Nicole Schmitt

Research output

Research output per year 2000 2007 2011 2013 2014 2015 2016 2018 2019

• 71 Journal article
• 1 Conference abstract for conference
• 1 Poster
• 1 Conference abstract in journal

Research output per year

Research output per year

Search results

• 2019

  Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia

  David, J-P., Lisewski, U., Crump, S. M., Jepps, T. A., Bocksteins, E., Wilck, N., Lossie, J., Roepke, T. K., Schmitt, N. & Abbott, G. W., Feb 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 2, p. 2537-2552 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brugada Syndrome 100%
  • Intracardiac 65%
  • Atrial Fibrillation 64%
  • Cardiac Arrhythmias 61%
  • Mutation 61%
  7 Citations (Scopus)

• Reappraisal of variants previously linked with sudden infant death syndrome: results from three population-based cohorts

  Paludan-Mueller, C., Ghouse, J., Vad, O. B., Herfelt, C. B., Lundegaard, P., Ahlberg, G., Schmitt, N., Svendsen, J. H., Haunso, S., Bundgaard, H., Hansen, T., Kanters, J. K. & Olesen, M. S., 1 Sept 2019, In: European Journal of Human Genetics. 27, 9, p. 1427-1435

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sudden Infant Death 100%
  • Medical Genetics 43%
  • Syncope 35%
  • Genomics 32%
  • Population 31%
  3 Citations (Scopus)
• 2018

  Functional consequences of genetic variation in sodium channel modifiers in early onset lone atrial fibrillation

  Denti, F., Paludan-Müller, C., Olesen, S-P., Haunsø, S., Svendsen, J. H., Olesen, M. S., Bentzen, B. H. & Schmitt, N., Mar 2018, In: Personalized Medicine. 15, 2, p. 93-102 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sodium Channels 100%
  • Genetic Variation 81%
  • Atrial Fibrillation 75%
  • Electrophysiology 23%
  • Genetic Testing 21%
  2 Citations (Scopus)

• Homozygosity for SCN4A Arg1142Gln causes congenital myopathy with variable disease expression

  Sloth, C. K., Denti, F., Schmitt, N., Bentzen, B. H., Fagerberg, C., Vissing, J. & Gaist, D., Oct 2018, In: Neurology: Genetics. 4, 5, p. e267 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  27 Downloads (Pure)

• Multiple genetic variations in sodium channel subunits in a case of sudden infant death syndrome

  Denti, F., Bentzen, B. H., Wojciak, J., Thomsen, N. M., Scheinman, M. & Schmitt, N., Jun 2018, In: Pacing and Clinical Electrophysiology. 41, 6, p. 620-626

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sudden Infant Death 100%
  • Sodium Channels 95%
  • Genetic Variation 78%
  • Sudden Death 56%
  • Fathers 53%
  2 Citations (Scopus)

• PKD Phosphorylation as Novel Pathway of K_V11.1 Regulation

  Steffensen, A. B., Bomholtz, S. H., Andersen, M. N., Olsen, J. V., Mutsaers, N., Lundegaard, P. R., Lundby, A. & Schmitt, N., 1 Jul 2018, In: Cellular Physiology and Biochemistry. 47, 4, p. 1742-1750 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • protein kinase D 100%
  • Phosphorylation 65%
  • Mass Spectrometry 56%
  • Voltage-Gated Potassium Channels 41%
  • Electrophysiology 35%
  2 Citations (Scopus)

  53 Downloads (Pure)

• Spinal dorsal horn astrocytes release GABA in response to synaptic activation

  Christensen, R. K., Delgado-Lezama, R., Russo, R. E., Lind, B. L., Alcocer, E. L., Rath, M. F., Fabbiani, G., Schmitt, N., Lauritzen, M., Petersen, A. V., Carlsen, E. M. & Perrier, J-F., 2018, In: The Journal of Physiology. 596, 20, p. 4983-4994 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Spinal Cord Dorsal Horn 100%
  • gamma-Aminobutyric Acid 83%
  • Astrocytes 79%
  • Glutamic Acid 33%
  • Electronic Data Processing 19%
  14 Citations (Scopus)

