Michael Gajhede

Publikation

Publikationer pr. år 1985 2001 2005 2006 2007 2008 2009 2011 2012 2013 2019

• 127 Tidsskriftartikel
• 6 Datasæt
• 1 Kommentar/debat
• 1 Letter
• 1 Mere
  • 1 Review

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2019

  Molecular architecture of the Jumonji C family histone demethylase KDM5B

  Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, O., Lousen, R., Bucciarelli, S., Mehta, V., Sellés-Baiget, S., Solbak, S. M. Ø., Bach, A., Mesa, P., Hernandez, P. A., Montoya, G., Nguyen, T. T. T. N., Rand, K. D., Boesen, T. & Gajhede, M., 1 dec. 2019, I: Scientific Reports. 9, 13 s., 4019.

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  • Histone Demethylases 100%
  • Lysine 66%
  • Histones 64%
  • Electron Microscopy 59%
  • Hydrogen Deuterium Exchange-Mass Spectrometry 58%
  3 Citationer (Scopus)

  57 Downloads (Pure)

• Molecular Dynamics Simulations Reveal the Proton:Peptide Coupling Mechanism in the Bacterial Proton-Coupled Oligopeptide Transporter YbgH

  Aduri, N. G., Montefiori, M., Khalil, R., Gajhede, M., Jørgensen, F. S. & Mirza, O., 25 jan. 2019, I: ACS Omega. 4, 1, s. 2040-2046 7 s.

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  • Oligopeptides 100%
  • Peptide Coupling 76%
  • Peptides 68%
  • Protons 62%
  • Oligopeptide 60%
• 2018

  Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state

  Aduri, N. G., Ernst, H. A., Prabhala, B. K., Bhatt, S., Boesen, T., Gajhede, M. & Mirza, O., 8 jan. 2018, I: Biochemical and Biophysical Research Communications. 495, 2, s. 1738-1743 6 s.

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  • Folic Acid Transporters 100%
  • Glycols 83%
  • Maltose 76%
  • Folate 67%
  • Folic Acid 65%
  3 Citationer (Scopus)

• Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

  Backe, M. B., Andersson, J. L., Bacos, K., Christensen, D. P., Hansen, J. B., Dorosz, J. J., Gajhede, M., Dahlby, T., Bysani, M., Kristensen, L. H., Ling, C., Olsen, L. & Mandrup-Poulsen, T., 15 jan. 2018, I: Molecular and Cellular Endocrinology. 460, s. 47-56 10 s.

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  • GSK-J4 100%
  • Insulin Derivative 68%
  • Lysine 65%
  • Apoptosis 40%
  • Gene Expression 40%
  13 Citationer (Scopus)

• Peptides Derived from Histone 3 and Modified at Position 18 Inhibit Histone Demethylase KDM6 Enzymes

  Jones, S. E., Olsen, L., Dorosz, J., Seger, S. T., Andersson, J. L., Kristensen, L. H. & Gajhede, M., 4 sep. 2018, I: ChemBioChem. 19, 17, s. 1817-1822

  Publikation: Bidrag til tidsskrift › Letter › peer review

  • Histone Demethylases 100%
  • Histone 73%
  • Histones 64%
  • Peptides 43%
  • Peptide 39%

• Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity

  Jones, S. E., Olsen, L. & Gajhede, M., 6 feb. 2018, I: Biochemistry. 57, 5, s. 585–592

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  • Histone Demethylases 100%
  • Histone 73%
  • Lysine 66%
  • Histones 64%
  • Zinc 52%
  9 Citationer (Scopus)

• The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

  Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, P. R., Brasen, C., Gajhede, M., Rahman, M. & Mirza, O., 19 jan. 2018, I: The Journal of Biological Chemistry. 293, s. 1007-1017

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  • Oligopeptides 100%
  • Chloramphenicol 88%
  • Oligopeptide 84%
  • Protons 74%
  • Escherichia coli 51%
  7 Citationer (Scopus)
• 2017

  Expression, purification and characterization of the human MTA2-RBBP7 complex

  Brasen, C., Dorosz, J., Wiuf, A., Boesen, T., Mirza, O. & Gajhede, M., 1 maj 2017, I: Biochimica et biophysica acta. 1865, 5, s. 531-538 8 s.

