Annette Eva Langkilde

Research output

Research output per year 2002 2008 2009 2012 2014 2015 2018 2019

• 16 Journal article
• 3 Book chapter
• 1 Ph.D. thesis

Research output per year

Research output per year

Search results

• 2019

  Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

  Cholak, E., Bucciarelli, S., Bugge, K., Johansen, N. T., Vestergaard, B., Arleth, L., Kragelund, B. B. & Langkilde, A. E., 17 Dec 2019, In: Biochemistry.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Synucleins 100%
  • Amyloid 62%
  • Nucleation 53%
  • Lipid 45%
  • Lipids 43%
  5 Citations (Scopus)
• 2018

  Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

  Seuring, C., Ayyer, K., Filippaki, E., Barthelmess, M., Longchamp, J-N., Ringler, P., Pardini, T., Wojtas, D. H., Coleman, M. A., Dörner, K., Fuglerud, S., Hammarin, G., Habenstein, B., Langkilde, A. E., Loquet, A., Meents, A., Riek, R., Stahlberg, H., Boutet, S., Hunter, M. S., & 7 othersKoglin, J., Liang, M., Ginn, H. M., Millane, R. P., Frank, M., Barty, A. & Chapman, H. N., 1 Dec 2018, In: Nature Communications. 9, 1, 10 p., 1836.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Coherent X-Ray 100%
  • Tobacco Mosaic Virus 87%
  • Graphite 74%
  • X-Ray Diffraction 65%
  • Amyloid Fibril 64%
  21 Citations (Scopus)

  50 Downloads (Pure)

• Noninvasive Structural Analysis of Intermediate Species During Fibrillation: An Application of Small-Angle X-Ray Scattering

  Langkilde, A. E., Herranz-Trillo, F., Bernadó, P. & Vestergaard, B., 8 Jun 2018, Amyloid Proteins: methods and protocols. Sigurdsson, E., Calero, M. & Gasset, M. (eds.). Humana Press, Vol. 1779. p. 209-239 31 p. (Methods in Molecular Biology).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  • X-Rays 100%
  • Structural Models 50%
  • Amyloid 40%
  2 Citations (Scopus)
• 2016

  Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization

  Pedersen, T. S., Tian, X., Thorolfsson, M., Karkov, H. S., Rasmussen, H. B., Langkilde, A. E. & Vestergaard, B., 1 Mar 2016, In: Pharmaceutical Research. 33, 3, p. 716-28 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Neutralization 100%
  • Immunoglobulin G 74%
  • Monoclonal Antibodies 72%
  • Oligomerization 67%
  • Oligomer 52%
  31 Citations (Scopus)
• 2015

  Formation of covalent di-tyrosine dimers in recombinant α-synuclein

  van Maarschalkerweerd, A., Pedersen, MN., Peterson, H., Nilsson, M., Nguyen, TTT., Skamris, T., Rand, K., Vetri, V., Langkilde, AE. & Vestergaard, B., 19 Oct 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-12 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Synucleins 100%
  • Tyrosine 60%
  • Parkinson Disease 36%
  • Intrinsically Disordered Proteins 32%
  • Recombinant Proteins 21%
  9 Citations (Scopus)

• In-depth analysis of subclass-specific conformational preferences of IgG antibodies

  Tian, X., Vestergaard, B., Thorolfsson, M., Yang, Z., Rasmussen, H. B. & Langkilde, A. E., 1 Jan 2015, In: IUCrJ. 2, 1, p. 9-18 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Antibodies 100%
  • antibodies 93%
  • X ray scattering 81%
  • Statistical Ensemble 78%
  • Small Angle X-Ray Scattering 76%
  38 Citations (Scopus)

• The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy

  Langkilde, A. E., Morris, K. L., Serpell, L. C., Svergun, D. I. & Vestergaard, B., 1 Apr 2015, In: Acta crystallographica. Section D, Biological crystallography. 71, Pt 4, p. 882-95 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • X-Ray Diffraction 100%
  • Amyloid 79%
  • Peptide Fragments 74%
  • Electron Microscopy 72%
  • Peptides 53%
  35 Citations (Scopus)

  91 Downloads (Pure)
• 2014

  Protein/lipid coaggregates are formed during α-synuclein-induced disruption of lipid bilayers

  van Maarschalkerweerd, A., Vetri, V., Langkilde, A. E., Foderà, V. & Vestergaard, B., 13 Oct 2014, In: Biomacromolecules. 15, 10, p. 3643-54 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amyloid 100%
  • Lipid bilayers 95%
  • Lipids 78%
  • Proteins 53%
  • Membrane Lipids 40%
  33 Citations (Scopus)

• Small-Angle X-ray Scattering Screening Complements Conventional Biophysical Analysis: Comparative Structural and Biophysical Analysis of Monoclonal Antibodies IgG1, IgG2, and IgG4

  Tian, X., Langkilde, A. E., Thorolfsson, M., Rasmussen, H. B. & Vestergaard, B., Jun 2014, In: Journal of Pharmaceutical Sciences. 103, 6, p. 1701-10 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Small Angle X-Ray Scattering 100%
  • X-Rays 79%
  • Immunoglobulin G 77%
  • Monoclonal Antibodies 75%
  • Solution Behavior 41%
  35 Citations (Scopus)
• 2013

