Structural basis for KV7.1/KCNEx interactions in the IKs channel complex

Alicia Lundby; Gea-Ny Tseng; Nicole Schmitt

doi:10.1016/j.hrthm.2009.12.017

Structural basis for KV7.1/KCNEx interactions in the IKs channel complex

Alicia Lundby, Gea-Ny Tseng, Nicole Schmitt

18 Citations (Scopus)

Abstract

The cardiac I_Ks current is involved in action potential repolarization, where its primary function is to limit action potential prolongation during sympathetic stimulation. The I_Ks channel is mainly composed of K_V7.1 ion channels associated with KCNE1 auxiliary subunits. The availability of KCNE1 solution structure by nuclear magnetic resonance spectroscopy in conjunction with biochemical assays addressing K _V7.1-KCNE1 residue interactions has provided new insights into the structural basis for K_V7.1 modulation by KCNE1. Recent evidence further suggests that KCNE2 may associate with the K_V7.1-KCNE1 channel complex and modulate its current amplitude. Here we review recent studies in this area and discuss potential roles for multiple KCNE_x subunits in I_Ks generation and modulation as well as the clinical relevance of the new information.

Original language	English
Journal	Heart Rhythm
Volume	7
Issue number	5
Pages (from-to)	708-713
ISSN	1547-5271
DOIs	https://doi.org/10.1016/j.hrthm.2009.12.017
Publication status	Published - May 2010

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title = "Structural basis for KV7.1/KCNEx interactions in the IKs channel complex",

abstract = "The cardiac IKs current is involved in action potential repolarization, where its primary function is to limit action potential prolongation during sympathetic stimulation. The IKs channel is mainly composed of KV7.1 ion channels associated with KCNE1 auxiliary subunits. The availability of KCNE1 solution structure by nuclear magnetic resonance spectroscopy in conjunction with biochemical assays addressing K V7.1-KCNE1 residue interactions has provided new insights into the structural basis for KV7.1 modulation by KCNE1. Recent evidence further suggests that KCNE2 may associate with the KV7.1-KCNE1 channel complex and modulate its current amplitude. Here we review recent studies in this area and discuss potential roles for multiple KCNEx subunits in IKs generation and modulation as well as the clinical relevance of the new information.",

author = "Alicia Lundby and Gea-Ny Tseng and Nicole Schmitt",

note = "Copyright {\textcopyright} 2009. Published by Elsevier Inc.",

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T1 - Structural basis for KV7.1/KCNEx interactions in the IKs channel complex

AU - Lundby, Alicia

AU - Tseng, Gea-Ny

AU - Schmitt, Nicole

PY - 2010/5

Y1 - 2010/5

N2 - The cardiac IKs current is involved in action potential repolarization, where its primary function is to limit action potential prolongation during sympathetic stimulation. The IKs channel is mainly composed of KV7.1 ion channels associated with KCNE1 auxiliary subunits. The availability of KCNE1 solution structure by nuclear magnetic resonance spectroscopy in conjunction with biochemical assays addressing K V7.1-KCNE1 residue interactions has provided new insights into the structural basis for KV7.1 modulation by KCNE1. Recent evidence further suggests that KCNE2 may associate with the KV7.1-KCNE1 channel complex and modulate its current amplitude. Here we review recent studies in this area and discuss potential roles for multiple KCNEx subunits in IKs generation and modulation as well as the clinical relevance of the new information.

AB - The cardiac IKs current is involved in action potential repolarization, where its primary function is to limit action potential prolongation during sympathetic stimulation. The IKs channel is mainly composed of KV7.1 ion channels associated with KCNE1 auxiliary subunits. The availability of KCNE1 solution structure by nuclear magnetic resonance spectroscopy in conjunction with biochemical assays addressing K V7.1-KCNE1 residue interactions has provided new insights into the structural basis for KV7.1 modulation by KCNE1. Recent evidence further suggests that KCNE2 may associate with the KV7.1-KCNE1 channel complex and modulate its current amplitude. Here we review recent studies in this area and discuss potential roles for multiple KCNEx subunits in IKs generation and modulation as well as the clinical relevance of the new information.

U2 - 10.1016/j.hrthm.2009.12.017

DO - 10.1016/j.hrthm.2009.12.017

M3 - Journal article

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SN - 1547-5271

VL - 7

SP - 708

EP - 713

JO - Heart Rhythm

JF - Heart Rhythm

IS - 5

ER -

Structural basis for KV7.1/KCNEx interactions in the IKs channel complex

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