• SUMO co-expression modifies KV 11.1 channel activity

  Steffensen, A. B., Andersen, M. N., Mutsaers, N., Mujezinovic, A. & Schmitt, N., Mar 2018, In: Acta Physiologica (Print). 222, 3, 11 p., e12974.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sumoylation 100%
  • Kinetics 35%
  • Voltage-Gated Potassium Channels 32%
  • Xenopus laevis 29%
  • Site-Directed Mutagenesis 26%
  4 Citations (Scopus)
• 2017

  Deep sequencing of atrial fibrillation patients with mitral valve regurgitation shows no evidence of mosaicism but reveals novel rare germline variants

  Gregers, E., Ahlberg, G., Christensen, T., Jabbari, J., Larsen, K. O., Herfelt, C. B., Henningsen, K. M., Andreasen, L., Thiis, J. J., Lund, J., Holme, S., Haunsø, S., Bentzen, B. H., Schmitt, N., Svendsen, J. H. & Olesen, M. S., Oct 2017, In: Heart Rhythm. 14, 10, p. 1531-1538

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mosaicism 100%
  • Mitral Valve Insufficiency 88%
  • High-Throughput Nucleotide Sequencing 77%
  • Atrial Fibrillation 72%
  • Genes 14%
  6 Citations (Scopus)

• In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis

  Colman, M. A., Ni, H., Liang, B., Schmitt, N. & Zhang, H., Jun 2017, In: PLoS Computational Biology. 13, 6, 21 p., e1005587.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genetic Variation 100%
  • genetic variation 78%
  • mutation 64%
  • Mutation 64%
  • Computer Simulation 61%
  19 Citations (Scopus)

  109 Downloads (Pure)

• Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway

  Jensen, C. S., Watanabe, S., Stas, J. I., Klaphaak, J., Yamane, A., Schmitt, N., Olesen, S-P., Trimmer, J. S., Rasmussen, H. B. & Misonou, H., 29 Nov 2017, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 37, 48, p. 11523-11536 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Axon Initial Segment 100%
  • Secretory Pathway 76%
  • Neurons 40%
  • Membranes 23%
  • Delayed Rectifier Potassium Channels 22%
  27 Citations (Scopus)
• 2016

  Iron Overload Leading to Torsades de Pointes in β-Thalassemia and Long QT Syndrome

  Refaat, M. M., El Hage, L., Steffensen, A. B., Hotait, M., Schmitt, N., Scheinman, M. & Badhwar, N., 1 Mar 2016, In: Cardiac Electrophysiology Clinics. 8, 1, p. 247-256 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Torsades de Pointes 100%
  • Long QT Syndrome 97%
  • Thalassemia 91%
  • Iron Overload 89%
  • Mutation 42%
  4 Citations (Scopus)

• pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts

  Skarsfeldt, M. A., Jepps, T. A., Bomholtz, S. H., Abildgaard, L., Sørensen, U. S., Gregers, E., Svendsen, J. H., Diness, J. G., Grunnet, M., Schmitt, N., Olesen, S-P. & Bentzen, B. H., 1 Apr 2016, In: Pfluegers Archiv. 468, 4, p. 643-654 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Refractory 100%
  • Antiarrhythmic Agent 79%
  • Heart 62%
  • Action Potentials 49%
  • Atrial Fibrillation 48%
  8 Citations (Scopus)

• Polyunsaturated fatty acids are potent openers of human M-channels expressed in Xenopus laevis oocytes

  Liin, S. I., Karlsson, U., Bentzen, B. H., Schmitt, N. & Elinder, F., 1 Sept 2016, In: Acta Physiologica (Print). 218, 1, p. 28-37 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Xenopus laevis 100%
  • Unsaturated Fatty Acids 91%
  • Oocytes 79%
  • Spinal Ganglia 39%
  • Docosahexaenoic Acids 28%
  15 Citations (Scopus)