  Wildtype and A30P mutant alpha-synuclein form different fibril structures

  Nielsen, S. B., Macchi, F., Raccosta, S., Langkilde, A. E., Giehm, L., Kyrsting, A. H., Svane, A. S. P., Manno, M., Christiansen, G., Nielsen, N. C., Oddershede, L. B., Vestergaard, B. & Otzen, D., 4 Jul 2013, In: PLOS ONE. 8, 7, e67713.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • thioflavin T 100%
  • Parkinson disease 93%
  • Mutant 86%
  • alpha-Synuclein 82%
  • Parkinson's Disease 79%
  43 Citations (Scopus)

  1349 Downloads (Pure)
• 2012

  Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

  Clausen, T. M., Christoffersen, S., Dahlbäck, M., Langkilde, A. E., Jensen, K. E., Resende, M., Agerbæk, M. Ø., Andersen, D., Berisha, B., Ditlev, S. B., Pinto, V. V., Nielsen, M. A., Theander, T. G., Larsen, S. & Salanti, A., 6 Jul 2012, In: Journal of Biological Chemistry. 287, 28, p. 23332-45 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Plasmodium falciparum VAR2CSA protein 100%
  • Chondroitin Sulfates 53%
  • Chondroitin Sulfate 53%
  • Protein Binding 43%
  • Malaria 39%
  114 Citations (Scopus)

• Structural characterization of prefibrillar intermediates and amyloid fibrils by small-angle X-ray scattering

  Langkilde, A. E. & Vestergaard, B., 2012, Amyloid proteins: methods and protocols. Sigurdsson, E. M., Calero, M. & Gasset, M. (eds.). 2 ed. New York: Springer Science+Business Media, Vol. 849. p. 137-155 18 p. (Methods in Molecular Biology, Vol. 849).

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  • Synucleins 100%
  • Amyloid 62%
  • X-Rays 50%
  • Insulin 44%
  • Proteins 24%
  10 Citations (Scopus)
• 2011

  The first lesson in the classroom - getting students engaged in active learning process

  Langkilde, A. E., 2011, Improving University Science Teaching and Learning: Pedagogical Projects 2010. Ulriksen, L., Rump, C. & Hansen, H. W. (eds.). Department of Science Education, University of Copenhagen, Vol. 3. p. 3-17

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
• 2009

  Methods for structural characterization of prefibrillar intermediates and amyloid fibrils

  Langkilde, A. E. & Vestergaard, B., 2009, In: FEBS Letters. 583, 16, p. 2600-2609

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Amyloid Fibril 100%
  • Small Angle X-Ray Scattering 82%
  • Amyloid 79%
  • X-Rays 65%
  • Strength 53%
  55 Citations (Scopus)

• Sparing the ortho-position in nucleophilic aromatic substitution-specific displacement of the 4-SePh group in 2,4-bis(phenylseleno)nitrobenzene

  Stuhr-Hansen, N., Götze, T. F., Henriksen, L., Sølling, T. I., Langkilde, A. E. & Sørensen, H. O., 2009, In: Heteroatom Chemistry. 20, 2, p. 101-108

  Research output: Contribution to journal › Journal article › Research › peer-review

  5 Citations (Scopus)
• 2008

  High resolution X-ray diffraction of macromolecular crystals: The challenge of obtaining accurate data and extracting valid information

  Langkilde, A. E., 2008, Kemisk Institut, Københavns Universitet.

  Research output: Book/Report › Ph.D. thesis

• Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

  Langkilde, A. E., Kristensen, S. M., Lo Leggio, L., Mølgaard, A., Jensen, J. H., Houk, A. R., Poulsen, J-C. N., Larsen, S. Y. & Kauppinen, S., 2008, In: Acta Crystallographica. Section D: Biological Crystallography. 64, p. 851-863

  Research output: Contribution to journal › Journal article › Research › peer-review

  31 Citations (Scopus)
• 2005

  Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

  Barfod, R., Eriksen, J., Golding, B. T., Hammershøi, A., Jacobsen, T. A., Langkilde, A. E., Larsen, S., Mønsted, O., Sargeson, A. M. & Sørensen, H. O., 2005, In: Dalton Transactions (Print Edition). 3, p. 491-500 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  8 Citations (Scopus)
• 2004

  Structures of three salts of phthalic acid; variation in crystal packing and geometry of the hydrogen phthalate ion

  Langkilde, A. E., Madsen, D. & Larsen, S., 2004, In: Acta Crystallographica. B60, p. 502-511

  Research output: Contribution to journal › Journal article › Research › peer-review

  15 Citations (Scopus)
• 2002

  Diastereomeric salts of lactic acid and 1-phenylethylamine, their structures and relative stabilities

  Langkilde, A. E., Oddershede, J. & Larsen, S., 2002, In: Acta Crystallographica B. 58, p. 1044-1050

  Research output: Contribution to journal › Journal article › Research › peer-review

  8 Citations (Scopus)