Céline Galvagnion-Büll

Research output

Research output per year 2008 2014 2015 2016 2018 2019

• 20 Journal article
• 2 Review
• 1 Comment/debate
• 1 Other contribution

Research output per year

Research output per year

Search results

• 2019

  An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

  Agerschou, E. D., Flagmeier, P., Saridaki, T., Galvagnion, C., Komnig, D., Heid, L., Prasad, V., Shaykhalishahi, H., Willbold, D., Dobson, C. M., Voigt, A., Falkenbürger, B., Hoyer, W. & Buell, A. K., Aug 2019, In: eLife. 8

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Synucleins 100%
  • Amyloid Fibril 78%
  • Amyloid 62%
  • Carrier Proteins 56%
  • Nucleation 53%
  22 Citations (Scopus)

• Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils

  Galvagnion, C., 19 Dec 2019, In: The Journal of Physical Chemistry Letters.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amyloid 100%
  • Lipids 78%
  • Amyloid Fibril 70%
  • Phase transitions 60%
  • lipids 57%
  10 Citations (Scopus)
• 2018

  Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

  Habchi, J., Chia, S., Galvagnion, C., Michaels, T. C. T., Bellaiche, M. M. J., Ruggeri, F. S., Sanguanini, M., Idini, I., Kumita, J. R., Sparr, E., Linse, S., Dobson, C. M., Knowles, T. P. J. & Vendruscolo, M., 1 Jun 2018, In: Nature Chemistry. 10, 6, p. 673-683 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Membrane Lipids 100%
  • Cholesterol 89%
  • Nucleation 60%
  • Agglomeration 50%
  • Amyloid 32%
  86 Citations (Scopus)

  13 Downloads (Pure)

• C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

  van der Wateren, I. M., Knowles, T. P. J., Buell, A. K., Dobson, C. M. & Galvagnion, C., 7 Jul 2018, In: Chemical Science. 9, 25, p. 5506-5516 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amyloid Fibril 100%
  • pH Value 35%
  • Disorder 12%
  • Protein 11%
  • Nucleation 11%
  23 Citations (Scopus)

  5 Downloads (Pure)

• Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

  Brown, J. W. P., Meisl, G., Knowles, T. P. J., Buell, A. K., Dobson, C. M. & Galvagnion, C., 10 Jul 2018, In: Chemical communications (Cambridge, England). 54, 56, p. 7854-7857 4 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amyloid 100%
  • Lipids 78%
  • Amyloid Fibril 70%
  • Energy barriers 44%
  • Energy Barrier 28%
  13 Citations (Scopus)

  17 Downloads (Pure)

• Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions

  Gang, H., Galvagnion, C., Meisl, G., Müller, T., Pfammatter, M., Buell, A. K., Levin, A., Dobson, C. M., Mu, B. & Knowles, T. P. J., 6 Mar 2018, In: Analytical Chemistry. 90, 5, p. 3284-3290 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Lipids 100%
  • Microfluidics 79%
  • Proteins 68%
  • Thermodynamics 63%
  • Biological membranes 43%
  12 Citations (Scopus)

• Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

  Perni, M., Flagmeier, P., Limbocker, R., Cascella, R., Aprile, F. A., Galvagnion, C., Heller, G. T., Meisl, G., Chen, S. W., Kumita, J. R., Challa, P. K., Kirkegaard, J. B., Cohen, S. I. A., Mannini, B., Barbut, D., Nollen, E. A. A., Cecchi, C., Cremades, N., Knowles, T. P. J., Chiti, F., & 3 othersZasloff, M., Vendruscolo, M. & Dobson, C. M., 17 Aug 2018, In: ACS chemical biology. 13, 8, p. 2308-2319 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • 24-dihydroxy-5-cholestane 24-sulfate 3-N-1(spermine)-7 100%
  • Squalamine 84%
  • Synucleins 69%
  • Disorder 39%
  • Oligomer 36%
  32 Citations (Scopus)
• 2017