• Structural interplay of Kv7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (Kv7.1-A287T)

  Rothenberg, I., Piccini, I., Wrobel, E., Stallmeyer, B., Müller, J., Greber, B., Strutz-Seebohm, N., Schulze-Bahr, E., Schmitt, N. & Seebohm, G., 1 Nov 2016, In: HeartRhythm Case Reports. 2, 6, p. 521-529 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  2 Citations (Scopus)

• The anticonvulsant retigabine suppresses neuronal Kv2-mediated currents

  Stas, J. I., Bocksteins, E., Jensen, C. S., Schmitt, N. & Snyders, D. J., 13 Oct 2016, In: Scientific Reports. 6, 12 p., 35080.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • ezogabine 100%
  • Anticonvulsants 57%
  • Epilepsy 8%
  • Neurons 6%
  • Apoptosis 6%
  13 Citations (Scopus)

  73 Downloads (Pure)

• The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size

  Christensen, A. H., Chatelain, F. C., Huttner, I. G., Olesen, M. S., Soka, M., Feliciangeli, S., Horvat, C., Santiago, C. F., Vandenberg, J. I., Schmitt, N., Olesen, S-P., Lesage, F. & Fatkin, D., 1 Aug 2016, In: Journal of Molecular and Cellular Cardiology. 97, p. 24-35 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Potassium Channels 100%
  • Heart Rate 63%
  • Zebrafish 44%
  • Atrial Fibrillation 25%
  • Messenger RNA 16%
  8 Citations (Scopus)
• 2015

  Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells

  Adinolfi, B., Carpi, S., Romanini, A., Da Pozzo, E., Castagna, M., Costa, B., Martini, C., Olesen, S-P., Schmitt, N., Breschi, M. C., Nieri, P. & Fogli, S., 1 Jul 2015, In: Anticancer Research. 35, 7, p. 3781-6 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Clotrimazole 100%
  • Melanoma 58%
  • Annexin A5 39%
  • DNA Fragmentation 37%
  • Cell Survival 26%
  13 Citations (Scopus)

• Astrocytes gate synaptic transmission from unmyelinated sensory afferents

  Perrier, J-F. M., Christensen, R. K., Delgado-Lezama, R., Russo, R., Lind, B. L., Alcocer, E. L., Fabbiani, G., Schmitt, N., Lauritzen, M., Petersen, A. V. & Carlsen, E. M., Aug 2015, In: Glia. 63, S1, p. E241-E241 T08-22B .

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels

  David, J-P., Stas, J. I., Schmitt, N. & Bocksteins, E., 5 Aug 2015, In: Scientific Reports. 5, p. 1-14 14 p., 12813.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fluorescence Resonance Energy Transfer 100%
  • Voltage-Gated Potassium Channels 98%
  • HEK293 Cells 81%
  • Immunohistochemistry 52%
  12 Citations (Scopus)

• High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance

  Steffensen, A. B., Refaat, M. M., David, J-P., Mujezinovic, A., Calloe, K., Wojciak, J., Nussbaum, R. L., Scheinman, M. M. & Schmitt, N., 12 Jun 2015, In: Scientific Reports. 5, p. 1-13 13 p., 10009.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Long QT Syndrome 100%
  • Ion Channels 75%
  • Incidence 37%
  • Xenopus laevis 22%
  • Syncope 20%
  8 Citations (Scopus)

• IKs Gain- and Loss-of-Function In Early-Onset Lone Atrial Fibrillation

  Steffensen, A. B., Refsgaard, L., Andersen, M. N., Vallet, C., Mujezinovic, A., Haunsø, S., Svendsen, J. H., Olesen, S-P., Olesen, M. S. & Schmitt, N., 2015, In: Journal of Cardiovascular Electrophysiology. 26, 7, p. 715-23 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Atrial Fibrillation 100%
  • Mutation 55%
  • Potassium 22%
  • Gain of Function Mutation 16%
  • Long QT Syndrome 16%
  18 Citations (Scopus)

• Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I_Ks channel

  Liin, S. I., Silverå Ejneby, M., Barro-Soria, R., Skarsfeldt, M. A., Larsson, J. E., Starck Härlin, F., Parkkari, T., Bentzen, B. H., Schmitt, N., Larsson, H. P. & Elinder, F., 5 May 2015, In: Proceedings of the National Academy of Science of the United States of America. 112, 18, p. 5714–5719 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Unsaturated Fatty Acids 100%
  • Static Electricity 10%
  • Tail 9%
  • Cardiac Myocytes 8%
  • Guinea Pigs 8%
  44 Citations (Scopus)

• Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking

  Andersen, M. N., Hefting, L. L., Steffensen, A. B., Schmitt, N., Olesen, S-P., Olsen, J. V., Lundby, A. & Rasmussen, H. B., 15 Nov 2015, In: American Journal of Physiology: Cell Physiology. 309, 10, p. C693-C706 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cyclic AMP-Dependent Protein Kinases 100%
  • Ubiquitination 18%
  • KCNQ1 Potassium Channel 15%
  • Epithelium 13%
  • Phosphorylation 12%
  4 Citations (Scopus)
• 2014

  Brugada syndrome risk loci seem protective against atrial fibrillation

  Andreasen, L., Nielsen, J. B., Darkner, S., Christophersen, I. E., Jabbari, J., Refsgaard, L., Thiis, J. J., Sajadieh, A., Tveit, A., Haunsø, S., Svendsen, J. H., Schmitt, N. & Olesen, M. S., 26 Mar 2014, In: European Journal of Human Genetics. 22, p. 1357-1361 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brugada Syndrome 100%
  • Atrial Fibrillation 64%
  • Alleles 24%
  • Odds Ratio 16%
  • Genome-Wide Association Study 13%
  11 Citations (Scopus)

• Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

  Schmitt, N., Grunnet, M. & Olesen, S-P., Apr 2014, In: Physiological Reviews. 94, 2, p. 609-53 45 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Potassium Channels 100%
  • Atrial Fibrillation 77%
  • Cardiac Arrhythmias 74%
  • Heart 56%
  • Action Potentials 39%
  126 Citations (Scopus)

• Fast detection of extrasynaptic GABA with a whole-cell sniffer

  Christensen, R. K., Petersen, A. V., Schmitt, N. & Perrier, J-F., 15 May 2014, In: Frontiers in Cellular Neuroscience. 8, p. 1-9 9 p., 00133.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Butyric Acid 100%
  • Synapses 13%
  • Kidney 11%
  • Nerve Tissue 8%
  • Extracellular Space 8%
  9 Citations (Scopus)

  48 Downloads (Pure)

• From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group

  Blom, S. M., Rottländer, M., Kehler, J., Bundgaard, C., Schmitt, N. & Jensen, H. S., 23 Jun 2014, In: PloS one. 9, 6, 9 p., e100209.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Inhibitor 100%
  • Activation 93%
  • Modulator 77%
  • inhibitor 74%
  • Chemical activation 70%
  10 Citations (Scopus)

• Gain-of-function mutations in potassium channel subunit KCNE2 associated with early-onset lone atrial fibrillation

  Nielsen, J. B., Bentzen, B. H., Olesen, M. S., David, J-P., Olesen, S-P., Haunsø, S., Svendsen, J. H. & Schmitt, N., Apr 2014, In: Biomarkers in Medicine. 8, 4, p. 557-570 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gain of Function Mutation 100%
  • Potassium Channels 86%
  • Atrial Fibrillation 67%
  • Mutation 63%
  • Missense Mutation 26%
  15 Citations (Scopus)

• Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

  Liang, B., Soka, M., Christensen, A. H., Olesen, M. S., Larsen, A. P., Knop, F. K., Wang, F., Nielsen, J. B., Andersen, M. N., Humphreys, D., Mann, S. A., Huttner, I. G., Vandenberg, J. I., Svendsen, J. H., Haunsø, S., Preiss, T., Seebohm, G., Olesen, S-P., Schmitt, N. & Fatkin, D., Feb 2014, In: Journal of Molecular and Cellular Cardiology. 67, p. 69-76 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Potassium Channels 100%
  • Genetic Variation 84%
  • Atrial Fibrillation 77%
  • Action Potentials 31%
  • Embryonic Structures 28%
  48 Citations (Scopus)

• Investigations of the Navβ1b sodium channel subunit in human ventricle; functional characterization of the H162P Brugada Syndrome mutant

  Yuan, L., Koivumaki, J., Liang, B., Lorentzen, L. G., Tang, C., Andersen, M. N., Svendsen, J. H., Tfelt-Hansen, J., Maleckar, M., Schmitt, N., Olesen, M. S. & Jespersen, T., 15 Apr 2014, In: American Journal of Physiology: Heart and Circulatory Physiology. 306, 8, p. H1204-12

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brugada Syndrome 100%
  • Sodium Channels 85%
  • Computer Simulation 34%
  • Action Potentials 32%
  • Loss of Function Mutation 20%
  17 Citations (Scopus)

• Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning

  Eckey, K., Wrobel, E., Strutz-Seebohm, N., Pott, L., Schmitt, N. & Seebohm, G., 15 Aug 2014, In: The Journal of Biological Chemistry. 289, 33, p. 22749-58 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 1,2-dioctanoylglycerol 100%
  • Voltage-Gated Potassium Channels 80%
  • Long QT Syndrome 79%
  • Intracellular Membranes 77%
  • Phosphatidylinositol 73%
  20 Citations (Scopus)

• Specific Sorting and Post-Golgi trafficking of Dendritic Potassium Channels in Living Neurons

  Jensen, C. S., Watanabe, S., Rasmussen, H. B., Schmitt, N., Olesen, S-P., Frost, N. A., Blanpied, T. A. & Misonou, H., 11 Apr 2014, In: The Journal of Biological Chemistry. 289, p. 10566-10581 16 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Potassium Channels 100%
  • Dendrites 90%
  • Ion Channels 86%
  • Neurons 53%
  • Golgi Apparatus 49%
  30 Citations (Scopus)

• Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation

  Olesen, M. S., Andreasen, L., Jabbari, J., Refsgaard, L., Haunsø, S., Olesen, S-P., Nielsen, J. B., Schmitt, N. & Svendsen, J. H., Feb 2014, In: Heart Rhythm. 11, 2, p. 246-251 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Atrial Fibrillation 100%
  • Genes 45%
  • Exome 26%
  • Gene Frequency 21%
  • N-propionylprocainamide 21%
  37 Citations (Scopus)
• 2013

  A Common Structural Component for β-Subunit Mediated Modulation of Slow Inactivation in Different KV Channels

  Strutz-Seebohm, N., Henrion, U., Schmitt, N., Schulze-Bahr, E. & Seebohm, G., Jul 2013, In: Cellular Physiology and Biochemistry. 31, 6, p. 968-980 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Potassium 100%
  • Tandem Pore Domain Potassium Channels 50%
  • Ions 45%
  • Binding Sites 42%
  • Amino Acids 38%
  5 Citations (Scopus)

• A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation

  Olesen, M. S. S., Refsgaard, L., Holst, A. G., Larsen, A. P., Grubb, S., Haunsø, S., Svendsen, J. H., Olesen, S-P., Schmitt, N. & Callø, K., 1 Jun 2013, In: Cardiovascular Research. 98, 3, p. 488-495 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gain of Function Mutation 100%
  • Atrial Fibrillation 67%
  • Mutation 42%
  • Brugada Syndrome 34%
  • Potassium 22%
  73 Citations (Scopus)

  1 Downloads (Pure)

• Characterization and mechanisms of action of novel Na_V1.5 channel mutations associated with Brugada syndrome

