Nicole Schmitt

Research output

Research output per year 2000 2007 2011 2013 2014 2015 2016 2018 2019

• 71 Journal article
• 1 Conference abstract for conference
• 1 Poster
• 1 Conference abstract in journal

Research output per year

Research output per year

Search results

• 2011

  Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A

  Calloe, K., Schmitt, N., Grubb, S., Pfeiffer, R., David, J-P., Kanter, R., Cordeiro, J. M., Antzelevitch, C. & Callø, K., Oct 2011, In: Canadian Journal of Physiology and Pharmacology. 89, 10, p. 723-36 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tachycardia 100%
  • Mutation 86%
  • Ranolazine 81%
  • Brugada Syndrome 71%
  • Long QT Syndrome 67%
  5 Citations (Scopus)

• Mutations in sodium channel {beta}-subunit SCN3B are associated with early-onset lone atrial fibrillation

  Olesen, M. S., Jespersen, T., Nielsen, J. B., Liang, B., Møller, D. V., Hedley, P., Christiansen, M., Varro, A., Olesen, S-P., Haunsø, S., Schmitt, N. & Svendsen, J. H., 1 Mar 2011, In: Cardiovascular Research. 89, 4, p. 786-793 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Voltage-Gated Sodium Channel beta-3 Subunit 100%
  • Atrial Fibrillation 37%
  • Mutation 23%
  • Sodium Channels 14%
  • Sodium 10%
  91 Citations (Scopus)
• 2010

  Differential effects of ICA-27243 on cloned K(V)7 channels

  Blom, S. M., Schmitt, N. & Jensen, H. S., Sept 2010, In: Pharmacology. 86, 3, p. 174-81 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • N-(6-Chloropyridin-3-yl)-3,4-difluorobenzamide 100%
  • ezogabine 65%
  • Rubidium 10%
  • Binding Sites 10%
  • Xenopus laevis 7%
  22 Citations (Scopus)

• Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2

  Lundby, A., Jespersen, T., Schmitt, N., Grunnet, M., Olesen, S-P., Cordeiro, J. M. & Calloe, K., Aug 2010, In: British Journal of Pharmacology. 160, 8, p. 2028-44 17 p.

  Research output: Contribution to journal › Journal article › Research

  • 1-(3,5-bis-trifluoromethylphenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)urea 100%
  • Kv Channel-Interacting Proteins 82%
  • Canidae 11%
  • Oocytes 7%
  • CHO Cells 5%
  34 Citations (Scopus)

• Overlapping LQT1 and LQT2 phenotype in a patient with long QT syndrome associated with loss-of-function variations in KCNQ1 and KCNH2

  Cordeiro, J. M., Perez, G. J., Schmitt, N., Pfeiffer, R., Nesterenko, V. V., Burashnikov, E., Veltmann, C., Borggrefe, M., Wolpert, C., Schimpf, R. & Antzelevitch, C., Dec 2010, In: Canadian Journal of Physiology and Pharmacology. 88, 12, p. 1181-90 10 p.

  Research output: Contribution to journal › Journal article › Research

  • Long QT Syndrome 100%
  • Phenotype 46%
  • Andersen Syndrome 45%
  • Mutation 43%
  • Ventricular Premature Complexes 30%
  7 Citations (Scopus)

• Structural basis for KV7.1/KCNEx interactions in the IKs channel complex

  Lundby, A., Tseng, G-N. & Schmitt, N., May 2010, In: Heart Rhythm. 7, 5, p. 708-713

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Action Potentials 100%
  • Ion Channels 54%
  • Magnetic Resonance Spectroscopy 46%
  18 Citations (Scopus)
• 2009

  Functional properties of human neuronal Kv11 channels

  Einarsen, K., Calloe, K., Grunnet, M., Olesen, S-P. & Schmitt, N., 2009, In: Pflügers Archiv: European Journal of Physiology. 458, 4, p. 689-700 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Membrane Potential 100%
  • Protein Isoforms 74%
  • Voltage 66%
  • Xenopus laevis 53%
  • Oocytes 42%
  7 Citations (Scopus)

• Phosphorylation of connexin43 on serine 306 regulates electrical coupling

  Procida, K., Jørgensen, L., Schmitt, N., Delmar, M., Taffet, S. M., Holstein-Rathlou, N-H., Nielsen, M. S. & Braunstein, T. H., 2009, In: Heart Rhythm. 6, 11, p. 1632-8 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Connexin 43 100%
  • Serine 79%
  • Phosphorylation 56%
  • Biotinylation 22%
  • Connexins 20%
  43 Citations (Scopus)

• The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes

  Blom, S. M., Schmitt, N. & Jensen, H. S., 2009, In: PLoS ONE. 4, 12, p. e8251

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oocyte 100%
  • ezogabine 91%
  • Modulator 81%
  • Acrylamide 72%
  • Activation 64%
  18 Citations (Scopus)
• 2008

  KCNE3 mutation V17M identified in a patient with lone atrial fibrillation.

  Lundby, A., Ravn, L. S., Svendsen, J. H., Hauns, S., Olesen, S-P. & Schmitt, N., 2008, In: Cellular Physiology and Biochemistry. 21, 1-3, p. 47-54 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  66 Citations (Scopus)
• 2007

  Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.

