Research output per year
Research output per year
Research activity per year
Research Focus
Using a combination of electrophysiology, synthetic amino acids, protein engineering and spectroscopic approaches, we focus on the function and pharmacology of a therapeutically relevant class of membrane proteins called ion channels. For further details see www.theplesslab.com
Academic Positions
2014-present Associate Professor, University of Copenhagen, Copenhagen, Denmark
Education
2008-2013 Postdoc, University of British Columbia, Vancouver, Canada
2005-2008 PhD, University of Queensland, Brisbane, Australia
1998-2004 Graduate degree (diploma), University of Hamburg, Germany
Selected Publications:
Lynagh, T. (...) Pless, S.A.; “Acid-sensing ion channels emerged over 600 MYA and are conserved throughout the deuterostomes”; PNAS, 2018, 115(33):8430-8435
Wulf, M. & Pless, S.A.; "High-sensitivity fluorometry to resolve ion channel conformational dynamics"; Cell Reports, 2018, 22(6):1615-1626
Kim, R.Y., et al.; “PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels”; Proc Nat Acad Sci (PNAS), 2017, 114(45):E9702-E9711
Lynagh, T. (...) Pless, S.A.; “A selectivity filter at the intracellular end of the acid-sensing ion channel pore”; eLife, 2017, 6. pii: e24630. doi: 10.7554/eLife.24630
Kim, R.Y. & Yau, M.C. et al.; “Atomic basis for therapeutic activation of neuronal potassium channels”; Nature Communications, 2015, 6:8116. doi: 10.1038/ncomms9116
Pless, S.A. et al.; “Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels”, eLife, 2013, 2:e01289. doi: 10.7554/eLife.01289
Pless, S.A. et al.; “A novel mechanism for fine-tuning open state stability in a voltage-gated potassium channel”; Nature Communications, 2013, 4:1784. doi: 10.1038/ncomms2761
Pless, S.A. et al.; “Contributions of counter charge in a potassium channel voltage sensor”; cover article in Nature Chemical Biology, 2011, 7(9):617-23
Pless, S.A. et al.; “Molecular basis for inhibition of cardiac sodium channels by class Ib anti-arrhythmic drugs”; Nature Communications, 2011, 2:351. doi: 10.1038/ncomms1351
Selected Fellowships
2018-2021 DFF Sapere Aude Starting Grant
2017-2020 Carlsberg Foundation Distinguished Assoc. Prof. Fellowship
2013-2018 Lundbeck Foundation Fellowship
2011-2013 Michael Smith Foundation Postdoctoral Research Fellowship
2011-2013 Banting Postdoctoral Research Fellowship
2009-2011 Heart & Stroke Foundation Postdoctoral Research Fellowship
2005-2008 University of Queensland International Postgraduate Scholarship
2005-2008 University of Queensland Ernest Singer Scholarship
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Review › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Research output: Contribution to journal › Comment/debate › Research › peer-review
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Research output: Contribution to journal › Journal article › Research › peer-review
Borg, C. B. (Creator), Braun, N. (Creator), Heusser, S. A. (Creator), Bay, Y. (Creator), Weis, D. (Creator), Galleano, I. (Creator), Lund, C. (Creator), Tian, W. (Creator), Haugaard-Kedström, L. M. (Creator), Bennett, E. P. (Creator), Lynagh, T. (Creator), Strømgaard, K. (Creator), Andersen, J. (Creator) & Pless, S. A. (Creator), Zenodo, 2020
DOI: 10.5281/zenodo.3686254, https://zenodo.org/record/3686254
Dataset
Holm, C. M. (Creator), Topaktas, A. B. (Creator), Dannesboe, J. (Creator), Pless, S. A. (Creator) & Heusser, S. A. (Creator), Zenodo, 9 Apr 2024
DOI: 10.5281/zenodo.10948949, https://zenodo.org/records/10948949
Dataset
Braun, N. (Creator), Friis, S. (Creator), Ihling, C. (Creator), Sinz, A. (Creator), Andersen, J. (Creator) & Pless, S. A. (Creator), Zenodo, 2021
DOI: 10.5281/zenodo.4906985, https://zenodo.org/record/4906985
Dataset