Morten Frödin - Research output - University of Copenhagen Research Portal

Research activity per year

36 Journal article
1 Book chapter
1 Comment/debate

38 results

2019
In Vivo Editing of the Adult Mouse Liver Using CRISPR/Cas9 and Hydrodynamic Tail Vein Injection
Niola, F., Dagnæs-Hansen, F. & Frödin, M., 2019, CRISPR Gene Editing: Methods and Protocols. Luo, Y. (ed.). New York, NY: Humana Press, Vol. 1961. p. 329-341 13 p. 20. (Methods in molecular biology (Clifton, N.J.)).
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
2018

Correction: p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity
Frank, S. R., Köllmann, C. P., Luong, P., Galli, G. G., Zou, L., Bernards, A., Getz, G., Calogero, R. A., Frödin, M. & Hansen, S. H., 2018, In: The Journal of Cell Biology. 217, 9, p. 3313 1 p.
Research output: Contribution to journal › Comment/debate › Research › peer-review

36 Downloads (Pure)
De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium
Lavrsen, K., Dabelsteen, S., Vakhrushev, S. Y., Levann, A. M. R., Haue, A. D., Dylander, A., Mandel, U., Hansen, L., Frödin, M., Bennett, E. P. & Wandall, H. H., 26 Jan 2018, In: The Journal of Biological Chemistry. 293, p. 1298-1314
Research output: Contribution to journal › Journal article › Research › peer-review
32 Citations (Scopus)
p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity
Frank, S. R., Köllmann, C. P., Luong, P., Galli, G. G., Zou, L., Bernards, A., Getz, G., Calogero, R. A., Frödin, M. & Hansen, S. H., 1 Sept 2018, In: The Journal of Cell Biology. 217, 9, p. 3183-3201 19 p.
Research output: Contribution to journal › Journal article › Research › peer-review
8 Citations (Scopus)

48 Downloads (Pure)
2017
CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma
Engelholm, L. H., Riaz, A., Serra, D., Dagnæs-Hansen, F., Johansen, J. V., Santoni-Rugiu, E., Hansen, S. H., Niola, F. & Frödin, M., 1 Dec 2017, In: Gastroenterology. 153, 6, p. 1662-1673.e10
Research output: Contribution to journal › Journal article › Research › peer-review
34 Citations (Scopus)

140 Downloads (Pure)
Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis
Lonowski, L. A., Narimatsu, Y., Riaz, A., Delay, C. M. E., Yang, Z., Niola, F., Duda, K., Ober, E. A., Clausen, H., Wandall, H. H., Hansen, S. H., Bennett, E. P. & Frödin, M., 1 Mar 2017, In: Nature Protocols. 12, 3, p. 581-603 23 p.
Research output: Contribution to journal › Journal article › Research › peer-review
54 Citations (Scopus)
The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion
Frank, S. R., Köllmann, C. P., van Lidth de Jeude, J. F., Thiagarajah, J. R., Engelholm, L. H., Frödin, M. & Hansen, S. H., 30 Mar 2017, In: Oncogene. 36, 13, p. 1816-1828 13 p.
Research output: Contribution to journal › Journal article › Research › peer-review
14 Citations (Scopus)

