Brian Tate Weinert

Research output

Research output per year 2011 2012 2014 2015 2019 2019

• 21 Journal article
• 3 Review
• 2 Comment/debate

Research output per year

Research output per year

Search results

• 2019

  Acetylation of intrinsically disordered regions regulates phase separation

  Saito, M., Hess, D., Eglinger, J., Fritsch, A. W., Kreysing, M., Weinert, B. T., Choudhary, C. & Matthias, P., Jan 2019, In: Nature Chemical Biology. 15, 1, p. 51-61

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • Organelles 91%
  • Membranes 56%
  • Intrinsically Disordered Proteins 46%
  • RNA Helicases 44%
  60 Citations (Scopus)

• Analysis and Interpretation of Protein Post-Translational Modification Site Stoichiometry

  Prus, G., Hoegl, A., Weinert, B. T. & Choudhary, C., Nov 2019, In: Trends in Biochemical Sciences. 44, 11, p. 943-960

  Research output: Contribution to journal › Review › peer-review

  • Post-Translational Protein Modification 100%
  • Post Translational Protein Processing 66%
  • Reaction Stoichiometry 52%
  • Modification 35%
  • Mass Spectrometry 19%
  13 Citations (Scopus)

• Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation

  Hansen, B. K., Gupta, R., Baldus, L., Lyon, D., Narita, T., Lammers, M., Choudhary, C. & Weinert, B. T., 1 Dec 2019, In: Nature Communications. 10, 11 p., 1055.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • acetylation 100%
  • Acetylation 61%
  • stoichiometry 55%
  • Reaction Stoichiometry 47%
  • proteins 46%
  36 Citations (Scopus)

  31 Downloads (Pure)

• Functions and mechanisms of non-histone protein acetylation

  Narita, T., Weinert, B. T. & Choudhary, C., 1 Mar 2019, In: Nature Reviews. Molecular Cell Biology. 20, p. 156-174 19 p.

  Research output: Contribution to journal › Review › peer-review

  • Acetylation 100%
  • Proteins 34%
  • Post Translational Protein Processing 32%
  • Protein Stability 18%
  • Protein Folding 18%
  175 Citations (Scopus)

• Retraction

  Kaidi, A., Weinert, B. T., Choudhary, C. & Jackson, S. P., 19 Apr 2019, In: Science. 364, 6437, p. 247 1 p.

  Research output: Contribution to journal › Comment/debate › Research
• 2018

  Benchmarking common quantification strategies for large-scale phosphoproteomics

  Hogrebe, A., von Stechow, L., Bekker-Jensen, D. B., Weinert, B. T., Kelstrup, C. D. & Olsen, J. V., 2018, In: Nature Communications. 9, 1, p. 1-13 1045.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Phosphopeptides 100%
  • Benchmarking 80%
  • Isotope Labeling 54%
  • Phosphorylation 51%
  • Stable Isotope 40%
  101 Citations (Scopus)

  87 Downloads (Pure)

• Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

  Weinert, B. T., Narita, T., Satpathy, S., Srinivasan, B., Hansen, B. K., Schölz, C., Hamilton, W. B., Zucconi, B. E., Wang, W. W., Liu, W. R., Brickman, J. M., Kesicki, E. A., Lai, A., Bromberg, K. D., Cole, P. A. & Choudhary, C., 2018, In: Cell. 174, 1, p. 231-244.e12 27 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • p300-CBP-associated factor 30%
  • Gene Knockout Techniques 23%
  • Deacetylation 22%
  • Effector 20%
  91 Citations (Scopus)
• 2017

  Accurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome

  Weinert, B. T., Satpathy, S., Hansen, B. K., Lyon, D., Jensen, L. J. & Choudhary, C. R., May 2017, In: Molecular and Cellular Proteomics. 16, p. 759-769

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Sirtuins 100%
  • Acetylation 77%
  • Reaction Stoichiometry 59%
  • Escherichia coli 51%
  • Peptides 25%
  35 Citations (Scopus)

• Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

  Lasko, L. M., Jakob, C. G., Edalji, R. P., Qiu, W., Montgomery, D., Digiammarino, E. L., Hansen, T. M., Risi, R. M., Frey, R., Manaves, V., Shaw, B., Algire, M., Hessler, P., Lam, L. T., Uziel, T., Faivre, E., Ferguson, D., Buchanan, F. G., Martin, R. L., Torrent, M., & 16 othersChiang, G. G., Karukurichi, K., Langston, J. W., Weinert, B. T., Choudhary, C., de Vries, P., Van Drie, J. H., McElligott, D., Kesicki, E., Marmorstein, R., Sun, C., Cole, P. A., Rosenberg, S. H., Michaelides, M. R., Lai, A. & Bromberg, K. D., 5 Oct 2017, In: Nature. 550, 7674, p. 128-132 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • CREB-Binding Protein 100%
  • Histone Acetyltransferases 91%
  • Castration 38%
  • Androgen Receptors 36%
  • Catalytic Domain 30%
  213 Citations (Scopus)
• 2016

  A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

  Starnes, L. M., Su, D., Pikkupeura, L. M., Weinert, B. T., Santos, M. A., Mund, A., Soria, R., Cho, Y-W., Pozdnyakova, I., Kubec Højfeldt, M., Lages Lino Vala, A., Yang, W., López-Méndez, B., Lee, J-E., Peng, W., Yuan, J., Ge, K., Montoya, G., Nussenzweig, A., Choudhary, C. R., & 1 othersDaniel, J. A., 15 Jan 2016, In: Genes & Development. 30, 2, p. 149-163 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Immunoglobulin Class Switching 100%
  • Methyltransferases 79%
  • Protein Domains 71%
  • Transcriptional Activation 64%
  • Leukemia 58%
  13 Citations (Scopus)

  72 Downloads (Pure)
• 2015

  Acetylation site specificities of lysine deacetylase inhibitors in human cells

  Schölz, C., Weinert, B. T., Wagner, S. A., Beli, P., Miyake, Y., Qi, J., Jensen, L. J., Streicher, W., McCarthy, A. R., Westwood, N. J., Lain, S., Cox, J., Matthias, P., Mann, M., Bradner, J. E. & Choudhary, C. R., 1 Apr 2015, In: Nature Biotechnology. 33, p. 415–423

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • Bufexamac 79%
  • Lysine 56%
  • Cells 56%
  • tubacin 37%
  159 Citations (Scopus)

• Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

  Weinert, B. T., Moustafa, T., Iesmantavicius, V., Zechner, R. & Choudhary, C. R., 3 Nov 2015, In: E M B O Journal. 34, 21, p. 2620-2632 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • Reaction Stoichiometry 76%
  • Fasting 11%
  • Liver 11%
  • Pharmacological Metabolism 11%
  77 Citations (Scopus)

• Avoiding abundance bias in the functional annotation of posttranslationally modified proteins

  Schölz, C., Lyon, D., Refsgaard, J. C., Jensen, L. J., Choudhary, C. R. & Weinert, B. T., 1 Nov 2015, In: Nature Methods. 12, p. 1003-4 2 p.

  Research output: Contribution to journal › Comment/debate › Research › peer-review

  24 Citations (Scopus)

• Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

  Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, B. T., Passmore, L. A., Patel, K. J., Olsen, J. V., Choudhary, C. R., Bekker-Jensen, S. & Mailand, N., 8 Jan 2015, In: Molecular Cell. 57, 1, p. 150-64 15 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Fanconi Anemia 100%
  • Sumoylation 75%
  • Ubiquitin 75%
  • DNA Damage 65%
  • Ligases 40%
  79 Citations (Scopus)
• 2014

  Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

  Weinert, B. T., Iesmantavicius, V., Moustafa, T., Schölz, C., Wagner, S. A., Magnes, C., Zechner, R. & Choudhary, C. R., 31 Jan 2014, In: Molecular Systems Biology. 10, 1, p. 716 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • Saccharomyces Cerevisiae 91%
  • Stoichiometry 89%
  • Yeast 69%
  • stoichiometry 64%
  146 Citations (Scopus)

• Convergence of Ubiquitylation and Phosphorylation Signaling in Rapamycin-Treated Yeast Cells

  Iesmantavicius, V., Weinert, B. T. & Choudhary, C. R., Aug 2014, In: Molecular & Cellular Proteomics. 13, 8, p. 1979-92 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitination 100%
  • Sirolimus 97%
  • Yeasts 74%
  • Phosphorylation 63%
  • Nutrient 49%
  41 Citations (Scopus)

• The growing landscape of lysine acetylation links metabolism and cell signalling

  Choudhary, C. R., Weinert, B. T., Nishida, Y., Verdin, E. & Mann, M., Aug 2014, In: Nature Reviews. Molecular Cell Biology. 15, 8, p. 536-50 15 p.

