Michael Lückmann

Publikation

Publikationer pr. år 2015 2015 2016 2017 2018 2019 2019

• 11 Tidsskriftartikel
• 1 Letter

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2019

  Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

  Jorgensen, A. S., Larsen, O., Uetz-von Allmen, E., Lückmann, M., Legler, D. F., Frimurer, T. M., Veldkamp, C. T., Hjortø, G. M. & Rosenkilde, M. M., 13 sep. 2019, I: Frontiers in Immunology. 10, 14 s., 2156.

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  • Chemokines 100%
  • Ligands 75%
  • Chemokine Receptors 71%
  • beta-Arrestin 1 69%
  • Mutagenesis 62%
  5 Citationer (Scopus)

  15 Downloads (Pure)

• Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1

  Lückmann, M., Trauelsen, M., Bentsen, M. A., Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, M. M., Papaleo, E., Lindorff-Larsen, K., Schwartz, T. W. & Frimurer, T. M., 2 apr. 2019, I: Proceedings of the National Academy of Sciences of the United States of America. 116, 14, s. 7123-7128

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  • Molecular Dynamics Simulation 100%
  • Lipid IV 83%
  • Carboxylic Acids 57%
  • Drug Discovery 46%
  • Fatty Acids 38%
  15 Citationer (Scopus)

  12 Downloads (Pure)
• 2018

  Ligand-selective small molecule modulators of the constitutively active vGPCR US28

  Amarandi, R-M., Luckmann, M., Melynis, M., Jakobsen, M. H., Fallah, Z., Spiess, K., Hjorto, G. M., Pui, A., Frimurer, T. M. & Rosenkilde, M. M., 15 jul. 2018, I: European Journal of Medicinal Chemistry. 155, s. 244-254

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  • Endocytosis 100%
  • Cytomegalovirus 98%
  • Anti HCMV 86%
  • CX3C Chemokine Receptor 1 82%
  • Arrestin 71%
  3 Citationer (Scopus)

• Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1

  Rexen Ulven, E., Trauelsen, M., Brvar, M., Lückmann, M., Bielefeldt, L. Ø., Jensen, L. K. I., Schwartz, T. W. & Frimurer, T. M., 1 dec. 2018, I: Scientific Reports. 8, 1, s. 1-18 10010.

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  • Succinic Acid 100%
  • Physiological Stress 24%
  • Solubility 20%
  • Retina 17%
  • Adipose Tissue 17%
  7 Citationer (Scopus)

  62 Downloads (Pure)

• The HETE Is on FFAR1 and Pancreatic Islet Cells

  Trauelsen, M., Lückmann, M., Frimurer, T. M. & Schwartz, T. W., 2018, I: Cell Metabolism. 27, 2, s. 273-275 3 s.

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  • Hydroxyeicosatetraenoic Acids 100%
  • Islets of Langerhans 67%
  • Insulin Secretion 67%
  • 20-hydroxy-5,8,11,14-eicosatetraenoic acid 53%
  • Glucose 42%
  6 Citationer (Scopus)

• Translating biased signaling in the ghrelin receptor system into differential in vivo functions

  Bidragets oversatte titel: Translating biased signaling in the ghrelin receptor system into differential in vivo functionsMende, F., Hundahl, C., Plouffe, B., Skov, L. J., Sivertsen, B., Madsen, A. N., Lückmann, M., Diep, T. A., Offermanns, S., Frimurer, T. M., Bouvier, M. & Holst, B., 23 okt. 2018, I: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, s. E10255-E10264 10 s.

