Kristian Strømgaard

Research output

Research output per year 1999 2009 2010 2011 2012 2013 2014 2015 2016 2017 2019

• 123 Journal article
• 4 Book chapter
• 3 Conference abstract in journal
• 3 Patent
• 7 More
  • 2 Poster
  • 2 Review
  • 1 Book
  • 1 Article in proceedings
  • 1 Letter

Research output per year

Research output per year

Search results

• 2019

  Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities

  Petersen, J., Strømgaard, K., Frølund, B. & Clemmensen, C., 1 Jul 2019, In: Drugs. 79, 11, p. 1187-1197 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Metabolic Diseases 100%
  • Glucagon-Like Peptide 1 55%
  • Pharmacological Phenomena 37%
  • Pharmaceutical Chemistry 32%
  • Drug Therapy 28%
  5 Citations (Scopus)

• Plant polyphenols inhibit functional amyloid and biofilm formation in Pseudomonas strains by directing monomers to off-pathway oligomers

  Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Sønderby, T. V., Shojaosadati, S. A., Morshedi, D., Strømgaard, K., Meisl, G., Sutherland, D., Pedersen, J. S. & Otzen, D. E., 2019, In: Biomolecules. 9, 11, 21 p., 659.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • (-)-Epigallocatechin 100%
  • Biofilm Formation 93%
  • Pseudomonas 82%
  • Polyphenols 81%
  • Polyphenol 76%
  8 Citations (Scopus)

  2 Downloads (Pure)

• Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

  Malfacini, D., Patt, J., Annala, S., Harpsøe, K., Eryilmaz, F., Reher, R., Crüsemann, M., Hanke, W., Zhang, H., Tietze, D., Gloriam, D. E., Bräuner-Osborne, H., Strømgaard, K., König, G. M., Inoue, A., Gomeza, J. & Kostenis, E., 12 Apr 2019, In: The Journal of Biological Chemistry. 294, 15, p. 5747-5758

  Research output: Contribution to journal › Journal article › Research › peer-review

  • FR900359 100%
  • Heterotrimeric GTP-Binding Proteins 64%
  • Protein Subunits 54%
  • Protein 19%
  • Psychological Inhibition 19%
  10 Citations (Scopus)

  18 Downloads (Pure)

• Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

  Bach, A., Clausen, B. H., Kristensen, L. K., Andersen, M. G., Ellman, D. G., Hansen, P. B. L., Hasseldam, H., Heitz, M., Özcelik, D., Tuck, E. J., Kopanitsa, M. V., Grant, S. G. N., Lykke-Hartmann, K., Johansen, F. F., Lambertsen, K. L. & Strømgaard, K., 15 May 2019, In: Neuropharmacology. 150, p. 100-111 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Disks Large Homolog 4 Protein 100%
  • Tat-NR2B9c 56%
  • Guanylate Kinases 40%
  • aspartic acid receptor 32%
  • Stroke 27%
  10 Citations (Scopus)

• Structure–Activity Relationship Studies of the Natural Product G _q/11 Protein Inhibitor YM-254890

  Xiong, X. F., Zhang, H., Boesgaard, M. W., Underwood, C. R., Bräuner-Osborne, H. & Strømgaard, K., 17 Apr 2019, In: ChemMedChem. 14, 8, p. 865-870

  Research output: Contribution to journal › Journal article › Research › peer-review

  • YM-254890 100%
  • FR900359 53%
  • Biological Products 50%
  • Occurrence in Nature 42%
  • Depsipeptide 35%
  10 Citations (Scopus)
• 2018

  Controlling Ca2+ Permeable alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers

  Norager, N. G., Poulsen, M. H. & Stromgaard, K., 13 Sept 2018, In: Journal of Medicinal Chemistry. 61, 17, p. 8048-8053

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ionotropic Glutamate Receptors 100%
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 92%
  • AMPA Receptors 88%
  • Photochromism 77%
  • Ion Channels 73%
  7 Citations (Scopus)

• Peptide Modulation of Acid-Sensing Ion Channels

  Borg, C. B., Haugaard-Kedstrom, L. M., Lynagh, T., Stromgaard, K. & Pless, S. A., 2 Feb 2018, p. 130A-130A.

