Primære forskningsområder

CV

CURRICULUM VITAE

Personal data

Name: Klaus Hansen

Nationality: Danish

Year of birth: 1962

Children: 2

Current position

2003 Associate professor, Biotech Research and Innovation Centre, University of Copenhagen

2008 Group leader at Biotech Research and Innovation Centre, University of Copenhagen

2013 Tenured group leader at Biotech Research and Innovation Centre, University of Copenhagen

Education

1990   M.Sc., Experimental Cell Biology, University of Southern Denmark, DK

1996 Ph.D., Doctor in Medical Sciences, Uppsala University, Ludwig Institute for Cancer Research (LICR), SE

1996-1998 Research Fellow, Danish Cancer Society, DK

Professional experience

1998-2003 Senior Researcher, Danish Cancer Society, DK

2003-   Associate Professor, Biotech Research and Innovation Centre, University of Copenhagen

Scientific focus

• Signalling to chromatin in epigenetics
• Polycomb protein biology in differentiation and disease

Academic activities

• Main supervisor for 2 graduated M.Sc. students and 4 graduated Ph.D. students.
• Several invited talks at international meetings and institutions.
• External Reviewer for international scientific journals such as Nature, Nature Cell biology, Nature Communications, Nature Reviews Molecular, Cellular Biology, Molecular Cell, Genes and Development etc.
• Reviewer for several granting agencies abroad.

International collaborations

• Several international collaborations related to our key focus areas.

Entrepreneurial achievements

• Co-founder of EpiTherapeutics ApS (2008); Company sold to Gilead, Inc 2015.
• Licensed antibodies for commercial use.
• Developed a software EaSeq for genome wide data analysis
• Collaborated with Prof. Henrik Semp at the Danish Stem Cell Centre and Novo Nordisk A/S, to develop insulin producing b-cells from human embryonic stem cells.

Publications (selected of 39)

• b-Catenin Regulates Primitive Streak Induction through collaborative Interactions with OCT4 and SMAD2/3. Nina S. Funa, Karen A. Schachter, Mads Lerdrup, Jenny Ekberg, Katja Hess, Nikolaj Dietrich, Christian Honore, Klaus Hansen and Henrik Semb. Cell Stem Cell  16, 1-14, June 4, 2015
• The lncRNA MIR31HG regulates p16^INK4A expression to modulate senescence. Marta Montes, Morten M Nielsen, Giulia Maglieri, Anders Jacobsen, Jonas Hørfeldt,  Shuchi Agrawal-Singh, Klaus Hansen, Kristian Helin, Harmen J G van de Werken, Jakob S Pedersenand Anders H Lund. Nature Communications 6: 6967, April 24, 2015
• A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-induced dyskinesia and DFosB expression. Michael Feyder, Erik Södersten, Emanuela Santini, Vincent Vialou, Quincey LaPlant, Emily Watts, Giada Spigolon, Klaus Hansen, Jocelyne Caboche, Eric Nestler, and Gilberto Fisone. Biological Psychiatry, July, 2014.
• Dopamine Signaling leads to loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism. Erik Södersten, Michael Feyder, Mads Lerdrup, Ana-Luisa Gomes, Hanna Kryh, Giada Spigolon, Jocelyne Caboche, Gilberto Fisone and Klaus Hansen. PLoS Genetics, September 25, 2014
• Nikolaj Dietrich, Mads Lerdrup, Eskild Landt, Shuchi Agrawal-Singh, Mads Bak, Niels Tommerup, Juri Rappsilber, Erik Södersten and Klaus Hansen. REST-Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells. PLoS Genetics, February 2012.
• Simmi Suman Gehani, Shuchi Agrawal-Singh, Nikolaj Dietrich, Nicolaj Strøyer Christophersen, Kristian Helin and Klaus Hansen. Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. Mol Cell, 2010 Sept. 24; 39: 886-900
• Klaus H. Hansen, Adrian Bracken, Diego Pasini, Simmi S. Gehani, Nikolaj Dietrich, Astrid Monrad, Juri Rappsilber, Mads Lerdrup and Kristian Helin. A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol. 2008 Nov;10(11):1291-300.
• Pasini D, Hansen KH, Christensen J, Agger K, Cloos PA and Helin K. Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev 2008, May 15; 22(10):1345-55
• Jesper Christensen; Karl Agger; Paul A Cloos; Diego Pasini; Simon Rose; Lau Sennels; Juri Rappsilber; Klaus H Hansen; Anna E Salcini; Kristian Helin. The Retinoblastoma bindning protein 2 belongs to a family of demethylases specific for tri-, and di-methyl lysine 4 on histone H3. Cell,  2007,128, 1-14, March 23
• Adrian P. Bracken, Daniela Kleine-Kohlbrecher, Dieogo Pasini, Nikolaj Dietrich, Gaetano Gargiulo, Chantal Beekman, Kim Theilgaard-Mönch, Saverio Minucci, Bo T. Porse, Jean-Christophe Marine, Klaus H. Hansen and Kristian Helin. The Polycomb group proteins bind througout the INK4A-ARF locus and are disassociated in  senescent cells. Genes Dev. 2007 21: 525-530
• Nikolaj Dietrich, Adrian Bracken, Emmanuelle Trinh, Kristian Helin and Klaus H. Hansen. Bypass of senescence by the polycomb protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J. 2007 Mar 21;26(6):1637-48

•   Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, Hansen KH and  Helin K. The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature. 2006 Jul 20: 442(7100): 307-11

• Adrian Bracken, Nikolaj Dietrich, Diego Pasini, Klaus H. Hansen and Kristian Helin. Genome-wide Mapping of Polycomb Target Genes Unravels their Roles in Cell Fate Transitions. Genes Dev. 2006 May 1;20(9):1123-36.