Publikationer pr. år
Publikationer pr. år
Personlig profil
Kort præsentation
In my PhD thesis work I studied different aspects of hypoxia and the transcription factor HIF-1 in hematopoietic stem cell (HSC) biology. My work led to findings that support a role for hypoxic regulation of HSCs via VEGFA-induction and Cripto/GRP78 signaling. After joining the lab of Bo porse, I have been working on projects characterizing the role of the transcription factor Erg and alternative splicing in hematopoiesis.
CV
Education
2006–2011
PhD in Stem Cell Biology. Lund University, Sweden.
2001–2005
MSc in Medical Science. Biomedicine program, Lund University, Sweden.
Career
Oct 2011–present
Postdoc, laboratory of Bo Porse, Biotech Research and Innovation Centre (BRIC) and the Finsen Laboratory, Copenhagen, Denmark.
Feb 2006–Sept 2011
PhD student, Lund Stem Cell Center, Lund University, Sweden. Supervisor: Jörg Cammenga.
Title of thesis: The Hypoxic Hematopoietic Stem Cell Niche–Consequences of Hypoxia-induced Transcription on Stem Cell Fate.
Sept 2004–June 2005
Master student, Division of Molecular Medicine and Gene therapy, laboratory of Stefan Karlsson, Lund University.
Title of thesis: Generation of lentiviral vectors expressing siRNA against p21 and Pre-B-cell leukemia factor 1 for expansion of hematopoeitic stem cells.
Primære forskningsområder
- Hematopoiesis
- Hematopoietic stem cells
- Alternative splicing
Fingeraftryk
Dyk ned i forskningsemnerne, hvor Matilda Carolina Rehn er aktive. Disse emneetiketter kommer fra dennes persons arbejder. Sammen danner de et unikt fingerprint.
- 6 Lignende profiler
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ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
Søndergaard, E., Rauch, A., Michaut, M., Rapin, N., Rehn, M., Wilhelmson, A. S., Camponeschi, A., Hasemann, M. S., Bagger, F. O., Jendholm, J., Knudsen, K. J., Mandrup, S., Mårtensson, I. L. & Porse, B. T., 26 nov. 2019, I: Cell Reports. 29, 9, s. 2756-2769.e6 21 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment
Lauridsen, F. KB., Jensen, T. L., Rapin, N., Aslan, D., Wilhelmson, A. S., Pundhir, S., Rehn, M., Paul, F., Giladi, A., Hasemann, M. S., Serup, P., Amit, I. & Porse, B. T., 17 jul. 2018, I: Cell Reports. 24, 3, s. 766-780 15 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation
Knudsen, K. J., Rehn, M. C., Hasemann, M. S., Rapin, N. P. J-P., Bagger, F. O., Ohlsson, E. K., Willer, A., Frank, A-K., Søndergaard, E., Jendholm, L. J., Thorén, L. A. M., Lee, J., Rak, J., Theilgaard-Mønch, K. & Porse, B. T., 15 sep. 2015, I: Genes & Development. 29, s. 1915-1929 15 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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HIF-1α can act as a tumor suppressor gene in murine acute myeloid leukemia
Velasco-Hernandez, T., Hyrenius-Wittsten, A., Rehn, M., Bryder, D. & Cammenga, J., 4 dec. 2014, I: Blood. 124, 24, s. 3597-607 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Hypoxic induction of vascular endothelial growth factor regulates erythropoiesis but not hematopoietic stem cell function in the fetal liver
Rehn, M., Kertész, Z. & Cammenga, J., 1 nov. 2014, I: Experimental Hematology. 42, 11, s. 941-4.e1Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF-1α in the hypoxic bone marrow niche
Miharada, K., Karlsson, G., Rehn, M., Rörby, E., Siva, K., Cammenga, J. & Karlsson, S., aug. 2012, I: Annals of the New York Academy of Sciences. 1266, s. 55-62 8 s.Publikation: Bidrag til tidsskrift › Review › peer review
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(H)if blood stem cells gO2 sleep: what can wake them up?
Rehn, M. & Cammenga, J., 31 okt. 2011, I: Cell Cycle. 10, 20, s. 3419-20 2 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Formidling
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Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78
Miharada, K., Karlsson, G., Rehn, M., Rörby, E., Siva, K., Cammenga, J. & Karlsson, S., 4 okt. 2011, I: Cell Stem Cell. 9, 4, s. 330-44 15 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review