Anders Skov Kristensen

2018

Modeling and Mutational Analysis of the Binding Mode for the Multimodal antidepressant Drug Vortioxetine to the Human 5-HT 3A Receptor

Ladefoged, L. K., Munro, L., Pedersen, A. J., Lummis, S. C. R., Bang-andersen, B., Balle, T., Schiøtt, B. & Kristensen, A. S., 1 Dec 2018, In: Molecular Pharmacology. 94, 6, p. 1421-1434

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

2017

Identification and Characterization of the Binding Pocket for Negative Allosteric Modulators in AMPA Receptors

Stenum-Berg, C., Abiega, S. C., Thisted, C. L. & Kristensen, A. S., 3 Feb 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, p. 418A-418A

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

2016

Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands

Andersen, J., Ladefoged, L. K., Kristensen, T. N. B., Munro, L., Grouleff, J., Stuhr-Hansen, N., Kristensen, A. S., Schiøtt, B. & Strømgaard, K., 19 Oct 2016, In: A C S Chemical Neuroscience. 7, 10, p. 1406-1417 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

Kristensen, A. S., Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, R. P., Gajhede, M., Kastrup, J. S. & Traynelis, S. F., 1 Feb 2016, In: Molecular Pharmacology. 89, 2, p. 253-262 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Structural rearrangement of the intracellular domains during AMPA receptor activation

Zachariassen, L. G., Katchan, L., Jensen, A. G., Pickering, D. S., Plested, A. & Kristensen, A. S., 5 Jul 2016, In: Proceedings of the National Academy of Sciences USA (PNAS). 113, 27, p. E3950-E3959 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter

Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, A. S., Bøgesø, K. P., Gether, U., Strømgaard, K., Bang-Andersen, B. & Loland, C. J., 1 Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

2015

Binding of ArgTX-636 in the NMDA receptor ion channel

Poulsen, M. H., Andersen, J., Christensen, R., Hansen, K. B., Traynelis, S. F., Strømgaard, K. & Kristensen, A. S., 16 Jan 2015, In: Journal of Molecular Biology. 427, 1, p. 176-89 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

11 Citations (Scopus)

Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter

Andersen, J., Ladefoged, L. K., Wang, D., Kristensen, T. N. B., Bang-Andersen, B., Kristensen, A. S., Schiøtt, B. & Strømgaard, K., 21 Sept 2015, In: A C S Chemical Neuroscience. 6, 11, p. 1892-900 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

Andersen, J., Ringsted, K. B., Bang-Andersen, B., Strømgaard, K. & Kristensen, A. S., 27 Oct 2015, In: Scientific Reports. 5, p. 1-12 12 p., 15650.

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation

Rannversson, H., Wilson, P., Kristensen, K. B., Sinning, S., Kristensen, A. S., Strømgaard, K. & Andersen, J., 5 Jun 2015, In: The Journal of Biological Chemistry. 290, 23, p. 14582-94 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Substrate and Inhibitor-Specific Conformational Changes in the Human Serotonin Transporter Revealed by Voltage-Clamp Fluorometry

Söderhielm, P. C., Andersen, J., Munro, L., Nielsen, A. T. & Kristensen, A. S., 1 Oct 2015, In: Molecular Pharmacology. 88, 4, p. 676-88 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

4 Citations (Scopus)

Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family

Nissen, K. B., Kedström, L. M. H., Wilbek, T. S., Nielsen, L. S., Åberg, E., Kristensen, A. S., Bach, A., Jemth, P. & Strømgaard, K., 6 Feb 2015, In: PLOS ONE. 10, 2, p. 1-17 17 p., e0117668.

