Brian Lohse

Research output

Research output per year 2005 2005 2006 2007 2014 2015 2017

• 23 Journal article
• 2 Letter
• 1 Article in proceedings
• 1 Review

Research output per year

Research output per year

Search results

• 2017

  Pitfalls to avoid when using phage display for snake toxins

  Laustsen, A. H., Lauridsen, L. P., Lomonte, B., Andersen, M. R. & Lohse, B., 1 Feb 2017, In: Toxicon. 126, p. 79-89 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Biotinylation 100%
  • Snakes 90%
  • Snake Venom 88%
  • Bacteriophages 69%
  • Toxin 67%
  6 Citations (Scopus)
• 2016

  From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy

  Laustsen, A. H., Engmark, M., Milbo, C., Johannesen, J., Lomonte, B., Gutiérrez, J. M. & Lohse, B., 1 Sept 2016, In: Current Pharmaceutical Design. 22, 34, p. 5270-5293 24 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Snake Bites 100%
  • Snake Venom 91%
  • Snakes 70%
  • Prey Cleavage 54%
  • Antivenins 50%
  65 Citations (Scopus)

• Synthesis and characterisation of substrate-based peptides as inhibitors of histone demethylase KDM4C

  Nielsen, S. D., Leurs, U., Bergner, M., Barris, S. A., Devkota, K., Meyer, K., Iaria, D., McCaughan, J., Lohse, B., Kristensen, J. L. & Clausen, R. P., 1 Sept 2016, In: Protein and Peptide Letters. 23, 9, p. 772 - 776 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Histone Demethylases 100%
  • Pentapeptide 83%
  • Histone 73%
  • Lysine 66%
  • Click Chemistry 55%
• 2015

  A fluorescence resonance energy transfer-based method for histone methyltransferases

  Devkota, K., Lohse, B., Nyby Jakobsen, C., Berthelsen, J. & Clausen, R. P., 1 May 2015, In: Analytical Biochemistry. 476, p. 78-80 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Histone Methyltransferases 100%
  • Fluorescence Resonance Energy Transfer 97%
  • Resonance Energy 92%
  • Histone 78%
  • Peptides 46%
  1 Citation (Scopus)

• Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis

  Laustsen, A. H., Gutiérrez, J. M., Rasmussen, A. R., Engmark, M., Gravlund, P., Sanders, K. L., Lohse, B. & Lomonte, B., 1 Dec 2015, In: Toxicon. 107, p. 187-96 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Elapid Venoms 100%
  • Olea 88%
  • Venoms 76%
  • Venom 74%
  • Proteome 67%
  28 Citations (Scopus)

• Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

  Laustsen, A. H. & Lohse, B., 11 Aug 2015, In: Toxicon. 104, p. 43-45 3 p.

  Research output: Contribution to journal › Letter › peer-review

  51 Citations (Scopus)

• Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins

  Laustsen, A. H., Lohse, B. & Rasmussen, A. R., 1 Jun 2015, In: Toxicon. 99, p. 23-35 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Naja naja 100%
  • Snakes 80%
  • Venoms 74%
  • Venom 73%
  • Toxin 59%
  41 Citations (Scopus)

• Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development

  Laustsen, A. H., Lomonte, B., Lohse, B., Fernandez, J. & Gutiérrez, J. M., 4 Apr 2015, In: Journal of Proteomics. 119, p. 126–142 17 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Dendroaspis 100%
  • Antivenins 78%
  • Venoms 67%
  • Venom 65%
  • Toxin 53%
  63 Citations (Scopus)
• 2014

  Analogues of the natural product Sinefungin as inhibitors of EHMT1 and EHMT2

  Devkota, K., Lohse, B., Liu, Q., Wang, M-W., Stærk, D., Berthelsen, J. & Clausen, R. P., 10 Apr 2014, In: A C S Medicinal Chemistry Letters. 5, 4, p. 293-297

  Research output: Contribution to journal › Letter › peer-review

  • sinefungin 100%
  • Methyltransferase Inhibitor 93%
  • Sinefungin 91%
  • Methyltransferases 59%
  • Biological Products 52%
  28 Citations (Scopus)

• Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

  Leurs, U., Lohse, B., Ming, S. A., Cole, P. A., Clausen, R. P., Kristensen, J. L. & Rand, K. D., 2 Dec 2014, In: Analytical Chemistry. 86, 23, p. 11734-11741 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Phage display 100%
  • Deuterium 74%
  • Ligands 69%
  • Peptides 68%
  • Mass spectrometry 67%
  14 Citations (Scopus)

  6 Downloads (Pure)

• Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

  Leurs, U., Lohse, B., Rand, K. D., Ming, S., Riise, E. S., Cole, P. A., Kristensen, J. L. & Clausen, R. P., 19 Sept 2014, In: A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Histone Demethylases 100%
  • Histone 73%
  • Peptides 21%
  • Catalytic Domain 20%
  • Hydrogen Deuterium Exchange-Mass Spectrometry 19%
  18 Citations (Scopus)

