Lykke Sylow

2019

Current advances in our understanding of exercise as medicine in metabolic disease

Sylow, L. & Richter, E., 2019, In: Current Opinion in Physiology. 12, p. 12-19 8 p.

Research output: Contribution to journal › Review › peer-review

17 Citations (Scopus)

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

Henríquez-Olguin, C., Knudsen, J. R., Raun, S. H., Li, Z., Dalbram, E., Treebak, J. T., Sylow, L., Holmdahl, R., Richter, E., Jaimovich, E. & Jensen, T. E., 1 Dec 2019, In: Nature Communications. 10, 11 p., 4623.

Research output: Contribution to journal › Journal article › Research › peer-review

50 Citations (Scopus)

16 Downloads (Pure)

Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle

Han, X., Møller, L. L. V., De Groote, E., Bojsen-Møller, K. N., Davey, J., Henríquez-Olguin, C., Li, Z., Knudsen, J. R., Jensen, T. E., Madsbad, S., Gregorevic, P., Richter, E. & Sylow, L., 1 Dec 2019, In: Journal of Cachexia, Sarcopenia and Muscle.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry

Nelson, M. E., Parker, B. L., Burchfield, J. G., Hoffman, N. J., Needham, E. J., Cooke, K. C., Naim, T., Sylow, L., Ling, N. X. Y., Francis, D., Norris, D. M., Chaudhuri, R., Oakhill, J. S., Richter, E., Lynch, G. S., Stöckli, J. & James, D. E., 16 Dec 2019, In: E M B O Journal. e102578.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Rho GTPases-emerging regulators of glucose homeostasis and metabolic health

Møller, L. L. V., Klip, A. & Sylow, L., May 2019, In: Cells. 8, 5, 21 p., 434.

Research output: Contribution to journal › Review › peer-review

40 Downloads (Pure)

2018

Differential effects of high-fat diet and exercise training on bone and energy metabolism

Picke, A.-K., Sylow, L., Møller, L. L. V., Kjøbsted, R., Schmidt, F. N., Steejn, M. W., Salbach-Hirsch, J., Hofbauer, C., Blüher, M., Saalbach, A., Busse, B., Rauner, M. & Hofbauer, L. C., Nov 2018, In: Bone. 116, p. 120-134 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training

Kleinert, M., Parker, B. L., Jensen, T. E., Raun, S. H., Pham, P., Han, X., James, D. E., Richter, E. & Sylow, L., 1 Dec 2018, In: Scientific Reports. 8, 11 p., 10723.

Research output: Contribution to journal › Journal article › Research › peer-review

16 Citations (Scopus)

84 Downloads (Pure)

Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt

Raun, S. H., Ali, M. S., Kjøbsted, R., Møller, L. L. V., Federspiel, M. A., Richter, E., Jensen, T. E. & Sylow, L., 15 Jun 2018, In: Journal of Physiology. 596, 12, p. 2283-2299 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

β-actin shows limited mobility and is only required for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle

Madsen, A. L. B., Knudsen, J. R., Henriquez-Olguin, C., Angin, Y., Zaal, K. J., Sylow, L., Schjerling, P., Ralston, E. & Jensen, T. E., Jul 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 1, p. E110-E125 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

2017

Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects

Gliemann, L., Rytter, N., Lindskrog, M., Slingsby, M. H. L., Åkerström, T., Sylow, L., Richter, E. & Hellsten, Y., 15 Aug 2017, In: Journal of Physiology. 595, 16, p. 5557-5571 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Exercise increases human skeletal muscle insulin sensitivity via coordinated increases in microvascular perfusion and molecular signaling

Sjøberg, K. A., Frøsig, C., Kjøbsted, R., Sylow, L., Kleinert, M., Betik, A. C., Shaw, C. S., Kiens, B., Wojtaszewski, J., Rattigan, S., Richter, E. & McConell, G. K., 1 Jun 2017, In: Diabetes. 66, 6, p. 1501-1510 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

78 Citations (Scopus)

Exercise-stimulated glucose uptake - regulation and implications for glycaemic control

Sylow, L., Kleinert, M., Richter, E. & Jensen, T. E., 1 Mar 2017, In: Nature Reviews Endocrinology. 13, 3, p. 133-148 16 p.