  Research output: Contribution to conference › Poster › Research

  83 Downloads (Pure)

• Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations

  Sereikaitė, V., Jensen, T. M. T., Bartling, C. R. O., Jemth, P., Pless, S. A. & Strømgaard, K., 18 Oct 2018, In: ChemBioChem. 19, 20, p. 2136-2145

  Research output: Contribution to journal › Review › peer-review

  • Hydrogen Bonding 100%
  • Amides 98%
  • Esters 84%
  • Mutation 70%
  • Hydrogen Bond 50%
  5 Citations (Scopus)

• Probing the Mint2 Protein-Protein Interaction Network Relevant to the Pathophysiology of Alzheimer's Disease

  Jensen, T. M. T., Albertsen, L., Bartling, C. R. O., Haugaard-kedström, L. M. & Strømgaard, K., 4 Jun 2018, In: ChemBioChem. 19, 11, p. 1119-1122 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Protein Interaction Maps 100%
  • Alzheimer Disease 62%
  • Presenilin-1 55%
  • Amyloid beta-Protein Precursor 46%
  • Protein 33%
  3 Citations (Scopus)

• Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms

  Bleem, A., Christiansen, G., Madsen, D. J., Maric, H., Strømgaard, K., Bryers, J. D., Daggett, V., Meyer, R. L. & Otzen, D. E., 2018, In: Journal of Molecular Biology. 430, 20, p. 3751-3763 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Protein Engineering 100%
  • Biofilms 71%
  • Amyloid 69%
  • Pseudomonas aeruginosa 68%
  • Extracellular Polymeric Substance Matrix 14%
  17 Citations (Scopus)

• Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359

  Zhang, H., Nielsen, A. L., Boesgaard, M. W., Harpsøe, K., Daly, N. L., Xiong, X., Underwood, C. R., Haugaard-kedström, L. M., Bräuner-osborne, H., Gloriam, D. E. & Strømgaard, K., 5 Aug 2018, In: European Journal of Medicinal Chemistry. 156, p. 847-860

  Research output: Contribution to journal › Journal article › Research › peer-review

  • FR900359 100%
  • YM-254890 92%
  • Depsipeptides 77%
  • Depsipeptide 65%
  • GTP-Binding Proteins 47%
  7 Citations (Scopus)
• 2017

  Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats: PSD-95 inhibition in experimental TBI

  Sommer, J. B., Bach, A., Rytter, H. M., Gynther, M., Bjerre, A-S., Gram, M. G., Marschner, L., Strømgaard, K., Mogensen, J. & Pickering, D. S., 2017, In: Neurochemical Research. 42, 12, p. 3401-3413 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell Death 100%
  • Traumatic Brain Injury 92%
  • Psychological Inhibition 76%
  • Dose 71%
  • Pharmacokinetics 70%
  5 Citations (Scopus)

• Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats

  Sommer, J. B., Bach, A., Malá, H., Strømgaard, K., Mogensen, J. & Pickering, D. S., Oct 2017, In: Pharmacology, Biochemistry and Behavior. 161, p. 62-67 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Brain Fornix 100%
  • Neuroprotective 84%
  • Traumatic Brain Injury 52%
  • Neuroprotective Agents 26%
  • Psychological Inhibition 21%
  2 Citations (Scopus)

• Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

  Maric, H. M., Hausrat, T. J., Neubert, F., Dalby, N. O., Doose, S., Sauer, M., Kneussel, M. & Strømgaard, K., 1 Feb 2017, In: Nature Chemical Biology. 13, p. 153-160 11 p., 2246.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • gephyrin 100%
  • Synaptic Transmission 57%
  • Peptides 39%
  • 3-aminobutyric acid 23%
  • Central Nervous System Agents 17%
  20 Citations (Scopus)

• In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury

  Sommer, J. B., Bach, A., Rytter, H. M., Strømgaard, K., Mogensen, J. & Pickering, D. S., 1 Jan 2017, In: European Journal of Neuroscience. 45, 2, p. 238-248 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dizocilpine Maleate 100%
  • Traumatic Brain Injury 81%
  • Cell Death 62%
  • N-Methylaspartate 59%
  • Stroke 56%
  8 Citations (Scopus)

• Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors

  Roszko, K. L., Bi, R., Gorvin, C. M., Bräuner-Osborne, H., Xiong, X-F., Inoue, A., Thakker, R. V., Strømgaard, K., Gardella, T. & Mannstadt, M., 9 Feb 2017, In: JCI insight. 2, 3, 15 p., e91079.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Familial Hypercalciuric Hypocalcemia 100%
  • Hypocalcemia 65%
  • YM-254890 53%
  • Calcium-Sensing Receptors 36%
  • Gain of Function Mutation 36%
  18 Citations (Scopus)

  59 Downloads (Pure)

• Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers

  Rannversson, H., Andersen, J., Bang-Andersen, B. & Strømgaard, K., 20 Oct 2017, In: ACS chemical biology. 12, 10, p. 2558-2562 5 p.

  Research output: Contribution to journal › Letter › peer-review

  • Escitalopram 100%
  • Paroxetine 86%
  • Citalopram 72%
  • Serotonin Plasma Membrane Transport Proteins 71%
  • Serotonin 63%
  11 Citations (Scopus)

• PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarization in cortical spreading depression

  Kucharz, K., Søndergaard Rasmussen, I., Bach, A., Strømgaard, K. & Lauritzen, M., 1 May 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 5, p. 1820-1828

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Tat-NPEG4(IETDV)2 100%
  • Disks Large Homolog 4 Protein 61%
  • Cortical Spreading Depression 60%
  • N-Methyl-D-Aspartate Receptors 41%
  • Somatosensory Cortex 9%
  16 Citations (Scopus)

• Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions

  Pedersen, S. W., Albertsen, L., Moran, G. E., Levesque, B., Pedersen, S. B., Bartels, L., Wapenaar, H., Ye, F., Zhang, M., Bowen, M. E. & Strømgaard, K., 15 Sept 2017, In: ACS chemical biology. 12, 9, p. 2313-2323 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Disks Large Homolog 4 Protein 100%
  • PDZ Domains 92%
  • Phosphorylation 45%
  • Protein 27%
  • Proteins 24%
  20 Citations (Scopus)

• Stoichiometry of Toxin Binding to Acid-Sensing Ion Channels

  Borg, C. B., Lynagh, T., Haugaard-Kedstrom, L. M., Stromgaard, K. & Pless, S. A., 3 Feb 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, p. 420A-420A

  Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

• Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein

  Zhang, H., Xiong, X., Boesgaard, M. W., Underwood, C. R., Bräuner-Osborne, H. & Strømgaard, K., 7 Jun 2017, In: ChemMedChem. 12, 11, p. 830-834 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • YM-254890 100%
  • Depsipeptides 83%
  • Gq-G11 GTP-Binding Protein alpha Subunits 80%
  • Depsipeptide 70%
  • Structure-Activity Relationship 60%
  16 Citations (Scopus)

• Targeting PSD-95 as a Novel Approach in the Treatment of Stroke

  Haugaard-Kedstrom, L. M., Fernandes, E. F. A. & Stromgaard, K., 2017, Neuroprotective Therapy for Stroke and Ischemic Disease . Springer, p. 157-184 28 p. (Springer Series in Translational Stroke Research).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
• 2016

  Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor

  Bach, A., Pedersen, T. B. & Strømgaard, K., 1 Mar 2016, In: MedChemComm. 7, 3, p. 531-536 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Click Chemistry 100%
  • Peptidomimetics 90%
  • PDZ Domains 86%
  • Triazoles 84%
  • Peptidomimetic 75%
  4 Citations (Scopus)

  73 Downloads (Pure)

• Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function

  Andreasen, J. T., Nasser, A., Caballero-Puntiverio, M., Sahlholt, M., Bach, A., Gynther, M., Strømgaard, K. & Pickering, D. S., 5 Jun 2016, In: European Journal of Pharmacology. 780, p. 166-73 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Disks Large Homolog 4 Protein 100%
  • UCCB01-125 99%
  • Freund's Adjuvant 63%
  • Hypersensitivity 54%
  • Cognition 52%
  3 Citations (Scopus)

• Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

  Rannversson, H., Andersen, J., Hall, L. S., Bang-Andersen, B., Park, M., Huber, T., Sakmar, T. P. & Strømgaard, K., 19 Apr 2016, In: Nature Communications. 7, p. 1-9 9 p., 11261.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • serotonin 100%
  • transporter 87%
  • Antidepressant Agent 84%
  • Serotonin Plasma Membrane Transport Proteins 76%
  • Serotonin 67%
  34 Citations (Scopus)

• Importance of a Conserved Lys/Arg Residue for Ligand/PDZ Domain Interactions as Examined by Protein Semisynthesis

  Pedersen, S. W., Moran, G. E., Sereikaité, V., Kedström, L. M. H. & Strømgaard, K., 17 Oct 2016, In: ChemBioChem. 17, 20, p. 1936-1944 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lys-Arg 100%
  • PDZ Domains 89%
  • Ligands 45%
  • Peptide 37%
  • Ligand 28%
  3 Citations (Scopus)

• Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands

  Andersen, J., Ladefoged, L. K., Kristensen, T. N. B., Munro, L., Grouleff, J., Stuhr-Hansen, N., Kristensen, A. S., Schiøtt, B. & Strømgaard, K., 19 Oct 2016, In: A C S Chemical Neuroscience. 7, 10, p. 1406-1417 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Serotonin Plasma Membrane Transport Proteins 100%
  • Dopamine Plasma Membrane Transport Proteins 98%
  • Serotonin 88%
  • Dopamine 75%
  • Binding Sites 61%
  13 Citations (Scopus)

• Ligand binding to the PDZ domains of postsynaptic density protein 95

  Toto, A., Pedersen, S. W., Karlsson, O. A., Moran, G. E., Andersson, E., Chi, C. N., Strømgaard, K., Gianni, S. & Jemth, P., 1 May 2016, In: Protein Engineering Design and Selection (Print). 29, 5, p. 169-75 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Disks Large Homolog 4 Protein 100%
  • PDZ Domains 92%
  • Ligands 88%
  • Proteins 60%
  • Protein 27%
  5 Citations (Scopus)

• Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling

  Cheng, J., Sahani, S., Hausrat, T. J., Yang, J-W., Ji, H., Schmarowski, N., Endle, H., Liu, X., Li, Y., Böttche, R., Radyushkin, K., Maric, H. M., Hoerder-Suabedissen, A., Molnár, Z., Prouvot, P-H., Trimbuch, T., Ninnemann, O., Huai, J., Fan, W., Visentin, B., & 7 othersSabbadini, R., Strømgaard, K., Stroh, A., Luhmann, H. J., Kneussel, M., Nitsch, R. & Vogt, J., 5 Oct 2016, In: Neuron. 92, 1, p. 126-142 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • radixin 100%
  • lysophosphatidic acid 88%
  • Axon Guidance 83%
  • Thalamus 65%
  • Phospholipids 59%
  32 Citations (Scopus)

• Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter

  Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, A. S., Bøgesø, K. P., Gether, U., Strømgaard, K., Bang-Andersen, B. & Loland, C. J., 1 Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Allosteric Site 100%
  • talopram 98%
  • Citalopram 88%
  • Serotonin Plasma Membrane Transport Proteins 87%
  • Structure-Activity Relationship 82%
  17 Citations (Scopus)

• Synthesis of symmetrical and non-symmetrical bivalent neurotransmitter ligands

  Stuhr-Hansen, N., Andersen, J., Thygesen, M. B. & Strømgaard, K., Mar 2016, In: ChemistrySelect. 1, 3, p. 407-413 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Neurotransmitter 100%
  • Serotonin 99%
  • Dopamine 42%
  • Ligand 39%
  • Indole Skeleton 37%
  1 Citation (Scopus)

• Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

  Xiong, X., Zhang, H., Underwood, C. R., Harpsøe, K., Gardella, T. J., Wöldike, M. F., Mannstadt, M., Gloriam, D. E., Bräuner-osborne, H. & Strømgaard, K., 1 Nov 2016, In: Nature Chemistry. 8, 11, p. 1035-1041 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteins 100%
  • Total Synthesis 95%
  • Occurrence in Nature 60%
  • Depsipeptide 49%
  • Protein 45%
  33 Citations (Scopus)
• 2015

