Targeting the Intrinsically Disordered Structural Ensemble of alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease

Gergely Toth; Shyra J. Gardai; Wagner Zago; Carlos W. Bertoncini; Nunilo Cremades; Susan L. Roy; Mitali A. Tambe; Jean-Christophe Rochet; Celine Galvagnion; Gaia Skibinski; Steven Finkbeiner; Michael Bova; Karin Regnstrom; San-San Chiou; Jennifer Johnston; Kari Callaway; John P. Anderson; Michael F. Jobling; Alexander K. Buell; Ted A. Yednock; Tuomas P. J. Knowles; Michele Vendruscolo; John Christodoulou; Christopher M. Dobson; Dale Schenk; Lisa McConlogue

doi:10.1371/journal.pone.0087133

Targeting the Intrinsically Disordered Structural Ensemble of alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease

Gergely Toth, Shyra J. Gardai, Wagner Zago, Carlos W. Bertoncini, Nunilo Cremades, Susan L. Roy, Mitali A. Tambe, Jean-Christophe Rochet, Celine Galvagnion, Gaia Skibinski, Steven Finkbeiner, Michael Bova, Karin Regnstrom, San-San Chiou, Jennifer Johnston, Kari Callaway, John P. Anderson, Michael F. Jobling, Alexander K. Buell, Ted A. YednockTuomas P. J. Knowles, Michele Vendruscolo, John Christodoulou, Christopher M. Dobson, Dale Schenk, Lisa McConlogue

89 Citations (Scopus)

Original language	English
Journal	PLOS ONE
Volume	9
Issue number	2
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0087133
Publication status	Published - 14 Feb 2014
Externally published	Yes

Access to Document

10.1371/journal.pone.0087133

journal.pone.0087133&type=printableFinal published version, 692 KBLicence: CC BY

Cite this

Toth, G., Gardai, S. J., Zago, W., Bertoncini, C. W., Cremades, N., Roy, S. L., Tambe, M. A., Rochet, J-C., Galvagnion, C., Skibinski, G., Finkbeiner, S., Bova, M., Regnstrom, K., Chiou, S-S., Johnston, J., Callaway, K., Anderson, J. P., Jobling, M. F., Buell, A. K., ... McConlogue, L. (2014). Targeting the Intrinsically Disordered Structural Ensemble of alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease. PLOS ONE, 9(2). https://doi.org/10.1371/journal.pone.0087133

Toth, G, Gardai, SJ, Zago, W, Bertoncini, CW, Cremades, N, Roy, SL, Tambe, MA, Rochet, J-C, Galvagnion, C, Skibinski, G, Finkbeiner, S, Bova, M, Regnstrom, K, Chiou, S-S, Johnston, J, Callaway, K, Anderson, JP, Jobling, MF, Buell, AK, Yednock, TA, Knowles, TPJ, Vendruscolo, M, Christodoulou, J, Dobson, CM, Schenk, D & McConlogue, L 2014, 'Targeting the Intrinsically Disordered Structural Ensemble of alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease', PLOS ONE, vol. 9, no. 2. https://doi.org/10.1371/journal.pone.0087133

@article{a3e58d35cf344dea9e296f1af49faa9a,

title = "Targeting the Intrinsically Disordered Structural Ensemble of alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease",

author = "Gergely Toth and Gardai, {Shyra J.} and Wagner Zago and Bertoncini, {Carlos W.} and Nunilo Cremades and Roy, {Susan L.} and Tambe, {Mitali A.} and Jean-Christophe Rochet and Celine Galvagnion and Gaia Skibinski and Steven Finkbeiner and Michael Bova and Karin Regnstrom and San-San Chiou and Jennifer Johnston and Kari Callaway and Anderson, {John P.} and Jobling, {Michael F.} and Buell, {Alexander K.} and Yednock, {Ted A.} and Knowles, {Tuomas P. J.} and Michele Vendruscolo and John Christodoulou and Dobson, {Christopher M.} and Dale Schenk and Lisa McConlogue",

year = "2014",

month = feb,

day = "14",

doi = "10.1371/journal.pone.0087133",

language = "English",

volume = "9",

journal = "PLoS Computational Biology",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "2",

}

TY - JOUR

T1 - Targeting the Intrinsically Disordered Structural Ensemble of alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease

AU - Toth, Gergely

AU - Gardai, Shyra J.

AU - Zago, Wagner

AU - Bertoncini, Carlos W.

AU - Cremades, Nunilo

AU - Roy, Susan L.

AU - Tambe, Mitali A.

AU - Rochet, Jean-Christophe

AU - Galvagnion, Celine

AU - Skibinski, Gaia

AU - Finkbeiner, Steven

AU - Bova, Michael

AU - Regnstrom, Karin

AU - Chiou, San-San

AU - Johnston, Jennifer

AU - Callaway, Kari

AU - Anderson, John P.

AU - Jobling, Michael F.

AU - Buell, Alexander K.

AU - Yednock, Ted A.

AU - Knowles, Tuomas P. J.

AU - Vendruscolo, Michele

AU - Christodoulou, John

AU - Dobson, Christopher M.

AU - Schenk, Dale

AU - McConlogue, Lisa

PY - 2014/2/14

Y1 - 2014/2/14

U2 - 10.1371/journal.pone.0087133

DO - 10.1371/journal.pone.0087133

M3 - Journal article

SN - 1932-6203

VL - 9

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 2

ER -

Targeting the Intrinsically Disordered Structural Ensemble of alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease

Access to Document

Fingerprint

Cite this