Research output: Contribution to journal › Review › peer-review

149 Citations (Scopus)

Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

Kleinert, M., Parker, B. L., Fritzen, A. M., Knudsen, J. R., Jensen, T. E., Kjøbsted, R., Sylow, L., Ruegg, M. A., James, D. E. & Richter, E., 15 Jul 2017, In: Journal of Physiology. 595, 14, p. 4845-4855 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Rac1 and AMPK account for the majority of muscle glucose uptake stimulated by ex vivo contraction but not in vivo exercise

Sylow, L., Møller, L. L. V., Kleinert, M., D'Hulst, G., De Groote, E., Schjerling, P., Steinberg, G. R., Jensen, T. E. & Richter, E., 1 Jun 2017, In: Diabetes. 66, 6, p. 1548-1559 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2016

Decreased spontaneous activity in AMPK alpha 2 muscle specific kinase dead mice is not caused by changes in brain dopamine metabolism

Møller, L. L. V., Sylow, L., Gøtzsche, C. R., Serup, A. K. L., Christiansen, S. H., Weikop, P., Kiens, B., Woldbye, D. P. D. & Richter, E., 1 Oct 2016, In: Physiology & Behavior. 164, Part A, p. 300-305 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

Kleinert, M., Parker, B. L., Chaudhuri, R., Fazakerley, D. J., Serup, A. K. L., Thomas, K. C., Krycer, J. R., Sylow, L., Fritzen, A. M., Hoffman, N. J., Jeppesen, J. F., Schjerling, P., Ruegg, M. A., Kiens, B., James, D. E. & Richter, E., 1 Aug 2016, In: Molecular Metabolism. 5, 8, p. 646-655 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

208 Downloads (Pure)

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

Sylow, L., Laurent, I., Kleinert, M., Møller, L. L. V., Ploug, T., Schjerling, P., Bilan, P. J., Klip, A., Jensen, T. E. & Richter, E., 1 Sept 2016, In: Journal of Physiology. 594, 17, p. 4997-5008 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

52 Citations (Scopus)

Rac1 in muscle is dispensable for improved insulin action after exercise in mice

Sylow, L., Møller, L. L. V., D'Hulst, G., Schjerling, P., Jensen, T. E. & Richter, E., Aug 2016, In: Endocrinology. 157, 8, p. 3009-3015 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

The cancer drug Dasatinib increases PGC-1α in adipose tissue but has adverse effects on glucose tolerance in obese mice

Sylow, L., Long, J., Lokurkar, I. A., Zeng, X., Richter, E. & Spiegelman, B. M., Nov 2016, In: Endocrinology. 157, 11, p. 4184-4191 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells

Sylow, L., 1 Sept 2016, In: Laboratory Investigation. 96, 9, p. 1026 1 p.

Research output: Contribution to journal › Comment/debate › Research

1 Citation (Scopus)

2015

Acute systemic insulin intolerance does not alter the response of the Akt/GSK-3 pathway to environmental hypoxia in human skeletal muscle

D'Hulst, G., Sylow, L., Hespel, P. & Deldicque, L., 1 Jun 2015, In: European Journal of Applied Physiology. 115, 6, p. 1219-1231 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

Jensen, T. E., Ross, F. A., Kleinert, M., Sylow, L., Knudsen, J. R., Gowans, G. J., Hardie, D. G. & Richter, E., 1 May 2015, In: Biochemical Journal. 467, 3, p. 461-472 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

Reply from Lykke Sylow, Lisbeth L. V. Møller, Maximilian Kleinert, Erik A. Richter and Thomas E. Jensen

Sylow, L., Møller, L. L. V., Kleinert, M., Richter, E. & Jensen, T. E., 1 May 2015, In: Journal of Physiology. 593, 9, p. 2239-2240 2 p.

