Christian Reinhard Otto Bartling

Christian Reinhard Otto Bartling

M. Sc.

 https://orcid.org/0000-0002-0602-4738
20182018

Research activity per year

Personal profile

CV

Personal Details:

Last name:

Bartling

First name:

Christian Reinhard Otto

Date of birth:

11.05.1989

Place of birth:

Herford, Germany

Family status:

unmarried

E-mail (work):

[email protected]

School Education:

1995 - 1999:Primary School Herringhausen, Germany
1999 - 2008:

Ravensberger Gymnasium Herford, Germany

Intensive courses: Chemistry, Biology

Miscellaneous: University Trail course in Chemistry, University of Bielefeld

 Tertiary Education:

October 2008 – April 2013  

University of Göttingen, Germany

Degree: Bachelor of Science, Chemistry

Thesis title: “Transition Metal catalyzed Transformation of Cyclopropane containing Molecules: Applications in Indole Synthesis”

May 2013 – February 2015  

University of Göttingen, Germany

Degree: Master of Science, Chemistry

Thesis title: “Total Synthesis of Analogues of Cyclic Depsipeptide YM-254890”

August 2013 – December 2013  

ERASMUS exchange semester

Norwegian University of Science and Technology, Trondheim, Norway with Associated Professor Bård Helge Hoff

Project title: “Synthesis and EGFR Tyrosine Kinase Activity of substituted new Furopyrimidines”

April 2014 – November 2014  

ERASMUS internship

University of Copenhagen, Denmark, Master Thesis with Professor Kristian Strømgaard

Thesis title: “Total Synthesis of Analogues of Cyclic Depsipeptide YM-254890”

June 2015 – ongoing

University of Copenhagen

Department of Drug Design and Pharmacology, Center for Biopharmaceuticals

PhD Student with Professor PhD Kristian Strømgaard

Thesis title: “Design and synthesis of novel dimeric inhibitors of Mint2”

March 2017 – April 2017

Boston University, USA

Department of Biology

External research stay with Associate Professor Angela Ho

Publications:

January 2014

Poster

Conference: “29. Organisk Kjemisk Vintermøte (OKV29)“

Poster Title: “Challenges in Synthesis of electron rich Furopyrimidines“ (presented by a third party)

December 2016

Poster

Conference: “Protein-Protein-Interactions London 2016”

Poster Title: “Probing the Interaction between Mint2 and Amyloid Precursor Protein”

Awards and Funding:

March 2017

Travel Award Grant – 8500 DKK

Conference: ”American Peptide Symposium 2017”

Poster Title: “Probing the protein-protein interactions between Mint2 and amyloid precursor protein as putative treatment for Alzheimer’s disease”

Work Experience:

Summer 2009; 2010

Life guard at outdoor pools in the city of Enger, Germany

Spring 2012

Autumn 2012/2013

Tutoring the “Chemical laboratory course for medical students“ – student assistant, seminar and practical course, University of Göttingen, Germany

Spring 2013

Tutoring the “Basic organic laboratory course for biochemistry students” – student assistant, practical course, University of Göttingen, Germany

March 2015 – May 2015

Research Assistant at the Department of Drug Design and Pharmacology, Chemical Biology Group, Kristian Strømgaard, University of Copenhagen, Denmark

Engagement/Activities:

2002 – 2014

Member of DLRG Enger e.V. (German Life Saving Association)

2004 – 2012

Member of Turngemeide Herford e.V. (track-and-field club)

Summer 2008

Ostwestfalen-Champion over 400 m

Participation at the Western-German Athletic Championship, 4 x 100m relay (4th place)

Current research

My PhD project focuses around the question whether it is possible to modulate the development and progression of Alzheimer’s disease (AD) by inhibiting disease relevant protein-protein interactions (PPIs) using peptide ligands.

PPIs are vital for cellular and biochemical processes and hence are promising drug targets. However, targeting PPIs is often challenging as the binding sites are typically shallow and devoid of obvious binding pockets. The Munc18-interacting (Mint) protein family, Mint1-3, are multidomain scaffolding proteins comprising a phosphotyrosine binding domain (PTB) and two PSD-95/discs large/zonula occludens 1 (PDZ) domains. The two members, Mint1 and Mint2, are primarily expressed in neurons and being assigned to key functions in synaptic vesicle exocytosis, protein transport and synapse formation. Furthermore, Mint1 and Mint2 are important for amyloid precursor protein (APP) processing through a direct interaction via the endoplasmatic sorting motif of APP with the PTB domain in Mint. Proteases process APP into the plaque forming Aβ peptide, which is the main component of the toxic amyloid plaques found in excess in brains of patients suffering from AD.

By mapping the interaction between APP and Mint2, we envisioned to design novel PPI inhibitors for the Mint2/APP-interaction. After determining the minimal binding peptide sequence of APP, this peptide was subjected to extensive mutational scans, allowing us to highlight structural properties in the APP sequence crucial for the interaction with Mint2. Based on this data, peptides characterized by significantly improved affinity and metabolic stability have been developed. In collaboration, lead compounds have recently been tested in neurons. Importantly, we were able to show that these conceptually new inhibitors are able to reduce the formation of the toxic Aβ peptide.

In perspective, we expect that these novel peptide inhibitors will be evaluated in relevant AD models in vivo.

Education/Academic qualification

University of Göttingen

Award Date: 19 Feb 2015

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