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

2014

Analogues of 3-Hydroxyisoxazole-Containing Glutamate Receptor Ligands Based on the 3-Hydroxypyrazole-Moiety: Design, Synthesis and Pharmacological Characterization

Jørgensen, L., Nielsen, B., Pickering, D. S., Kristensen, A. S., Frydenvang, K. A., Madsen, U. & Clausen, R. P., 24 Sept 2014, In: Neurochemical Research. 39, 10, p. 1895-1905 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites

Sørensen, L., Strømgaard, K. & Kristensen, A. S., 18 Apr 2014, In: ACS chemical biology. 9, 4, p. 935-44 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Evaluation of PhTX-74 as Subtype-Selective Inhibitor of GluA2-Containing AMPA Receptors

Poulsen, M. H., Lucas, S., Strømgaard, K. & Kristensen, A. S., Feb 2014, In: Molecular Pharmacology. 85, 2, p. 261-268 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

12 Citations (Scopus)

Forster Resonance Energy Transfer (FRET) Analysis of Dual CFP/YFP Labeled AMPA Receptors Reveals Structural Rearrangement within the C-Terminal Domain during Receptor Activation

Zachariassen, L. G., Katchan, M., Plested, A., Pickering, D. S. & Kristensen, A. S., 16 Feb 2014. 1 p.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Inhibition of AMPA Receptors by Polyamine Toxins is Regulated by Agonist Efficacy and Stargazin

Poulsen, M. H., Lucas, S., Strømgaard, K. & Kristensen, A. S., 24 Sept 2014, In: Neurochemical Research. 39, 10, p. 1906-1913 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (prozac)

Andersen, J., Stuhr-Hansen, N., Zachariassen, L. G., Koldsø, H., Schiøtt, B., Strømgaard, K. & Kristensen, A. S., May 2014, In: Molecular Pharmacology. 85, 5, p. 703-14 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

46 Citations (Scopus)

Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

Pedersen, S. W., Pedersen, S. B., Anker, L., Hultqvist, G., Kristensen, A. S., Jemth, P. & Strømgaard, K., 2014, In: Nature Communications. 5, p. 1-11 11 p., 3215.

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors

Nørager, N. G., Poulsen, M. H., Jensen, A. G., Jeppesen, N. S., Kristensen, A. S. & Strømgaard, K., 12 Jun 2014, In: Journal of Medicinal Chemistry. 57, 11, p. 4940-9 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

2013

Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons

Nørager, N. G., Jensen, C. B., Rathje, M., Andersen, J., Madsen, K. L., Kristensen, A. S. & Strømgaard, K., 20 Sept 2013, In: A C S Chemical Biology. 8, 9, p. 2033-2041 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors

Poulsen, M. H., Lucas, S., Bach, T. B., Barslund, A. F., Wenzler, C., Jensen, C. B., Kristensen, A. S. & Strømgaard, K., 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 1171-1181 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

2012

A heteromeric snake toxin and the molecular details of pain perception

Strømgaard, K. & Kristensen, A. S., 23 Apr 2012, In: Angewandte Chemie International Edition. 51, 17, p. 4009-4011

Research output: Contribution to journal › Journal article › Research › peer-review

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

Bach, A., Clausen, B. H., Møller, M., Vestergaard, B., Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, J. S., Gajhede, M., Jemth, P., Kristensen, A. S., Lundström, P., Lambertsen, K. L. & Strømgaard, K. (., 28 Feb 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322

Research output: Contribution to journal › Journal article › Research › peer-review

118 Citations (Scopus)

General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors

Lucas, S., Poulsen, M. H., Nørager, N. G., Barslund, A. F., Bach, T. B., Kristensen, A. S. & Strømgaard, K., 26 Nov 2012, In: Journal of Medicinal Chemistry. 55, 22, p. 10297-10301 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S₁ substrate binding pocket

Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, A. G., Strømgaard, K. & Kristensen, A. S., 21 Dec 2012, In: The Journal of Biological Chemistry. 287, 52, p. 43694-43707 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket

Sørensen, L., Andersen, J., Thomsen, M., Hansen, S. M. R., Zhao, X., Sandelin, A. G., Strømgaard, K. & Kristensen, A. S., 21 Dec 2012, In: Journal of Biological Chemistry. 287, p. 43694-43707 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