Research output: Contribution to journal › Comment/debate › Research

Stretch-stimulated glucose transport in skeletal muscle is regulated by Rac1

Sylow, L., Møller, L. L. V., Kleinert, M., Richter, E. & Jensen, T. E., 1 Feb 2015, In: Journal of Physiology. 593, 3, p. 645-656 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

2014

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

Kleinert, M., Sylow, L., Fazakerley, D. J., Krycer, J. R., Thomas, K. C., Oxbøll, A.-J., Jordy, A. B., Jensen, T. E., Yang, G., Schjerling, P., Kiens, B., James, D. E., Ruegg, M. A. & Richter, E., Sept 2014, In: Molecular Metabolism. 3, 6, p. 630-641 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

Akt and Rac1 signalling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

Sylow, L., Kleinert, M., Pehmøller, C., Prats Gavalda, C., Chiu, T. T., Klip, A., Richter, E. & Jensen, T. E., 2014, In: Cellular Signalling. 26, 2, p. 323-331 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

85 Citations (Scopus)

Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca²⁺ release

Jensen, T. E., Sylow, L., Rose, A. J., Madsen, A. L. B., Angin, Y., Maarbjerg, S. J. & Richter, E., 1 Oct 2014, In: Molecular Metabolism. 3, 7, p. 742-753 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

44 Citations (Scopus)

Is contraction-stimulated glucose transport feedforward regulated by Ca²⁺?

Jensen, T. E., Angin, Y., Sylow, L. & Richter, E., 1 Dec 2014, In: Experimental Physiology. 99, 12, p. 1562-1568 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Rac1- a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

Sylow, L., Møller, L. L. V., Kleinert, M., Richter, E. & Jensen, T. E., 1 Dec 2014, In: Experimental Physiology. 99, 12, p. 1574-1580 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

2013

Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

Beck Jørgensen, S., O'Neill, H. M., Sylow, L., Honeyman, J., Hewitt, K. A., Palanivel, R., Fullerton, M. D., Öberg, L., Balendran, A., Galic, S., van der Poel, C., Trounce, I. A., Lynch, G. S., Schertzer, J. D. & Steinberg, G. R., Jan 2013, In: Diabetes. 62, 1, p. 56-64 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

95 Citations (Scopus)

Involvement of Rac1 and the actin cytoskeleton in insulin- and contraction-stimulated intracellular signaling and glucose uptake in mature skeletal muscle

Sylow, L., 2013, Department of Nutrition, Exercise and Sports, Faculty of Sciences, University of Copenhagen.

Research output: Book/Report › Ph.D. thesis

LKB1 regulates lipid oxidation during exercise independently of AMPK

Jeppesen, J. F., Maarbjerg, S. J., Jordy, A. B., Fritzen, A. M., Pehmøller, C., Sylow, L., Serup, A. K. L., Jessen, N., Thorsen, K., Prats Gavalda, C., Qvortrup, K., Dyck, J. R. B., Hunter, R. W., Sakamoto, K., Thomson, D. M., Schjerling, P., Wojtaszewski, J., Richter, E. & Kiens, B., May 2013, In: Diabetes. 62, 5, p. 1490-1499 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

Sylow, L., Jensen, T. E., Kleinert, M., Mouatt, J. R., Maarbjerg, S. J., Jeppesen, J. F., Prats Gavalda, C., Chiu, T. T., Boguslavsky, S., Klip, A., Schjerling, P. & Richter, E., Apr 2013, In: Diabetes. 62, 4, p. 1139-1151 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

95 Citations (Scopus)

Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle

Sylow, L., Jensen, T. E., Kleinert, M., Højlund, K., Kiens, B., Wojtaszewski, J., Prats Gavalda, C., Schjerling, P. & Richter, E., Jun 2013, In: Diabetes. 62, 6, p. 1865-1875 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

114 Citations (Scopus)

2012

Overexpression of monocarboxylate transporter-1 (Slc16a1) in mouse pancreatic ß-cells leads to relative hyperinsulinism during exercise

Pullen, T. J., Sylow, L., Sun, G., Halestrap, A. P., Richter, E. & Rutter, G. A., Jul 2012, In: Diabetes. 61, 7, p. 1719-1725 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

2011

Current understanding of increased insulin sensitivity after exercise - emerging candidates

Maarbjerg, S. J., Sylow, L. & Richter, E., Jul 2011, In: Acta Physiologica. 202, 3, p. 323-335 13 p.

Research output: Contribution to journal › Review › peer-review

72 Citations (Scopus)

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Chiu, T. T., Jensen, T. E., Sylow, L., Richter, E. & Klip, A., Oct 2011, In: Cellular Signalling. 23, 10, p. 1546-1554 9 p.

Research output: Contribution to journal › Review › peer-review

97 Citations (Scopus)

Lykke Sylow

Research output

Search results