Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters

Jacob Andersen; Anders Skov Kristensen; Benny Bang-Andersen; Kristian Strømgaard

doi:10.1039/b903035m

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters

Jacob Andersen, Anders Skov Kristensen, Benny Bang-Andersen, Kristian Strømgaard

77 Citations (Scopus)

Abstract

The biogenic monoamine transporters are integral membrane proteins that perform active transport of extracellular dopamine, serotonin and norepinephrine into cells. These transporters are targets for therapeutic agents such as antidepressants, as well as addictive substances such as cocaine and amphetamine. Seminal advances in the understanding of the structure and function of this transporter family have recently been accomplished by structural studies of a bacterial transporter, as well as medicinal chemistry and pharmacological studies of mammalian transporters. This feature article focuses on antidepressant drugs that act on the serotonin and/or the norepinephrine transporters. Specifically, we focus on structure-activity relationships of these drugs with emphasis on relationships between their molecular properties and the current knowledge of transporter structure.

Original language	English
Journal	Chemical Communications
Issue number	25
Pages (from-to)	3677-3692
ISSN	1359-7345
DOIs	https://doi.org/10.1039/b903035m
Publication status	Published - 2009

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Former Faculty of Pharmaceutical Sciences

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10.1039/b903035m

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title = "Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters",

abstract = "The biogenic monoamine transporters are integral membrane proteins that perform active transport of extracellular dopamine, serotonin and norepinephrine into cells. These transporters are targets for therapeutic agents such as antidepressants, as well as addictive substances such as cocaine and amphetamine. Seminal advances in the understanding of the structure and function of this transporter family have recently been accomplished by structural studies of a bacterial transporter, as well as medicinal chemistry and pharmacological studies of mammalian transporters. This feature article focuses on antidepressant drugs that act on the serotonin and/or the norepinephrine transporters. Specifically, we focus on structure-activity relationships of these drugs with emphasis on relationships between their molecular properties and the current knowledge of transporter structure.",

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author = "Jacob Andersen and Kristensen, {Anders Skov} and Benny Bang-Andersen and Kristian Str{\o}mgaard",

note = "Keywords: Animals; Antidepressive Agents; Humans; Models, Molecular; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors; Structure-Activity Relationship",

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doi = "10.1039/b903035m",

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AU - Kristensen, Anders Skov

AU - Bang-Andersen, Benny

AU - Strømgaard, Kristian

N1 - Keywords: Animals; Antidepressive Agents; Humans; Models, Molecular; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors; Structure-Activity Relationship

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AB - The biogenic monoamine transporters are integral membrane proteins that perform active transport of extracellular dopamine, serotonin and norepinephrine into cells. These transporters are targets for therapeutic agents such as antidepressants, as well as addictive substances such as cocaine and amphetamine. Seminal advances in the understanding of the structure and function of this transporter family have recently been accomplished by structural studies of a bacterial transporter, as well as medicinal chemistry and pharmacological studies of mammalian transporters. This feature article focuses on antidepressant drugs that act on the serotonin and/or the norepinephrine transporters. Specifically, we focus on structure-activity relationships of these drugs with emphasis on relationships between their molecular properties and the current knowledge of transporter structure.

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JO - Chemical Communications

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ER -

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters

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