Annette Eva Langkilde

2019

Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

Cholak, E., Bucciarelli, S., Bugge, K., Johansen, N. T., Vestergaard, B., Arleth, L., Kragelund, B. B. & Langkilde, A. E., 17 Dec 2019, In: Biochemistry.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2018

Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

Seuring, C., Ayyer, K., Filippaki, E., Barthelmess, M., Longchamp, J.-N., Ringler, P., Pardini, T., Wojtas, D. H., Coleman, M. A., Dörner, K., Fuglerud, S., Hammarin, G., Habenstein, B., Langkilde, A. E., Loquet, A., Meents, A., Riek, R., Stahlberg, H., Boutet, S. & Hunter, M. S. & 7 others, Koglin, J., Liang, M., Ginn, H. M., Millane, R. P., Frank, M., Barty, A. & Chapman, H. N., 1 Dec 2018, In: Nature Communications. 9, 1, 10 p., 1836.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

50 Downloads (Pure)

Noninvasive Structural Analysis of Intermediate Species During Fibrillation: An Application of Small-Angle X-Ray Scattering

Langkilde, A. E., Herranz-Trillo, F., Bernadó, P. & Vestergaard, B., 8 Jun 2018, Amyloid Proteins: methods and protocols. Sigurdsson, E., Calero, M. & Gasset, M. (eds.). Humana Press, Vol. 1779. p. 209-239 31 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

2 Citations (Scopus)

2016

Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization

Pedersen, T. S., Tian, X., Thorolfsson, M., Karkov, H. S., Rasmussen, H. B., Langkilde, A. E. & Vestergaard, B., 1 Mar 2016, In: Pharmaceutical Research. 33, 3, p. 716-28 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

2015

Formation of covalent di-tyrosine dimers in recombinant α-synuclein

van Maarschalkerweerd, A., Pedersen, M., Peterson, H., Nilsson, M., Nguyen, T., Skamris, T., Rand, K., Vetri, V., Langkilde, A. & Vestergaard, B., 19 Oct 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-12 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

In-depth analysis of subclass-specific conformational preferences of IgG antibodies

Tian, X., Vestergaard, B., Thorolfsson, M., Yang, Z., Rasmussen, H. B. & Langkilde, A. E., 1 Jan 2015, In: IUCrJ. 2, 1, p. 9-18 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy

Langkilde, A. E., Morris, K. L., Serpell, L. C., Svergun, D. I. & Vestergaard, B., 1 Apr 2015, In: Acta crystallographica. Section D, Biological crystallography. 71, Pt 4, p. 882-95 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

91 Downloads (Pure)

2014

Protein/lipid coaggregates are formed during α-synuclein-induced disruption of lipid bilayers

van Maarschalkerweerd, A., Vetri, V., Langkilde, A. E., Foderà, V. & Vestergaard, B., 13 Oct 2014, In: Biomacromolecules. 15, 10, p. 3643-54 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

Small-Angle X-ray Scattering Screening Complements Conventional Biophysical Analysis: Comparative Structural and Biophysical Analysis of Monoclonal Antibodies IgG1, IgG2, and IgG4

Tian, X., Langkilde, A. E., Thorolfsson, M., Rasmussen, H. B. & Vestergaard, B., Jun 2014, In: Journal of Pharmaceutical Sciences. 103, 6, p. 1701-10 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

35 Citations (Scopus)

2013

Wildtype and A30P mutant alpha-synuclein form different fibril structures

Nielsen, S. B., Macchi, F., Raccosta , S., Langkilde, A. E., Giehm, L., Kyrsting, A. H., Svane, A. S. P., Manno, M., Christiansen, G., Nielsen, N. C., Oddershede, L. B., Vestergaard, B. & Otzen, D., 4 Jul 2013, In: PLOS ONE. 8, 7, e67713.

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

1349 Downloads (Pure)

2012

Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

Clausen, T. M., Christoffersen, S., Dahlbäck, M., Langkilde, A. E., Jensen, K. E., Resende, M., Agerbæk, M. Ø., Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, M. A., Theander, T. G., Larsen, S. & Salanti, A., 6 Jul 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

114 Citations (Scopus)

Structural characterization of prefibrillar intermediates and amyloid fibrils by small-angle X-ray scattering

Langkilde, A. E. & Vestergaard, B., 2012, Amyloid proteins: methods and protocols. Sigurdsson, E. M., Calero, M. & Gasset, M. (eds.). 2 ed. New York: Springer Science+Business Media, Vol. 849. p. 137-155 18 p. (Methods in Molecular Biology, Vol. 849).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

10 Citations (Scopus)

2011

The first lesson in the classroom - getting students engaged in active learning process

Langkilde, A. E., 2011, Improving University Science Teaching and Learning: Pedagogical Projects 2010. Ulriksen, L., Rump, C. & Hansen, H. W. (eds.). Department of Science Education, University of Copenhagen, Vol. 3. p. 3-17

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

2009

Methods for structural characterization of prefibrillar intermediates and amyloid fibrils

Langkilde, A. E. & Vestergaard, B., 2009, In: FEBS Letters. 583, 16, p. 2600-2609

Research output: Contribution to journal › Journal article › Research › peer-review

55 Citations (Scopus)

Sparing the ortho-position in nucleophilic aromatic substitution-specific displacement of the 4-SePh group in 2,4-bis(phenylseleno)nitrobenzene

Stuhr-Hansen, N., Götze, T. F., Henriksen, L., Sølling, T. I., Langkilde, A. E. & Sørensen, H. O., 2009, In: Heteroatom Chemistry. 20, 2, p. 101-108

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2008

High resolution X-ray diffraction of macromolecular crystals: The challenge of obtaining accurate data and extracting valid information

Langkilde, A. E., 2008, Kemisk Institut, Københavns Universitet.

Research output: Book/Report › Ph.D. thesis

Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

Langkilde, A. E., Kristensen, S. M., Lo Leggio, L., Mølgaard, A., Jensen, J. H., Houk, A. R., Poulsen, J.-C. N., Larsen, S. Y. & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

2005

Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

Barfod, R., Eriksen, J., Golding, B. T., Hammershøi, A., Jacobsen, T. A., Langkilde, A. E., Larsen, S., Mønsted, O., Sargeson, A. M. & Sørensen, H. O., 2005, In: Dalton Transactions (Print Edition). 3, p. 491-500 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

2004

Structures of three salts of phthalic acid; variation in crystal packing and geometry of the hydrogen phthalate ion

Langkilde, A. E., Madsen, D. & Larsen, S., 2004, In: Acta Crystallographica. B60, p. 502-511

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

2002

Diastereomeric salts of lactic acid and 1-phenylethylamine, their structures and relative stabilities

Langkilde, A. E., Oddershede, J. & Larsen, S., 2002, In: Acta Crystallographica B. 58, p. 1044-1050

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Annette Eva Langkilde

Research output

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