  Binding of ArgTX-636 in the NMDA receptor ion channel

  Poulsen, M. H., Andersen, J., Christensen, R., Hansen, K. B., Traynelis, S. F., Strømgaard, K. & Kristensen, A. S., 16 Jan 2015, In: Journal of Molecular Biology. 427, 1, p. 176-89 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • argiotoxin-636 100%
  • aspartic acid receptor 56%
  • N-Methyl-D-Aspartate Receptors 46%
  • Ion Channels 46%
  • Ligand-Gated Ion Channels 9%
  11 Citations (Scopus)

• Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter

  Andersen, J., Ladefoged, L. K., Wang, D., Kristensen, T. N. B., Bang-Andersen, B., Kristensen, A. S., Schiøtt, B. & Strømgaard, K., 21 Sept 2015, In: A C S Chemical Neuroscience. 6, 11, p. 1892-900 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vortioxetine 100%
  • Antidepressant Agent 72%
  • Serotonin Plasma Membrane Transport Proteins 65%
  • Serotonin 58%
  • Antidepressive Agents 47%
  17 Citations (Scopus)

• Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

  Andersen, J., Ringsted, K. B., Bang-Andersen, B., Strømgaard, K. & Kristensen, A. S., 27 Oct 2015, In: Scientific Reports. 5, p. 1-12 12 p., 15650.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Norepinephrine Plasma Membrane Transport Proteins 100%
  • Dopamine Plasma Membrane Transport Proteins 85%
  • Binding Sites 53%
  • Illicit Drugs 38%
  • Amino Acid Sequence 16%
  20 Citations (Scopus)

• Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor

  Nissen, K. B., Andersen, J. J., Haugaard-Kedström, L. M., Bach, A. & Strømgaard, K., 12 Feb 2015, In: Journal of Medicinal Chemistry. 58, p. 1575-1580 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fatty Acid Derivative 100%
  • Post-Synaptic Density 92%
  • Fatty Acids 58%
  • Peptides 43%
  • Drug Target 39%
  7 Citations (Scopus)

• Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors

  Maric, H-M., Kasaragod, V. B., Kedström, L. M. H., Hausrat, T. J., Kneussel, M., Schindelin, H. & Strømgaard, K., 7 Jan 2015, In: Angewandte Chemie (International ed. in English). 54, 2, p. 490-4 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Neurotransmitter 100%
  • Dimers 90%
  • Peptides 78%
  • Brain 74%
  • Peptide 51%
  18 Citations (Scopus)

• Fatty acid derivatives of dimeric inhibitors of PSD-95

  Strømgaard, K., Bach, A. & Nissen, K. B., 4 Jun 2015, IPC No. A61K38/17 , Patent No. WO2015/078477A1, Priority date 1 Dec 2013, Priority No. DK/2013/70735

  Research output: Patent

• Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

  Wilbek, T. S., Skovgaard, T., Sorrell, F. J., Knapp, S., Berthelsen, J. & Strømgaard, K., 2 Jan 2015, In: ChemBioChem. 16, 1, p. 59-63 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Death-Associated Protein Kinases 100%
  • Ischemia 47%
  • Stroke 43%
  • Protein 26%
  11 Citations (Scopus)

• Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation

  Rannversson, H., Wilson, P., Kristensen, K. B., Sinning, S., Kristensen, A. S., Strømgaard, K. & Andersen, J., 5 Jun 2015, In: The Journal of Biological Chemistry. 290, 23, p. 14582-94 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Serotonin Plasma Membrane Transport Proteins 100%
  • Serotonin 88%
  • Mutation 27%
  • Binding Sites 15%
  • Binding Site 11%
  5 Citations (Scopus)

• Polyamine toxins from spiders and wasps: Polyamine toxins from spiders and wasps

  Xiong, X. & Strømgaard, K., 2015, Polyamines: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer, Japan, p. 201-214 14 p.

