Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

Theis S Wilbek; Tine Skovgaard; Fiona J Sorrell; Stefan Knapp; Jens Berthelsen; Kristian Strømgaard

doi:10.1002/cbic.201402512

Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

Theis S Wilbek, Tine Skovgaard, Fiona J Sorrell, Stefan Knapp, Jens Berthelsen, Kristian Strømgaard

11 Citations (Scopus)

Abstract

A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia.

Original language	English
Journal	ChemBioChem
Volume	16
Issue number	1
Pages (from-to)	59-63
Number of pages	5
ISSN	1439-4227
DOIs	https://doi.org/10.1002/cbic.201402512
Publication status	Published - 2 Jan 2015

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title = "Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1",

abstract = "A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia.",

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AU - Knapp, Stefan

AU - Berthelsen, Jens

AU - Strømgaard, Kristian

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AB - A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia.

U2 - 10.1002/cbic.201402512

DO - 10.1002/cbic.201402512

M3 - Journal article

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Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

Abstract

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