Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

TY - JOUR

T1 - Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

AU - Holst, J J

AU - Orskov, C

AU - Nielsen, O V

AU - Schwartz, T W

PY - 1987

Y1 - 1987

N2 - By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.

AB - By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.

KW - Animals

KW - Glucagon

KW - Ileum

KW - Insulin

KW - Intestinal Mucosa

KW - Peptides

KW - Swine

M3 - Journal article

C2 - 3542566

SN - 0014-5793

VL - 211

SP - 169

EP - 174

JO - F E B S Letters

JF - F E B S Letters

IS - 2

ER -