54 Citations (Scopus)

2011

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

Bach, A., Eildal, J. N. N., Stuhr-Hansen, N., Deeskamp, R., Gottschalk, M., Pedersen, S. W., Kristensen, A. S. & Strømgaard, K. (. 1. A., 10 Mar 2011, In: Journal of Medicinal Chemistry. 54, 5, p. 1333-1346

Research output: Contribution to journal › Journal article › Research › peer-review

58 Citations (Scopus)

Mechanism of Ca²⁺/calmodulin-dependent kinase II regulation of AMPA receptor gating

Kristensen, A. S., Jenkins, M. A., Banke, T. G., Schousboe, A., Makino, Y., Johnson, R. C., Huganir, R. & Traynelis, S. F., 1 Jun 2011, In: Nature Neuroscience. 14, 6, p. 727-735

Research output: Contribution to journal › Journal article › Research › peer-review

160 Citations (Scopus)

Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters

Andersen, J., Stuhr-Hansen, N., Zachariassen, L., Toubro, S., Hansen, S. M. R., Eildal, J. N. N., Bond, A. D., Bøgesø, K. P., Bang-Andersen, B., Kristensen, A. S. & Strømgaard, K., 19 Jul 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 29, p. 12137-12142

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

Kristensen, A. S., Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Løland, C. J., Strømgaard, K. & Gether, U., 1 Sept 2011, In: Pharmacological Reviews. 63, 3, p. 585-640 56 p.

Research output: Contribution to journal › Journal article › Research › peer-review

480 Citations (Scopus)

Small molecules from spiders used as chemical probes

Olsen, C. A., Kristensen, A. S. & Strømgaard, K., 25 Nov 2011, In: Angewandte Chemie International Edition. 50, 48, p. 11296-11311

Research output: Contribution to journal › Review › peer-review

20 Citations (Scopus)

Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata

Barslund, A. F., Poulsen, M. H., Bach, T. B., Lucas, S., Kristensen, A. S. & Strømgaard, K., 25 Mar 2011, In: Journal of Natural Products. 74, 3, p. 483-486

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

The Value of Example Solutions in Pharmacy Education: The role of seniority and gender.

Sandelin, A. G., Hansen, H. R., Baldursdóttir, S. G., Kristensen, A. S., Bak, L. K., Christiansen, F. V. & Selhuber-Unkel, C. J. M., 2011, In: Pharmacy Education. 11, 1, p. 32-37 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2010

Antidepressive lægemidler: nu i 3D

Andersen, J., Sørensen, L., Strømgaard, K. & Kristensen, A. S., Dec 2010, In: Lægemiddelforskning. 2010, p. 25-27

Research output: Contribution to journal › Journal article › Communication

3461 Downloads (Pure)

Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: Discovery of nanomolar, nonselective, and use-dependent antagonists

Frølund, S., Bella, A., Kristensen, A. S., Ziegler, H. L., Witt, M., Olsen, C. A., Strømgaard, K., Franzyk, H. & Jaroszewski, J. W., 28 Oct 2010, In: Journal of Medicinal Chemistry. 53, 20, p. 7441-7451

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example

Chi, C. N., Bach, A., Gottschalk, M., Kristensen, A. S., Strømgaard, K. & Jemth, P., 3 Sept 2010, In: Journal of Biological Chemistry. 285, 36, p. 28252-28260

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter

Andersen, J., Olsen, L., Hansen, K. B., Taboureau, O., Jørgensen, F. S., Jørgensen, A. M., Bang-Andersen, B., Egebjerg, J., Strømgaard, K. & Kristensen, A. S., 15 Jan 2010, In: Journal of Biological Chemistry. 285, 3, p. 2051-2063

Research output: Contribution to journal › Journal article › Research › peer-review