  Callø, K., Refaat, M. M., Grubb, S., Wojciak, J., Campagna, J., Thomsen, N. M., Nussbaum, R. L., Scheinman, M. M. & Schmitt, N., Feb 2013, In: Circulation. Arrhythmia and Electrophysiology (Online). 6, 1, p. 177-184 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brugada Syndrome 100%
  • Loss of Function Mutation 40%
  • Mutation 40%
  • Haploinsufficiency 23%
  • Sodium Channels 21%
  29 Citations (Scopus)

  1337 Downloads (Pure)

• Contribution of KV7 Channels to Basal Coronary Flow and Active Response to Ischemia

  Khanamiri, S., Soltysinska, E., Jepps, T. A., Bentzen, B. H., Chadha, P. S., Schmitt, N., Greenwood, I. A. & Olesen, S-P., 30 Sept 2013, In: Hypertension. 62, 6, p. 1090-1097 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ischemia 100%
  • Coronary Vessels 54%
  • 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 33%
  • Adenosine A2A Receptors 30%
  • Isolated Heart Preparation 29%
  58 Citations (Scopus)

• Dysfunction of the heteromeric K_V7.3/K_V7.5 potassium channel is associated with autism spectrum disorders

  Nielsen, M. G., Rasmussen, H. B., Callø, K., F. Sequeira, A., Baretto, M., Oliveira, G., Almeida, J., B. Lauritsen, M., Ullmann, R., Boonen, S. E., Brøndum-Nielsen, K., M. Kalscheuer, V., Tümer, Z., M. Vicente, A., Schmitt, N. & Tommerup, N., 2013, In: Frontiers in Genetics. 4, 54, p. 1-13 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • KCNQ3 Potassium Channel 100%
  • Autism Spectrum Disorder 52%
  • Rolandic Epilepsy 51%
  • Idiopathic Generalized Epilepsy 49%
  • Nucleotides 40%
  30 Citations (Scopus)

  2451 Downloads (Pure)

• Genetic Modifier of the QTc Interval Associated With Early-Onset Atrial Fibrillation

  Andreasen, L., Nielsen, J. B., Christophersen, I. E., Holst, A. G., Sajadieh, A., Tveit, A., Haunsø, S., Svendsen, J. H., Schmitt, N. & Olesen, M. S., Oct 2013, In: Canadian Journal of Cardiology. 29, 10, p. 1234-40 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Atrial Fibrillation 100%
  • Genome-Wide Association Study 26%
  • Logistic Models 16%
  • Long QT Syndrome 16%
  • Linkage Disequilibrium 14%
  7 Citations (Scopus)

• Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation

  Christophersen, I. E., Olesen, M. S., Liang, B., Andersen, M. N., Larsen, A. P., Nielsen, J. B., Haunsø, S., Olesen, S-P., Tveit, A., Svendsen, J. H. & Schmitt, N., 21 May 2013, In: European Heart Journal.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Genetic Variation 100%
  • Potassium 93%
  • Atrial Fibrillation 92%
  • Loss of Function Mutation 38%
  • Kv1.5 Potassium Channel 33%
  84 Citations (Scopus)

• Gliadin Fragments and a Specific Gliadin 33-mer Peptide Close KATP Channels and Induce Insulin Secretion in INS-1E Cells and Rat Islets of Langerhans

  Dall, M., Calloe, K., Haupt-Jorgensen, M., Larsen, J., Schmitt, N., Josefsen, K. & Buschard, K., 13 Jun 2013, In: PLOS ONE. 8, 6, p. 1-10 10 p., e66474.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Secretion 100%
  • Insulin 96%
  • Peptides 95%
  • Gliadin 94%
  • insulin secretion 88%
  18 Citations (Scopus)

• In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of β-Adrenergic Receptor Signaling

  Lundby, A., Andersen, M. N., Steffensen, A. B., Horn, H., Kelstrup, C. D., Francavilla, C., Jensen, L. J., Schmitt, N., Thomsen, M. B. & Olsen, J. V., 4 Jun 2013, In: Science Signaling. 6, 278, p. rs11 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Adrenergic Receptors 100%
  • Adrenergic 82%
  • Phosphorylation 72%
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 66%
  • Protein 43%
  108 Citations (Scopus)