  Calloe, K., Ravn, L. S., Schmitt, N., Sui, J. L., Duno, M., Haunso, S., Grunnet, M., Svendsen, J. H. & Olesen, S-P., 2007, In: Biochemical and Biophysical Research Communications. 364, 4, p. 889-95 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  25 Citations (Scopus)

• KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval.

  Lundby, A., Ravn, L. S., Svendsen, J. H., Olesen, S-P. & Schmitt, N., 2007, In: Heart Rhythm. 4, 12, p. 1532-41 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  74 Citations (Scopus)

• KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes.

  Calloe, K., Nielsen, M. S., Grunnet, M., Schmitt, N. & Jorgensen, N. K., 2007, In: BBA General Subjects. 1773, 6, p. 764-73 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  18 Citations (Scopus)

• Modulation of ERG channels by XE991.

  Elmedyb, P., Calloe, K., Schmitt, N., Hansen, R. S., Grunnet, M. & Olesen, S-P., 2007, In: Basic & Clinical Pharmacology & Toxicology. 100, 5, p. 316-22 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • XE991 100%
  • KCNQ Potassium Channels 83%
  • Ether-A-Go-Go Potassium Channels 45%
  • Potassium Channel Blockers 33%
  • Xenopus laevis 26%
  24 Citations (Scopus)

• Mutations in the Kv1.5 channel gene KCNA5 in cardiac arrest patients.

  Nielsen, N. H., Winkel, B. G., Kanters, J. K., Schmitt, N., Hofman-Bang, J., Jensen, H. S., Bentzen, B. H., Sigurd, B., Larsen, L. A., Andersen, P. S., Kjeldsen, K., Grunnet, M., Christiansen, M., Olesen, S-P. & Haunsø, S., 2007, In: Biochemical and Biophysical Research Communications. 354, 3, p. 776-82 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  22 Citations (Scopus)

• Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment.

  Rasmussen, H. B., Frøkjaer-Jensen, C., Jensen, C. S., Jensen, H. S., Jørgensen, N. K., Misonou, H., Trimmer, J. S., Olesen, S-P. & Schmitt, N., 2007, In: Journal of Cell Science. 120, Pt 6, p. 953-63 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  84 Citations (Scopus)

• The novel C-terminal KCNQ1 mutation M520R alters protein trafficking.

  Schmitt, N., Calloe, K., Nielsen, N. H., Buschmann, M., Speckmann, E-J., Schulze-Bahr, E. & Schwarz, M., 2007, In: Biochemical and Biophysical Research Communications. 358, 1, p. 304-10 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  24 Citations (Scopus)
• 2006

  Calmodulin is essential for cardiac IKS channel gating and assembly: impaired function in long-QT mutations.

  Shamgar, L., Ma, L., Schmitt, N., Haitin, Y., Peretz, A., Wiener, R., Hirsch, J., Pongs, O. & Attali, B., 2006, In: Circulation Research. 98, 8, p. 1055-63 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  138 Citations (Scopus)

• Long QT 1 mutation KCNQ1A344V increases local anesthetic sensitivity of the slowly activating delayed rectifier potassium current.

  Siebrands, C. C., Binder, S., Eckhoff, U., Schmitt, N. & Friederich, P., 2006, In: Anesthesiology. 105, 3, p. 511-20 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Long QT Syndrome 100%
  • Local Anesthetics 79%
  • Potassium 69%
  • Mutation 43%
  • Pharmacogenetics 34%
  25 Citations (Scopus)

• The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.

  Bentzen, B. H., Schmitt, N., Calloe, K., Dalby Brown, W., Grunnet, M. & Olesen, S-P., 2006, In: Neuropharmacology. 51, 6, p. 1068-77 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • KCNQ Potassium Channels 100%
  • ezogabine 88%
  • BMS204352 72%
  • Acrylamide 69%
  • S-3-1 compound 41%
  74 Citations (Scopus)
• 2005

  Functional assessment of compound mutations in the KCNQ1 and KCNH2 genes associated with long QT syndrome.

  Grunnet, M., Behr, E. R., Calloe, K., Hofman-Bang, J., Till, J., Christiansen, M., McKenna, W. J., Olesen, S-P. & Schmitt, N., 2005, In: Heart Rhythm. 2, 11, p. 1238-49 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Long QT Syndrome 100%
  • Mutation 43%
  • Genes 30%
  • Phenotype 23%
  • Genotype 18%
  26 Citations (Scopus)

• Local anesthetic interaction with human ether-a-go-go-related gene (HERG) channels: role of aromatic amino acids Y652 and F656.

  Siebrands, C. C., Schmitt, N. & Friederich, P., 2005, In: Anesthesiology. 103, 1, p. 102-12 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Aromatic Amino Acids 100%
  • Ether 78%
  • Local Anesthetics 72%
  • Ropivacaine 52%
  • Bupivacaine 45%
  30 Citations (Scopus)
• 2003

  KCNQ1 channels sense small changes in cell volume.

  Grunnet, M., Jespersen, T., MacAulay, N., Jørgensen, N. K., Schmitt, N., Pongs, O., Olesen, S-P. & Klærke, D. A., 2003, In: Journal of Physiology. 549, Pt 2, p. 419-27 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  76 Citations (Scopus)
• 2000

  A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly.

  Schmitt, N., Schwarz, M., Peretz, A., Abitbol, I., Attali, B. & Pongs, O., 2000, In: EMBO Journal. 19, 3, p. 332-40 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  136 Citations (Scopus)