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  • Nucleosomes 100%
  • Histone 91%
  • Histones 79%
  • Purification 57%
  • Deacetylation 57%
  4 Citationer (Scopus)

• Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR

  Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, M., Hansen, P. R. & Mirza, O., jun. 2017, I: Research in Microbiology. 168, 5, s. 443-449

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  • Oligopeptides 100%
  • Protons 74%
  • Escherichia coli 51%
  • Pharmaceutical Preparations 30%
  • ubenimex 27%
  6 Citationer (Scopus)

• Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8

  Dorosz, J., Olsen, L., Seger, S. T., Steinhauer, C., Bouras, G., Helgstrand, C., Wiuf, A. & Gajhede, M., 18 jul. 2017, I: ChemBioChem. 18, 14, s. 1369-1375 7 s.

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  • Histone Demethylases 100%
  • Histone 73%
  • Histones 64%
  • Cyclic Peptides 49%
  • Cyclic Peptide 32%
  1 Citationer (Scopus)

• The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region

  Tapken, D., Steffensen, T. B., Leth, R., Kristensen, L. B., Gerbola, A., Gajhede, M., Jørgensen, F. S., Olsen, L. & Kastrup, J. S., 7 apr. 2017, I: Scientific Reports. 7, 12 s., 46145.

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  • Ionotropic Glutamate Receptors 100%
  • Serine 72%
  • Ligands 35%
  • Calorimetry 34%
  • Electrophysiology 27%
  8 Citationer (Scopus)

  86 Downloads (Pure)

• The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1

  Meno, K. H., Kastrup, J. S., Kuo, I-C., Chua, K. Y. & Gajhede, M., 1 apr. 2017, I: Allergy. 72, 4, s. 665-670 6 s., 13111.

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  • Dermatophagoides pteronyssinus antigen p 1 100%
  • Mites 79%
  • Allergens 59%
  • Epitopes 54%
  • Immunoglobulin E 39%
  8 Citationer (Scopus)
• 2016

  Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

  Kristensen, A. S., Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, R. P., Gajhede, M., Kastrup, J. S. & Traynelis, S. F., 1 feb. 2016, I: Molecular Pharmacology. 89, 2, s. 253-262 10 s.

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  • Glutamic Acid 100%
  • Ligands 80%
  • Pharmacology 75%
  • 7-chlorokynurenic acid 39%
  • quinoline 32%
  12 Citationer (Scopus)

• Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine Binding Protein as a Structural Surrogate

  Shahsavar, A., Gajhede, M., Kastrup, J. S. & Balle, T., 1 jun. 2016, I: Basic & Clinical Pharmacology & Toxicology Online. 118, 6, s. 399–407 9 s.

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  • Nicotinic Receptors 100%
  • Acetylcholine 96%
  • Carrier Proteins 76%
  • Drug 47%
  • Protein 37%
  23 Citationer (Scopus)
• 2015

  Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

  Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, J. S., Balle, T. & Gajhede, M., 1 okt. 2015, I: Molecular Pharmacology. 88, 4, s. 697-707 11 s.

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  • Lymnaea AChBP protein 100%
  • Nicotinic Receptors 69%
  • Acetylcholine 58%
  • Carrier Proteins 53%
  • Binding Sites 48%
  17 Citationer (Scopus)

• Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface

  Ahring, P. K., Olsen, J. A., Nielsen, E. Ø., Peters, D., Pedersen, M. H. F., Rohde, L. A., Kastrup, J. S. J., Shahsavar, A., Indurthi, D. C., Chebib, M., Gajhede, M. & Balle, T., maj 2015, I: Neuropharmacology. 92, s. 135-45 11 s.