  Research output: Contribution to journal › Review › peer-review

  • Acylation 100%
  • Acetylation 95%
  • Lysine 88%
  • Signal Transduction 71%
  • Sirtuins 24%
  725 Citations (Scopus)
• 2013

  Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli

  Weinert, B. T., Iesmantavicius, V., Wagner, S. A., Schölz, C., Gummesson, B., Beli, P., Nyström, T. & Choudhary, C. R., 25 Jul 2013, In: Molecular Cell. 51, 2, p. 265-272 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • acetyl phosphate 100%
  • Acetylation 61%
  • Lysine 56%
  • Escherichia coli 40%
  • Bacteria 11%
  252 Citations (Scopus)

• Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation

  Weinert, B. T., Schölz, C., Wagner, S. A., Iesmantavicius, V., Su, D., Daniel, J. A. & Choudhary, C. R., 29 Aug 2013, In: Cell Reports. 4, 4, p. 842-51 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • Eukaryota 98%
  • Lysine 92%
  • Yeasts 76%
  • Tricarboxylic Acid 61%
  377 Citations (Scopus)
• 2012

  Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae

  Henriksen, P., Wagner, S. A., Weinert, B. T., Sharma, S., Bacinskaja, G., Rehman, M., Juffer, A. H., Walther, T. C., Lisby, M. & Choudhary, C. R., Nov 2012, In: Molecular & Cellular Proteomics. 11, 11, p. 1510-1522 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • Proteome 99%
  • Lysine 92%
  • Saccharomyces cerevisiae 87%
  • Saccharomycetales 21%
  182 Citations (Scopus)

• Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues

  Wagner, S. A., Beli, P., Weinert, B. T., Schölz, C. F., Kelstrup, C. D., Young, C., Nielsen, M. L., Olsen, J. V., Brakebusch, C. & Choudhary, C. R., Dec 2012, In: Molecular & Cellular Proteomics.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitination 100%
  • Proteomics 84%
  • Protein 38%
  • Post Translational Protein Processing 38%
  • Glycine 37%
  189 Citations (Scopus)

• Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns

  Lundby, A., Hansen, K. L., Weinert, B. T., Breinholt Bekker-Jensen, D., Secher, A., Skovgaard, T., Kelstrup, C., Dmytriyev, A., Choudhary, C. R., Lundby, C. & Olsen, J. V., 30 Aug 2012, In: Cell Reports. 2, 2, p. 419-431 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Organ Specificity 100%
  • Acetylation 82%
  • Lysine 76%
  • Proteomics 72%
  • Myosin Type II 72%
  355 Citations (Scopus)

• Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3

  Sol, E. M., Wagner, S. A., Weinert, B. T., Kumar, A., Kim, H-S., Deng, C-X. & Choudhary, C. R., 7 Dec 2012, In: PloS one. 7, 12, p. e50545

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • Sirtuin 3 93%
  • Proteomics 84%
  • proteomics 72%
  • Substrate 67%
  97 Citations (Scopus)

• Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response

  Beli, P., Lukashchuk, N., Wagner, S. A., Weinert, B. T., Olsen, J. V., Baskcomb, L., Mann, M., Jackson, S. P. & Choudhary, C. R., 27 Apr 2012, In: Molecular Cell. 46, 2, p. 212-25 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteomics 100%
  • DNA Damage 94%
  • RNA 75%
  • Protein Phosphatase 2C 31%
  • DNA 30%
  196 Citations (Scopus)
• 2011

  A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

  Wagner, S. A., Beli, P., Weinert, B. T., Nielsen, M. L., Cox, J., Mann, M. & Choudhary, C. R., 1 Oct 2011, In: Molecular and Cellular Proteomics. 10, 10, p. M111.013284

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Ubiquitination 100%
  • Proteome 96%
  • Modification 51%
  • Proteasome Inhibitor 46%
  • Protein 38%
  575 Citations (Scopus)

• Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation

  Weinert, B. T., Wagner, S. A., Horn, H., Henriksen, P., Liu, W. R., Olsen, J. V., Jensen, L. J. & Choudhary, C. R., 26 Jul 2011, In: Science Signaling. 4, 183, p. ra48

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Acetylation 100%
  • Proteome 99%
  • Lysine 92%
  • Drosophila 88%
  • Phosphorylation 29%
  187 Citations (Scopus)