• Trafficking of the IKs -Complex in MDCK Cells: Site of Subunit Assembly and Determinants of Polarized Localization

  David, J-P., Andersen, M. N., Olesen, S-P., Rasmussen, H. B. & Schmitt, N., Apr 2013, In: Traffic. 14, 4, p. 399-411 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Subcellular Localization 100%
  • Madin Darby Canine Kidney Cells 90%
  • Mutation 61%
  • Voltage-Gated Potassium Channels 48%
  • Membranes 43%
  9 Citations (Scopus)
• 2012

  Cellular mechanisms for presynaptic inhibition of sensory afferents

  Christensen, R. K., Delgado-Lezama, R., russo, R., lind, B., Schmitt, N., LOEZA-ALCOCER, M., Lauritzen, M. & Perrier, J-F. M., 2012. 1 p.

  Research output: Contribution to conference › Conference abstract for conference › Research

• High Prevalence of Long QT Syndrome Associated SCN5A Variants in Patients with Early-Onset Lone Atrial Fibrillation

  Olesen, M. S., Yuan, L., Liang, B., Holst, A. G., Nielsen, N., Nielsen, J. B., Hedley, P. L., Christiansen, M., Olesen, S-P., Haunsø, S., Schmitt, N., Jespersen, T. & Svendsen, J. H., Aug 2012, In: Circulation: Cardiovascular Genetics. 5, 4, p. 450-459 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Long QT syndrome type 3 100%
  • Long QT Syndrome 88%
  • Atrial Fibrillation 60%
  • Mutation 38%
  • Exome 13%
  96 Citations (Scopus)

• Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation

  Olesen, M. S., Bentzen, B. H., Nielsen, J. B., Steffensen, A. B., David, J-P., Jabbari, J., Jensen, H., Haunsø, S., Svendsen, J. H. & Schmitt, N., 3 Apr 2012, In: B M C Medical Genetics. 13, p. 24

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Potassium Channels 100%
  • Atrial Fibrillation 77%
  • Mutation 48%
  • potassium channel protein I(sk) 34%
  • Potassium 15%
  67 Citations (Scopus)
• 2011

  A Novel Nonsense Variant in Nav1.5 Cofactor MOG1 Eliminates Its Sodium Current Increasing Effect and May Increase the Risk of Arrhythmias

  Olesen, M. S., Jensen, N. F., Holst, A. G., Nielsen, J. B., Tfelt-Hansen, J., Jespersen, T., Sajadieh, A., Haunsø, S., Lund, J. T., Calloe, K., Schmitt, N. & Svendsen, J. H., 26 May 2011, In: Canadian Journal of Cardiology. 27, 4, p. 523.e17-23

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cardiac Arrhythmias 100%
  • Sodium 98%
  • Brugada Syndrome 40%
  • Genes 35%
  • CHO Cells 35%
  42 Citations (Scopus)

• Cellular mechanisms for presynaptic inhibition of sensory afferents.

  Perrier, J-F. M., delgado-lezama, R., Christensen, R. K., Lind, B., Schmitt, N., Loeza-Alcocer, E., petersen, A., Lauritzen, M. & russo, R., 2011. 1 p.

  Research output: Contribution to conference › Poster › Research

  • Spinal Nerve Roots 100%
  • Astrocytes 77%
  • 5-nitro-2-(3-phenylpropylamino)benzoic acid 53%
  • GABA Plasma Membrane Transport Proteins 52%
  • gamma-Aminobutyric Acid 48%

• Letter by Olesen et al regarding article, "MOG1: a new susceptibility gene for Brugada syndrome"

  Olesen, M. S., Holst, A. G. & Schmitt, N., Oct 2011, In: Circulation: Cardiovascular Genetics. 4, 5

  Research output: Contribution to journal › Journal article › Research › peer-review

  3 Citations (Scopus)