Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues

Kristina B. Emdal; Alicia Lundby

doi:10.1080/23723556.2019.1692643

Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues

Molecular Cardiology and Membrane Proteins

Abstract

We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.

Original language	English
Article number	e1692643
Journal	Molecular & Cellular Oncology
Number of pages	3
ISSN	2372-3556
DOIs	https://doi.org/10.1080/23723556.2019.1692643
Publication status	Published - 2 Jan 2020

Keywords

Proteomics
tyrosine kinase signaling
interaction proteomics
oncogenic signaling rewiring

Access to Document

10.1080/23723556.2019.1692643Licence: CC BY-NC-ND

OA-Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proOA-ximity of tyrosine residues-1Final published version, 2.37 MBLicence: CC BY-NC-ND

Cite this

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title = "Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues",

abstract = "We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.",

keywords = "Proteomics, tyrosine kinase signaling, interaction proteomics, oncogenic signaling rewiring",

author = "Emdal, {Kristina B.} and Alicia Lundby",

year = "2020",

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T1 - Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues

AU - Emdal, Kristina B.

AU - Lundby, Alicia

PY - 2020/1/2

Y1 - 2020/1/2

N2 - We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.

AB - We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.

KW - Proteomics

KW - tyrosine kinase signaling

KW - interaction proteomics

KW - oncogenic signaling rewiring

U2 - 10.1080/23723556.2019.1692643

DO - 10.1080/23723556.2019.1692643

M3 - Comment/debate

C2 - 31993501

SN - 2372-3556

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

M1 - e1692643

ER -