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  • Ghrelin Receptor 100%
  • YIL 781 78%
  • Arrestin 50%
  • Ligands 49%
  • GTP-Binding Proteins 34%
  17 Citationer (Scopus)
• 2017

  Biased agonism and allosteric modulation of GPR183- a 7TM receptor also known as EBV-induced EBI2

  Daugvilaite, V., Madsen, C. M., Lückmann, M., Castello Echeverria, C., Sailer, A. W., Frimurer, T. M., Rosenkilde, M. M. & Benned-Jensen, T., 2017, I: British Journal of Pharmacology. 174, 13, s. 2031–2042

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  • 7,25-dihydroxycholesterol 100%
  • Human Herpesvirus 4 57%
  • Sodium 47%
  • Oxysterols 41%
  • GTP-Binding Proteins 28%
  6 Citationer (Scopus)

• Structure-based discovery of novel US28 small molecule ligands with different modes of action

  Lückmann, M., Amarandi, R-M., Papargyri, N., Jakobsen, M. H., Christiansen, E., Jensen, L. J., Pui, A., Schwartz, T. W., Rosenkilde, M. M. & Frimurer, T. M., 1 mar. 2017, I: Chemical Biology & Drug Design. 89, 3, s. 289–296

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  • Inverse Agonist 100%
  • VUF 2274 91%
  • Agonist 67%
  • Ligands 49%
  • G-Protein-Coupled Receptors 35%
  4 Citationer (Scopus)
• 2016

  In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist

  Lückmann, M., Holst, B., Schwartz, T. W. & Frimurer, T. M., 1 jan. 2016, I: Molecular Informatics. 35, s. 19-24 6 s.

  Publikation: Bidrag til tidsskrift › Letter › peer review

  • Neurotensin 100%
  • neurotensin type 1 receptor 76%
  • Binding sites 61%
  • Peptides 57%
  • Ligands 49%
  5 Citationer (Scopus)

• Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

  Barington, L., Rummel, P. C., Lückmann, M., Pihl, H., Larsen, O., Daugvilaite, V., Johnsen, A. H., Frimurer, T. M., Karlshøj, S. & Rosenkilde, M. M., 29 jul. 2016, I: The Journal of Biological Chemistry. 291, 31, s. 16208-16220

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  • Chemokine Receptors 100%
  • Disulfides 94%
  • Chemokines 83%
  • Disulfide 73%
  • Chemokine CCL1 41%
  8 Citationer (Scopus)
• 2015

  GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

  Pedersen, M. H., Bentsen, M. A., Husted, A. S., Ekberg, J. P., Wright, M. J., Di Salvo, J., Weinglass, A. B., Engelstoft, M. S., Madsen, A. N., Lückmann, M., Miller, M. W., Trujillo, M. E., Frimurer, T. M., Holst, B., Howard, A. D. & Schwartz, T. W., 1 jan. 2015, I: Molecular Metabolism. 4, 1, s. 3-14 12 s.

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  • TAK-875 100%
  • Incretins 89%
  • Secretagogues 84%
  • 3-cyclopropyl-3-(3-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-(1,1'-biphenyl)-4-yl)methoxy)phenyl)propanoic acid 79%
  • Glucagon-Like Peptide 1 60%
  124 Citationer (Scopus)

• Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists

  Sasmal, P. K., Krishna, C. V., Sudheerkumar Adabala, S., Rawoof, K. A., Thadi, A., Sukumar, K. P., Cheera, S., Abbineni, C., Rao, K. V. L. N., Prasanthi, A., Nijhawan, K., Jaleel, M., Ramachandran Iyer, L., Chaitanya, T. K., Tiwari, N. K., Krishna, N. L., Potluri, V., Khanna, I., Frimurer, T. M., Lückmann, M., & 3 flereRist, Ø., Elster, L. & Högberg, T., 15 feb. 2015, I: Bioorganic & Medicinal Chemistry Letters. 25, 4, s. 887-92 6 s.

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  • 2-aminobenzimidazole 100%
  • 2-Aminobenzimidazole 73%
  • kappa Opioid Receptor 63%
  • Agent Interacting With Transmitter, Hormone or Drug Receptor 55%
  • Computer Simulation 46%
  7 Citationer (Scopus)