Kjeld Møllgård

2019

Astrogliogenesis in human fetal brain: complex spatiotemporal immunoreactivity patterns of GFAP, S100, AQP4 and YKL-40

Holst, C. B., Brøchner, C. B., Vitting-Seerup, K. & Møllgård, K., Sept 2019, In: Journal of Anatomy. 235, 3, p. 590-615 26 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Comparison of cultured human cardiomyocyte clusters obtained from embryos/fetuses or derived from human embryonic stem cells

Grubb, S. J., Vestergaard, M. L., Andersen, A. S., Rasmussen, K. K., Mamsen, L., Tuckute, G., Grunnet-Lauridsen, K., Møllgård, K., Ernst, E., Christensen, S. T., Calloe, K. & Andersen, C. Y., 1 May 2019, In: Stem Cells and Development. 28, 9, p. 608-619

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Developmental differences in the expression of ABC transporters at rat brain barrier interfaces following chronic exposure to diallyl sulfide

Koehn, L. M., Dziegielewska, K. M., Møllgård, K., Saudrais, E., Strazielle, N., Ghersi-Egea, J-F., Saunders, N. R. & Habgood, M. D., 1 Dec 2019, In: Scientific Reports. 9, 1, p. 5998

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing

Adorjan, I., Tyler, T., Bhaduri, A., Demharter, S., Finszter, C. K., Bako, M., Sebok, O. M., Nowakowski, T. J., Khodosevich, K., Møllgård, K., Kriegstein, A. R., Shi, L., Hoerder-Suabedissen, A., Ansorge, O. & Molnár, Z., Sept 2019, In: Journal of Anatomy. 235, 3, p. 543-554 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

2 Downloads (Pure)

PDGF-B Is Required for Development of the Glymphatic System

Munk, A. S., Wang, W., Bèchet, N. B., Eltanahy, A. M., Cheng, A. X., Sigurdsson, B., Benraiss, A., Mäe, M. A., Kress, B. T., Kelley, D. H., Betsholtz, C., Møllgård, K., Meissner, A., Nedergaard, M. & Lundgaard, I., 2019, In: Cell Reports. 26, 11, p. 2955-2969.e3 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

42 Downloads (Pure)

Recent developments in understanding barrier mechanisms in the developing brain: Drugs and drug transporters in pregnancy, susceptibility or protection in the fetal brain?

Saunders, N. R., Dziegielewska, K. M., Møllga°rd, K. & Habgood, M. D., 2019, In: Annual Review of Pharmacology and Toxicology. 59, p. 487-505 19 p.

Research output: Contribution to journal › Review › peer-review

11 Citations (Scopus)

The origin of a new progenitor stem cell group in human development: An Immunohistochemical-, light- and electronmicroscopical analysis

Wartenberg, H., Miething, A. & Møllgård, K., 2019, Springer. 79 p. (Advances in Anatomy Embryology and Cell Biology; No. 230).

Research output: Book/Report › Book › Research › peer-review

2018

Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain

Saunders, N. R., Dziegielewska, K. M., Møllgård, K. & Habgood, M. D., 2018, In: Journal of Physiology. 596, 23, p. 5723-5756 34 p.

Research output: Contribution to journal › Review › peer-review

33 Citations (Scopus)

48 Downloads (Pure)

The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development

Rasmussen, K. K., Skat-Rørdam, J., Andersen, P., Warzecha, C. B., Pye, M., Andersen, T. A., Ajbro, K. D., Bendsen, E., Narimatsu, M., Vilhardt, F., Pedersen, L. B., Wrana, J. L., Anderson, R. H., Møllgård, K., Christensen, S. T. & Larsen, L. A., 2018, In: Scientific Reports. 8, 1, 14 p., 9542.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

82 Downloads (Pure)

The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS

Weller, R. O., Sharp, M. M., Christodoulides, M., Carare, R. O. & Møllgård, K., 2018, In: Acta Neuropathologica. 135, 3, p. 363-385 23 p.