200 Downloads (Pure)
2015
A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment
Nyegaard, M., Rendtorff, N. D., Nielsen, M. S., Corydon, T. J., Demontis, D., Starnawska, A., Hedemand, A., Buniello, A., Niola, F., Overgaard, M. T., Leal, S. M., Ahmad, W., Wikman, F. P., Petersen, K. B., Crueger, D. G., Oostrik, J., Kremer, H., Tommerup, N., Froedin, M., Steel, K. P., & 2 othersTranebjaerg, L. & Borglum, A. D., 1 Jul 2015, In: P L o S Genetics. 11, 7, p. 1-25 25 p., e1005386.
Research output: Contribution to journal › Journal article › Research › peer-review
8 Citations (Scopus)
Engineered CHO cells for production of diverse, homogeneous glycoproteins
Yang, Z., Wang, S., Halim, A., Schulz, M. A., Frödin, M., Rahman, S. H., Vester-Christensen, M. B., Behrens, C., Kristensen, C., Vakhrushev, S. Y., Bennett, E. P., Wandall, H. H. & Clausen, H., 10 Aug 2015, In: Nature Biotechnology. 33, 8, p. 842-844 3 p.
Research output: Contribution to journal › Journal article › Research › peer-review
129 Citations (Scopus)
Fast and sensitive detection of indels induced by precise gene targeting
Yang, Z., Steentoft, C., Hauge, C., Hansen, L., Thomsen, A. L., Niola, F., Vester-Christensen, M. B., Frödin, M., Clausen, H., Wandall, H. H. & Bennett, E. P., 19 May 2015, In: Nucleic Acids Research. 43, 9, p. 1-8 8 p., e59.
Research output: Contribution to journal › Journal article › Research › peer-review
83 Citations (Scopus)
2014
High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs
Duda, K., Lonowski, L. A., Kofoed-Nielsen, M., Ibarra, A., Delay, C. M., Kang, Q., Yang, Z., Pruett-Miller, S. M., Bennett, E. P., Wandall, H. H., Davis, G. D., Hansen, S. H. & Frödin, M., 2 Jun 2014, In: Nucleic Acids Research. 42, 10, p. 1-16 16 p., e84.
Research output: Contribution to journal › Journal article › Research › peer-review
56 Citations (Scopus)
2012
A βPIX-PAK2 complex confers protection against Scrib-dependent and cadherin-mediated apoptosis
Frank, S. R., Bell, J. H., Frödin, M. & Hansen, S. H., 9 Oct 2012, In: Current biology : CB. 22, 19, p. 1747-54 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
18 Citations (Scopus)
Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
Serafimova, I. M., Pufall, M. A., Krishnan, S., Duda, K., Cohen, M. S., Maglathlin, R. L., McFarland, J. M., Miller, R. M., Frödin, M. & Taunton, J., May 2012, In: Nature Chemical Biology. 8, 5, p. 471-6 6 p.
Research output: Contribution to journal › Journal article › Research › peer-review
266 Citations (Scopus)
2011
High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases
Chen, F., Pruett-Miller, S. M., Huang, Y., Gjoka, M., Duda, K., Taunton, J., Collingwood, T. N., Frödin, M. & Davis, G. D., Sept 2011, In: Nature Methods. 8, 9, p. 753-5 3 p.
Research output: Contribution to journal › Journal article › Research › peer-review
316 Citations (Scopus)
2009
Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1)
Dettori, R., Sonzogni, S., Meyer, L., Lopez-Garcia, L. A., Morrice, N. A., Zeuzem, S., Engel, M., Piiper, A., Neimanis, S., Frödin, M. & Biondi, R. M., 2009, In: Journal of Biological Chemistry. 284, 44, p. 30318-27 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
21 Citations (Scopus)
RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells
Doehn, U., Hauge, C., Frank, S. R., Jensen, C. A. J., Duda, K., Nielsen, J. V., Cohen, M. S., Johansen, J. V., Winther, B. R., Lund, L. R., Winther, O., Taunton, J., Hansen, S. H. & Frödin, M., 2009, In: Molecular Cell. 35, 4, p. 511-22 11 p.
Research output: Contribution to journal › Journal article › Research › peer-review
154 Citations (Scopus)
2007

A RSK kinase inhibitor reporting its selectivity in vivo.
Frödin, M., 2007, In: Nature Chemical Biology. 3, 3, p. 138-9 1 p.
Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.
Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frödin, M., Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R., 2007, In: Biochemical Journal. 401, 1, p. 29-38 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
209 Citations (Scopus)
Heregulin-induced epigenetic regulation of the utrophin-A promoter.
Basu, U., Gyrd-Hansen, M., Baby, S. M., Lozynska, O., Krag, T. O. B., Jensen, C. J., Frödin, M. & Khurana, T. S., 2007, In: FEBS Letters. 581, 22, p. 4153-8 5 p.
Research output: Contribution to journal › Journal article › Research › peer-review
13 Citations (Scopus)
Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation.
Hauge, C., Antal, T. L., Hirschberg, D., Doehn, U., Thorup, K., Idrissova, L., Hansen, K., Jensen, O. N., Jørgensen, T. J., Biondi, R. M. & Frödin, M., 2007, In: EMBO Journal. 26, 9, p. 2251-61 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
76 Citations (Scopus)
2006

RSK and MSK in MAP kinase signalling.
Hauge, C. & Frödin, M., 2006, In: Journal of Cell Science. 119, Pt 15, p. 3021-3 2 p.
Research output: Contribution to journal › Journal article › Research › peer-review