76 Citations (Scopus)

2009

Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction

Bach, A., Chi, C. N., Pang, G. F., Olsen, L., Kristensen, A. S., Jemth, P. & Strømgaard, K., 2009, In: Angewandte Chemie - International Edition. 48, 51, p. 9685-9689

Research output: Contribution to journal › Journal article › Research › peer-review

41 Citations (Scopus)

Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction

Gottschalk, M., Bach, A., Hansen, J. L., Krogsgaard-Larsen, P., Kristensen, A. S. & Strømgaard, K., 2009, In: Neurochemical Research. 34, 10, p. 1729-1737

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Location of the antidepressant binding site in the serotonin transporter: importance of SER-438 in recognition of citalopram and tricyclic antidepressants

Andersen, J., Taboureau, O., Hansen, K. B., Olsen, L., Egebjerg, J., Strømgaard, K. & Kristensen, A. S., 2009, In: Journal of Biological Chemistry. 284, 15, p. 10276-10284

Research output: Contribution to journal › Journal article › Research › peer-review

92 Citations (Scopus)

Modulation of the dimer interface at ionotropic glutamate-like receptor d2 by D-serine and extracellular calcium

Hansen, K. B., Naur, P., Kurtkaya, N. L., Kristensen, A. S., Gajhede, M., Kastrup, J. S. & Traynelis, S. F., 2009, In: Journal of Neuroscience. 29, 4, p. 907-917

Research output: Contribution to journal › Journal article › Research › peer-review

38 Citations (Scopus)

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters

Andersen, J., Kristensen, A. S., Bang-Andersen, B. & Strømgaard, K., 2009, In: Chemical Communications. 25, p. 3677-3692

Research output: Contribution to journal › Journal article › Research › peer-review

77 Citations (Scopus)

Skræddersyede proteiner: uden naturens begrænsninger

Strømgaard, K., Jensen, M. S. & Kristensen, A. S., 2009, In: Lægemiddelforskning. p. 10-12

Research output: Contribution to journal › Journal article › Communication

1992 Downloads (Pure)

Synthesis and biological activity of argiotoxin 636 and analogues: selective antagonists for ionotropic glutamate receptors

Nelson, J. K., Frølund, S. U., Tikhonov, D. B., Kristensen, A. S. & Strømgaard, K., 2009, In: Angewandte Chemie - International Edition. 48, 17, p. 3087-3091

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

Clausen, R. P., Naur, P., Kristensen, A. S., Greenwood, J. R., Strange, M., Bräuner-Osborne, H., Jensen, A. A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, B., Pickering, D. S., Brehm, L., Gajhede, M., Krogsgaard-Larsen, P. & Kastrup, J. S., 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922

Research output: Contribution to journal › Journal article › Research › peer-review

20 Citations (Scopus)

2008

Electrophysiological characterization of analogues of philanthotoxin-343 on ionotropic glutamate receptors

Frølund, S. U., Ziegler, H. L., Franzyk, H., Strømgaard, K., Kristensen, A. S. & Jaroszewski, J. W., 2008.

Research output: Contribution to conference › Poster › Research

From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies

Eildal, J. N. N., Andersen, J., Kristensen, A. S., Jørgensen, A. M., Bang-Andersen, B., Jørgensen, M. & Strømgaard, K., 2008, In: Journal of Medicinal Chemistry. 51, 10, p. 3045-3048

Research output: Contribution to journal › Journal article › Research › peer-review

50 Citations (Scopus)

Protein-protein interaktion: et nyt mål for udvikling af lægemidler

Bach, A., Gottschalk, M., Kristensen, A. S. & Strømgaard, K., 2008, In: Lægemiddelforskning. p. 10-12

Research output: Contribution to journal › Journal article › Communication

2036 Downloads (Pure)

2007

Expressed protein ligation of ionotropic glutamate receptors

Jensen, M. S., Kristensen, A. S. & Strømgaard, K., 2007, In: Biopolymers. 88, 4, p. 602

Research output: Contribution to journal › Conference abstract in journal › Research

Anders Skov Kristensen

Research output

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