Research output: Contribution to journal › Review › peer-review

57 Citations (Scopus)

117 Downloads (Pure)

2017

Anatomical and Molecular insight into the developing entorhinal cortex in a large mammalian species, the pig.

Liu, Y., Peralvo Vidal, J. M., Thomsen, P. D., Møllgård, K., Kirkeby, A. & Hall, V. J., 2017.

Research output: Contribution to conference › Conference abstract for conference › Research

Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development

Møllgård, K., Dziegielewska, K. M., Holst, C. B., Habgood, M. D. & Saunders, N. R., 2017, In: Scientific Reports. 7, 1, 16 p., 11603.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

129 Downloads (Pure)

General Introduction to Barrier Mechanisms in the Central Nervous System

Saunders, NR., Dziegielewska, K., Møllgård, K. & Habgood, M. D., 2017, The Blood Brain Barrier and Inflammation . Lyck, R. & Enzmann, G. (eds.). Switzerland: Springer, p. 1-22 23 p. (Progress in Inflammation Research).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Human embryonic stem cell derived cardiomyocytes self-arrange with areas of different subtypes during differentiation

Vestergaard, M. L., Grubb, S., Rasmussen, K. K., Anderson-Jenkins, Z. L., Grunnet-Lauridsen, K., Callø, K., Clausen, C., Christensen, S. T., Møllgård, K. & Andersen, C. Y., 1 Nov 2017, In: Stem Cells and Development. 26, 21, p. 1566-1577 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

2016

BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

Rasmussen, R. D., Gajjar, M. K., Tuckova, L., Jensen, K. E., Maya-Mendoza, A., Holst, C. B., Mollgaard, K., Rasmussen, J. S., Brennum, J., Bartek, J. J., Syrucek, M., Sedlakova, E., Andersen, K. K., Frederiksen, M. H., Bartek, J. & Hamerlik, P., 15 Nov 2016, In: Nature Communications. 7, 13398.

Research output: Contribution to journal › Journal article › Research › peer-review

57 Citations (Scopus)

112 Downloads (Pure)

Correction: Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural Approach

Liddelow, S. A., Dziegielewska, K. M., Ek, C. J., Habgood, M. D., Bauer, H., Bauer, H-C., Lindsay, H., Wakefield, M. J., Strazielle, N., Kratzer, I., Møllgård, K., Ghersi-Egea, J-F. & Saunders, N. R., 19 Jan 2016, In: P L o S One. 11, 1, 2 p., e0147680.

Research output: Contribution to journal › Comment/debate › Research

3 Citations (Scopus)

Reply: Methodological considerations in measuring different AMH splice forms using ELISA: validity of proAMH ELISA

Mamsen, L. S., Munthe-Fog, L., Petersen, T. S., Jeppesen, J. V., Møllgård, K., Grøndahl, M. L., Larsen, A., Ernst, E., Oxvig, C., Kumar, A., Kalra, B. & Andersen, C. Y., 1 May 2016, In: Molecular Human Reproduction. 22, 5, p. 374-375

Research output: Contribution to journal › Comment/debate › Research

3 Citations (Scopus)

SSEA-4 and YKL-40 positive progenitor subtypes in the subventricular zone of developing human neocortex

Brøchner, C. B. & Møllgård, K., 1 Jan 2016, In: Glia. 64, 1, p. 90-104 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

6 Citations (Scopus)

83 Downloads (Pure)

The biological significance of brain barrier mechanisms: help or hindrance in drug delivery to the central nervous system?

Saunders, N. R., Habgood, M. D., Møllgård, K. & Dziegielewska, K. M., 10 Mar 2016, In: F1000Research. 5, 15 p., 313.