  A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

  Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Müller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., Chen, S. W., Limbocker, R., Sormanni, P., Heller, G. T., Aprile, F. A., Cremades, N., Cecchi, C., Chiti, F., Nollen, E. A. A., Knowles, T. P. J., & 4 othersVendruscolo, M., Bax, A., Zasloff, M. & Dobson, C. M., 7 Feb 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 6, p. E1009-E1017

  Research output: Contribution to journal › Journal article › Research › peer-review

  • squalamine 100%
  • Synucleins 91%
  • Biological Products 59%
  • Parkinson Disease 16%
  • Membrane Lipids 11%
  126 Citations (Scopus)

• The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson's Disease

  Galvagnion, C., 2017, In: Journal of Parkinson's Disease. 7, 3, p. 433-450 18 p.

  Research output: Contribution to journal › Review › peer-review

  • Synucleins 100%
  • Parkinson Disease 55%
  • Lipids 43%
  • Proteins 13%
  • Lewy Body Disease 11%
  92 Citations (Scopus)
• 2016

  Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of alpha-synuclein

  Galvagnion, C., Brown, J. W. P., Ouberai, M. M., Flagmeier, P., Vendruscolo, M., Buell, A. K., Sparr, E. & Dobson, C. M., 28 Jun 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7065-7070

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Synucleins 100%
  • alpha-Synuclein 79%
  • Kinetics 47%
  • Lipids 43%
  • Membranes 39%
  120 Citations (Scopus)

• Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

  Chattopadhyay, A., O'Connor, C. J., Zhang, F., Galvagnion, C., Galloway, W. R. J. D., Tan, Y. S., Stokes, J. E., Rahman, T., Verma, C., Spring, D. R. & Itzhaki, L. S., 5 Apr 2016, In: Scientific Reports. 6

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oncogene Proteins 100%
  • Proteins 32%
  • Ankyrin Repeat 21%
  • Tumor Suppressor Protein p53 19%
  • DNA Damage 12%
  21 Citations (Scopus)

• Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of alpha-synuclein aggregation

  Flagmeier, P., Meisl, G., Vendruscolo, M., Knowles, T. P. J., Dobson, C. M., Buell, A. K. & Galvagnion, C., 13 Sept 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. 10328-10333

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Synucleins 100%
  • alpha-Synuclein 79%
  • Parkinson Disease 55%
  • Mutation 36%
  • Amyloid 31%
  108 Citations (Scopus)

• β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces

  Brown, J. W. P., Buell, A. K., Michaels, T. C. T., Meisl, G., Carozza, J., Flagmeier, P., Vendruscolo, M., Knowles, T. P. J., Dobson, C. M. & Galvagnion, C., 3 Nov 2016, In: Scientific Reports. 6, p. 36010

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Synucleins 100%
  • Competitive Binding 84%
  • Amyloid 13%
  • Intrinsically Disordered Proteins 10%
  • Lipids 9%
  35 Citations (Scopus)
• 2015

  Fundamental mechanisms of amyloid fibers by the formation of a-synuclein protein in Parkinson's disease quantitative Modeling

  Galvagnion, C. & Buell, A. K., 2015, In: Medecine Sciences. 31, 6-7, p. 597-600

  Research output: Contribution to journal › Comment/debate › Research › peer-review

• Lipid vesicles trigger alpha-synuclein aggregation by stimulating primary nucleation

  Galvagnion, C., Buell, A. K., Meisl, G., Michaels, T. C. T., Vendruscolo, M., Knowles, T. P. J. & Dobson, C. M., Mar 2015, In: Nature Chemical Biology. 11, 3, p. 229-U101

  Research output: Contribution to journal › Journal article › Research › peer-review

  • alpha-Synuclein 100%
  • Amyloid 79%
  • Synucleins 63%
  • Intrinsically Disordered Proteins 60%
  • Lipids 54%
  287 Citations (Scopus)

• The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments

  Granata, D., Baftizadeh, F., Habchi, J., Galvagnion, C., De Simone, A., Camilloni, C., Laio, A. & Vendruscolo, M., 26 Oct 2015, In: Scientific Reports. 5

  Research output: Contribution to journal › Journal article › Research › peer-review

  • peptides 100%
  • free energy 73%
  • proteins 41%
  • simulation 34%
  • folding 26%
  65 Citations (Scopus)
• 2014

  Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy

  Pinotsi, D., Buell, A. K., Galvagnion, C., Dobson, C. M., Schierle, G. S. K. & Kaminski, C. F., 8 Jan 2014, In: Nano Letters. 14, 1, p. 339-345

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amyloid 100%
  • Growth kinetics 85%
  • Self assembly 77%
  • Amyloid Fibril 70%
  • Microscopic examination 63%
  115 Citations (Scopus)

• Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

  Levin, A., Mason, T. O., Adler-Abramovich, L., Buell, A. K., Meisl, G., Galvagnion, C., Bram, Y., Stratford, S. A., Dobson, C. M., Knowles, T. P. J. & Gazit, E., 13 Nov 2014, In: Nature Communications. 5

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dipeptides 100%
  • Supramolecular Polymer 98%
  • Thermodynamics 94%
  • diphenylalanine 81%
  • assemblies 79%
  121 Citations (Scopus)

• Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation

  Buell, A. K., Galvagnion, C., Gaspar, R., Sparr, E., Vendruscolo, M., Knowles, T. P. J., Linse, S. & Dobson, C. M., 27 May 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 21, p. 7671-7676

  Research output: Contribution to journal › Journal article › Research › peer-review

  • nucleation 100%
  • Parkinson disease 85%
  • proteins 42%
  • lysosomes 42%
  • oligomers 31%
  308 Citations (Scopus)

• Targeting the Intrinsically Disordered Structural Ensemble of alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease

  Toth, G., Gardai, S. J., Zago, W., Bertoncini, C. W., Cremades, N., Roy, S. L., Tambe, M. A., Rochet, J-C., Galvagnion, C., Skibinski, G., Finkbeiner, S., Bova, M., Regnstrom, K., Chiou, S-S., Johnston, J., Callaway, K., Anderson, J. P., Jobling, M. F., Buell, A. K., Yednock, T. A., & 6 othersKnowles, T. P. J., Vendruscolo, M., Christodoulou, J., Dobson, C. M., Schenk, D. & McConlogue, L., 14 Feb 2014, In: PLOS ONE. 9, 2

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Parkinson's Disease 100%
  • Synucleins 99%
  • Parkinson disease 88%
  • alpha-Synuclein 78%
  • Protein 68%
  89 Citations (Scopus)
• 2013

  alpha-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling

  Ouberai, M. M., Wang, J., Swann, M. J., Galvagnion, C., Guilliams, T., Dobson, C. M. & Welland, M. E., 19 Jul 2013

  Research output: Other contribution › Research

  • Synucleins 100%
  • alpha-Synuclein 79%
  • Lipids 43%
  • Membranes 39%
  131 Citations (Scopus)

• Production and initial structural characterization of the TM4TM5 helix-loop-helix domain of the translocator protein

  Galvagnion, C., Montaville, P., Coic, Y. -M. & Jamin, N., Feb 2013, In: Journal of Peptide Science. 19, 2, p. 102-109

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Helix-Loop-Helix Motifs 100%
  • Circular Dichroism 77%
  • Micelles 75%
  • Detergents 66%
  • dodecylphosphocholine 58%
  3 Citations (Scopus)
• 2009

  Folding and Association of Thermophilic Dimeric and Trimeric DsrEFH Proteins: Tm0979 and Mth1491

  Galvagnion, C., Smith, M. T. J., Broom, A., Vassall, K. A., Meglei, G., Gaspar, J. A., Stathopulos, P. B., Cheyne, B. & Meiering, E. M., 7 Apr 2009, In: Biochemistry. 48, 13, p. 2891-2906

  Research output: Contribution to journal › Journal article › Research › peer-review

  13 Citations (Scopus)
• 2008

  Conformational stability and folding mechanisms of dimeric proteins

  Rumfeldt, J. A. O., Galvagnion, C., Vassall, K. A. & Meiering, E. M., Sept 2008, In: Progress in Biophysics & Molecular Biology. 98, 1, p. 61-84

  Research output: Contribution to journal › Review › peer-review

  78 Citations (Scopus)