Kristina Bennet Emdal

2020

Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues

Emdal, K. B. & Lundby, A., 2 Jan 2020, In: Molecular & Cellular Oncology. 3 p., e1692643.

Research output: Contribution to journal › Comment/debate › Research › peer-review

2019

Dynamic lineage priming is driven via direct enhancer regulation by ERK

Hamilton, W. B., Mosesson, Y., Monteiro, R. S., Emdal, K. B., Knudsen, T. E., Francavilla, C., Barkai, N., Olsen, J. V. & Brickman, J. M., 14 Nov 2019, In: Nature. 575, p. 355-360

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

Lundby, A., Franciosa, G., Emdal, K. B., Refsgaard, J. C., Gnosa, S. P., Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, M., Montoya, G., Jensen, L. J. & Olsen, J. V., 3 Oct 2019, In: Cell. 179, 2, p. 543-560

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

2018

Identifying and targeting sporadic oncogenic genetic aberrations in mouse models of triple-negative breast cancer

Liu, H., Murphy, C. J., Karreth, F. A., Emdal, K. B., Yang, K., White, F. M., Elemento, O., Toker, A., Wulf, G. M. & Cantley, L. C., 2018, In: Cancer Discovery. 8, 3, p. 354-369 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Randall, E. C., Emdal, K. B., Laramy, J. K., Kim, M., Roos, A., Calligaris, D., Regan, M. S., Gupta, S. K., Mladek, A. C., Carlson, B. L., Johnson, A. J., Lu, F-K., Xie, X. S., Joughin, B. A., Reddy, R. J., Peng, S., Abdelmoula, W. M., Jackson, P. R., Kolluri, A., Kellersberger, K. A., & 8 othersAgar, J. N., Lauffenburger, D. A., Swanson, K. R., Tran, N. L., Elmquist, W. F., White, F. M., Sarkaria, J. N. & Agar, N. Y. R., 1 Dec 2018, In: Nature Communications. 9, 1, p. 4904

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

Emdal, K. B., Pedersen, A-K., Bekker-Jensen, D. B., Lundby, A., Claeys, S., De Preter, K., Speleman, F., Francavilla, C. & Olsen, J. V., 20 Nov 2018, In: Science Signaling. 11, 557, p. 1-17 17 p., eaap9752.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

2017

Characterization of in vivo resistance to osimertinib and JNJ-61186372, an EGFR/Met bispecific antibody, reveals unique and consensus mechanisms of resistance

Emdal, K. B., Dittmann, A., Reddy, R. J., Lescarbeau, R. S., Moores, S. L., Laquerre, S. & White, F. M., 1 Nov 2017, In: Molecular Cancer Therapeutics. 16, 11, p. 2572-2585 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Combinatorial Drug Screening Identifies Ewing Sarcoma–specific Sensitivities

Radic-Sarikas, B., Tsafou, K. P., Emdal, K. B., Papamarkou, T., Huber, K. V. M., Mutz, C., Toretsky, J. A., Bennett, K. L., Olsen, J. V., Brunak, S., Kovar, H. & Superti-Furga, G., 1 Jan 2017, In: Molecular Cancer Therapeutics. 16, 1, p. 88-101 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

2015

Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation

Emdal, K. B., Pedersen, A-K., Bekker-Jensen, D. B., Tsafou, K. P., Horn, H., Lindner, S., Schulte, J. H., Eggert, A., Jensen, L. J., Francavilla, C. & Olsen, J. V., 28 Apr 2015, In: Science Signaling. 8, 374, ra40.

Research output: Contribution to journal › Journal article › Research › peer-review

45 Citations (Scopus)

2013

Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs

Francavilla, C., Rigbolt, K. T. G., Emdal, K. B., Carraro, G., Vernet, E., Bekker-Jensen, D. B., Streicher, W., Wikström, M., Sundström, M., Bellusci, S., Cavallaro, U., Blagoev, B. & Olsen, J. V., 26 Sept 2013, In: Molecular Cell. 51, 6, p. 707-22 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

82 Citations (Scopus)

2012

NF_kB signaling is important for growth of antiestrogen resistant breast cancer cells

Yde, C. W., Emdal, K. B., Guerra, B. & Lykkesfeldt, A. E., Aug 2012, In: Breast Cancer Research and Treatment. 135, 1, p. 67-78 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

2010

Breast cancer cells can switch between estrogen receptor alpha and ErbB signaling and combined treatment against both signaling pathways postpones development of resistance

Sonne-Hansen, K., Norrie, I. C., Emdal, K. B., Benjaminsen, R. V., Frogne, T., Christiansen, I. J., Kirkegaard, T. & Lykkesfeldt, A. E., Jun 2010, In: Breast Cancer Research and Treatment. 121, 3, p. 601-13 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Kristina Bennet Emdal

Research output

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