Research output: Contribution to journal › Review › peer-review

62 Citations (Scopus)

176 Downloads (Pure)

2015

Human Embryonic and Hepatic Stem Cell Differentiation Visualized in Two and Three Dimensions Based on Serial Sections

Vestentoft, P. S., Brøchner, C. B., Lynnerup, N., Andersen, C. Y. & Møllgård, K., 2015, Human Embryonic Stem Cell Protocols. Springer Science+Business Media, Vol. 1307. p. 245-262 18 p. (Methods in Molecular Biology, Vol. 1307).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

1 Citation (Scopus)

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study

Saunders, N. R., Dziegielewska, K. M., Møllgård, K., Habgood, M. D., Wakefield, M. J., Lindsay, H., Stratzielle, N., Ghersi-Egea, J-F. & Liddelow, S. A., 28 Apr 2015, In: Frontiers in Neuroscience. 9, 21 p., 123.

Research output: Contribution to journal › Journal article › Research › peer-review

23 Citations (Scopus)

Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?

Saunders, N. R., Dziegielewska, K. M., Møllgård, K. & Habgood, M. D., 29 Oct 2015, In: Frontiers in Neuroscience. 9, 16 p., 385.

Research output: Contribution to journal › Review › peer-review

122 Citations (Scopus)

Outer brain barriers in rat and human development

Brøchner, C. B., Holst, C. B. & Møllgård, K., 16 Mar 2015, In: Frontiers in Neuroscience. 9, 16 p., 75.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Proteolytic processing of anti-Müllerian hormone differs between human fetal testes and adult ovaries

Mamsen, L. S., Petersen, T. S., Jeppesen, J. V., Møllgård, K., Grøndahl, M. L., Ernst, E., Oxvig, C., Kumar, A., Kalra, B. & Andersen, C. Y., Jul 2015, In: Molecular Human Reproduction. 21, 7, p. 571-582 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

18 Citations (Scopus)

The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions

Whish, S., Dziegielewska, K. M., Møllgård, K., Noor, N. M., Liddelow, S. A., Habgood, M. D., Richardson, S. J. & Saunders, N. R., 12 Feb 2015, In: Frontiers in Neuroscience. 9, 15 p., 16.

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

2014

Brain Barriers and a Subpopulation of Astroglial Progenitors of Developing Human Forebrain Are Immunostained for the Glycoprotein YKL-40

Bjørnbak, C., Brøchner, C. B., Larsen, L. A., Johansen, J. S. & Møllgård, K., May 2014, In: Journal of Histochemistry and Cytochemistry. 62, 5, p. 369-88 20 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Cellular Specificity of the Blood-CSF Barrier for Albumin Transfer across the Choroid Plexus Epithelium

Liddelow, S. A., Dzięgielewska, K. M., Møllgård, K., Whish, S. C., Noor, N. M., Wheaton, B. J., Gehwolf, R., Wagner, A., Traweger, A., Bauer, H., Bauer, H-C. & Saunders, N. R., 11 Sept 2014, In: PloS one. 9, 9, p. 1-11 11 p., e106592.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Epigenetic remodelling and dysregulation of DLGAP4 is linked with early-onset cerebellar ataxia

Minocherhomji, S., Hansen, C., Kim, H-G., Mang, Y., Bak, M., Guldberg, P., Papadopoulos, N., Eiberg, H., Doh, G. D., Møllgård, K., Hertz, J. M., Nielsen, J. E., Ropers, H-H., Tümer, Z., Tommerup, N., Kalscheuer, V. M. & Silahtaroglu, A., 1 Dec 2014, In: Human Molecular Genetics. 23, 23, p. 6163-6176 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history

Saunders, N. R., Dreifuss, J-J., Dziegielewska, K. M., Johansson, P. A., Habgood, M. D., Møllgård, K. & Bauer, H-C., 16 Dec 2014, In: Frontiers in Neuroscience. 8, p. 1-26 26 p., 404.