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  1 Citation (Scopus)

• Rigidified Clicked Dimeric Ligands for Studying the Dynamics of the PDZ1-2 Supramodule of PSD-95

  Eildal, J. N. N., Bach, A., Dogan, J., Ye, F., Zhang, M., Jemth, P. & Strømgaard, K., 2 Jan 2015, In: ChemBioChem. 16, p. 64–69 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ligands 100%
  • PDZ Domains 98%
  • Ligand 61%
  • Biological Role 58%
  • Protein 58%
  11 Citations (Scopus)

• Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family

  Nissen, K. B., Kedström, L. M. H., Wilbek, T. S., Nielsen, L. S., Åberg, E., Kristensen, A. S., Bach, A., Jemth, P. & Strømgaard, K., 6 Feb 2015, In: PLOS ONE. 10, 2, p. 1-17 17 p., e0117668.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Protein-protein Interaction 100%
  • Guanylate Kinases 96%
  • Ligands 84%
  • Inhibitor 80%
  • Affine transformation 71%
  10 Citations (Scopus)
• 2014

  Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites

  Sørensen, L., Strømgaard, K. & Kristensen, A. S., 18 Apr 2014, In: ACS chemical biology. 9, 4, p. 935-44 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Serotonin Plasma Membrane Transport Proteins 100%
  • Serotonin 88%
  • Phosphorylation 55%
  • Phosphotransferases 28%
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 18%
  17 Citations (Scopus)

• Evaluation of PhTX-74 as Subtype-Selective Inhibitor of GluA2-Containing AMPA Receptors

  Poulsen, M. H., Lucas, S., Strømgaard, K. & Kristensen, A. S., Feb 2014, In: Molecular Pharmacology. 85, 2, p. 261-268 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Isoxazoles 100%
  • propionic acid 92%
  • AMPA Receptors 82%
  • Inhibitory Concentration 50 27%
  • Polyamines 23%
  12 Citations (Scopus)

• Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids

  Stuhr-Hansen, N., Padrah, S. & Strømgaard, K., 2014, In: Tetrahedron Letters. 55, 30, p. 4149-4151 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Hydroxy Acids 100%
  • Carboxylic Acids 89%
  • Carboxylic Acid 53%
  • Hydroxylation 53%
  • Amino Acids 48%
  6 Citations (Scopus)

• Inhibition of AMPA Receptors by Polyamine Toxins is Regulated by Agonist Efficacy and Stargazin

  Poulsen, M. H., Lucas, S., Strømgaard, K. & Kristensen, A. S., 24 Sept 2014, In: Neurochemical Research. 39, 10, p. 1906-1913 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Isoxazoles 100%
  • propionic acid 92%
  • Polyamines 82%
  • AMPA Receptors 82%
  • Propionic Acid 75%
  3 Citations (Scopus)

• Mechanistic insight into benzenethiol catalyzed amide bond formations from thioesters and primary amines

  Stuhr-Hansen, N., Bork, N. & Strømgaard, K., 14 Aug 2014, In: Organic & Biomolecular Chemistry. 12, 30, p. 5745-51 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Thioester 100%
  • Primary Amine 81%
  • Thiophenol 78%
  • Amide 60%
  • Acid 29%
  8 Citations (Scopus)

• Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (prozac)

  Andersen, J., Stuhr-Hansen, N., Zachariassen, L. G., Koldsø, H., Schiøtt, B., Strømgaard, K. & Kristensen, A. S., May 2014, In: Molecular Pharmacology. 85, 5, p. 703-14 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Norepinephrine Plasma Membrane Transport Proteins 100%
  • Fluoxetine 96%
  • Serotonin Plasma Membrane Transport Proteins 86%
  • Antidepressive Agents 75%
  • Serotonin 71%
  46 Citations (Scopus)

• Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin

  Maric, H-M., Kasaragod, V. B., Hausrat, T. J., Kneussel, M., Tretter, V., Strømgaard, K. & Schindelin, H., 22 Dec 2014, In: Nature Communications. 5, p. 1-11 11 p., 5767.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • gephyrin 100%
  • Glycine Receptors 84%
  • glycine 77%
  • Drug Target 70%
  • Neurotransmitter 68%
  34 Citations (Scopus)