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  • epibatidine 100%
  • Nicotinic Receptors 68%
  • Ligands 43%
  • Binding Sites 31%
  • Acetylcholine 19%
  18 Citationer (Scopus)

• Structure and binding properties of a cameloid nanobody raised against KDM5B

  Wiuf, A., Kristensen, L. H., Kristensen, O., Dorosz, J., Jensen, J. & Gajhede, M., 1 okt. 2015, I: Acta crystallographica. Section F, Structural biology communications. 71, Pt 10, s. 1235-1241 7 s.

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  • Single-Domain Antibodies 100%
  • Crystallization 81%
  • Asymmetric Unit 63%
  • P4322 61%
  • crystallization 51%
  4 Citationer (Scopus)
• 2014

  L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

  Krintel, C., Frydenvang, K., Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, M., Pickering, D. S. & Kastrup, J. S., maj 2014, I: F E B S Journal. s. 2422–2430 9 s.

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  • Ionotropic Glutamate Receptors 100%
  • varespladib methyl 78%
  • Glutamate Receptors 67%
  • Ligands 52%
  • Purification 50%
  12 Citationer (Scopus)

• Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors

  Olsen, J. A., Balle, T., Gajhede, M., Ahring, P. K. & Kastrup, J. S. J., 17 mar. 2014, I: PLOS ONE. 9, 3, s. e91232 8 s.

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  • Acetylcholine 100%
  • Molecular recognition 95%
  • Carrier Proteins 89%
  • nicotinic receptors 74%
  • Crystal structure 71%
  28 Citationer (Scopus)

• Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

  Venskutonyte, R., Larsen, A. P., Frydenvang, K. A., Gajhede, M., Gefflaut, T., Pickering, D. S., Bunch, L. & Kastrup, J. S. J., 1 okt. 2014, I: ChemMedChem. 9, 10, s. 2254-2259 6 s.

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  • GluK3 kainate receptor 100%
  • Kainic Acid Receptors 62%
  • Molecular Recognition 45%
  • Glutamic Acid 40%
  • Ligands 32%
  7 Citationer (Scopus)

• Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors

  Olsen, J. A., Ahring, P. K., Kastrup, J. S. J., Gajhede, M. & Balle, T., 5 sep. 2014, I: The Journal of Biological Chemistry. 289, 36, s. 24911-21 11 s.

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  • 3-(3-(pyridine-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile 100%
  • Nicotinic Receptors 51%
  • Acetylcholine 49%
  • Agonist 33%
  • Cysteine Loop Ligand-Gated Ion Channel Receptors 32%
  26 Citationer (Scopus)
• 2013

  Chemical and thermal unfolding of calreticulin

  Duus, K., Larsen, N., Tran, T. A. T., Güven, E., Skov, L. K., Jespersgaard, C., Gajhede, M. & Houen, G., maj 2013, I: Protein and Peptide Letters. 20, s. 562-568

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  • Calreticulin 100%
  • Fluorescent Dye 75%
  • Urea 56%
  • Hot Temperature 55%
  • Chemical Stability 44%
  3 Citationer (Scopus)

• Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

  Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, B., Gajhede, M., Kastrup, J. S., Jensen, A. A., Pickering, D. S., Frydenvang, K., Gefflaut, T. & Bunch, L., 28 feb. 2013, I: Journal of Medicinal Chemistry. 56, 4, s. 1614-1628

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  • Excitatory Amino Acid 100%
  • Amino Acid Transport Systems 93%
  • Ionotropic Glutamate Receptors 91%
  • Excitatory Amino Acids 86%
  • Structure-Activity Relationship 80%
  32 Citationer (Scopus)

• Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

  Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, M., Pickering, D. S., Traynelis, S. F., Kastrup, J. S. & Bräuner-Osborne, H., 15 nov. 2013, I: The Journal of Biological Chemistry. 288, s. 33124-35 12 s.

