Michael Lückmann

2019

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

Jorgensen, A. S., Larsen, O., Uetz-von Allmen, E., Lückmann, M., Legler, D. F., Frimurer, T. M., Veldkamp, C. T., Hjortø, G. M. & Rosenkilde, M. M., 13 Sept 2019, In: Frontiers in Immunology. 10, 14 p., 2156.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

15 Downloads (Pure)

Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1

Lückmann, M., Trauelsen, M., Bentsen, M. A., Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, M. M., Papaleo, E., Lindorff-Larsen, K., Schwartz, T. W. & Frimurer, T. M., 2 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7123-7128

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

12 Downloads (Pure)

2018

Ligand-selective small molecule modulators of the constitutively active vGPCR US28

Amarandi, R.-M., Luckmann, M., Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, K., Hjorto, G. M., Pui, A., Frimurer, T. M. & Rosenkilde, M. M., 15 Jul 2018, In: European Journal of Medicinal Chemistry. 155, p. 244-254

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1

Rexen Ulven, E., Trauelsen, M., Brvar, M., Lückmann, M., Bielefeldt, L. Ø., Jensen, L. K. I., Schwartz, T. W. & Frimurer, T. M., 1 Dec 2018, In: Scientific Reports. 8, 1, p. 1-18 10010.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

62 Downloads (Pure)

The HETE Is on FFAR1 and Pancreatic Islet Cells

Trauelsen, M., Lückmann, M., Frimurer, T. M. & Schwartz, T. W., 2018, In: Cell Metabolism. 27, 2, p. 273-275 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Translating biased signaling in the ghrelin receptor system into differential in vivo functions

Mende, F., Hundahl, C., Plouffe, B., Skov, L. J., Sivertsen, B., Madsen, A. N., Lückmann, M., Diep, T. A., Offermanns, S., Frimurer, T. M., Bouvier, M. & Holst, B., 23 Oct 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. E10255-E10264 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

2017

Biased agonism and allosteric modulation of GPR183- a 7TM receptor also known as EBV-induced EBI2

Daugvilaite, V., Madsen, C. M., Lückmann, M., Castello Echeverria, C., Sailer, A. W., Frimurer, T. M., Rosenkilde, M. M. & Benned-Jensen, T., 2017, In: British Journal of Pharmacology. 174, 13, p. 2031–2042

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

Structure-based discovery of novel US28 small molecule ligands with different modes of action

Lückmann, M., Amarandi, R.-M., Papargyri, N., Jakobsen, M. H., Christiansen, E., Jensen, L. J., Pui, A., Schwartz, T. W., Rosenkilde, M. M. & Frimurer, T. M., 1 Mar 2017, In: Chemical Biology & Drug Design. 89, 3, p. 289–296

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

2016

In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist

Lückmann, M., Holst, B., Schwartz, T. W. & Frimurer, T. M., 1 Jan 2016, In: Molecular Informatics. 35, p. 19-24 6 p.

Research output: Contribution to journal › Letter › peer-review

5 Citations (Scopus)

Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

Barington, L., Rummel, P. C., Lückmann, M., Pihl, H., Larsen, O., Daugvilaite, V., Johnsen, A. H., Frimurer, T. M., Karlshøj, S. & Rosenkilde, M. M., 29 Jul 2016, In: The Journal of Biological Chemistry. 291, 31, p. 16208-16220

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

2015

GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

Pedersen, M. H., Bentsen, M. A., Husted, A. S., Ekberg, J. P., Wright, M. J., Di Salvo, J., Weinglass, A. B., Engelstoft, M. S., Madsen, A. N., Lückmann, M., Miller, M. W., Trujillo, M. E., Frimurer, T. M., Holst, B., Howard, A. D. & Schwartz, T. W., 1 Jan 2015, In: Molecular Metabolism. 4, 1, p. 3-14 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

124 Citations (Scopus)

Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists

Sasmal, P. K., Krishna, C. V., Sudheerkumar Adabala, S., Rawoof, K. A., Thadi, A., Sukumar, K. P., Cheera, S., Abbineni, C., Rao, K. V. L. N., Prasanthi, A., Nijhawan, K., Jaleel, M., Ramachandran Iyer, L., Chaitanya, T. K., Tiwari, N. K., Krishna, N. L., Potluri, V., Khanna, I., Frimurer, T. M. & Lückmann, M. & 3 others, Rist, Ø., Elster, L. & Högberg, T., 15 Feb 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 4, p. 887-92 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Michael Lückmann

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