha, A., Rantzau, N., Tutkus, M., Borch-Jensen, J., Hedegård, P., Stamou, D., Møller, B. L. & Hatzakis, N., 21 Mar 2014, In: ACS chemical biology. 9, 3, p. 630-634 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Nanodisc 100%
  • Cytochrome P450 79%
  • Cytochrome P-450 Enzyme System 72%
  • Oxidoreductases 68%
  • Detergent 34%
  39 Citations (Scopus)
• 2013

  Amphipol trapping of a functional CYP system

  Laursen, T., Naur, P. & Møller, B. L., Feb 2013, In: Biotechnology and Applied Biochemistry. 60, 1, p. 119-127 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cytochrome P-450 Enzyme System 100%
  • Oxidoreductases 82%
  • Cytochrome P450 58%
  • cytochrome P-450 CYP71E1 (sorghum) 53%
  • Surfactant 36%
  9 Citations (Scopus)

• Isolation of monodisperse nanodisc-reconstituted membrane proteins using free flow electrophoresis

  Justesen, B. H., Laursen, T., Weber, G., Fuglsang, A. T., Møller, B. L. & Günther-Pomorski, T., 2 Apr 2013, In: Analytical Chemistry. 85, 7, p. 3497-3500 4 p.

  Research output: Contribution to journal › Letter › peer-review

  • Electrophoresis 100%
  • Proteins 70%
  • Membranes 64%
  • Recovery 12%
  14 Citations (Scopus)

• The binding of UDP-glucosyltransferase to the cytochrome P450s in dhurrin biosynthesis

  Baden, C. K., Laursen, T., Kannangara, R. M., Bertram, N., Cardenas Gomez, M. & Møller, B. L., 2013. 1 p.

  Research output: Contribution to conference › Poster › Research

  966 Downloads (Pure)
• 2012

  A combined biochemical screen and TILLING approach identifies mutations in Sorghum bicolor L. Moench resulting in acyanogenic forage production

  Blomstedt, C. K., Gleadow, R. M., O'Donnell, N., Naur, P., Jensen, K., Laursen, T., Olsen, C. E., Stuart, P., Hamill, J. D., Møller, B. L. & Neale, A. D., Jan 2012, In: Plant Biotechnology Journal. 10, 1, p. 54-66 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • dhurrin 100%
  • Sorghum 71%
  • forage production 52%
  • Sorghum bicolor 45%
  • lesions (plant) 42%
  72 Citations (Scopus)

• Monitoring shifts in the conformation equilibrium of the membrane protein cytochrome P450 reductase (POR) in nanodiscs

  Wadsäter, M. H., Laursen, T., Singha, A., Hatzakis, N., Stamou, D., Barker, R., Mortensen, K., Feidenhans'l, R. K., Møller, B. L. & Cardenas Gomez, M., 5 Oct 2012, In: Journal of Biological Chemistry. 287, 41, p. 34596-34603 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • NADPH-Ferrihemoprotein Reductase 100%
  • Nanodisc 98%
  • Cytochrome P450 78%
  • Neutrons 65%
  • Membrane Proteins 61%
  46 Citations (Scopus)
• 2011

  Conformational changes of the NADPH-dependent cytochrome P450 reductase in the course of electron transfer to cytochromes P450

  Laursen, T., Jensen, K. & Møller, B. L., Jan 2011, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1814, 1, p. 132-138 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • NADPH-Ferrihemoprotein Reductase 100%
  • Cytochrome P450 78%
  • Cytochrome P-450 Enzyme System 71%
  • Electrons 58%
  • Electron Transfer 51%
  78 Citations (Scopus)
• 2009

  Functional expression of N-terminally tagged membrane bound cytochrome P450

  Hamann, T., Laursen, T. & Møller, B. L., 2009, In: Protein Expression and Purification. 68, 1, p. 18-21 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  4 Citations (Scopus)