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  • N Methyl Dextro Aspartic Acid Receptor Blocking Agent 100%
  • Glycine 67%
  • N-Methyl-D-Aspartate Receptors 66%
  • Antagonist 61%
  • Binding Sites 51%
  17 Citationer (Scopus)

• Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

  Fiorentini, M., Bach, A., Strømgaard, K., Kastrup, J. S. & Gajhede, M., apr. 2013, I: Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, s. 587-94 8 s.

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  • Guanylate Kinases 100%
  • PDZ Domains 91%
  • X Ray Crystallography 89%
  • Fluorescence Polarization 89%
  • Fluorescence Spectrometry 84%
  5 Citationer (Scopus)

• Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

  Harpsøe, K., Hald, H., Timmermann, D. B., Jensen, M. L., Dyhring, T., Nielsen, E. Ø., Peters, D., Balle, T., Gajhede, M., Kastrup, J. S. J. & Ahring, P. K., 25 jan. 2013, I: Journal of Biological Chemistry. 288, 4, s. 2559-2570 12 s.

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  • 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene 100%
  • cytisine 65%
  • Cytisine 64%
  • Nicotinic Receptors 44%
  • Acetylcholine 42%
  19 Citationer (Scopus)

• Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

  Krintel, C., Harpsøe, K., Zachariassen, L. G., Peters, D., Frydenvang, K., Pickering, D. S., Gajhede, M. & Kastrup, J. S., sep. 2013, I: Acta crystallographica. Section D, Biological crystallography. 69, Pt 9, s. 1645-52 8 s.

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  • 1-(quinoxalin-6-ylcarbonyl)piperidine 100%
  • AMPA Receptors 59%
  • Glutamate Receptors 54%
  • varespladib methyl 52%
  • Ligands 35%
  8 Citationer (Scopus)

• Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists

  Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, A. A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, J. S., Gajhede, M., Frølund, B. & Balle, T., 14 feb. 2013, I: Journal of Medicinal Chemistry. 56, 3, s. 940-951

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  12 Citationer (Scopus)

• The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology

  Skov, L. K., Pizzut-Serin, S., Remaud-Simeon, M., Ernst, H. A., Gajhede, M. & Mirza, O. A., sep. 2013, I: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, Pt 9, s. 973-8 6 s.

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  • amylosucrase 100%
  • Deinococcus 75%
  • Sucrose 44%
  • Catalytic Domain 43%
  • topology 41%
  21 Citationer (Scopus)

• Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.

  Olsen, J. A., Kastrup, J. S. J., Peters, D., Gajhede, M., Balle, T. & Ahring, P. K., 13 dec. 2013, I: Journal of Biological Chemistry. 288, 50, s. 35997 10 s.

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  • 3-(3-(pyridine-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile 100%
  • Cysteine Loop Ligand-Gated Ion Channel Receptors 81%
  • Allosteric Site 65%
  • Nicotinic Receptors 51%
  • Acetylcholine 49%
  33 Citationer (Scopus)
• 2012

  A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

  Bach, A., Clausen, B. H., Møller, M., Vestergaard, B., Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, J. S., Gajhede, M., Jemth, P., Kristensen, A. S., Lundström, P., Lambertsen, K. L. & Strømgaard, K. C., 28 feb. 2012, I: Proceedings of the National Academy of Sciences of the United States of America. 109, 9, s. 3317-3322

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  • Tat-NPEG4(IETDV)2 100%
  • Disks Large Homolog 4 Protein 61%
  • Brain 20%
  • Ternary Complex Factors 17%
  • X Ray Crystallography 13%
  118 Citationer (Scopus)

• Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

  Shahsavar, A., Kastrup, J. S., Nielsen, E. Ø., Kristensen, J. L., Gajhede, M. & Balle, T., 22 aug. 2012, I: P L o S One. 7, 8, s. e40757

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  • Lymnaea AChBP protein 100%
  • Acetylcholine 84%
  • Antagonism 78%
  • Carrier Proteins 75%
  • Crystal Structure 65%
  35 Citationer (Scopus)

• Identification of catechols as histone-lysine demethylase inhibitors

  Nielsen, A. L., Kristensen, L. H., Stephansen, K. B., Kristensen, J. B. L., Helgstrand, C., Lees, M., Cloos, P., Helin, K., Gajhede, M. & Olsen, L., 24 apr. 2012, I: F E B S Letters. 586, 8, s. 1190-4 5 s.

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  • Catechols 100%
  • Histone Demethylases 88%
  • Catechol 61%
  • Occurrence in Nature 50%
  • catechol 42%
  29 Citationer (Scopus)

• Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

  Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, K., Gajhede, M., Kastrup, J. S. & Balle, T., 3 feb. 2012, I: The Journal of Biological Chemistry. 287, 6, s. 4248-4259

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  • 1,4-diazepane 100%
  • Lymnaea AChBP protein 90%
  • nicotinic receptor alpha4beta2 89%
  • Crystallography 61%
  • Halogens 61%
  39 Citationer (Scopus)

• Kainate induces various domain closures in AMPA and kainate receptors

  Venskutonyte, R., Frydenvang, K., Hald, H., Rabassa, A. C. D., Gajhede, M., Ahring, P. K. & Kastrup, J. S., sep. 2012, I: Neurochemistry International. 61, 4, s. 536-545

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  • Kainic Acid Receptors 100%
  • AMPA Receptors 87%
  • Kainic Acid 85%
  • Ligands 34%
  • Glutamic Acid 21%
  10 Citationer (Scopus)

• Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

  Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, B., Gajhede, M., Kastrup, J. S. J., Bunch, L., Frydenvang, K. & Pickering, D. S., okt. 2012, I: Journal of Structural Biology. 180, 1, s. 39-46

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  • Calcium Gluconate 100%
  • Ionotropic Glutamate Receptors 91%
  • Glutamic Acid 59%
  • Pharmacology 45%
  • AMPA Receptors 26%
  9 Citationer (Scopus)

• Snegleprotein øger forståelsen af vigtige receptorer i hjernen

  Shahsavar, A., Nielsen, E. Ø., Kristensen, J. L., Gajhede, M., Balle, T. & Kastrup, J. S. J., 2012, I: Lægemiddelforskning. 2012, s. 48-50 3 s.

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• Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

  Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, P., Kastrup, J. S., Helin, K., Olsen, L. & Gajhede, M., jun. 2012, I: F E B S Journal. 279, 11, s. 1905-1914

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  • 2,4-pyridinedicarboxylic acid 100%
  • H3K4Me3 86%
  • Histone Demethylases 67%
  • histone H3 trimethyl Lys4 66%
  • Jumonji Domain-Containing Histone Demethylases 58%
  51 Citationer (Scopus)

• Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

  Krintel, C., Frydenvang, K., Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, M. & Kastrup, J. S., 1 jan. 2012, I: Biochemical Journal. 441, 1, s. 173-178

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  • 4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide 100%
  • Ionotropic Glutamate Receptors 53%
  • Thermodynamics 48%
  • Glutamate Receptors 44%
  • IDRA 21 28%
  29 Citationer (Scopus)
• 2011

  Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate

  Venskutonyte, R., Frydenvang, K., Gajhede, M., Bunch, L., Pickering, D. S. & Kastrup, J. S., dec. 2011, I: Journal of Structural Biology. 176, 3, s. 307-314

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  • Ionotropic Glutamate Receptors 100%
  • Glutamic Acid 65%
  • Binding Sites 57%
  • Ligands 52%
  • Gluk1 kainate receptor 21%
  17 Citationer (Scopus)

• Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

  Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, J. L., Kastrup, J. S., Clausen, R. P., Olsen, L. & Gajhede, M., 23 jun. 2011, I: F E B S Letters. 585, 12, s. 1951-1956

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  • Histone Demethylases 100%
  • Oncogenic 96%
  • Enzyme Kinetics 83%
  • Histone 73%
  • Kinetics 49%
  15 Citationer (Scopus)

• Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1

  Holm, J., Ferreras, M., Ipsen, H., Würtzen, P. A., Gajhede, M., Larsen, J. N., Lund, K. & Spangfort, M. D., 20 maj 2011, I: Journal of Biological Chemistry. 286, 20, s. 17569-17578

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  • Malus 100%
  • Allergen 93%
  • Epitope 76%
  • Allergens 70%
  • Epitopes 64%
  28 Citationer (Scopus)

• Inhibitors of histone demethylases

  Lohse, B., Kristensen, J. L., Kristensen, L. H., Agger, K., Helin, K., Gajhede, M. & Clausen, R. P., 15 jun. 2011, I: Bioorganic & Medicinal Chemistry. 19, 12, s. 3625-3636 11 s.

  Publikation: Bidrag til tidsskrift › Review › peer review

  • Histone Demethylases 100%
  • Demethylation 81%
  • Histone 73%
  • Lysine 65%
  • Enzyme Inhibitors 39%
  83 Citationer (Scopus)

• Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule

  Kulahin, N., Kristensen, O., Rasmussen, K. K., Olsen, L., Rydberg, P., Vestergaard, B., Kastrup, J. S., Berezin, V., Bock, E., Walmod, P. S. & Gajhede, M., 9 feb. 2011, I: Structure. 19, 2, s. 203-211

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  • Structural Models 100%
  • Dimerization 96%
  • Cell Adhesion Molecules 94%
  • Fibronectin Type III Domain 67%
  • Immunoglobulin Domains 55%
  19 Citationer (Scopus)

• Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

  Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, M., Clausen, R. P. & Kristensen, J. L., 19 sep. 2011, I: Angewandte Chemie International Edition. 50, 39, s. 9100-9103

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  • Amino acids 100%
  • Histone 90%
  • Lysine 79%
  • Amino-Acid Residue 75%
  • Substrates 58%
  30 Citationer (Scopus)
• 2010

  Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

  Owczarek, S., Kiryushko, D., Hald Larsen, M., Kastrup, J. S. J., Gajhede, M., Sandi, C., Berezin, V., Bock, E. & Soroka, V., apr. 2010, I: The FASEB Journal. 24, 4, s. 1139-1150 12 s.

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  • Receptor, Fibroblast Growth Factor, Type 1 100%
  • Fibroblast Growth Factor Receptors 88%
  • Immunoglobulins 24%
  • Protein Isoforms 22%
  • Peptides 17%
  34 Citationer (Scopus)

• Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus

  Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, M., Kastrup, J. S. & Mirza, O. A., jun. 2010, I: Protein Expression and Purification. 71, 2, s. 179-183

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  • Alanine 100%
  • Serine 95%
  • Cysteine 92%
  • human SLC7A10 protein 47%
  • Gastrin-Secreting Cells 25%
  1 Citationer (Scopus)
• 2009

  At være eller ikke være en antagonist

  Frydenvang, K. A., Naur, P., Gajhede, M. & Kastrup, J. S. J., 2009, I: Lægemiddelforskning. s. 43-45

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Formidling

  2064 Downloads (Pure)

• Crystal structure of NCAM2 IgIV-Fn3I

  Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, J. S. J., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, M., 2009

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• Crystal structure of NCAM2 IgIV-Fn3II

  Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, J. S. J., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, M., 2009

  Publikation: Bidrag der ikke har en tekstform › Datasæt › Forskning