Research output per year
Research output per year
Personal profile
Short presentation
Myresearch focuses on the biosynthesis, evolution and physiological function of specialized metabolites in plants. I have a special focus on the superfamily of cytochromes P450 (CYPs), their redox partner, the NADPH-dependent cytochrome P450 oxidoreductase (POR), and UDP-glycosyltransferases. Together, these enzymes play key roles in metabolite biosynthesis, which ultimately allow plants to respond and interact with their biotic and abiotic environment.
Cyanogenic glucosides, a class of amino acid-derived defense compounds, are biosynthesized by the combined action of CYPs, POR and UDP-glycosyltransferases. The biosynthetic pathway has evolved independently in different linages and provide a unique system to study genetic signatures behind specialized metabolite biosynthesis and evolution.
I am a member of the research groups:
- Plant Ecophysiology
- Dynamic Metabolons
- Synthetic Biology
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A Combinatorial Approach To Study Cytochrome P450 Enzymes for De Novo Production of Steviol Glucosides in Baker’s Yeast
Gold, N. D., Fossati, E., Hansen, C. I. C., DiFalco, M., Douchin, V. & Martin, V. J. J., 26 Nov 2018, In: A C S Synthetic Biology. 7, 12, p. 2918-2929Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamic metabolic solutions to the sessile life style of plants
Baden, C. K., Gallage, N. J., Hansen, C. I. C., Møller, B. L. & Laursen, T., 2018, In: Natural Product Reports. 35, 11, p. 1140-1155 16 p.Research output: Contribution to journal › Review › peer-review
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Reconfigured Cyanogenic Glucoside Biosynthesis in Eucalyptus cladocalyx Involves a Cytochrome P450 CYP706C55
Hansen, C. I. C., Sørensen, M., Veiga, T. A. M., Zibrandtsen, J. F. S., Heskes, A. M., Olsen, C. E., Boughton, B. A., Møller, B. L. & Neilson, E. H. J., 2018, In: Plant Physiology. 178, 3, p. 1081-1095 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Microbial synthesis of plant alkaloids
Pyne, M. E., Narcross, L., Hansen, C. I. C., Campbell, A., Davies, M. E., Bourgeois, L., Fossati, E. & Martin, V. J. J., 16 Nov 2017, Biotechnology of natural products. Schwab, W., Lange, B. M. & Wüst, M. (eds.). Springer, p. 99-130 32 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Glucosinolate diversity within a phylogenetic framework of the tribe Cardamineae (Brassicaceae) unraveled with HPLC-MS/MS and NMR-based analytical distinction of 70 desulfoglucosinolates
Olsen, C. E., Huang, X.-C., Hansen, C. I. C., Cipollini, D., Ørgaard, M., Matthes, A., Geu-Flores, F., Koch, M. A. & Agerbirk, N., 1 Dec 2016, In: Phytochemistry. 132, p. 33-56 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Methyl transfer in glucosinolate biosynthesis mediated by indole glucosinolate O-Methyltransferase 5
Pfalz, M., Mukhaimar, M., Perreau, F., Kirk, J., Hansen, C. I. C., Olsen, C. E., Agerbirk, N. & Kroymann, J., Dec 2016, In: Plant Physiology. 172, 4, p. 2190-2203 14 p.Research output: Contribution to journal › Journal article › Research › peer-review