Research output: Contribution to journal › Journal article › Research › peer-review

101 Citations (Scopus)

239 Downloads (Pure)

Zbtb20 Defines a Hippocampal Neuronal Identity Through Direct Repression of Genes That Control Projection Neuron Development in the Isocortex

Nielsen, J. V., Thomassen, M., Møllgård, K., Noraberg, J. & Jensen, N. A., May 2014, In: Cerebral Cortex. 24, 5, p. 1216-1229 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

2013

Expression and cellular distribution of ubiquitin in response to injury in the developing spinal cord of Monodelphis domestica

Noor, N. M., Møllgård, K., Wheaton, B. J., Steer, D. L., Truettner, J. S., Dziegielewska, K. M., Dietrich, W. D., Smith, A. I. & Saunders, N. R., 23 Apr 2013, In: PLOS ONE. 8, 4, p. e62120

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach

Liddelow, S. A., Dziegielewska, K. M., Ek, C. J., Habgood, M. D., Bauer, H., Bauer, H-C., Lindsay, H., Wakefield, M. J., Strazielle, N., Kratzer, I., Møllgård, K., Ghersi-Egea, J-F. & Saunders, N. R., 2 Jul 2013, In: PLOS ONE. 8, 7, p. e65629

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

Mutations in c10orf11, a melanocyte-differentiation gene, cause autosomal-recessive albinism

Grønskov, K., Dooley, C. M., Østergaard, E., Kelsh, R. N., Hansen, L., Levesque, M. P., Vilhelmsen, K., Møllgård, K., Stemple, D. L. & Rosenberg, T., 7 Mar 2013, In: American Journal of Human Genetics. 92, 3, p. 415-21 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

64 Citations (Scopus)

2012

Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach

Liddelow, S. A., Temple, S., Møllgård, K., Gehwolf, R., Wagner, A., Bauer, H., Bauer, H-C., Phoenix, T. N., Dziegielewska, K. M. & Saunders, N. R., 26 Mar 2012, In: P L o S One. 7, 3, p. e33554

Research output: Contribution to journal › Journal article › Research › peer-review

52 Citations (Scopus)

The migration and loss of human primordial germ stem cells from the hind gut epithelium towards the gonadal ridge

Mamsen, L. S., Brøchner, C. B., Byskov, A. G. & Møllgård, K., 2012, In: International Journal of Developmental Biology. 56, 10-12, p. 771-8 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

59 Citations (Scopus)

YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers

Brøchner, C. B., Johansen, J. S., Larsen, L. A., Bak, M., Mikkelsen, H. B., Byskov, A. G., Andersen, C. Y. & Møllgård, K., Mar 2012, In: Journal of Histochemistry and Cytochemistry. 60, 3, p. 188-204 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

30 Citations (Scopus)

2011

Engaging neuroscience to advance translational research in brain barrier biology: Neurodevelopment and the brain barriers

Molnar, Z., Saunders, NR., Anthony, D., Bauer, HK., Bauer, H., Dammann, O., Daneman, R., Dziegielewska, K., Ek, J., Ferretti, P., Habgood, M., Harry, J., Johansson, P., Liddelow, S., Møllgård, K., Stolp, H., Watts, R. & Virgintino, D., 1 Mar 2011, In: Nature Reviews. Neuroscience. 12, 3, Suppl Mat: 4, p. 69-93 25 p.

Research output: Contribution to journal › Journal article › Research › peer-review

370 Citations (Scopus)

From pluripotency to early differentiation of human embryonic stem cell cultures evaluated by electron microscopy and immunohistochemistry

Jacobsen, J. V., Andersen, C. Y., Hyttel, P. & Møllgård, K., 2011, Embryonic stem cells: basic biology to bioengineering. Kallos, M. S. (ed.). InTech, p. 171-190 20 p.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

In human granulosa cells from small antral follicles, androgen receptor mRNA and androgen levels in follicular fluid correlate with FSH receptor mRNA

Nielsen, M. E., Rasmussen, I. A., Kristensen, S. G., Christensen, S. T., Møllgård, K., Andersen, E. A. W., Byskov, A. G. S. & Andersen, C. Y., Jan 2011, In: Molecular Human Reproduction. 17, 1, p. 63-70 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

100 Citations (Scopus)

No evidence for the presence of oogonia in the human ovary after their final clearance during the first two years of life