140 Citations (Scopus)
2005
Analysis of 65 tuberous sclerosis complex (TSC) patients by TSC2 DGGE, TSC1/RSC2 MLPA, and TSC1 long-range PCR sequencing, and report of 28 novel mutations
Rendtorff, N. D., Bjerregaard, B., Frödin, M., Kjaergaard, S., Hove, H., Skovby, F., Brøndum-Nielsen, T. D. T. S. G. K. & Schwartz, M., 2005, In: Human Mutation. 26, 4, p. 374-383 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
36 Citations (Scopus)
Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.
Dümmler, B. A., Hauge, C., Silber, J., Yntema, H. G., Kruse, L. S., Kofoed, B., Hemmings, B. A., Alessi, D. R. & Frödin, M., 2005, In: Journal of Biological Chemistry. 280, 14, p. 13304-14 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
84 Citations (Scopus)
Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein.
Artus, J., Vandormael-Pournin, S., Frödin, M., Nacerddine, K., Babinet, C. & Cohen-Tannoudji, M., 2005, In: Molecular and Cellular Biology. 25, 14, p. 6289-302 13 p.
Research output: Contribution to journal › Journal article › Research › peer-review
19 Citations (Scopus)
2004
Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.
Silverman, E., Frödin, M., Gammeltoft, S. & Maller, J. L., 2004, In: Molecular and Cellular Biology. 24, 24, p. 10573-83 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
31 Citations (Scopus)
2003
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.
Zhao, J., Yuan, X., Frödin, M. & Grummt, I., 2003, In: Molecular Cell. 11, 2, p. 405-13 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
190 Citations (Scopus)
Xp38gamma/SAPK3 promotes meiotic G(2)/M transition in Xenopus oocytes and activates Cdc25C.
Perdiguero, E., Pillaire, M-J., Bodart, J-F., Hennersdorf, F., Frödin, M., Duesbery, N. S., Alonso, G. & Nebreda, A. R., 2003, In: EMBO Journal. 22, 21, p. 5746-56 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
39 Citations (Scopus)
2002
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.
Frödin, M., Antal, T. L., Dümmler, B. A., Jensen, C. J., Deak, M., Gammeltoft, S. & Biondi, R. M., 2002, In: EMBO Journal. 21, 20, p. 5396-407 11 p.
Research output: Contribution to journal › Journal article › Research › peer-review
206 Citations (Scopus)
2001
Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation.
Rendtorff, N. D., Frödin, M., Attié-Bitach, T., Vekemans, M. & Tommerup, N., 2001, In: Genomics. 71, 1, p. 40-52 12 p.
Research output: Contribution to journal › Journal article › Research › peer-review
21 Citations (Scopus)
2000
A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.
Frödin, M., Jensen, C. A. J., Merienne, K. & Gammeltoft, S., 2000, In: EMBO Journal. 19, 12, p. 2924-34 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
248 Citations (Scopus)
1999
90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.
Jensen, C. A. J., Buch, M. B., Krag, T. O., Hemmings, B. A., Gammeltoft, S. & Frödin, M., 1999, In: Journal of Biological Chemistry. 274, 38, p. 27168-76 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
202 Citations (Scopus)
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.
Frödin, M. & Gammeltoft, S., 1999, In: Molecular and Cellular Endocrinology. 151, 1-2, p. 65-77 12 p.
Research output: Contribution to journal › Journal article › Research › peer-review
594 Citations (Scopus)
Transforming growth factor-beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary cells in vitro.
Wolf, N., Krohn, K., Bieger, S., Frödin, M., Gammeltoft, S., Krieglstein, K. & Unsicker, K., 1999, In: Neuroscience. 90, 2, p. 629-41 12 p.
Research output: Contribution to journal › Journal article › Research › peer-review
16 Citations (Scopus)
1995
Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.
Frödin, M., Sekine, N., Roche, E., Filloux, C., Prentki, M., Wollheim, C. B. & Van Obberghen, E., 1995, In: Journal of Biological Chemistry. 270, 14, p. 7882-9 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
194 Citations (Scopus)
Neuronal localization of pituitary adenylate cyclase-activating polypeptide 38 in the adrenal medulla and growth-inhibitory effect on chromaffin cells.
Frödin, M., Hannibal, J., Wulff, B. S., Gammeltoft, S. & Fahrenkrug, J., 1995, In: Neuroscience. 65, 2, p. 599-608 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
66 Citations (Scopus)
Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP.
Peraldi, P., Frödin, M., Barnier, J. V., Calleja, V., Scimeca, J. C., Filloux, C., Calothy, G. & Van Obberghen, E., 1995, In: FEBS Letters. 357, 3, p. 290-6 6 p.
Research output: Contribution to journal › Journal article › Research › peer-review
75 Citations (Scopus)
1994
Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.
Frödin, M., Peraldi, P. & Van Obberghen, E., 1994, In: Journal of Biological Chemistry. 269, 8, p. 6207-14 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
313 Citations (Scopus)
Insulin-like growth factors act synergistically with basic fibroblast growth factor and nerve growth factor to promote chromaffin cell proliferation.
Frödin, M. & Gammeltoft, S., 1994, In: Proceedings of the National Academy of Science of the United States of America. 91, 5, p. 1771-5 4 p.
Research output: Contribution to journal › Journal article › Research › peer-review
67 Citations (Scopus)