Research output per year
Research output per year
Personal profile
Short presentation
One of my main research interests is to understand the role of lipids in the initiation and spreading of neurodegenerative diseases.
Current research
My current research aims at providing mechanistic insights into the interplay between disruptions in lipid homeostasis and Parkinson's Disease. In order to adress this question, we use a multidisciplinary approach at the interface between biology and biophysics including the study of different PD cellular models and the characterisation of protein-membrane interactions and aggregation at the molecular level.
Primary fields of research
- Neurodegenerative Diseases
- Protein and lipid biophysics
- Cellular disease models
CV
Education:
2011: PhD in Chemistry, Université Pierre et Marie Curie, Paris, France
2007: Diplôme d'ingénieur, École Nationale Supérieure de Chimie de Rennes, France
2007: Master of Science, University of Waterloo, Ontario, Canada
Recent positions:
April 2016 - March 2019: Post-doctoral Research Fellow at the DZNE Bonn and Heinrich-Heine-Universität, Institute of Physical Biology, Düsseldorf, Germany
June 2011 - March 2016: Post-doctoral Research Fellow, University of Cambridge
Grants and Fellowships (250,000 €):
2017: Horizon 2020 – Marie Curie Individual Fellowship
2016: Alexander von Humboldt Research Fellowship for postdoctoral researchers
Invited talks at international conferences:
October 2019: CECAM "Modeling phase separation in health and disease: from nano- to meso-scale", Toulouse, France
May 2019: “Membrane Lipids” - German Society of Fat Science, Berlin, Germany
June 2017: Gordon Conference on Membrane Protein Folding, Stonehill College, MA, USA
April 2017: Hengstberger Symposion “alpha-Synuclein and the Blood-Brain Barrier in Parkinson’s Disease”, Heidelberg, Germany
Introductory remarks on publicationslist
H-index: 14
Number of citations (without self citations): 1,032
Source: web of science
Education/Academic qualification
1 Jan 2008 → 18 Mar 2011
University of Waterloo
1 Sept 2005 → 31 Dec 2007
1 Sept 2003 → 1 Dec 2007
Keywords
- Faculty of Health and Medical Sciences
- Parkinson's disease
- Amyloid fibrils
- Alpha-synuclein
- Lipids
- Kinetic analysis
- Biophysics
- Cellular biology
- Molecular biology
Fingerprint
Dive into the research topics where Céline Galvagnion-Büll is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils
Agerschou, E. D., Flagmeier, P., Saridaki, T., Galvagnion, C., Komnig, D., Heid, L., Prasad, V., Shaykhalishahi, H., Willbold, D., Dobson, C. M., Voigt, A., Falkenbürger, B., Hoyer, W. & Buell, A. K., Aug 2019, In: eLife. 8Research output: Contribution to journal › Journal article › Research › peer-review
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Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils
Galvagnion, C., 19 Dec 2019, In: The Journal of Physical Chemistry Letters.Research output: Contribution to journal › Journal article › Research › peer-review
10 Citations (Scopus) -
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
Habchi, J., Chia, S., Galvagnion, C., Michaels, T. C. T., Bellaiche, M. M. J., Ruggeri, F. S., Sanguanini, M., Idini, I., Kumita, J. R., Sparr, E., Linse, S., Dobson, C. M., Knowles, T. P. J. & Vendruscolo, M., 1 Jun 2018, In: Nature Chemistry. 10, 6, p. 673-683 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH
van der Wateren, I. M., Knowles, T. P. J., Buell, A. K., Dobson, C. M. & Galvagnion, C., 7 Jul 2018, In: Chemical Science. 9, 25, p. 5506-5516 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils
Brown, J. W. P., Meisl, G., Knowles, T. P. J., Buell, A. K., Dobson, C. M. & Galvagnion, C., 10 Jul 2018, In: Chemical communications (Cambridge, England). 54, 56, p. 7854-7857 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions
Gang, H., Galvagnion, C., Meisl, G., Müller, T., Pfammatter, M., Buell, A. K., Levin, A., Dobson, C. M., Mu, B. & Knowles, T. P. J., 6 Mar 2018, In: Analytical Chemistry. 90, 5, p. 3284-3290 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
Perni, M., Flagmeier, P., Limbocker, R., Cascella, R., Aprile, F. A., Galvagnion, C., Heller, G. T., Meisl, G., Chen, S. W., Kumita, J. R., Challa, P. K., Kirkegaard, J. B., Cohen, S. I. A., Mannini, B., Barbut, D., Nollen, E. A. A., Cecchi, C., Cremades, N., Knowles, T. P. J., Chiti, F., & 3 others, 17 Aug 2018, In: ACS chemical biology. 13, 8, p. 2308-2319 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Müller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., Chen, S. W., Limbocker, R., Sormanni, P., Heller, G. T., Aprile, F. A., Cremades, N., Cecchi, C., Chiti, F., Nollen, E. A. A., Knowles, T. P. J., & 4 others, 7 Feb 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 6, p. E1009-E1017Research output: Contribution to journal › Journal article › Research › peer-review