  79 Downloads (Pure)
• 2013

  Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro

  Lohse, B., Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, P. A. C., Kristensen, J. L. & Clausen, R. P., 2 Jul 2013, In: P L o S One. 8, 7, p. e67653

  Research output: Contribution to journal › Journal article › Research › peer-review

  • histone demethylases 100%
  • Histone Demethylases 88%
  • Substrate 70%
  • post-translational modification 63%
  • Post Translational Protein Processing 62%
  18 Citations (Scopus)
• 2012

  Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C)

  Leurs, U., Clausen, R. P., Kristensen, J. L. & Lohse, B., 15 Sept 2012, In: Bioorganic & Medicinal Chemistry Letters. 22, 18, p. 5811-3 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Histone Demethylases 100%
  • 4-hydroxypyrazole 74%
  • Histone 73%
  • Lysine 65%
  • X-Linked Mental Retardation 53%
  15 Citations (Scopus)
• 2011

  Inhibitors of histone demethylases

  Lohse, B., Kristensen, J. L., Kristensen, L. H., Agger, K., Helin, K., Gajhede, M. & Clausen, R. P., 15 Jun 2011, In: Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.

  Research output: Contribution to journal › Review › peer-review

  • Histone Demethylases 100%
  • Demethylation 81%
  • Histone 73%
  • Lysine 65%
  • Enzyme Inhibitors 39%
  83 Citations (Scopus)

• Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

  Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, M., Clausen, R. P. & Kristensen, J. L., 19 Sept 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amino acids 100%
  • Histone 90%
  • Lysine 79%
  • Amino-Acid Residue 75%
  • Substrates 58%
  30 Citations (Scopus)
• 2010

  Histonhaler: et nyt mål inden for kræftbehandling

  Kristensen, J. L., Lohse, B. & Clausen, R. P., Dec 2010, In: Lægemiddelforskning. 2010, p. 7-9

  Research output: Contribution to journal › Journal article › Communication

  1024 Downloads (Pure)
• 2008

   Acridizinium-Substituted Dendrimers As a New Potential Rewritable Optical Data Storage Material for Blu-ray

  Lohse, B., 2008, In: Chemistry of Materials. 20, 21, p. 6715-6720 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  25 Citations (Scopus)

• Encapsulation efficiency measured on single small unilamellar vesicles

  Lohse, B., Bolinger, P. Y. & Stamou, D., 2008, In: Journal of the American Chemical Society. 130, 44, p. 14372-14373 1 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  66 Citations (Scopus)
• 2007

  Self-assembly of uracil-PAMAM dendrimer systems into domains of micrometer length scale

  Lohse, B., 2007, In: Macromolecules. 40, 6, p. 1779-1781 3 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  7 Citations (Scopus)

• Self-assembly of uracil-PAMAM dendrimer systems into domains of micrometer length scale

  Lohse, B., Ivanov, M. T., Andreasen, J. W., Vestberg, R., Hvilsted, S., Berg, R. H., Ramanujam, P. S., Hawker, C. J. & Mortensen, K., 20 Mar 2007, In: Macromolecules. 40, 6, p. 1779-1781

  Research output: Contribution to journal › Journal article › Research › peer-review

  7 Citations (Scopus)

• UV-Photodimerization in Uracil-substituted dendrimers for high density data storage

  Lohse, B., 2007, In: Journal of Polymer Science. Part A, Polymer Chemistry. 45, 19, p. 4401-4412 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  12 Citations (Scopus)
• 2006

  Cycloaddition in peptides for high-capacity optical storage

  Lohse, B., 2006, In: Japanese Journal of Applied Physics. 45, 1B, p. 488-492 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  4 Citations (Scopus)

• N-1-alkylated pyrimidine films as a new potential optical data storage medium

  Lohse, B., 2006, In: Chemistry of Materials. 18, 20, p. 4808-4816 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  13 Citations (Scopus)

• Organic materials for UV holographic and digital storage

  Lohse, B., 2006, Proceedings of SPIE. SPIE - International Society for Optical Engineering, p. 6252 7 p.

  Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

  2 Citations (Scopus)
• 2005

  Photodimerization in pyrimidine-substituted dipeptides

  Lohse, B., 2005, In: Journal of Peptide Science. 11, 8, p. 499-505 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  11 Citations (Scopus)

• Photodimerization in substituted di- and oligopeptides by UV-light for optical data storage: Part 2

  Lohse, B., 2005, In: Biopolymers. 80, 4, p. 576

  Research output: Contribution to journal › Journal article › Research › peer-review

• Photodimerization in substituted di- and oligopeptides by UV-light for optical data storage: Part 1

  Lohse, B., 2005, In: Biopolymers. 80, 4, p. 504

  Research output: Contribution to journal › Journal article › Research › peer-review