Byskov, A. G., Høyer, P. E., Andersen, C. Y., Kristensen, S. G., Jespersen, Å. & Møllgård, K., Aug 2011, In: Human Reproduction. 26, 8, p. 2129-2139 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

59 Citations (Scopus)

SPARC/osteonectin, an endogenous mechanism for targeting albumin to the blood-cerebrospinal fluid interface during brain development

Liddelow, S. A., Dziegielewska, K. M., Møllgård, K., Phoenix, T. N., Temple, S., Vandeberg, J. L. & Saunders, N. R., 1 Oct 2011, In: European Journal of Neuroscience. 34, 7, p. 1062-73 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver

Vestentoft, P. S., Jelnes, P., Hopkinson, B. M., Vainer, B., Møllgård, K., Quistorff, B. & Bisgaard, H. C., 2011, In: B M C Developmental Biology. 11, p. 56

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

Three-dimensional reconstructions of intrahepatic bile duct tubulogenesis in human liver

Vestentoft, P. S., Jelnes, P., Hopkinson, B. M., Vainer, B., Møllgård, K., Quistorff, B. & Bisgaard, H. C., 2011, In: BMC Developmental Biology. 11, p. 56

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

2010

A two- and three-dimensional approach for visualizing human embryonic stem cell differentiation: chapter 10

Brøchner, C. B., Vestentoft, P. S., Lynnerup, N., Andersen, C. Y. & Møllgård, K., 2010, In: Methods in Molecular Biology. 584, p. 179-193 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Dissecting spatio-temporal protein networks driving human heart development and related disorders

Hansen, K. L., Møllgård, K., Greenway, S., Wakimoto, H., Gorham, J. M., Workman, C. T., Bendsen, E., Hansen, N. T., Rigina, O., Roque, F. S., Wiese, C., Christoffels, V. M., Roberts, A. E., Smoot, L. B., Pu, W. T., Donahoe, P. K., Tommerup, N., Brunak, S., Seidman, C. E., Seidman, J. G., & 1 othersLarsen, L. A., 2010, In: Molecular Systems Biology. 6, p. 381

Research output: Contribution to journal › Journal article › Research › peer-review

72 Citations (Scopus)

Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain

Larsen, K. B., Lutterodt, M. C., Møllgård, K. & Møller, M., Jul 2010, In: Journal of Histochemistry and Cytochemistry. 58, 7, p. 669-78 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

40 Citations (Scopus)

Haploinsufficiency of TAB2 causes congenital heart defects in humans

Thienpont, B., Zhang, L., Postma, A. V., Breckpot, J., Tranchevent, L-C., Van Loo, P., Møllgård, K., Tommerup, N., Bache, I., Tümer, Z., van Engelen, K., Menten, B., Mortier, G., Waggoner, D., Gewillig, M., Moreau, Y., Devriendt, K. & Larsen, L. A., 11 Jul 2010, In: American Journal of Human Genetics. 86, 6, p. 839-49 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

57 Citations (Scopus)

Human primordial germ cells migrate along nerve fibers and Schwann cells from the dorsal hind gut mesentery to the gonadal ridge

Møllgård, K., Jespersen, Å., Lutterodt, M. C., Andersen, C. Y., Høyer, P. E. & Byskov, A. G. S., 21 Jun 2010, In: Molecular Human Reproduction. 16, 9, p. 621-631 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

52 Citations (Scopus)

Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain

Larsen, K. B., Lutterodt, M. C., Laursen, H., Graem, N., Pakkenberg, B., Møllgård, K. & Møller, M., Jul 2010, In: Developmental Neuroscience. 32, 2, p. 149-62 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Subplate in the developing cortex of mouse and human

Wang, W. Z., Hoerder-Suabedissen, A., Oeschger, F. M., Bayatti, N., Ip, B. K., Lindsay, S., Supramaniam, V., Srinivasan, L., Rutherford, M., Møllgård, K., Clowry, G. J. & Molnár, Z., Oct 2010, In: Journal of Anatomy. 217, p. 368-380 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

61 Citations (Scopus)

Kjeld Møllgård

Research output

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